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Advancing cancer cachexia diagnosis with -omics technology and exercise as molecular medicine

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Sports Medicine and Health Science 2024年第1期6卷 1-15页

作者： Stuart J.Hesketh university of central lancashire School of MedicinePrestonUK

Muscle atrophy exacerbates disease outcomes and increases mortality,whereas the preservation of skeletal muscle mass and function play pivotal roles in ensuring long-term health and overall *** atrophy represents a significant clinical challenge,involving the continued loss of muscle mass and strength,which frequently accompany the development of numerous types of *** cachexia is a highly prevalent multifactorial syndrome,and although cachexia is one of the main causes of cancer-related deaths,there are still no approved management strategies for the *** etiology of this condition is based on the upregulation of systemic inflammation factors and catabolic stimuli,resulting in the inhibition of protein synthesis and enhancement of protein *** necessary cellular processes are disrupted by cachectic pathology,which mediate intracellular signalling pathways resulting in the net loss of muscle and ***,the exact underpinning molecular mechanisms of how these changes are orchestrated are incompletely *** work is still required,but structured exercise has the capacity to counteract numerous detrimental effects linked to cancer *** through the stimulation of muscle protein synthesis,enhancement of mitochondrial function,and the release of *** a result,muscle mass and strength increase,leading to improved mobility,and *** review summarises existing knowledge of the complex molecular networks that regulate cancer cachexia and exercise,highlighting the molecular interplay between the two for potential therapeutic ***,the utility of mass spectrometry-based proteomics is considered as a way of establishing early diagnostic biomarkers of cachectic patients.

关键词： Cancer cachexia Exercise Muscle atrophy Molecular medicine Omics

Long-term sustainability and resilience enhancement of building portfolios

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Resilient Cities and Structures 2023年第2期2卷 13-23页

作者： Ghazanfar Ali Anwar You Dong Mustesin Ali Khan Department of Civil and Environmental Engineering The Hong Kong Polytechnic UniversityHung HomKowloonHong KongChina Fire Safety Engineering University of Central LancashireDohaQatar

The role of community building portfolios in socioeconomic development and the growth of the built environ-ment cannot be *** to these structures can have far-reaching consequences on socioeconomic and environmental aspects,requiring a long-term perspective for *** communities aim to enhance their resilience and sustainability,there is a cost burden that needs to be *** address this issue,this pa-per proposes a community-level performance enhancement approach that focuses on optimizing the long-term resilience and sustainability of community building portfolios,taking into account recurrent seismic hazards.A Gaussian process surrogate-based multi-objective optimization framework is utilized to optimize the cost objec-tive while considering performance indicators for resilience and *** proposed framework involves using performance-based assessment methods to evaluate the socioeconomic and environmental consequences under stochastic and recurrent seismic hazard *** evaluated indicators are then used to efficiently optimize the community resilience and sustainability,taking into account the retrofit ***,approximate Pareto-optimal solutions are extracted and utilized for *** summary,this paper presents a novel approach for optimizing the long-term resilience and sustainability of community building portfolios by consid-ering recurrent seismic *** proposed framework incorporates performance-based assessment methods and multi-objective optimization techniques to achieve an optimal balance between cost,resilience,and sustain-ability,with the ultimate goal of enhancing community well-being and decision-making in the face of seismic hazards.

关键词： Multi-objective Long-term Seismic hazards Sustainability Resilience Socioeconomic Environmental Buildings Optimization Decision-making

Business Life Cycle and Capital Structure： Evidence from Chinese Manufacturing Firms

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China & World Economy 2015年第2期23卷 22-39页

作者： Lin Tian Liang Han Song Zhang Surrey Business School University of Surrey Guildford UK School of Economics and Management Shihezi University Shihezi Xinjiang School University of Surrey Guildford Surrey UK lancashire Business School University of Central Lancashire Preston UK

This paper uses a panel data-fixed effect approach and data collected from Chinese public manufacturing firms between 1999 and 2011 to investigate the impacts of business life cycle stages on capital structure. We find that cash flow patterns capture more information on business life cycle stages than firm age and have a stronger impact on capital structure decision-making. We also find that the adjustment speed of capital structure varies significantly across life cycle stages and that non-sequential transitions over life cycle stages play an important role in the determination of capital structure. Our study indicates that it is important for policy-makers to ensure that products and financial markets are well-balanced.

