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心脏移植患者基底细胞癌和鳞状细胞癌的免疫抑制水平及其他危险因素

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世界核心医学期刊文摘（皮肤病学分册） 2005年第2期1卷 2-2页

作者： Fortina A.B. Piaserico S. Caforio A.L.P. 刘超 Unit of Dermatology Dept. of Med. and Surgical Sciences University of Padua Via Cesare Battisti 206 35128 Padua Italy Dr.

Objectives: To examine risk factors for the development of squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) in a cohort of heart transplant (HT) recipients and, in particular, to evaluate the role of the cumulative doses of different immunosuppressive drugs. Design: Prospective nonconcurrent study. Setting: A dermatology clinic at a university hospital. Patients: A total of 230 HT recipients 18 years or older at the time of transplantation with at least 3 years of follow-up. Main Outcome Measures: The risk of SCC and BCC in HT recipients and the relationship between development of SCC and BCC and cumulative doses of different immunosuppressive agents, controlling for other potential risk factors (age, sex, sunlight exposure, skin type, and presence of warts). Results: The cumulative immunosuppressive drug dose 3 years after transplantation (calculated by a weighted linear combination of azathioprine, cyclosporine, and corticosteroid cumulative doses ) was independently associated with an increased risk of developing SCC but not BCC. On multivariate analysis, patients receiving a WLC higher than the 75th percentile 3 years after HT had a 4 times higher risk of SCC than recipients of a WLC lower than the 50th percentile 3 years after HT (95%confidence interval, 1.4-11.4; P = .008). Other significant risk factors for SCC development were older age at transplantation and a greater occupational sunlight exposure. The risk of developing BCC was only associated with older age at transplantation and skin type II. Conclusions: The risk of SCC but not of BCC in HT recipients was related to the level of global immunosuppression rather than to 1 specific drug. The level of immunosuppression should be kept as low as possible consistent with survival and function of the transplanted organ.

关键词：基底细胞癌心脏移植免疫抑制累积剂量剂量计算皮肤类型日光暴晒病毒疣有显著性差异硫唑嘌呤

Evolution of People Living with HIV and AIDS in Medical Consultation at 17 ESOPE Sites in Mali

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Journal of Pharmacy and Pharmacology 2019年第9期7卷 504-509页

作者： S.Traore K.Kayentao B.Traore I.Coulibaly N.Telly S.Diop S.Doumbia M.Traore Department Surveillance Epidemiology Coordination Unit of the AIDS Control Sector Committee of the Ministry of Health and Public Health (CSLS/MSHP) BPE 594 Mali Department Parasitoly Center for International Excellence Studies USSTB Medical College (ICER-Mali)University Of ScienceTechnology of Bamako Faculty of medicine and Odontostomalogy Point G Mali Department of Public Health Teaching and Research Medical and Dental College of Stomatology (DERSP) University Of ScienceTechnology of Bamako Faculty of medicine and Odontostomalogy Point G Mali Director-General of the Center for Disease Support (CNAM) Djikoroni Para BP 251 Para Mali Director- General ofNational Institute of Public Health (INRSP) B.P. 1771 Bamako Mali

Despite the efforts made by the Malian government with technical and financial partners in the fight against HIV and AIDS, there are no data on the evolution of people with HIV in medical consultation in antiretroviral treatment sites. The objective of this work is to fill this gap by generating factual data describing the evolution of the number of people with HIV in medical consultation in Mali. To achieve this goal, we conducted a cross-sectional study using data from the Coordination Unit of the Sectoral Committee for AIDS Control of the Ministry of Health and Public hygiene. Sampling was comprehensive including all people living with HIV. The data collected concerned those of the years 1999 to 2014 by the ESOPE software and analyzed with Stata version 12. A Total of 39,619 people were enrolled in the study. And 26,212 people living with HIV in the 17 ESOPE sites of Mali were female. Patients aged 25-34 and 35-44 years were strongly represented in consultation in the years 2007 and 2011, and those aged 15-24 were the least frequent. HIV1 was the most dominant with 97%. The majority of patients presented for initial consultation were clinical stages 2 and 3 in all years. Cases of lost sites seen in the more common in hospitals are 62.79% at the hospital of Mopti and 57% at the university hospital of Point G. The number of cases of people living with HIV in medical consultation has progressively augmented from 1999-2007. Then it dropped from 2008-2010. After this number has increased by 2011, it dropped again in 2012-2014. This study made it possible to note the evolution of the patients in medical consultation in ESOPE antiretroviral treatment sites according to the years and events (safe, subsidized by activities by the global fund). The activities of sensitization and communications, case research should be strengthened by involving the community.

