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Design and synthesis of novel fluorogenic substrates for the detection of metallo-β-lactamases

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Design and synthesis of novel fluorogenic substrates for the...

Different Models of Community-based Rehabilitation Services for Children with Disabilities

中国化学会第九届全国有机化学学术会议

作者： Yi-Lin Zhang Ke-Wu Yang Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry and Materials ScienceNorthwest University

＜正＞Antibiotic resistance is an emerging clinic threat worldwide due to the overuse of ***,β-lactamases have been increasingly reported as the cause of therapeutic failures in *** some classicalβ-lactamase inhibitors have successfully been used in hospital treatment,there are no inhibitors of metallo-β-lactamases（MβLs）for *** MβLs exhibit the

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Different Models of Community-based Rehabilitation Services ...

Cell:新分子或可有效清除肝脏和血液中的脂肪

中国康复医学会首届儿童康复学术会议暨中国残疾人康复协会第八届小儿脑瘫学术会议

作者： Dahong Zhuo MD Dept.of Rehabilitation Medicine Sun Yat-sen university WHO Collaborating Center for Rehabilitation 510089GuangzhouChina

In the first part of the paper, the author analyzed the advantages of community-based rehabilitation (CBR) for children with disabilities (CWD). Then the author summarized the models of CBR services in the world for CWD as follows: (1) home-based rehabilitation supported by CBR workers;(2) home-visits by physicians or nurses/therapists from the community hospital;(3) day care rehab program in community mini-rehab clinic/kindergarten;(4) rehab counseling for case management;(5) parents’ school/parents’ club of special children;(6) fortified nutrition program for community children.

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现代生物医学进展 2017年第4期17卷 I0004-I0004页

作者： Brian Finan Christoffer Clemmensen Zhimeng Zhu Kerstin Stemmer Karine Gauthier Luisa M uuml ller Meri De Angelis Kristin Moreth Frauke Neff Diego Perez-Tilve Katrin Fischer Dominik Lutter Miguel A. S aacute nchez-Garrido Peng Liu Jan Tuckermann Mohsen Malehmir Marc E. Healy Achim Weber Mathias Heikenwalder Martin Jastroch Maximilian Kleinert Sigrid Jall Sara Brandt Fr eacute d eacute ric Flamant Karl-Werner Schramm Heike Biebermann Yvonne D ouml ring Christian Weber Kirk M. Habegger Michaela Keuper Vasily Gelfanov Fa Liu Josef K ouml hrle Jan Rozman Helmut Fuchs Valerie Gailus-Durner Martin Hrabě de Angelis Susanna M. Hofmann Bin Yang Matthias H. Tsch ouml p Richard DiMarchi Timo D. M uuml ller Institute for Diabetes and Obesity Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany Department of Chemistry Indiana University Bloomington IN 47405 USA Institut de Génomique Fonctionnelle de Lyon Université de Lyon Centre National de la Recherche Scientifique (CNRS) Institut National de la Recherche Agronomique (INRA) École Normale Supérieure de Lyon 69364 Lyon France Molecular EXposomics Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) 85764 Neuherberg Germany German Mouse clinic Institute of Experimental Genetics Helmholtz Zentrum München German Research Center for Environmental Health 85764 Neuherberg Germany Division of Endocrinology Department of Internal Medicine Metabolic Diseases Institute University of Cincinnati College of Medicine Cincinnati OH 45237 USA Institute of Comparative Molecular Endocrinology University of Ulm 89081 Ulm Germany Department of Pathology and Molecular Pathology University Zurich and University Hospital Zurich 8091 Zurich Switzerland Institute of Virology Technische Universität München 81675 Munich Germany Institute of Experimental Pediatric Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany Department of Medicine Institute for Cardiovascular Prevention Ludwig-Maximilians-Universität München 80336 Munich Germany Comprehensive Diabetes Center and Department of Medicine-Endocrinology Diabetes & Metabolism University of Alabama at Birmingham Birmingham AL 35294 USA Institute for Diabetes and Regeneration Helmholtz Diabetes Center at Helmholtz Zentrum München German Research Center for Environmental Health (GmbH) Neuherberg 85764 Germany Calibrium LLC Carmel IN 46032 USA Institute for Experimental Endocrinology Charité-Universitätsmedizin Berlin Berlin 13353 Germany German Center for Diabetes Research (DZD) 85764 Neuherberg Germany

