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Outpatient Management of Sickle Cell Disease: Assessment of 13 Years Follow-Up of Pediatric Patients at the Sylvanus Olympio university Hospital

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Open Journal of Pediatrics 2022年第2期12卷 413-423页

作者： Koffi Mawuse Guedenon Djatougbe Ayaovi Elie Akolly Essohana Padaro Ounoo Elom Takassi Etsè Akpako Balakibawi Esso Kokou Dzata Adama Dodji Gbadoe Department of Pediatrics CHU Sylvanus Olympio University of Lomé Lomé Togo Department of Hematology CHU Campus University of Lomé LoméTogo university of maryland medical Systems/midtown campus Baltimore MD USA

Objective: To evaluate thirteen years of ambulatory follow-up of patients with major forms of sickle cell disease. Methods: This was a study of 1055 records of sickle cell patients aged 6 months to 45 years followed between 2006 and 2018. Results: Six hundred and eighty-one (64.5%) homozygous SS, 283 (26.8%) SC, 86 (8.2%) SF, 4 (0.4%) S? thalassemia and 1 (0.1%) SD sickle cell patients were followed. The majority of the patients (97.9%) were living in the capital city of Lomé and its surrounding suburbs. Most children (67.3%) were less than 5-year-old when they were diagnosed with sickle cell disease, and only 21.3% of cases were discovered before the first year birthday of the patients. Osteo-articular vaso occlusive crisis (VOC) was the principal symptom at the onset of the diagnosis, approximately 28.9% of the cases, followed by severe anemia (19%), then hand-foot syndrome in 15.6%. The systematic screening was performed in 5.4%. Twenty-six percent were G6PD deficient, 4 were HIV immunocompromised, and 29.7% were transfused. Among the degenerative complications, 2.4% had retinopathy, 1.9% osteonecrosis of the femoral head, 1.4% leg ulcers, and 0.8% cardiomyopathy. Salmonella typhi was the main cause of infection, 51.4% of the cases. The mean baseline hemoglobin level (n = 27) was 7.67 ± 1.64 g/dl. Four (0.4%) patients had a splenectomy. The mortality rate was 2.4%. The primary cause of death was anemia (28%), followed by sepsis in 20% of the cases. One case of suicide was documented as the cause of death. Conclusion: Outpatient medical follow-up of sickle cell patients is essential in sub-Saharan African countries where neonatal screening does not exist, and diagnosis is often late. The improvement in quality of life observed should be studied.

关键词： Sickle Cell Disease Outpatient Follow-Up Lomé

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Is endoscopic retrograde appendicitis therapy a better modality for acute uncomplicated appendicitis? A systematic review and metaanalysis

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World Journal of Clinical Cases 2021年第33期9卷 10208-10221页

作者： Ying Wang Chen-Yu Sun Jie Liu Yue Chen Chandur Bhan John Pocholo Whitaker Tuason Sudha Misra Yu-Ting Huang Shao-Di Ma Xing-Yu Cheng Qin Zhou Wen-Chao Gu Dan-Dan Wu Xia Chen Department of Endoscopy center The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Internal Medicine AMITA Health Saint Joseph Hospital ChicagoChicagoIL 60657United States Department of Gastroenterology The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina Department of Clinical Medicine School of the First Clinical MedicineAnhui Medical UniversityHefei 230032Anhui ProvinceChina university of maryland medical center midtown campus BaltimoreMD 21201United States Department of Epidemiology and Health Statistics School of Public Health Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Radiation Oncology Mayo ClinicRochesterMN 55905United States Department of Diagnostic Radiology and Nuclear Medicine Gunma University Graduate School of MedicineMaebashi 371-8511Japan Department of Nursing The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefei 230001Anhui ProvinceChina

