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Identification of cellular genes showing differential expression associated with hepatitis B virus infection

World Journal of Hepatology 2012年第4期4卷 139-148页

作者： Yasuo Fukuhara Takeshi Suda Makoto Kobayashi Yasushi Tamura Masato Igarashi Nobuo Waguri Hirokazu Kawai Yutaka Aoyagi Division of Gastroenterology and Hepatology Graduate School of Medical and Dental Sciences Niigata University 1-757 Asahimachi-dori Chuo-ku Niigata Niigata 951-8122 Japan

AIM: To investigate the impact of hepatitis B virus (HBV) infection on cellular gene expression, by conducting both in vitro and in vivo studies. METHODS: Knockdown of HBV was targeted by stable expression of short hairpin RNA (shRNA) in huH-1 cells. Cellular gene expression was compared using a human 30K cDNA microarray in the cells and quantified by real-time reverse transcription-polymerase chain reaction (RT-PCR) (qRT-PCR) in the cells, hepatocellular carcinoma (HCC) and surrounding non-cancerous liver tissues (SL). RESULTS: The expressions of HBsAg and HBx protein were markedly suppressed in the cells and in HBx transgenic mouse liver, respectively, after introduction of shRNA. Of the 30K genes studied, 135 and 103 genes were identified as being down- and up-regulated, respectively, by at least twofold in the knockdown cells. Functional annotation revealed that 85 and 62 genes were classified into four up-regulated and five down-regulated functional categories, respectively. When gene expression levels were compared between HCC and SL, eight candidate genes that were confirmed to be up- or down-regulated in the knockdown cells by both microarray and qRT-PCR analyses were not expressed as expected from HBV reduction in HCC, but had similar expression patterns in HBV- and hepatitis C virus-associated cases. In contrast, among the eight genes, only APM2 was constantly repressed in HBV non-associated tissues irrespective of HCC or SL. CONCLUSION: The signature of cellular gene expression should provide new information regarding the pathophysiological mechanisms of persistent hepatitis and hepatocarcinogenesis that are associated with HBV infection.

关键词： Hepatitis B virus Differential gene expression Hepatocellular carcinoma Gene expression signature Adipose most abundant 2

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Long-term survival of a case with multiple liver metastases from duodenal gastrointestinal stromal tumor drastically reduced by the treatment with imatinib and hepatectomy

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World Journal of Gastroenterology 2006年第17期12卷 2793-2797页

作者： Chouhei Sakakura Akeo Hagiwara Koji Soga Koji Miyagawa Susumu Nakashima Tetsuji Yoshikawa Shuichi Kin Yuenn Nakase Nobuki Yamaoka Yoshihiko Sagara Hisakazu Yamagishi Department of Digestive Surgery Kyoto Prefectural university of Medicine Kawaramachi-doriKamigyokuKyoto 602-0841Japan

Constitutive activation of KIT receptor tyrosine kinase is a critical factor in the pathogenesis of gastrointestinal stromal tumors （GISTs）. But there is little information on whether combination of imatinib mesylate （IM） and surgical treatment can prolong survival in the cases with unresectable multiple liver metastases. We report a case of postoperative recurrence of GIST treated by the tyrosine kinase inhibitor IN and surgical treatment. The initial complete response （CR） to treatment continued for 18 mo, but single liver metastasis showed regrowth in the left hepatic lobe during IN treatment. After partial resection of the recurrent tumor, postoperative course was uneventful and the patient has survived without recurrence for 24 too. Currently, imatinib is the first- line therapy for non-resectable GISTs, but a single agent therapy often leads to tumor resistance. Even if tolerance to imatinib occurs, a combination of imatinib and surgical treatment can prolong survival in some cases as reported here. However, further studies on a large number of cases of recurrent GIST are necessary to evaluate the effectiveness of IN treatment combined with surgery.

关键词： GIST Imatinib mesylate Liver metastases

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Drug/polymer nanoparticles prepared using unique spray nozzles and recent progress of inhaled formulation

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Asian Journal of Pharmaceutical Sciences 2014年第5期9卷 236-243页

作者： Tetsuya Ozeki Tatsuaki Tagami Drug Delivery and Nano Pharmaceutics Graduate School of Pharmaceutical SciencesNagoya City University3-1 Tanabe-doriMizuho-kuNagoyaAichi 467-8603Japan

Inhaled formulations are promising for pulmonary and systemic non-pulmonary *** engineered particles including drugs and drug-loaded nanocarriers have been anticipated because they can improve drug delivery efficacy against target sites in the lungs or *** this review,unique spray nozzles(e.g.,four-fluid spray nozzle and twosolution mixing type nozzle)for the preparation of nanocomposite particles which mean microparticles containing drug nanoparticles are *** nozzles can produce nanocomposite particles in one-step and their spray drying system is suitable for *** particles are useful in improving drug absorption and delivery efficacy against alveolar *** addition,recent studies on several pulmonary diseases(tuberculosis,lung cancer,cystic fibrosis,pneumonia,vaccine and others)and related inhaled formulations were also reviewed.