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学... 详细信息

肥胖和糖尿病持续上升代表着我们的社会所面临的一个重大的负担。脂肪肝和动脉粥样硬化是这些代谢疾病常见的后果，但是开发一种高效且又安全的能够逆转肥胖、胰岛素抵抗性、脂肪肝和动脉粥样硬化的药物仍然是全球头等的一项重大的科学挑战。

关键词：脂肪肝 Cell 动脉粥样硬化血液肝脏清除分子代谢疾病

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黄精药理作用研究进展

中草药 2018年第18期49卷 4439-4445页

作者：赵文莉赵晔 Yiider Tseng 天津市南开医院天津300100 杭州得卜悠健康科技有限公司浙江杭州310018 Chemical Engineering Department University of Florida

黄精为我国常用传统中药,在长江以南大部分地区广泛分布,具有补益肝肾、延年益寿等作用,是自古以来的道家养生圣药。因其含有多糖、皂苷、黄酮、木脂素、氨基酸、醌类化合物、维生素、生物碱及多种微量元素等成分,从而具有较高的药用价... 详细信息

黄精为我国常用传统中药,在长江以南大部分地区广泛分布,具有补益肝肾、延年益寿等作用,是自古以来的道家养生圣药。因其含有多糖、皂苷、黄酮、木脂素、氨基酸、醌类化合物、维生素、生物碱及多种微量元素等成分,从而具有较高的药用价值和营养价值,国内各研究机构对其进行了较深入的研究,国外对其仍处于初步研究阶段。目前实验研究主要集中在黄精多糖、黄精醇、黄精皂苷提取物或黄精水提物上,以动物实验或单方和复方制剂的临床研究为主。其多种黄精制剂已广泛应用于临床,如黄精口服液、黄精茶、苁蓉精颗粒、黄精赞育胶囊、黄精精油眼罩等,发挥着不同的效用。查阅有关黄精的研究文献,对其药理作用进行全面的综合分析,多角度总结其效用价值,为黄精的深入开发与应用提供参考。

关键词：黄精黄精多糖黄精提取物细胞损伤抗氧化

特应性皮炎患儿SCORADs经验:主观症状与疾病的范围和程度不符

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世界核心医学期刊文摘（皮肤病学分册） 2006年第10期2卷 57-57页

作者： Hon K.-L.E. Leung T.F. Wong Y. Fok T.F. 王琼 Departmentof Pediatrics The Chinese University of Hong KongPrince of Wales HospitalClinical Science BuildingShatinHong Kong SARHong Kong

Background:Atopic dermatitis(AD)is a distressing disease associated with pruritus and sleep *** is not known how well these symptoms correlate with the extent and intensity of eczematous *** evaluated whether:(i)the level of sleep loss correlates with pruritus and(ii)the level of pruritus correlates with the extent or severity of AD in children according to the SCORing Atopic Dermatitis(SCORAD)***:Patients with AD younger than 18 years old were recruited from the pediatric dermatology clinic of a university teaching hospital,and AD severity was evaluated by the SCORAD ***:One hundred and eighty-two Chinese children with AD(107 boys and 75 girls)[mean(SD)age of 9.6(4.2)years] were *** mean(SD)overall SCORAD was 30.1(19.2).Sleep loss was strongly correlated with pruritus(r=0.57,P < 0.001).However,the two subjective symptoms were only weakly correlated with the objective signs(extent and intensity)of *** correlations between pruritus and extent and intensity were 0.42(P < 0.001)and 0.38(P < 0.001),respectively,and the correlations between sleep loss and extent and intensity were 0.38(P < 0.001)and 0.34(P < 0.001),***:We speculate that the lack of a better correlation was either because pruritus and sleep loss as reported by parents were imprecise,or that mechanisms other than disease extent or severity are responsible for the pathogenesis of these subjective symptoms.