BACKGROUND Previous studies had shown endoscopic retrograde appendicitis therapy(ERAT)is an effective treatment for acute ***,different studies reported conflicting outcomes regarding the effectiveness of ERAT in comparison with laparoscopic appendectomy(LA).AIM To compare the effectiveness of ERAT with *** Randomized controlled trials(RCTs)and retrospective studies of ERAT for acute uncomplicated appendicitis were searched in PubMed,Cochrane Library,Web of Science,Embase database,China National Knowledge Infrastructure(CNKI),the WanFang Database,and Chinese Scientific Journals Database(VIP)from the establishment date to March *** was assessed using the Isquared *** odds ratios(OR),weighted mean difference(WMD),and standard mean difference(SMD),with 95%confidence intervals(CI)were calculated through either fixed-effects or random-effects *** analysis was also *** bias was tested by Egger's test,and Begg’s *** quality of included RCT were evaluated by the Jadad scale,while Newcastle-Ottawa scale is adopted for assessing the methodological quality of case-control *** statistical analysis was performed using Stata 15.1 statistical *** statistical analysis was performed using Stata 15.1 statistical *** study is registered with PROSPERO,*** After screening,10 RCTs and 2 case-control studies were included in the current systematic ***,the length of hospitalizations[WMD=-1.15,95%CI:-1.99,-0.31;P=0.007]was shorter than LA ***,the level of postoperative CRP[WMD=-10.06,95%CI:(-17.39,-2.73);P=0.007],TNF-α[WMD=-7.70,95%CI:(-8.47,-6.93);P<0.001],and IL-6 Levels[WMD=-9.78,95%CI:(-10.69,-8.88);P<0.001;P<0.001]in ERAT group was significantly lower than LA ***,ERAT group had a lower incidence of intestinal obstruction than LA group.[OR=0.19,95%CI:(0.05,0.79);P=0.020].Moreover,the quality of 10 RCTs were low with 0-3 J

关键词： Endoscopic retrograde appendicitis therapy Acute appendicitis Meta analysis Laparoscopic appendectomy Randomized controlled study

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Robust Transcriptional Activation in Plants Using Multiplexed CRISPR-Act2.0 and mTALE-Act Systems

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Molecular Plant 2018年第2期11卷 245-256页

作者： Levi G. Lowder Jianping Zhou Yingxiao Zhang Aimee Malzahn Zhaohui Zhong Tzung-Fu Hsieh Daniel F. Voytas Yong Zhang Yiping Qi Department of Biology East Carolina University Greenville NC 27858 USA Department of Biotechnology School of Life Science and Technology Center for informational Biology University of Electronic Science and Technology of ChinaChengdu 610054 China Department of Plant Science and Landscape Architecture University of Maryland College Park MD 20742 USA Department of Plant and Microbial Biology and Plants for Human Health Institute North Carolina State University North Carolina Research Campus KannapolisNC 28O81 USA Department of Genetics Ceil Biology and Development Center for Genome Engineering University of Minnesota Minneapolis MN 55455 USA Institute for Bioscience and Biotechnology Research University of Maryland Rockville MD 20850 USA

User-friendly tools for robust transcriptional activation of endogenous genes are highly demanded in plants. We previously showed that a dCas9-VP64 system consisting of the deactivated CRISPR- associated protein 9 （dCasg） fused with four tandem repeats of the transcriptional activator VP16 0/1=64） could be used for transcriptional activation of endogenous genes in plants. In this study, we developed a second generation of vector systems for enhanced transcriptional activation in plants. We tested multiple strategies for dCasg-based transcriptional activation, and found that simultaneous recruitment of VP64 by dCas9 and a modified guide RNA scaffold gRNA2.0 （designated CRISPR-Act2.0） yielded stronger transcrip- tional activation than the dCas9-VP64 system. Moreover, we developed a multiplex transcription activator- likeeffector activation （mTALE-Act） system for simultaneous activation of up to four genes in plants. Our results suggest that mTALE-Act is even more effective than CRISPR-Act2.0 in most cases tested. In addition, we explored tissue-specific gene activation using positive feedback loops. Interestingly, our study revealed that certain endogenous genes are more amenable than others to transcriptional activation, and tightly regulated genes may cause target gene silencing when perturbed by activation probes. Hence, these new tools could be used to investigate gene regulatory networks and their control mechanisms. Assembly of multiplex CRISPR-Act2.0 and mTALE-Act systems are both based on streamlined and PCR-independent Golden Gate and Gateway cloning strategies, which will facilitate transcriptional activation applications in both dicots and monocots.

