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World Journal of AIDS 2016年第4期6卷 157-168页

作者： Polyxeni Pikea Efi Parpa Eleni Tsilika Antonis Galanos Kyriaki Mystakidou OKANA Antidrug Center Athens Greece Pain Relief and Palliative Care Unit Department of Radiology Areteion Hospital School of Medicine National and Kapodistrian University of Athens Athens Greece

Aims: The aim of this study was to validate the Greek translation of the university of california, los angeles Loneliness Scale (UCLA) in Greek adults with HIV. Methods: The UCLA Loneliness scale (version 3) was administered to 140 people with HIV. Participants also completed the Greek Hospital Anxiety and Depression Scale (G-HADS). Validity and reliability analyses were performed. Results: The Cronbach’s α coefficient for the total UCLA score was 0.9. Test-retest reliability analysis in a subgroup of patients (n = 40) revealed good short-term stability over a 2-week interval (ICC 0.8 - 0.9, p < 0.0005). Exploratory factor analysis generated a three factors structure for the Greek translation. Convergent validity was supported through the scale’s high correlations with G-HADS anxiety (0.382, p < 0.01) and depression (0.524, p < 0.005). Conclusion: The Greek UCLA Loneliness scale (version 3) is a valid and reliable instrument that can be usefully implemented into clinical practice in order to diagnose and treat loneliness among the Greek HIV positive patients.

关键词： UCLA Loneliness Scale People with HIV Reliability Validity

Immunoassay development guidelines for neurodegenerative disorders:lessons from a failed pS129-α-synuclein electrochemiluminescence immunoassay

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Neural Regeneration Research 2025年第10期20卷 2906-2908页

作者： Hash Brown Taha Alanna Morris Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA Deparmtent of Neurobiology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCAUSA

An aging population is a double-edged *** one hand,advancements in biotechnology and healthcare allow more people to enjoy longer *** the other hand,increases in the aging population accompany a surge in age-associated diseases,particularly neurodegenerative *** aging is the primary risk factor for many neurodegenerative disorders,living longer does not necessarily equate to maintaining a reasonable quality of life(Feigin et al.,2020).

关键词： aging degenerative necessarily

Biomarker bust:meta-analyses reveal unreliability of neuronal extracellular vesicles for diagnosing parkinsonian disorders

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Neural Regeneration Research 2025年第1期20卷 201-202页

作者： Hash Brown Taha Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA

A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor *** in this group are Parkinson’s disease(PD),dementia with Lewy bodies(DLB),multiple system atrophy(MSA),corticobasal syndrome(CBS),and progressive supranuclear palsy(PSP).These disorders are differentiated neuropathologically by their dominant protein pathologies involvingα-synuclein(α-syn)and/or tau,the types of brain cells affected,such as neurons,oligodendroglia,and astrocytes,and the specific brain regions involved(Tolosa et al.,2021).

关键词： disorders parkin

Neuroprotection by resveratrol-glucuronide and quercetin-glucuronide via binding to polyphenol-and glycosaminoglycan-binding sites in the laminin receptor

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Neural Regeneration Research 2025年第3期20卷 819-820页

作者： Rayudu Gopalakrishna Jennifer Aguilar Emily Lee William J.Mack Department of Integrative Anatomical Sciences Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA Department of Neurological Surgery Keck School of MedicineUniversity of Southern CaliforniaLos AngelesCAUSA

The dietary polyphenolic compounds resveratrol and quercetin prevent neurodegenerative diseases in experimental models;however, they reach the brain only in nanomolar concentrations in the glucuronidated and sulfated ... 详细信息

关键词： resveratrol molar dated

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao Chen Xinfei Wang Shaolei Wang Junyi Yin Ming Yang Xuxu Chen Xinhua Yin Yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

Flexible Strain Sensors with Ultra‑High Sensitivity and Wide Range Enabled by Crack‑Modulated Electrical Pathways

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Nano-Micro Letters 2025年第3期17卷 246-264页

作者： Yunzhao Bai Yunlei Zhou Xuanyu Wu Mengfei Yin Liting Yin Shiyuan Qu Fan Zhang Kan Li YongAn Huang State Key Laboratory of Intelligent Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Flexible Electronics Research Center Huazhong University of Science and TechnologyWuhan 430074People’s Republic of China Hangzhou Institute of Technology Xidian UniversityHangzhou 311200People’s Republic of China School of Mechano‑Electronic Engineering Xidian UniversityXi’an 710071People’s Republic of China Department of Aerospace and Mechanical Engineering University of Southern CaliforniaLos AngelesCA 90089USA

