检索结果-南通市图书馆

Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1069-1076页

作者： Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung Lo Jialiu Zeng Department of Clinical Neurosciences University of CambridgeCambridgeUK School of Applied Science Republic PolytechnicSingaporeSingapore Lee Kong Chian School of Medicine Nanyang Technological UniversitySingaporeSingapore

The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s ***-related conditions like type 2 diabetes and non-alcoholic fatty liver disease exacerbate this *** lipid accumulation,particularly in the liver,initiates a cascade of inflammatory processes that extend to the brain,influencing critical metabolic regulatory *** and palmitate,key lipid components,along with lipid transporters lipocalin-2 and apolipoprotein E,contribute to neuroinflammation by disrupting blood–brain barrier integrity and promoting *** insulin resistance further exacerbates brain insulin resistance and *** interventions targeting peripheral lipid metabolism and insulin signaling pathways have shown promise in reducing neuroinflammation in animal ***,translating these findings to clinical practice requires further investigation into human *** conclusion,metabolic dysfunction,peripheral inflammation,and insulin resistance are integral to neuroinflammation and *** these complex mechanisms holds potential for identifying novel therapeutic targets and improving outcomes for neurodegenerative diseases.

关键词： Alzheimer’s disease inflammatory cytokines insulin resistance lipid

在线全文

学校读者我要写书评

暂无评论

不完整需求信息下报童供应链鲁棒契约

中国科学:数学 2025年

作者：江厚元 Serguei Netessine Judge Business School University of Cambridge The Wharton School University of Pennsylvania

众所周知,当需求信息完整并且对零售商与供应商是对称时,批发价格契约无法协调报童供应链,而回购契约和收入分享契约则可以.通过鲁棒优化框架,本文研究如何制定批发价格契约和回购契约,并探讨这些常用供应链契约在需求信息有限和不完整... 详细信息

众所周知,当需求信息完整并且对零售商与供应商是对称时,批发价格契约无法协调报童供应链,而回购契约和收入分享契约则可以.通过鲁棒优化框架,本文研究如何制定批发价格契约和回购契约,并探讨这些常用供应链契约在需求信息有限和不完整时是否能协调供应链.本文采用极小极大遗憾值方法来构建零售商、供应商和系统问题的数学模型.本文得到如下结果.其一,除了退化解外,当需求变异和利润率都较大时,鲁棒批发价格契约和鲁棒回购契约都无法协调供应链.其二,供应商在鲁棒批发价格契约下的最大绝对遗憾值比在鲁棒回购契约下的最大绝对遗憾值小.其三,鲁棒批发价格契约的最大相对遗憾值通常小于鲁棒回购契约的最大相对遗憾值,并为鲁棒批发价格契约和鲁棒回购契约的最大相对遗憾值提供了渐近紧界.这些管理洞察表明,鲁棒批发价格契约不仅更易管理,而且相对于鲁棒回购契约还具有其他优势,这为批发价格契约在实践中比回购契约更受欢迎提供一些理论支持.本文还证明,无论需求信息是否完整,无论是鲁棒批发价格契约还是鲁棒回购契约,零售商在订购量上都比社会规划者更为保守.

关键词：报童供应链鲁棒契约批发价格契约回购契约供应链协调绝对遗憾值相对遗憾值

Microcapillary cell extrusion deposition with picolitre dispensing resolution

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2023年第1期6卷 1-11页

作者： Saeed Fathi Iek Man Lei Yang Cao Yan Yan Shery Huang Department of Engineering University of CambridgeCambridgeUK The Nanoscience Centre University of CambridgeCambridgeUK

Extrusion-based cell deposition has become a prominent technique for expanding bioprinting ***,the associated print resolution in the order of nanolitre or above has been a limiting *** demand for improving print resolution towards the scale of a single cell has driven the development of precision nozzle extrusion,although the benefits gained remain ***,aided by in situ imaging,we investigated the dynamics of cell organisation through an extrusion-based microcapillary tip with picolitre precision through in-air or immersion *** microcapillary extrusion setup,termed‘Picodis’,was demonstrated by generating droplets of colouring inks immersed in an immiscible ***,using 3T3 fibroblast cells as an experimental model,we demonstrated the deposition of cell suspension,and pre-aggregated cell ***,the dynamic organisation of cells within the microcapillary tip was described,along with cell ejection and deposition upon exiting the tip *** vision-assisted approach revealed that when dispersed in a culture medium,the movements of cells were distinctive based on the flow profiles and were purely driven by laminar fluid flow within a narrow *** primary process limitations were cell sedimentation,aggregation and compaction,along with trapped air *** use of picolitre-level resolution microcapillary extrusion,although it provides some level of control for a small number of cells,does not necessarily offer a reliable method when a specified number of cells are *** study provides insights into the process limitations of high-resolution cell ink extrusion,which may be useful for optimising biofabrication processes of cell-laden constructs for biomedical research.