关键词： CRISPR gRNA2.0 MS2-VP64 TALE-VP64 multiplex transcriptional activation

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Frustrated Magnetic Interactions and Quenched Spin Fluctuations in CrAs

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Chinese Physics Letters 2022年第12期39卷 89-93页

作者： Yayuan Qin Yao Shen Yiqing Hao Hongliang Wo Shoudong Shen Russell A.Ewings Yang Zhao Leland W.Harriger Jeffrey W.Lynn Jun Zhao State Key Laboratory of Surface Physics and Department of Physics Fudan UniversityShanghai 200433China Shanghai Qizhi Institute Shanghai 200232China ISIS Pulsed Neutron and Muon Source STFC Rutherford Appleton LaboratoryHarwell CampusDidcotOxonOX110QXUnited Kingdom NIST center for Neutron Research National Institute of Standards and TechnologyGaithersburgMD 20899USA Department of Materials Science and Engineering University of MarylandCollege ParkMD 20742USA Institute of Nanoelectronics and Quantum Computing Fudan UniversityShanghai 200433China Shanghai Research center for Quantum Sciences Shanghai 201315China

The discovery of pressure-induced superconductivity in helimagnets(CrAs,MnP)has attracted considerable interest in understanding the relationship between complex magnetism and unconventional ***,the nature of the magnetism and magnetic interactions that drive the unusual double-helical magnetic order in these materials remains ***,we report neutron scattering measurements of magnetic excitations in CrAs single crystals at ambient *** experiments reveal well defined spin wave excitations up to about 150 meV with a pseudogap below 7 meV,which can be effectively described by the Heisenberg model with nearest neighbor exchange *** surprisingly,the spin excitations are largely quenched above the Néel temperature,in contrast to cuprates and iron pnictides where the spectral weight is mostly preserved in the paramagnetic *** results suggest that the helimagnetic order is driven by strongly frustrated exchange interactions,and that CrAs is at the verge of itinerant and correlation-induced localized states,which is therefore highly pressure-tunable and favorable for superconductivity.

关键词： excitation exchange pressure

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补充甲状腺激素对亚临床甲状腺功能减退患者死亡率的影响

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国际内分泌代谢杂志 2021年第1期41卷 9-9页

作者：杨菊红(摘译) Peng CC Huang HK Wu BB Department of Internal Medicine University of Maryland Medical Center Midtown Campus Baltimore Maryland Departments of Family Medicine and medical Research Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan Institute of Epidemiology and Preventive Medicine College of Public Health National Taiwan University Taipei Taiwan Division of Endocrinology Diabetes and Nutrition University of Maryland School of Medicine Baltimore Maryland Johns Hopkins Bloomberg School of Public Health Baltimore Maryland Department of Dentistry National Taiwan University Hospital and School of Dentistry National Taiwan University Taipei Taiwan Department of medical Research National Taiwan University Hospital National Taiwan University Taipei Taiwan

最新发表的一项荟萃分析入选了5项观察性研究和两项随机对照试验,共21055例成人患者。结果发现,在总人群中,甲状腺激素治疗与全因死亡或心血管死亡无关。但亚组分析显示,在年龄小于65岁的人群中,甲状腺激素治疗明显降低患者的全因死亡率... 详细信息

最新发表的一项荟萃分析入选了5项观察性研究和两项随机对照试验,共21055例成人患者。结果发现,在总人群中,甲状腺激素治疗与全因死亡或心血管死亡无关。但亚组分析显示,在年龄小于65岁的人群中,甲状腺激素治疗明显降低患者的全因死亡率(相对风险=0.50,95%可信区间:0.29~0.85,P=0.011)和心血管死亡率(相对风险=0.54,95%可信区间:0.37~0.80,P=0.002)。