关键词： Pulmonary drug delivery Inhalation Lung diseases Spray drying One-step preparation of nanocomposite particles

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Highly stretchable, electrically conductive textiles fabricated from silver nanowires and cupro fabrics using a simple dipping-drying method

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Nano Research 2015年第5期8卷 1604-1614页

作者： Hui-Wang Cui Katsuaki Suganuma Hiroshi Uchida Institute of Scientific and Industrial Research Osaka University Mihogaoka 8-1 Ibaraki Osaka 567-0047 Japan Institute for Polymers and Chemicals Business Development Center Showa Denko K. K. 5-1 Yawata Kaigan Dori Ichihara Chiba 290-0067 Japan

In this study, we combined silver nanowires with cupro fabrics using a dipping- drying method to prepare electrically conductive fabrics. The silver nanowires were first adhered to and then absorbed by microfibers to form electrically conductive fibers. They also filled the gaps and spaces between the microfibers, and were stacked or piled together to form networks with high electrical conductivity. The electrically conductive fabric had low resistance and good stretchability, e.g., 0.0047-0.0091 Ωin the strain range of 0-190%. They also exhibited stable electrical conductivity, as well as excellent flexibility, which remained even when the fabric was stretched, shrunk, or bent. The results show that the electrically conductive fabric can be used as a smart textile, especially in fields associated with weaving, clothing, food products, lifestyle products, medicine, biology, electronics, aviation, and military equipment and accessories.

关键词： fabrics/textiles metals smart materials electrical properties

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Narrow portion of the terminal choledochus is a cause of upstream biliary dilatation in patients with anomalous union of the pancreatic and biliary ducts

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World Journal of Gastroenterology 2005年第41期11卷 6503-6507页

作者： Tatsuya Nomura Yoshio Shirai Toshifumi Wakai Naoyuki Yokoyama Jun Sakata Katsuyoshi Hatakeyama Division of Digestive and General Surgery Niigata university Graduate School of Medical and Dental Sciences 1 Asahimachi-doriNiigata951-8510Japan

AIM: To clarify the pathogenesis of biliary dilatation associated with anomalous union of the pancreatic and biliary ducts (AUPBD).METHODS: Direct cholangiopancreatograms of 350 adult patients with or with suspicion of hepatobiliary or pancreatic disorders were reviewed. AUPBD was diagnosed cholangiopancreatographically, when the pancreaticobiliary ductal union was located above the narrow distal segment of the bile duct, which represents the action of the sphincter of Oddi. The narrow portion of the terminal choledochus was defined as symmetrical stricture of the common bile duct just above the pancreaticobiliary ductal ***: AUPBD was found in 36 patients. Among cholangiopancreatographic features, the narrow portion of the terminal choledochus was the most pathognomonic for AUPBD (accuracy, 98%); it was present in 29 (81%)patients with AUPBD, but was not found in any patients without AUPBD. Among patients with AUPBD, biliary dilatation (＞10 mm) was more frequent in those with the narrow portion of the terminal choledochus (23/29)than in those without (2/7; P = 0.018) AUPBD. Among the patients with both AUPBD and the narrow portion of the terminal choledochus, there was a strong negative correlation between the minimum diameter of the narrow portion and the maximum diameter of the choledochus (r = -0.78, P＜0.001), suggesting that the degree of biliary narrowing at the narrow portion correlates with that of upstream biliary ***: The narrow portion of the terminal choledochus, a pathognomonic radiologic feature of AUPBD, may be a cause of biliary dilatation in patients with AUPBD.