关键词： Evolution HIV Sites of ESOPE Mali 1999 to 2014

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药物治疗慢性心力衰竭的患者管理策略

世界核心医学期刊文摘（心脏病学分册） 2006年第9期2卷 35-35页

作者： Reid M. Clark A. Murdoch D.L. 孙凯 Division of Community Based Sciences Public Health and Health PolicyUniversity of Glasgow1 Lilybank GardensGlasgowG12 8RZUnited Kingdom

Objectives: To explore patients views of the management of medication of chron ic heart failure(CHF); to explore in what circumstances they have difficulties i n managing medication. Design: Qualitative analysis of in-depth interviews usin g a constant comparative approach. Participants: Patients attending an outpatien ts clinic with a primary diagnosis of CHF due to left ventricular systolic dysfu nction, NYHA Class II or III symptoms, and a history of hospital admission for h eart failure. Results: 50 patients were recruited, average age 67.1 years with r anges bet ween 41 and 80 years. 26 were classified as NYHA Class II and 24 Class III. Patients reported developing routines and back up strategies to help with the complex task of medication-taking. They also described circumstances in whi ch they were more likely not to take medication. Conclusions: This study demonst rates, with a large sample of respondents, the complexities of medication-takin g and the difficulties of maintaining constant medication over a long period of time. The study provides examples of patients’strategies for so doing. Health c are professionals should recognise that concordance may vary but explore ways in which they can help patients establish routines.

关键词：慢性心力衰竭药物治疗患者管理左室收缩功能障碍 NYHA分级治疗管理比较方法门诊患者

基于CARE指南评价针刺不良事件报告的质量

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World Journal of Acupuncture-Moxibustion 2023年第4期33卷 342-351页

作者：唐晓宇郑妍郑成陈泽陈珏璇邓晶晶王倩玫徐之睿 David Riley 段玉婷唐纯志广州中医药大学针灸康复临床医学院中国广州511400 揭阳市人民医院中国揭阳522000 黑龙江中医药大学中国哈尔滨150000 兰州大学基础医学院循证医学研究所中国兰州73000 广州市妇女儿童医疗中心中医科中国广州522000 广州中医药大学第一附属医院中国广州510405 普宁市中医院中国揭阳515300 Maryland university of Integrative Health Department of ResearchLaurel 20725United States of America 广州医科大学附属中医医院循证医学研究室中国广州510140

Objective:As a popular complementary therapy,the safety of acupuncture must be *** case reports of adverse events(ACR-AEs)significantly contribute to the assessment of acupuncture ***,the reporting quality of ACR-AEs remains *** aimed to promote the application of the CARE(case report)guidelines and improve the reporting quality of ***:We systematically searched for ACR-AE from six databases:Medline,Embase,Chinese Biomedical Literature Service System,China National Knowledge Infrastructure,Wanfang Data,and VIP,and collected published ACR-AEs from January 1,2016,to December 31,*** included only case reports of adverse events related to acupuncture *** retrieved case reports were screened and filtered by two reviewers ***,basic information extraction and CARE evaluation of the included ACR-AEs ***:A total of 56 ACR-AE were included,15 of which were from *** top two major diseases were nervous system diseases(28.6%)and infections(21.4%).For all ACR-AEs,seven of 30 CARE subordinate items were reported in 30%or less,seven items were reported in 30-60%,and only five items got reporting proportion over 90%.In Chinese ACR-AE,only three items,"the main concerns and symptoms of the patient(5b)","types of intervention(9a)"and"adverse and unanticipated events(1od)"were sufficiently *** English ACR-AE,item"the main concerns and symptoms of the patient(5b)"and item"the primary takeaway lessons(11d)"were also generally ***:Overall,the reporting quality of ACR-AE was unsatisfactory,and we believe that a special reporting guideline for clinical cases targeted at acupuncture should be extended in future studies.

关键词： Acupuncture Adverse events CARE guidelines Case reports Reporting quality