关键词：相对风险观察性研究成人患者甲状腺激素亚临床甲状腺功能减退荟萃分析亚组分析全因死亡率

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Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic

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Stroke & Vascular Neurology 2021年第4期6卷 542-552,I0026-I0032页

作者： Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sug Neurology RadiologyBoston Medical CenterBostonMassachusettsUSA Neurology Marcus Stroke&Neuroscience CenterGrady Memorial HospitalEmory University School of MedicineAtlantaGAUSA Radiology Radiation OncologyBoston University School of MedicineBostonMassachusettsUSA Neurology National Hospital Organization Osaka National HospitalOsakaJapan Neurosurgery National Hospital Organization Osaka National HospitalOsakaJapan Neurology Alexandria UniversityAlexandriaEgypt Radiology Boston Medical CenterBostonMassachusettsUSA Department of Neurology Xinqiao HospitalChongqingChina Neurosurgery University of Cape TownRondeboschWestern CapeSouth Africa Neurosurgery Interventional NeuroradiologyClinica La Sagrada FamiliaBuenos AiresArgentina Neuroradiologie Neurologie VasculaireHospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Neurologie Vasculaire Hospices Civils de LyonLyonAuvergne-Rhône AlpesFrance Interventional Neuroradiology Fondation Ophtalmologique Adolphe de RothschildParisÎle-de FranceFrance Neurology Hospital Geral de FortalezaFortalezaBrazil Interventional Neuroradiology Hospital Geral de FortalezaFortalezaBrazil Neuroradiology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurosurgery Kobe City Medical Center General HospitalKobeHyogoJapan Interventional Neurovascular Unit University Hospital CareggiFirenzeToscanaItaly Neuroradiology University Hospital Centre ZagrebZagrebCroatia Interventional Neuroradiology Hopital BicetreLe Kremlin-BicetreFrance Stroke and Interventional Neuroradiology Lahore General HospitalLahorePakistan Neurological Institute Cleveland Clinic Abu DhabiAbu DhabiUAE Department of Radiology Beaumont HospitalDublinIreland Neurology Stroke UnitHospital-Estadual CentralVitoriaBrazil Neuroradiology Instituto de Neurocirugia Dr AsengoSantiagoChile Interventional Neuroradiology Institut National de NeurologieTunisTunisia Neurology Boston Medical CenterBostonMassachusettsUSA Neurosurgery Boston Medical Center

Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were *** study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar *** We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke *** with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,*** 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May *** prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal *** There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative *** analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this *** There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 *** findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction.

关键词： diagnosis representing subarachnoid

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Utilizing Anesthesiologists, Emergency and Critical Care Physicians with Telemedicine Monitoring to Develop Intubation and Ventilation Services in an Intensive Care Unit in the Austere medical Environment: A Case Series. Expansion of the EP/CC GAS Project

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Open Journal of Anesthesiology 2018年第6期8卷 183-197页

作者： Richard Skupski Arthur Toth Michael T. McCurdy Shane Kappler James Lantry Gerson Pyran Donald Zimmer Joseph Dynako Anne Grisoli David Zimmer John Wilson Bhavesh M. Patel Hannelisa Callisen Alyssa Chapital Lovely Nathalie Colas Marc Edson Augustin Nathalie Edema Enzo Del Brocco Richard Frechette Mark Thompson James Corcoran Michael Mazowiecki Mark Walsh Memorial Hospital Trauma center South Bend IN USA university of maryland School of Medicine Baltimore MD USA Indiana university School of Medicine South Bend Campus South Bend IN USA Mayo Clinic Rochester MN USA Mayo Clinic Phoenix AZ USA Hô spital Saint Luc Port-Au-Prince Haiti Excela Health Westmoreland Hospital Greensburg PA USA Saint Joseph Regional medical center Mishawaka IN USA