This study presents a breakthrough in flexible strain sensor technology with the development of an ultrahigh sensitivity and wide-range sensor,addressing the critical challenge of reconciling sensitivity with measurement *** by the structure of bamboo slips,we introduce a novel approach that utilises liquid metal to modulate the electrical pathways within a cracked platinum fabric *** resulting sensor demonstrates a gauge factor greater than 108 and a strain measurement capability exceeding 100%.The integration of patterned liquid metal enables customisable tuning of the sensor’s response,while the porous fabric structure ensures superior comfort and air permeability for the *** design not only optimises the sensor’s performance but also enhances the electrical stability that is essential for practical *** systematic investigation,we reveal the intrinsic mechanisms governing the sensor’s response,offering valuable insights for the design of wearable strain *** sensor’s exceptional performance across a spectrum of applications,from micro-strain to large-strain detection,highlights its potential for a wide range of real-world uses,demonstrating a significant advancement in the field of flexible electronics.

关键词： Flexible strain sensor Fabric Crack Response regulation Epidermal device

Ultrathin wavy Rh nanowires as highly effective electrocatalysts for methanol oxidation reaction with ultrahigh ECSA

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Nano Research 2019年第1期12卷 211-215页

作者： Xiaoyang Fu Zipeng Zhao Chengzhang Wan Yiliu Wang Zheng Fan Frank Song Bocheng Cao Mufan Li Wang Xue Yu Huang Xiangfeng Duan Department of Chemistry and Biochemistry University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA Department of Materials Science and Engineering University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA california Nanosystems Institute University of CaliforniaLos AngelesLos AngelesCalifornia 90095USA

Direct methanol fuel cells (DMFCs) have received tremendous research interests because of the facile storage of liquid methanol ***,the DMFC today is severely plagued by the poor kinetics and rather high overpotential in methanol oxidation reaction (MOR).Here we report the investigation of the ultrathin Rh wavy nanowires as a highly effective MOR *** show that ultrathin wavy Rh nanowires can be robustly synthesized with 2-3 nm *** studies show a current peak at the potential of 0.61 V *** hydrogen electrode (RHE),considerably lower than that of Pt based catalysts (~ 0.8-0.9 V ***).Importantly,with ultrathin diameters and favorable charge transport,the Rh nanowires catalysts exhibit an ultrahigh electrochemically active surface area determined from CO-stripping (ECSAco) of 144.2 m2/g,far exceeding that of the commercial Rh black samples (20 m2/g).Together,the Rh nanowire catalysts deliver a mass activity of 722 mA/mg at 0.61 V,considerably higher than many previously reported electrocatalysts at the same *** chronoamperometry studies also demonstrate good stability and CO-tolerance compared with the Rh black control sample,making ultrathin Rh wavy nanowires an attractive electrocatalyst for MOR.

关键词： rhodium nanowires electrocatalysis methanol oxidation reaction (MOR)

Three-dimensional graphene membrane cathode for high energy density rechargeable lithium-air batteries in ambient conditions

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Nano Research 2017年第2期10卷 472-482页

作者： Xing Zhong Benjamin Papandrea Yuxi Xu Zhaoyang Lin Hua Zhang Yuan Liu Yu Huang Xiangfeng Duan Department of Chemistry and Biochemistry University of California Los Angeles Los Angeles CA 90095 USA california Nanosystems Institute University of California Los Angeles Los Angeles CA 90095 USA Department of Materials Science and Engineering University of California Los Angeles Los Angeles CA 90095 USA