关键词： Anomalous Biliary dilatation Congenital biliary dilatation Congenital choledochal cyst Terminal choledochus Cholangiopancreatography

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Surface Modification of Ni-Cr-Mo Steel by Multifunction Cavitation

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材料科学与工程（中英文A版） 2017年第6期7卷 290-296页

作者： Masataka Ijiri Daichi Shimonishi Daisuke Nakagawa Kumiko Tanaka Toshihiko Yoshimura Tokyo university of Science Yamaguchi 1-1-1 Daigaku-Dori Sanyo-Onoda Yamaguchi 756-0084 Japan

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Fishermen Local Knowledge and Aquatic Environmental Change: Impacts on Fishing and Adaptation Strategies in Volta Basin

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Open Journal of Ecology 2021年第7期11卷 507-526页

作者： Rimwaodo Pierre Silga Adama Oueda Winkom Noellie Kpoda Komandan Mano Idrissa Ouedraogo D. M. Peter Weesie Boureima Gustave Kabre Life and Earth Sciences Training and Research Unit University Joseph Ki-Zerbo Ouagadougou Burkina Faso Applied Sciences and Technology Training and Research Unit University of Dédougou Dédougou Burkina Faso university of dori Dori Burkina Faso Sciences and Society Group (SSG) University of Groningen Groningen Netherlands

Climate researches predict that climate change will have an important impact on aquatic and terrestrial ecosystems. However, many fishermen do not have a lot of knowledge about climate change or how it might affect their fish catch yields and overall fishing operations in the future. The objective of this study was to assess local fishermen’s perception of global change on the ichthyofauna of the Volta Basin in Burkina Faso. Focus group interviews were conducted between March 2019 and July 2020 in 19 reservoirs of the Volta Basin. A total of 242 fishermen divided into 34 groups participated in the interviews. The results showed that fishermen are aware of climatic and anthropogenic threats to fish fauna. According to them, these global changes lead to important modifications in the structure of the ichthyofauna ranging from seasonal mortality of fish (Mormyridae) to the extinction of certain species such as those of the genera Lates, Hydrocynus and Heterotis. These changes also lead to a loss of fish habitat through silting and lower water levels in the reservoirs. Statistical analysis of the collected data showed that the main factors threatening the structure and dynamics of fish are mainly agriculture and market gardening around the dam lakes, the temperature increase and the trend of decreasing rainfall. Thus, the main pressures responsible for the mortality and/or extinction of fish are market gardening pollution (100%), bad fishing practices (63.15%) and high temperatures (47.5%). As for adaptation measures and management strategies, the most important were training and sensitization of stakeholders (78.94% of citations) followed by fish stocking (21.05%). This endogenous knowledge is important for the development of climate change adaptation programs.

关键词： Climate Variability Perception Fishing Burkina Faso

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Effect of multifunction cavitation using phosphoric acid on fatigue and surface properties of AZ31 magnesium alloy

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Journal of Magnesium and Alloys 2023年第6期11卷 1996-2005页

作者： Shunta Matsuoka Fumihiro Kato Toshihiko Yoshimura Masataka Ijiri Shoichi Kikuchi Graduate School of Integrated Science and Technology Shizuoka University3-5-1 JohokuNaka-kuHamamatsuShizuoka432-8561Japan Department of Mechanical Engineering Sanyo-Onoda City University1-1-1 Daigaku-DoriSanyo-OnodaYamaguchi 756-0884Japan Tokyo Metropolitan university 1-1 Minami-OsawaHachiojiTokyo 192-0397Japan Department of Mechanical Engineering Faculty of EngineeringShizuoka University3-5-1 JohokuNaka-kuHamamatsu-shiShizuoka 432-8561Japan

Magnesium alloy is attractive for lightweight construction but often suffers from poor corrosion resistance and low *** processing with chemicals,i.e.,multifunction cavitation(MFC),was introduced to form a high-corrosion film and improve the fatigue properties of an AZ31 magnesium *** analysis and plane bending fatigue tests were conducted for the MFC-treated magnesium alloy at a stress ratio,R,*** mechanical action of cavitation bubbles improved the fatigue life of magnesium alloys due to increasing the surface hardness and generating compressive residual ***,the combined mechanical and electrochemical action during MFC formed pits on the *** pits were large enough to easily nucleate an initial fatigue *** addition,the magnesium alloys without pit formation,for which a coating process using phosphoric acid was conducted after MFC using water,showed superior fatigue properties.

关键词： Magnesium alloy Multifunction cavitation Surface modification Fatigue Residual stress

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Clinical experience of hyperthermia for deep-seated malignant glioma

Clinical experience of hyperthermia for deep-seated malignan...