Background: Significant resource constraints and critical care training gaps are responsible for the limited development of intensive care units (ICUs) in resource limited settings. We describe the implementation of an ICU in Haiti and report the successes and difficulties encountered throughout the process. We present a consecutive case series investigating an anesthesiologist, emergency, and critical care physician implemented endotracheal intubation and mechanical ventilation protocol in an austere environment with the assistance of telemedicine. Methods: A consecutive case series of fifteen patients admitted to an ICU at St. Luc Hospital located in Portau-Prince, Haiti, between the months of February 2012 to April 2014 is reported. Causes of respiratory failure and the clinical course are presented. Patients were followed to either death or discharge. Results: Fifteen patients (eight women and seven men) were included in the study with an average age of 37.7 years. The mean duration of ventilation was three days. Of the fifteen patients intubated, five patients (33.3%) survived and were discharged from the ICU. Of the five surviving patients, two were intubated for status epilepticus, one for status asthmaticus and one for hyperosmolar coma associated with intracerebral hemorrhage. Of the patients dying on the ventilator, four patients died from pneumonia, two from renal failure, and one from tetanus. The remaining three died from strokes and cardiac arrests. Conclusions: Mortality of mechanically ventilated patients in a resource-limited country is significant. Focused training in core critical care skills aimed at increasing the endotracheal intubation and ventilatory management capacity of local medical staff should be a priority in order to continue to develop ICUs in these austere environments. Collaborative educational and training efforts directed by anesthesiologists, emergency, and critical care physicians, and aided by telemedicine can facilitate reali

关键词： Intensive Care Unit (ICU) Critical Care Mechanical Ventilation Endotracheal Ventilation Anesthesiologist Low and Moderate-Income Country Austere Environment Telemedicine

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Quality Matters:Biocuration Experts on the Impact of Duplication and Other Data Quality Issues in Biological Databases

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 91-103页

作者： Qingyu Chen Ramona Britto Ivan Erill Constance J.Jeffery Arthur Liberzon Michele Magrane Jun-ichi Onami Marc Robinson-Rechavi Jana Sponarova Justin Zobel Karin Verspoor School of Computing and Information Systems University of MelbourneMelbourneVIC 3010Australia European Molecular Biology Laboratory European Bioinformatics Institute(EMBL-EBI)Wellcome Trust Genome CampusCambridge CB101SDUK Department of Biological Sciences University of MarylandBaltimoreMD 21250USA Department of Biological Sciences University of Illinois at ChicagoChicagoIL 60607USA Broad Institute of MIT and Harvard CambridgeMA 02142USA Japan Science and Technology Agency National Bioscience Database CenterTokyo 102-8666Japan National Institute of Health Sciences Tokyo 158-8501Japan Swiss Institute of Bioinformatics CH-1015 LausanneSwitzerland Department of Ecology and Evolution University of LausanneCH-1015 LausanneSwitzerland Nebion AG 8048 ZurichSwitzerland

Introduction Biological databases represent an extraordinary collective volume of *** built up over decades and comprising many millions of contributions from the biomedical research community,biological databases provide worldwide access to a massive number of records(also known as entries)[1].Starting from individual laboratories,genomes are sequenced.

关键词： Impact collective massive

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Ground-based and additional science support for SMILE

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Earth and Planetary Physics 2024年第1期8卷 275-298页