关键词：特应性皮炎 SCORADs 瘙痒程度湿疹化严重度大学教学医院睡眠障碍患儿父母客观体征强

优化无创机械通气：哪个科室应护理这些患者？一项队列研究

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中国护理管理 2017年第8期17卷 1152-1152页

作者： Marta Raurell-Torredà E.Argilaga-Molero M.Colomer-Plana A.Ródenas-Fransico M.T.Ruiz-Garcia J.Uya Muntana 西班牙赫罗纳大学护理部巴塞罗那大学医院西班牙Dr.JosepTrueta大学医院西班牙Consorcihospitalari社区医院西班牙clinic大学医院巴塞罗那大学护理学院

背景:无创通气(NIV)已经不局限于在重症监护室(ICUs)使用,在急诊科(EDs)和普通病房,NIV也逐渐成为常规手段。目的:分析不同临床科室中,护理和NIV结局的关系。方法:根据患者特点、所提供的护理和所使用的医疗程序、评估治疗的成功和失败... 详细信息

背景:无创通气(NIV)已经不局限于在重症监护室(ICUs)使用,在急诊科(EDs)和普通病房,NIV也逐渐成为常规手段。目的:分析不同临床科室中,护理和NIV结局的关系。方法:根据患者特点、所提供的护理和所使用的医疗程序、评估治疗的成功和失败、接口不耐受以及并发症。并发症分析包括支气管吸引术、气胸、皮肤损伤、气道分泌物过多、眼刺激、意识水平恶化、胃扩张和面罩周围过量的空气消耗。结果:387例患者中,194例(50.1%)来自ICU,121例(31.3%)来自ED,38例(9.8%)来自术后病房,34例(8.8%)来自普通病房。校正APACHE评分和NIV适应证后,进行回归分析。结果显示,与社区医院ICU比较,在一所每年NIV病例数低于50例的大学医院的ICU,NIV失败的风险升高3.3倍[95%CI(1.2~9.2)];在ICUs和普通病房,12%的患者由于接口不耐受而中止使用NIV;急慢性肺病(ACLD)患者的NIV失败风险更低[OR 0.2,95%CI(0.06~0.69)];缺乏湿化与治疗失败没有相关性[OR 0.2,95%CI(0.1~0.4)];气道分泌物过多的相关因素是肺炎[OR 2.5,95%CI(1.1~5.9)]和早期中止和(或)拔管[OR 3.3,95%CI(1.2~8.9)];接口不耐受的相关因素是使用传统ICU呼吸机[OR 4.4,95%CI(2.1~9.2)]和过度空气消耗造成的鼻部皮肤损伤[OR 2.4,95%CI(1.1~5.3)],尤其是口鼻面罩的使用[OR 3.5,95%CI(1.1~11.3)]。结论:普通病房收治的急性呼吸衰竭的肺炎患者,其接口不耐受和NIV失败的风险增加。在任何给予NIV治疗的科室,旋转型面罩均能促进NIV的成功。

关键词：气道管理无创通气护理呼吸功能不全呼吸治疗急诊重症监护室皮肤损伤压力性溃疡面罩

ACUPUNCTURE clinic PATIENTS TREATED FOR LABOR PREPARATION:A PRELIMINARY OBSERVATIONAL STUDY

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Journal of Integrative Medicine 2014年第3期 290-290页

作者： Elizabeth Soliday Patrice Hapke Washington State university Vancouver Bastyr university

