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Prolonged intermittent theta burst stimulation restores the balance between A_(2A)R-and A_(1)R-mediated adenosine signaling in the 6-hydroxidopamine model of Parkinson's disease

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Neural Regeneration Research 2025年第7期20卷 2053-2067页

作者： Milica Zeljkovic Jovanovic Jelena Stanojevic Ivana Stevanovic Milica Ninkovic Tihomir V.Ilic Nadezda Nedeljkovic Milorad Dragic Laboratory for Neurobiology Department of General Physiology and BiophysicsFaculty of BiologyUniversity of BelgradeBelgradeSerbia Medical Faculty of Military Medical Academy University of DefenceBelgradeSerbia

An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's *** therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in *** transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's ***,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain *** purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated *** with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod ***,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate *** intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate *** with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor *** treatment with prolonged intermittent theta burst stimulation,complete motor recovery was *** improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst *** results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)***

关键词： A_(1)R A_(2A)R adenosine receptors adenosine ecto-5′-nucleotidase intermittent theta burst stimulation non-invasive brain stimulation Parkinson's disease purinergic signalling

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Beta thalassemia syndromes:New insights

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World Journal of Clinical Cases 2025年第10期13卷 1-8页

作者： Ana Dordevic Ines Mrakovcic-Sutic Sonja Pavlovic Milena Ugrin Jelena Roganovic Department of Business Development Jadran Galenski LaboratorijRijeka 51000Croatia Faculty of Medicine University of RijekaRijeka 51000Croatia Institute of Molecular Genetics and Genetic Engineering University of BelgradeBelgrade 11000Serbia Department of Pediatric Hematology and Oncology Children’s Hospital ZagrebZagreb 10000Croatia Faculty of Biotechnology and Drug Development University of RijekaRijeka 51000Croatia

Beta thalassemia(β-thalassemia)syndromes are a heterogeneous group of inherited hemoglobinopathies caused by molecular defects in the beta-globin gene that lead to the impaired synthesis of beta-globin chains of the *** hallmarks of the disease include ineffective erythropoiesis,chronic hemolytic anemia,and iron *** presentation ranges from asymptomatic carriers to severe anemia requiring lifelong blood transfusions with subsequent devastating *** management of patients with severeβ-thalassemia represents a global health problem,particularly in low-income *** recently,management strategies were limited to regular transfusions and iron chelation therapy,with allogeneic hematopoietic stem cell transplantation available only for a subset of *** understanding of the underlying pathophysiological mechanisms ofβ-thalassemia syndromes and associated clinical phenotypes has paved the way for novel therapeutic options,including pharmacologic enhancers of effective erythropoiesis and gene therapy.

关键词： Beta thalassemia Hemoglobin Molecular defects Ineffective erythropoiesis Hemolysis Transfusion Iron chelation Novel therapies

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Dielectric and infrared properties of SrTiO_3 single crystal doped by 3d (V,Mn,Fe,Ni) and 4f (Nd,Sm,Er) ions

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Chinese Physics B 2014年第2期23卷 369-374页

作者： S.Maletic D.Maletic I.Petronijevic J.Dojcilovic D.M.Popovic Faculty of Physics University of Belgrade Institute of Physics University of Belgrade

In this study, the effects of doping by 3d （V, Mn, Fe, Ni） and 4f （Nd, Sm, Er） ions on dielectric and infrared properties of SrTiO3 （STO） single crystals are investigated. It is well known that doping of the SrTiO3 can change the dielectric properties of the STO from an insulator to an n-type semiconductor, and even to a metallic conductor. Dielectric and infrared （IR） properties of the undoped STO and doped STO single crystals are analyzed using dielectric spectroscopy （80 kHz-5 MHz）, transmission （200 cm^-1-4000 cm^-1）, and reflection spectroscopy （50 cm^-1-2000 cm^-1）. It is found that doping by the 3d ions reduces the value of dielectric permittivity, but the trend of temperature dependence of the dielectric permittivity remains almost unchanged. On the other hand, dielectric spectroscopy measurements for samples doped by 4f ions show the anomalous behaviors of the dielectric permittivity at temperatures around the temperature of the structural phase transition. There are two fractures of temperature dependences of inverse dielectric permittivity εr^-1 （T）. Transmittance spectroscopy measurements show that there are differences in the shape of the spectrum in the mid-IR region between the undoped STO and the one doped by 4f ions. The differences in the reflectance spectrum between the STO：Nd and STO are analyzed in detail.