作者： J.A.Carter M.Dunlop C.Forsyth K.Oksavik E.Donovon A.Kavanagh S.E.Milan T.Sergienko R.C.Fear D.G.Sibeck M.Connors T.Yeoman X.Tan M.G.G.T.Taylor K.McWilliams J.Gjerloev R.Barnes D.D.Billet G.Chisham A.Dimmock M.P.Freeman D.-S.Han M.D.Hartinger S.-Y.W.Hsieh Z.-J.Hu M.K.James L.Juusola K.Kauristie E.A.Kronberg M.Lester J.Manuel J.Matzka I.McCrea Y.Miyoshi J.Rae L.Ren F.Sigernes E.Spanswick K.Sterne A.Steuwer T.Sun M.-T.Walach B.Walsh C.Wang J.Weygand J.Wild J.Yan J.Zhang Q.-H.Zhang Planetary Sciences Group School of Physics and AstronomyUniversity of LeicesterUniversity RoadLeicesterLE17RHUK Rutherford Appleton Laboratory Space Science Technology Facilities CouncilOxfordshireUK School of Space and Environment Beihang UniversityBeijing 100191China Key Laboratory of Space Environment Monitoring and Information Processing Ministry of Industry and Information TechnologyBeijing 100017China Department of Space and Climate Physics UCLMullard Space Science LaboratoryHolmbury St.MaryDorkingSurreyRH56NTUK Birkeland Centre for Space Science Department of Physics and Technology.University of BergenBergenNorway Department of Physics and Astronomy University of Calgary2500 University DriveCalgaryAlbertaCanada T2N 1N4 British Antarctic Survey CambridgeUK Swedish Institute of Space Physics KirunaSweden West Highfield campus University of SouthamptonUniversity RoadSO171BJUK Goddard Space Flight center NASAGreenbeltMarylandUSA Athabasca university AthabascaCanada ESTEC European Space AgencyNetherlands university of Saskatchewan SaskatoonCanada The Johns Hopkins university Applied Physics Laboratory LaurelMarylandUSA Swedish Institude of Space Physics UppsalaSE 75121Sweden Tongji university Shanghai 200092China center for Space Plasma Physics Space Science Institute4765 Walnut Street Suite BBoulderColorado80301USA Polar Research Institute of China Shanghai 200136China Finnish Meteorological Institute(FMI) Finland Department of Earth and Environmental Sciences(Geophysics) Ludwig Maximilian University of Munich(LMU)MunichTheresienstr.41MunichD-80333Germany Canadian Space Agency MontrealCanada GFZ German Research Centre for Geosciences PotsdamGermany Nagoya university Institute for Space Earth Environment ResearchCenter for Integrated Data ScienceNagoyaAichiJP 464-8601 Northumbria university Newcastle upon TyneTyne and WearUK NE18ST National Space Science center Chinese Academy SciencesBeijing 100190China Arctic Geophysics University Centre in Svalbard

The joint European Space Agency and Chinese Academy of Sciences Solar wind Magnetosphere Ionosphere Link Explorer(SMILE)mission will explore global dynamics of the magnetosphere under varying solar wind and interplanetary magnetic field conditions,and simultaneously monitor the auroral response of the Northern Hemisphere *** these large-scale responses with medium and fine-scale measurements at a variety of cadences by additional ground-based and space-based instruments will enable a much greater scientific impact beyond the original goals of the SMILE ***,we describe current community efforts to prepare for SMILE,and the benefits and context various experiments that have explicitly expressed support for SMILE can offer.A dedicated group of international scientists representing many different experiment types and geographical locations,the Ground-based and Additional Science Working Group,is facilitating these *** include constructing an online SMILE Data Fusion Facility,the discussion of particular or special modes for experiments such as coherent and incoherent scatter radar,and the consideration of particular observing strategies and spacecraft *** anticipate growing interest and community engagement with the SMILE mission,and we welcome novel ideas and insights from the solar-terrestrial community.