关键词： Microcapillary cell printing Resolution dispensing Cell sedimentation Single cell

Strain gradient plasticity: energetic or dissipative?

在线全文

学校读者我要写书评

暂无评论

Acta Mechanica Sinica 2015年第4期31卷 465-472页

作者： N.A.Fleck J.R.Willis Department of Engineering University of Cambridge Department of Applied Mathematics and Theoretical Physics University of Cambridge

Abstract For an infinite slab of strain gradient sensitive material subjected to plane-strain tensile loading, compu- tation established and analysis confirmed that passivation of the lateral boundaries at some stage of loading inhibits plastic deformation upon further loading. This result is not surprising in itself except that, remarkably, if the gradient terms contribute to the dissipation, the plastic deformation is switched off completely and only resumes at a clearly defined higher load, corresponding to a total strain ec, say. The analysis presented in this paper confirms the delay of plastic deformation following passivation and determines the exact manner in which the plastic flow resumes. The plastic strain rate is continuous at the exact point ec of resumption of plastic flow and, for the first small increment Ae = e - ec in the imposed total strain, the corresponding increment in plastic strain, AeP, is proportional to （Ae）2. The constant A in the relation AeP（0） = A（Ae）2, where AeP（0） denotes the plastic strain increment at the centre of the slab, has been determined explicitly; it depends on the hardening modulus of the material. The presence of energetic gradient terms has no effect on the value of ec unless the dissipative terms are absent, in which case passivation reduces the rate of plastic deformation but introduces no delay. This qualitative effect of dissipative gradient terms opens the possibility of experimen- tal discrimination of their presence or absence. The analysisemploys an incremental variational formulation that is likely to find use in other problems.

关键词： Strain gradient plasticity Boundary passivation Incremental variational principle

SARS-CoV-2 and innate immunity:the good,the bad,and the"goldilocks"

在线全文

学校读者我要写书评

暂无评论

Cellular & Molecular Immunology 2024年第2期21卷 171-183页

作者： Benjamin L.Sievers Mark T.K.Cheng Kata Csiba Bo Meng Ravindra K.Gupta Department of Medicine University of CambridgeCambridgeUK cambridge Institute of Therapeutic Immunology&Infectious Disease(CITID) Department of MedicineUniversity of CambridgeCambridgeUk

An ancient conflict between hosts and pathogens has driven the innate and adaptive arms of *** about this interplay can not only help us identify biological mechanisms but also reveal pathogen vulnerabilities that can be leveraged *** humoral response to SARS-CoV-2 infection has been the focus of intense research,and the role of the innate immune system has received significantly less ***,we review current knowledge of the innate immune response to SARS-CoV-2 infection and the various means SARS-CoV-2 employs to evade innate defense *** also consider the role of innate immunity in SARS-CoV-2 vaccines and in the phenomenon of long COVID.

关键词： SARS-CoV-2 Innate immune response Interferon Cytokines Inflammation Antiviral targets

MPM simulations of dam-break floods

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Hydrodynamics 2017年第3期29卷 397-404页

作者： Xuanyu Zhao Dongfang Liang Mario Martinelli Department of Engineering University of CambridgeCambridgeUK Deltares DelftThe Netherlands

Owing to its ability of modelling large deformations and the ease of dealing with moving boundary conditions,the material point method is gaining popularity in geotechnical engineering *** this paper,this promising Lagrangian method is applied to hydrodynamic problems to further explore its *** collapse of water columns with different initial aspect ratios is simulated by the material point *** order to test the accuracy and stability of the material point method,simulations are first validated using experimental data and results of mature numerical ***,the model is used to ascertain the critical aspect ratio for the widely-used shallow water equations to give satisfactory *** the comparisons between the simulations based on the material point method and the shallow water equations,the critical aspect ratio for the suitable use of the shallow water equations is found to be 1.