关键词： capital structure cash flow life cycle transition

Investigation and Technological Comparison of 4G and 5G Networks

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Journal of Computer and Communications 2021年第1期9卷 36-43页

作者： Yunman Hao university of central lancashire Preston UK

Mobile cellular data networks have allowed users to access the Internet whilst on the move. Many companies use this technology in their products. Examples of this would be Smart Meters in the home and Tesla cars having their “over the air updates”. Both of these two companies use the 4G and 5G technology. So this report will include a technical overview of the technology and protocols (LTE Advanced) used in 4G and 5G networks and how they provide services to the user and how data is transferred within the networks. And there are lots of different parts about the network architecture between the 4G and 5G systems. This report will talk about some different parts between these two systems and some challenges in them.

关键词： 4G 5G Protocols Networks Mobile Communication

Satellite Attitude Identification and Prediction Based on Neural Network Compensation

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Space(Science & Technology) 2023年第1期3卷 71-79页

作者： Zibin Sun Jules Simo Shengping Gong School of Aerospace Engineering Tsinghua UniversityBeijing 100084China School of Engineering University of Central LancashirePreston PR11XJUK School of Astronuatics Beihang UniversityBeijing 102206China

This paper proposed a new attitude determination method for low-orbit *** attitude prediction accuracy is greatly improved by adding the unmodeled environmental torque to the dynamic ***,the environmental torque extraction algorithm based on extended Kalman filter and series extended state observer is introduced,and the unmodeled part of dynamic is identified through the inverse dynamic ***,the collected data are analyzed and trained by a backpropagation neural network,resulting in an attitude-torque mapping network with compensation *** simulation results show that the proposed feedback attitude prediction algorithm can outperform standard methods and provide a high accurate picture of prediction and reliability with discontinuous measurement.

关键词： prediction network algorithm

Two-Body Abrasive Wear of the Surfaces of Pangolin Scales

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Journal of Bionic Engineering 2007年第2期4卷 77-84页

作者： Jin Tong Tie-biao Lu Yun-hai Ma Heng-kun Wang Lu-quan Ren R. D. Arnell The Key Laboratory of Terrain-Machine Bionics Engineering （Ministry of Education China） Jilin University Changchun 130025 P. R. China Jost Institute of Tribotechnology University of Central Lancashire Preston PR1 2HE UK

The Pangolin, a soil-burrowing animal, is covered with scales. These scales are often abraded by soil and rock and their surface is corrugated. The abrasive wear of the surface of the scales was examined. The scales were taken from a pangolin that had died of natural causes. The tests were run on a rotary disc abrasive wear tester. The abrasive material was quartz sand （96.5 wt.%） and bentonite （3.5 wt.%）. The morphology of the abraded surfaces and the abrasion were examined by stereoscopic microscopy and scanning electron microscopy. The concepts are proposed of ＂Guiding-Effect＂ and ＂Rolling-Effect＂ on the textured surfaces under free abrasive wear conditions and the critical dimensions of the ＂Rolling-Effect＂ are discussed.

关键词： pangolin scale surface morphology abrasive wear

The Study of Ischemic Stroke

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Journal of Clinical and Nursing Research 2021年第3期5卷 103-106页

作者： Yun Wang Biomedicine and Pharmacy University of Central Lancashire PrestonLancashire PR11LJUK

This study focuses on the pathology of ischemic stroke and the analysis of the *** stroke has become a serious disease that damages the health of the elderly year by ***,the continual analysis of ischemic stroke is able to make the disease be better prevented and effectively *** review contains diagnosis testing,treatment and prognoses,and analyzes the pros and cons of each method in each *** prognostics treatment of patients is certainly an important part to be considered because most of patients are *** to relieve the suffering of patients and help patients regain health are also the key points of this *** review then records an interview of a patient who has the ischemic stroke and *** interview mainly discusses the continuous treatment after left the hospital and the *** patient affirmed some new treatments and also posed some psychological *** general,medical staff not only need to think of treating the patienfs body,but also need to pay attention to the patienfs psychological condition.