关键词： magnetosphere ionosphere magnetosphere-ionosphere coupling ground-based experimentation SMILE conjunctions missions

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Dense matter with eXTP

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Science China(Physics,Mechanics & Astronomy) 2019年第2期62卷 28-44页

作者： Anna L.Watts WenFei Yu Juri Poutanen Shu Zhang Sudip Bhattacharyya Slavko Bogdanov Long Ji Alessandro Patruno Thomas E.Riley Pavel Bakala Altan Baykal Federico Bernardini Ignazio Bombaci Edward Brown Yuri Cavecchi Deepto Chakrabarty Jér?me Chenevez Nathalie Degenaar Melania Del Santo Tiziana Di Salvo Victor Doroshenko Maurizio Falanga Robert D.Ferdman Marco Feroci Angelo F.Gambino MingYu Ge Svenja K.Greif Sebastien Guillot Can Gungor Dieter H.Hartmann Kai Hebeler Alexander Heger Jeroen Homan Rosario Iaria Jean in 't Zand Oleg Kargaltsev Aleksi KurkelaTheoretical Physics Department CERN XiaoYu Lai Ang Li XiangDong Li ZhaoSheng Li Manuel Linares FangJun Lu Simin Mahmoodifar Mariano Méndez M.Coleman Miller Sharon Morsink Joonas N?ttil? Andrea Possenti Chanda Prescod-Weinstein JinLu Qu Alessandro Riggio Tuomo Salmi Andrea Sanna Andrea Santangelo Hendrik Schatz Achim Schwenk LiMing Song Eva?rámková Benjamin Stappers Holger Stiele Tod Strohmayer Ingo Tews Laura Tolos Gabriel T?r?k David Tsang Martin Urbanec Andrea Vacchi RenXin Xu YuPeng Xu Silvia Zane GuoBao Zhang ShuangNan Zhang WenDa Zhang ShiJie Zheng Xia Zhou Anton Pannekoek Institute for Astronomy University of Amsterdam Shanghai Astronomical Observatory Tuorla Observatory Department of Physics and Astronomy University of Turku Nordita KTH Royal Institute of Technology and Stockholm University Institute of High Energy Physics Chinese Academy Sciences Tata Institute of Fundamental Research Columbia Astrophysics Laboratory Columbia University Institut für Astronomie und Astrophysik Tübingen Universit?t Tübingen Leiden Observatory Leiden University Research center for Computational Physics and Data Processing Silesian University in Opava Physics Department Middle East Technical University INAF Osservatorio Astronomico di Roma New York university Abu Dhabi Dipartimento di Fisica Enrico Fermi University of Pisa INFN Italian National Institute for Nuclear Physics Department of Physics and Astronomy Michigan State University Department of Astrophysical Sciences Princeton University Mathematical Sciences and STAG Research Centre University of Southampton MIT Kavli Institute for Astrophysics and Space Research DTU Space Technical University of Denmark INAF/IASF Palermo via Ugo La Malfa 153 Universita degli Studi di Palermo Dipartimento di Fisica e Chimica International Space Science Institute (ISSI) Faculty of Science University of East Anglia INAF Istituto di Astrofisica e Planetologie Spaziali Institut für Kernphysik Technische Universit?t Darmstadt ExtreMe Matter Institute EMMI GSI Helmholtzzentrum für Schwerionenforschung GmbH Instituto de Astrof'?sica Pontificia Universidad Católica de Chile Department of Physics & Astronomy Kinard Lab of Physics Clemson University School of Physics and Astronomy Monash University SRON Netherlands Institute for Space Research Department of Physics The George Washington University Faculty of Science and Technology University of Stavanger School of Physics and Mechanical & Electrical Engineering Hubei University of Education Department of Astronomy Xiamen University (Haiyun Campus) School of Astronomy and Space

In this White Paper we present the potential of the Enhanced X-ray Timing and Polarimetry(eXTP) mission for determining the nature of dense matter; neutron star cores host an extreme density regime which cannot be replicated in a terrestrial laboratory. The tightest statistical constraints on the dense matter equation of state will come from pulse profile modelling of accretion-powered pulsars, burst oscillation sources, and rotation-powered pulsars. Additional constraints will derive from spin measurements, burst spectra, and properties of the accretion flows in the vicinity of the neutron star. Under development by an international Consortium led by the Institute of High Energy Physics of the Chinese Academy of Sciences, the eXTP mission is expected to be launched in the mid 2020 s.

关键词： neutron X-rays dense matter equation of state

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