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中国医师协会神经外科医师分会首届全国代表大会

作者： Hideaki Takahashi Ryuichi Tanaka Takeo Uzuka Igor Grinev Department of Neurosurgery Brain Research Institute Niigata University 1-757 Asahimachi-dori951-8585NiigataJAPAN Department of Neurosurgery Brain Research Institute Niigata University 1-757 Asahimachi-dori951-8585NiigataJAPAN Department of Neurosurgery Brain Research Institute Niigata University 1-757 Asahimachi-dori951-8585NiigataJAPAN Department of Neurosurgery Brain Research Institute Niigata University 1-757 Asahimachi-dori951-8585NiigataJAPAN

＜正＞Purpose We introduce our clinical experience with radio frequency （RF） interstitial hyperthermia for malignant glioma. From the preliminary experimental study to the prospect of the near future, we will dicuss. Material We retrospectively reviewed 76 patients. Fortythree primary malignant gliomas and 33 recurrent malignant gliomas were treated with thermoradiotherapy （60 Gy, conventionally fractionated external beam radiation）. These patients received no reductive surgery. Electrodes （RF antennas） were set into the tumor and thermistor catheter was placed through the tumor center with stereotactic procedure under local anesthesia. Hyperthermia was given by RF interstitial hyperthermia of 13. 56 MHz, and the tumor was heated by measuring the temperature at the tumor margin （Tt: temperature of target point）. Tumor response was evaluated according by follow - up CT scan. TTPs and survivals were estimated by Kaplan - Meier method. Result Tumor responses of primary malignant gliomas were CR in 10 cases and PR in 17 cases. The response rate （CR + PR / all） amounted to 62. 8%. These of recurrent cases were CR in 3 cases and PR 12 cases. The response rate amounted to 45. 5 % . In primary malignant gliomas, median survival was 18months. In comparison with control group （ n = 35）, it was 10 months longer. According to achieved temperature at the target point, these patients were divided in two groups. The first group was adequate heating group achieved Tt of 42 ℃at least and the second was inadequate heating group Tt of less than 42 ℃. The response rate of adequate heating group was 68% Comparing gliomas heated to a Tt ＞ 42 ℃and those heated to a Tt ＜ 42℃, Kaplan- Meier survival and TTP curves displayed improvement in adequate heating group. In adequate heating group, median TTP was 4months longer and median survival was 11 months longer than those of inadequate group. Conclusion RF interstitial hyperthermia resulted in a higher response rate for primary malignant gliomas.

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Machining Robot with Vibrational Motion and 3D Printer-like Data Interface

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International Journal of Automation and computing 2018年第1期15卷 1-12页

作者： Fusaomi Nagata Keigo Watanabe Maki K. Habib Department of Mechanical Engineering Faculty of Engineering Tokyo University of Science Yamaguchi 1-1-1 Daigaku-Dori Sanyo-Onoda 756-0884 Japan Department of Intelligent Mechanical Systems Division of Industrial Innovation Sciences Graduate School of Natural Science and Technology Okayama University 3-1-1 Tsushima-naka Kita-ku Okayama 700-8530 Japan American university 113 Kasr E1 Eini Street Cairo 11511 Egypt

In this paper, a vibration motion control is proposed and implemented on a foamed polystyrene machining robot to suppress the generation of undesirable cusp marks, and the basic performance of the controller is verified through machining experiments of foamed polystyrene. Then, a 3 dimensional （3D） printer-like data interface is proposed for the machining robot. The 3D data inter- face enables to control the machining robot directly using stereolithography （STL） data without conducting any computer-aided man- ufacturing （CAM） process. This is done by developing a robotic preprocessor that helps to remove the need for the conventional CAM process by directly converting the STL data into cutter location source data called cutter location （CL） or cutter location source （CLS） data. The STL is a file format proposed by 3D systems, and recently is supported by many computer aided design （CAD）/CAM soft- waxes. The STL is widely used for rapid prototyping with a 3D printer which is a typical additive manufacturing system. The STL deals with a triangular representation of a curved surface geometry. The developed 3D printer-like data interface allows to directly control the machining robot through a zigzag path, rectangular spiral path and circular spiral path generated according to the information included in STL data. The effectiveness and usefulness of the developed system are demonstrated through actual machining experiments.

关键词： Computer integrated manufacturing machining robot computer aided design (CAD)/computer-aided manufacturing(CAM) cutter location (CL) data vibrational motion stereolithography (STL) data preprocessor 3 dimensional (3D) printer-likedata interface.

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