关键词： Ischemic stroke Epidemiology Atherosclerosis Diagnostic test

Damping and power spectra of quasi-periodic intensity disturbances above a solar polar coronal hole

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Research in Astronomy and Astrophysics 2016年第6期16卷 85-92页

作者： Fang-Ran Jiao Li-Dong Xia Zheng-Hua Huang Bo Li Hui Fu Ding Yuan Kalugodu Chandrashekhar Shandong Provincial Key Laboratory of Optical Astronomy and Solar-Terrestrial Environment Institute of Space Sciences Shandong University Weihai 264209 Shandong China Jeremiah Horrocks Institute University of Central Lancashire Preston PR1 2HE UK

We study intensity disturbances above a solar polar coronal hole that can be seen in the AIA 171 and 193 ＆ passbands, aiming to provide more insights into their physical nature. The damping and power spectra of the intensity disturbances with frequencies from 0.07 mHz to 10.5 mHz are investigated. The damping of the intensity disturbances tends to be stronger at lower frequencies, and their damping behavior below 980＂（for comparison, the limb is at 945＂） is different from what happens above. No significant difference is found between the damping of the intensity disturbances in the AIA 171 ~ and that in the AIA 193 ]k. The indices of the power spectra of the intensity disturbances are found to be slightly smaller in the AIA 171/~ than in the AIA 193 ~, but the difference is within one standard deviation. An additional enhanced component is present in the power spectra in a period range of 8-40 min at lower heights. The power spectra of a spicule is highly correlated with its associated intensity disturbance, which suggests that the power spectra of the intensity disturbances might be a mixture of spicules and wave activities. We suggest that each intensity disturbance in the polar coronal hole is possibly a series of independent slow magnetoacoustic waves triggered by spicular activities.

关键词： Sun: corona- Sun: waves -- Sun: turbulence -- method: observational

Analysis of an SME using Silicon and Flexible Organic Solar Cells as Replacements for Fossil Fuel Sources of Electricity in UK and Iraq

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Journal of Environmental Science and Engineering(B) 2016年第4期5卷 173-178页

作者： Azad Azabany Ari Azabanee Khalid Khan Mahmood Shah Waqar Ahmed lancashire Business School university of central lancashire Preston PR1 2HE United Kingdom School of Engineering University of Central Lancashire Preston PR1 2HE United Kingdom School of Medicine University of Central Lancashire Preston PR1 2HE United Kingdom

Currently, 86% of the energy originates from fossil fuelsforelectricity. These are expected to run out, causing severe environmental damage threatening future generations. The total impact of Small and Medium Enterprises （SMEs） on the economy is significant. Solar cells harness the sun＇s energy to generate electricity in an environmentally friendly manner. This study compares silicon solar cells to flexible Organic Photovoltaic solar cells （OPV） for electricity energy for a micro-business in the UK and Iraq. It shows that it is feasible to replace existing fossil fuel sources with solar cells in Iraq due to a greater amount of solar radiation striking the earth＇s surface. Flexible solar cells can replace a proportion of the energy requirements in the UK and a larger proportion in Iraq. Using existing 20% efficient solar cells, 28% and 83% of the energy requirements of the microbusiness can be replaced in UK and Iraq respectively. Assuming 20% efficiency for solar cells placed on windows, 74% and 220% of the energy requirements of UK and Kurdistan can be replaced respectively and the surplus stored.

关键词： Energy management silicon solar cells flexible organic solar cells CO2 emissions Iraq United Kingdom.