关键词： Material point method dam-break floods Lagrangian method shallow water equations

Effect of a Traffic Speed Based Cruise Control on an Electric Vehicle’s Performance and an Energy Consumption Model of an Electric Vehicle

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 386-394页

作者： Anil K.Madhusudhanan Xiaoxiang Na Department of Engineering University of Cambridge

This paper proposes a cruise control system(CCS)to improve an electric vehicle's range,which is a significant hurdle in market penetration of electric vehicles.A typical driver or a conventional adaptive cruise control(ACC)controls an electric vehicle(EV)such that it follows a lead vehicle or drives close to the speed *** driving behaviour may cause the EV to cruise significantly above the average traffic *** may later require the EV to slow down due to the traffic ripples,wasting a part of the EV's kinetic *** addition,the EV will also waste higher speed dependent dissipative energies,which are spent to overcome the aerodynamic drag force and rolling *** paper proposes a CCS to address this *** proposed CCS controls an EV's speed such that it prevents the vehicle from speeding significantly above the average traffic *** addition,it maintains a safe inter-vehicular distance from the lead *** design and simulation analysis of the proposed CCS were in a MATLAB simulation *** simulation environment includes an energy consumption model of an EV,which was developed using data collected from an electric bus operation in *** the simulation analysis,the proposed system reduced the EV's energy consumption by approximately 36.6%in urban drive cycles and 15.4%in motorway drive ***,the experimental analysis using a Nissan e-NV200on two urban routes showed approximately 30.8%energy savings.

关键词： Cruise control electric vehicle(EV) energy performance safety traffic

Modelling of a Human Driver’s Interaction with Vehicle Automated Steering Using Cooperative Game Theory

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2019年第5期6卷 1095-1107页

作者： Xiaoxiang Na David J.Cole Department of Engineering University of Cambridge

The introduction of automated driving systems raised questions about how the human driver interacts with the automated system. Non-cooperative game theory is increasingly used for modelling and understanding such interaction, while its counterpart, cooperative game theory is rarely discussed for similar applications despite it may be potentially more suitable. This paper describes the modelling of a human driver’s steering interaction with an automated steering system using cooperative game theory. The distributed Model Predictive Control approach is adopted to derive the driver’s and the automated steering system’s strategies in a Pareto equilibrium sense, namely their cooperative Pareto steering strategies. Two separate numerical studies are carried out to study the influence of strategy parameters, and the influence of strategy types on the driver’s and the automated system’s steering performance. It is found that when a driver interacts with an automated steering system using a cooperative Pareto steering strategy, the driver can improve his/her performance in following a target path through increasing his/her effort in pursuing his/her own interest under the driver-automation cooperative control goal. It is also found that a driver’s adoption of cooperative Pareto steering strategy leads to a reinforcement in the driver’s steering angle control, compared to the driver’s adoption of non-cooperative Nash strategy. This in turn enables the vehicle to return from a lane-change maneuver to straight-line driving swifter.

关键词： Automated driving system cooperative game theory driver modelling

Distributed fiber optic monitoring of a CFA pile with a central reinforcement bar bundle

在线全文

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2021年第1期15卷 167-176页

作者： Yi RUI Nicholas de BATTISTA Cedric KECHAVARZI Xiaomin XU Mei YIN Centre for Smart Infrastructure and Construction Department of EngineeringUniversity of CambridgeCambridge CB21TNUK Department of Engineering University of CambridgeCambridge CB21TNUK

In this paper,we present an application of distributed fiber optic sensor(DFOS)technology to measure the strain of a continuous flight auger(CFA)test pile with a central reinforcement bar bundle,during a static load test carried out in *** distributed in nature,DFOS gives much more information about the pile performance as compared to traditional point sensors,such as identifying cross-sectional irregularities or other *** strain profiles recorded along the depth of the piles from the DFOS were used to calculate pile deformation(contraction),shaft friction,and tip resistance under various *** on this pile load test,a finite element(FE)analysis was performed using a one-dimensional nonlinear load-transfer *** by the shaft friction and tip resistance derived from the monitored data,the FE model was able to simulate the pile and soil performance during the load testing with good *** effect of the reinforcement cage and central reinforcement bar bundle were investigated,and it was found that the addition of a reinforcement cage would reduce the pile settlement by up to 20%.

关键词： continuous flight auger pile static load test central reinforcement bar bundle distributed fiber optic sensor finite element load transfer