Lithium-air batteries have attracted significant interest for applications in high energy density mobile power supplies, yet there are considerable challenges to the development of rechargeable Li-air batteries with stable cycling performance under ambient conditions. Here we report a three-dimensional （3D） hydrophobic graphene membrane as a moisture-resistive cathode for high performance Li-air batteries. The 3D graphene membrane features a highly interconnected graphene network for efficient charge transport, a highly porous structure for efficient diffusion of oxygen and electrolyte ions, a large specific surface area for high capacity storage of the insulating discharge product, and a network of highly tortuous hydrophobic channels for O2/H20 selectivity. These channels facilitate 02 ingression while retarding moisture diffusion and ensure excellent charge/ discharge cycling stability under ambient conditions. The membrane can thus enable robust Li-air batteries with exceptional performance, including a maximum cathode capacity that exceeds 5,700 mAh/g and excellent recharge cycling behavior （〉2,000 cycles at 140 mAh/g, and 〉100 cycles at 1,400 mAh/g）. The graphene membrane air cathode can deliver a lifetime capacity of 100,000-300,000 mAh/g, comparable to that of a typical lithium ion battery cathode. The stable operation of Li-air batteries with significantly improved single charge capacities and lifetime capacities comparable to those of Li-ion batteries may offer an attractive high energy density storage alternative for future mobile power supplies. These batteries may provide much longer battery lives and greatly reduced recharge frequency.

关键词： energy storage graphene framework three-dimensional(3D)-network lithium air-battery water resistive

Single-cell sorting based on secreted products for functionally defined cell therapies

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Microsystems & Nanoengineering 2022年第4期8卷 17-34页

作者： Hiromi Miwa Robert Dimatteo Joseph de Rutte Rajesh Ghosh Dino Di Carlo Department of Bioengineering University of California-Los AngelesLos AngelesCA 90095USA Department of Chemical and Biomolecular Engineering University of California-Los AngelesLos AngelesCA 90095USA Partillion Bioscience Los AngelesCA 90095USA Department of Mechanical and Aerospace Engineering University of California-Los AngelesLos AngelesCA 90095USA california NanoSystems Institute(CNSI) University of California-Los AngelesLos AngelesCA 90095USA

Cell therapies have emerged as a promising new class of“living”therapeutics over the last decade and have been particularly successful for treating hematological ***,cellular therapeutics are being developed with the aim of treating almost any disease,from solid tumors and autoimmune disorders to fibrosis,neurodegenerative disorders and even aging ***,their therapeutic potential has remained limited due to the fundamental differences in how molecular and cellular therapies *** the structure of a molecular therapeutic is directly linked to biological function,cells with the same genetic blueprint can have vastly different functional properties(e.g.,secretion,proliferation,cell killing,migration).Although there exists a vast array of analytical and preparative separation approaches for molecules,the functional differences among cells are exacerbated by a lack of functional potency-based sorting *** this context,we describe the need for next-generation single-cell profiling microtechnologies that allow the direct evaluation and sorting of single cells based on functional properties,with a focus on secreted molecules,which are critical for the in vivo efficacy of current cell *** first define three critical processes for single-cell secretion-based profiling technology:(1)partitioning individual cells into uniform compartments;(2)accumulating secretions and labeling via reporter molecules;and(3)measuring the signal associated with the reporter and,if sorting,triggering a sorting event based on these reporter *** summarize recent academic and commercial technologies for functional single-cell analysis in addition to sorting and industrial applications of these *** approaches fall into three categories:microchamber,microfluidic droplet,and lab-on-a-particle ***,we outline a number of unmet needs in terms of the discovery,design and manufacturing of cellular therapeutics a

关键词： therapies sorting realization

High-throughput terahertz imaging:progress and challenges

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Light(Science & Applications) 2023年第10期12卷 2053-2073页

作者： Xurong Li Jingxi Li Yuhang Li Aydogan Ozcan Mona Jarrahi Department of Electrical&Computer Engineering University of California Los Angeles(UCLA)Los AngelesCA90095USA california NanoSystems Institute(CNSI) University of California Los Angeles(UCLA)Los AngelesCA 90095USA Department of Bioengineering University of California Los Angeles(UCLA)Los AngelesCA 90095USA

Many exciting terahertz imaging applications,such as non-destructive evaluation,biomedical diagnosis,and security screening,have been historically limited in practical usage due to the raster-scanning requirement of imaging systems,which impose very low imaging ***,recent advancements in terahertz imaging systems have greatly increased the imaging throughput and brought the promising potential of terahertz radiation from research laboratories closer to real-world ***,we review the development of terahertz imaging technologies from both hardware and computational imaging *** introduce and compare different types of hardware enabling frequency-domain and time-domain imaging using various thermal,photon,and field image sensor *** discuss how different imaging hardware and computational imaging algorithms provide opportunities for capturing time-of-flight,spectroscopic,phase,and intensity image data at high ***,the new prospects and challenges for the development of future high-throughput terahertz imaging systems are briefly introduced.

关键词： hardware closer terahertz