关键词： doping dielectric properties phase transitions infrared spectroscopy

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Numerical modelling of supercritical flow in circular conduit bends using SPH method

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Journal of Hydrodynamics 2017年第2期29卷 344-352页

作者： Nikola M.Rosie Milena B.Kolarevie Ljubodrag M.Savie Dejana M.Doraevic Radomir S.Kapor Fuculty of Civil Engineering University of BelgradeBelgradeSerbia Energoproiekt-Hidroinzenjering BelgradeSerbia

The capability of 1he smoothed-particle hydrodynamics （SPH） method to model supercritical flow in circular pipe bends is considered. The standard SPH method, which makes use of dynamic boundary particles （DBP）, is supplemented with the original algorithm for the treatment of open boundaries. The method is assessed through a comparison with measured free-surface profiles in a pipe bend, and already proposed regression curves for eslimation of the flow-type in a pipe bend. The sensitivity of the model to different parameters is also evaluated. It is shown that an adequate choice of the artificial viscosity coefficient and the initial particle spacing can lead to correct presentation of the flow-type in a bend. Due to easiness of its implementation, the SPH method can he efficiently used in the design of circular conduits with supercritical flow in a bend, such as tunnel spillways, and bottom outlets of dams, or storm sewers.

关键词： Smoothed-particle hydrodynamics (SPH) super critical bend flow helical flow artificial viscosity

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In situ synthesis of potassium tungstophosphate supported on BEA zeolite and perspective application for pesticide removal

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Journal of Environmental Sciences 2019年第7期31卷 136-147页

作者： Bojana Nedic Vasiljevic Milena Obradovic Danica Bajuk-Bogdanovic Maja Milojevic-Rakic Zoran Jovanovic Nemanja Gavrilov Ivanka Holclajtner-Antunovic Faculty of Physical Chemistry University of Belgrade Belgrade 11158 Serbia Laboratory of Physics Vin?a Institute of Nuclear Sciences University of Belgrade Belgrade 11001 Serbia

Potassium tungstophosphate is supported on BEA zeolite by in situ synthesis for glyphosate removal. Spectroscopic measurements identified hydrogen bonding as a primal interaction of potassium salt and BEA zeolite. Composites are evaluated for glyphosate herbicide removal and adsorption process is analyzed using two isotherm models. Obtained adsorption capacities for all prepared composites lay between 45.2 and 92.2 mg of glyphosate per gram of investigated composite. Suspension acidity revealed that glyphosate is adsorbed mainly in the zwitter-ion form at the composite surface while the amount of potassium salt in the composites is crucial for the adsorption application. Exceptional adsorption behavior is postulated to come from a high degree of homogeneity among surface active sites which is confirmed by different experimental methods. Temperature programmed desorption of glyphosate coupled with mass spectrometer detected one broad, high-temperature peak which represents overlapped desorption processes from active sights of similar *** of potassium tungstophosphate affects active sites present in BEA zeolite for glyphosate desorption and significantly increases the amount of adsorbed pesticide in comparison to BEA zeolite. Supporting of potassium tungstophosphate on BEA zeolite via in situ synthesis procedure enables the formation of highly efficient adsorbents and revealed their perspective environmental application.

关键词： Composite materials Chemical synthesis Kinetics Adsorption Ultrasonics

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Control Strategy for DC Soft Open Points in Large-scale Distribution Networks with Distributed Generators

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CSEE Journal of Power and Energy Systems 2022年第3期8卷 732-742页

作者： Dejan Ivic Predrag Stefanov School of Electrical Engineering University of Belgrade11120 BelgradeSerbia

Development of power electronic devices and their implementation in power distribution networks significantly improves not only the easier integration of distributed generation into distribution networks but also the further refinement of control algorithms specialized in the application of power management procedures in distribution *** of DC Soft Open Points(DCSOP)for closing loops in distribution networks could serve as one of the most representative examples of the use of power electronic devices as management resources in modern distribution *** paper describes the possibilities of the application of DCSOP used for loops closure and power flow control in medium voltage distribution networks with integrated distributed *** all the benefits of loops closure and the controllability of the DCSOP,it is considered as a management resource capable of achieving the desired/optimal state in the distribution *** management strategy proposed in this paper covers two cases:the first case is where an adequate communication infrastructure is available when all DCSOP operations are based on Optimal Power Flow(OPF)calculations,and the second case is when OPF results are unavailable for some reason(most often due to communication interruptions)and DCSOP operations are based on processing available data using a neural network-based *** proposed management strategy has been implemented and tested on an IEEE 33 distribution test network with integrated distributed *** simulation results,described in this paper,can serve not only as a basis for further scientific research but also as a basis for the practical implementation of real controllers based on the proposed algorithm and its application in practice,and in real distribution networks.

关键词： DC soft open points(DCSOP) neural networks optimal power flow(OPF) optimization in distribution networks

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Mating behavior as an indicator of quality of Drosophila subobscura males？

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Insect Science 2017年第1期24卷 122-132页

作者： Marija Savic Veselinovic Sofija Pavkovic-Lucic Zorana Kurbalija Novicic Mihailo Jelic Marina Stamenkovic-Radak Marko Andjelkovic Faculty of Biology University of Belgrade Belgrade Serbia Institute for Biological Research 'Sinisa Stankovic' university of belgrade Belgrade Serbia Serbian Academy of Sciences and Arts Belgrade Serbia

According to current theoretical predictions, any deleterious mutations that reduce nonsexual fitness may have a negative influence on mating success. This means that sexual selection may remove deleterious mutations from the populations. Males of good genetic quality should be more successful in mating, compared to the males of lower genetic quality. As mating success is a condition dependent trait, large fractions of the genome may be a target of sexual selection and many behavioral traits are likely to be condition dependent. We manipulated the genetic quality of Drosophila subobscura males by inducing mutations with ionizing radiation and observed the effects of the obtained heterozygous mutations on male mating behavior： courtship occurrence, courtship latency, mating occurrence, latency to mating and duration of mating. We found possible effects of mutations. Females mated more frequently with male progeny of nonirradiated males and that these males courted females faster compared to the male progeny of irradiated males. Our findings indicate a possible important role of sexual selection in purging deleterious mutations.

关键词： condition dependence deleterious mutations female preference inbred lines ionizing radiation mutational load

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A comparison of power measurement techniques and electrical characterization of an atmospheric pressure plasma jet

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Plasma Science and Technology 2022年第10期24卷 74-85页

作者： Olivera JOVANOVIĆ Nevena PUAČ NikolaŠKORO Institute of Physics University of BelgradePregrevica 118Belgrade 11080Serbia

In the last two decades a growing interest has been shown in the investigation of atmospheric pressure plasma jets(APPJs)that operate in contact with liquid *** order to form a complete picture about such experimental systems,it is necessary to perform detailed diagnostics of plasma jets,as one step that will enable the adjustment of system properties for applications in different *** this work,we conducted a detailed electrical characterisation of a plasma system configuration used for water treatment.A helium plasma jet,with a pin electrode powered by a continuous sine wave at a frequency of 330 k Hz,formed a streamer that was in contact with a distilled water *** electrical circuit allowed the monitoring of electrical signals supplied to the jet and also to the plasma *** electrical characterisation together with power consumption measurements was obtained by using two different *** first method was based on the direct measurements of voltage and current signals,while in the second method we used'Lissajous figures'.We compared these two methods when used for discharge power estimation and addressed their advantages and *** results showed that both of these methods could be used to successfully determine power consumed by a discharge in contact with water,but only when taking into account power dissipation without plasma.

关键词： APPJ electrical characterization discharge power Lissajous figure

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Approximation of thermoelasticity contact problem with nonmonotone friction

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Applied Mathematics and Mechanics(English Edition) 2010年第1期31卷 77-86页

作者： Ivan ESTAK Boko S. JOVANOVI Faculty of Mine and Geology University of Belgrade Faculty of Mathematics University of Belgrade

The paper presents the formulation and approximation of a static thermoelasticity problem that describes bilateral frictional contact between a deformable body and a rigid foundation. The friction is in the form of a nonmonotone and multivalued law. The coupling effect of the problem is neglected. Therefore, the thermic part of the problem is considered independently on the elasticity problem. For the displacement vector, we formulate one substationary problem for a non-convex, locally Lipschitz continuous functional representing the total potential energy of the body. All problems formulated in the paper are approximated with the finite element method.

关键词： static thermoelastic contact nonmonotone multivalued friction hemivari-ational inequality substationary problem finite element approximation

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In vivo femtosecond laser nanosurgery of the cell wall enabling patch-clamp measurements on filamentous fungi

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Microsystems & Nanoengineering 2024年第2期10卷 251-267页

作者： Tanja Pajić Katarina Stevanović Nataša V.Todorović Aleksandar J.Krmpot Miroslav Živić Svetlana Savić-Šević Steva M.Lević Marina Stanić Dejan Pantelić Brana Jelenković Mihailo D.Rabasović Institute of Physiology and Biochemistry“Ivan Djaja” Faculty of BiologyUniversity of BelgradeStudentski trg 1611158BelgradeSerbia Institute for Biological Research“Siniša Stanković” University of BelgradeNational Institute of the Republic of SerbiaBulevar Despota Stefana 14211000BelgradeSerbia Institute of Physics belgrade University of BelgradeNational Institute of the Republic of SerbiaPregrevica 11811080BelgradeSerbia university of belgrade Faculty of AgricultureNemanjina Street 611080BelgradeSerbia Institute for Multidisciplinary Research University of BelgradeKneza Višeslava 111030BelgradeSerbia

Studying the membrane physiology of filamentous fungi is key to understanding their interactions with the environment and crucial for developing new therapeutic strategies for disease-causing ***,their plasma membrane has been inaccessible for a micron-sized patch-clamp pipette for pA current recordings due to the rigid chitinous cell ***,we report the first femtosecond IR laser nanosurgery of the cell wall of the filamentous fungi,which enabled patch-clamp measurements on protoplasts released from hyphae.A reproducible and highly precise(diffraction-limited,submicron resolution)method for obtaining viable released protoplasts was *** release from the nanosurgery-generated incisions in the cell wall was achieved from different regions of the *** plasma membrane of the obtained protoplasts formed tight and high-resistance(GΩ)contacts with the recording *** entire nanosurgical procedure followed by the patch-clamp technique could be completed in less than 1 *** to previous studies using heterologously expressed channels,this technique provides the opportunity to identify new ionic currents and to study the properties of the ion channels in the protoplasts of filamentous fungi in their native environment.

关键词： patch recording laser

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