Objective: To describe characteristics of and treatment effects in *** who had acupuncture for labor preparation(cervical ripening).Although acupuncture is increasingly used in the U.S., few observational studies of acupuncture patients have been *** particular consideration for vulnerable populations, we focusedthis preliminary inquiry on pregnant ***: Observational study surveyed background characteristics, birth variables(setting, interventions), and treatment satisfaction among former clinic patients treated in *** response rate was 51.3% and yielded 66 participants treated for labor ***: Acupuncture points were selected according to traditional Chinese medicine(TCM) system of diagnosis and pattern differentiation and on modified version of Roemer’s Scheme(Mannheim Model; Roemer, 2005).Results: Patients were in their mid-30s, educated, and most were *** underwent a mean of 2.2(SD=1.0; range 1-4) treatments beginning in pregnancy week ***(25.8%) planned out-of-hospital *** birthing mothers’ birth intervention rates were lower than those reported in national surveys, with a medical induction rate of 13.6% compared to 34% in Decercq et al(2006) and an episiotomy rate of 4.6% compared to 25% in Declercq et *** 18.2% labored cesarean rate was comparable to the national data(Menacker & Hamilton, 2010).No out-of-hospital births transferred to hospital, but one(5.88%) required labor stimulation(suppository).Treatment satisfaction ranged from high to very ***: This preliminary study of a *** clinic sample suggests benefits in terms of reducing certain birth interventions, and patients found acupuncture care and effects to be *** high percentage of home birth indicates a need to address treatment effects and overall safety in this subgroup.

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Listeriosis Knowledge and Attitude among Pregnant Women Attending a Tertiary Health Institution, South Western Nigeria

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Advances in Infectious Diseases 2020年第2期10卷 64-75页

作者： Emelda E. Chukwu Francisca O. Nwaokorie Center for Infectious Disease Research Microbiology Department of the Nigerian Institute of Medical Research Yaba Nigeria Department of Medical Laboratory Sciences College of Medicine University of Lagos Lagos Nigeria

Background: Listeriosis affects immunosuppressed individual’s especially pregnant women. Maternal infections are usually mild for the woman, but may have devastating effects on the unborn child, including miscarriage, stillbirth, preterm labour and serious neonatal illness. WHO recommends that pregnant women should be educated to avoid foods with high risk of contamination. This study seeks to evaluate knowledge and practices predisposing to listeria infections during pregnancy. Methodology: This is a cross-sectional study on pregnant women, attending the antenatal clinic of Lagos university Teaching hospital (LUTH) using semi structured questionnaires. The knowledge score of participants was collated and analyzed using SPSS version 26. Results: The mean age of the participants was 32.07 ± 5.6 years. Forty-three (30.7%) women have had previous miscarriages with the mean no of miscarriage of 1.54. Out of 147 participants, only 20 (13.6%) admitted having heard of listeriosis while 127 (86.4%) had never heard of listeriosis and none of the participants has ever been tested for listeriosis. The Overall knowledge score was poor, and this was irrespective of age and duration of pregnancy. However, women with graduate and/or postgraduate degrees were more likely to have heard of Listeriosis (X2 = 10.88, P = 0.028). Conclusion: Our study shows a low level of knowledge about this food-borne illness, which can lead to severe illnesses in pregnant women and their unborn child. It is necessarily to educate pregnant women on the risk of listeriosis. This would be a key factor in creating and implementing accurate measures of prevention and control.

关键词： Listeriosis Listeria monocytogenes Pregnant Women Fetal Death Nigeria

The Epidemiology and Spatial Analysis of Stroke in Trinidad and Tobago in the First Decade of the 21<sup>st</sup>Century (2000-2009)

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Health 2014年第8期6卷 729-737页

作者： Kameel Mungrue Kevin A. Saroop Ambika B. Samsundar Astrid Bhagwat Nadi Braithwaite Loraine P. Samai S. Sampath Sherrise Sandy Keri Springer Joella C. Subadar Eric Williams Medical Sciences Complex Public Health & Primary Care Department of Paraclinical Sciences Faculty of Medical Sciences University of the West Indies Mt Hope Trinidad and Tobago

Objective: To investigate the pattern and distribution of stroke in Trinidad and Tobago from 2000-2009. To identify the prevalence of co-morbid conditions among new stroke patients during the period under surveillance. Methods: Data were collected from May 2010 to July 2010 from the clinic of 728 new persons treated stroke at one of the main treatment centers. Variables measured included age, gender ethnicity, smoking status and co-morbid conditions. SPSS (Version 17) for Windows and ARC GIS version 9.3 were used to facilitate both descriptive and inferential data analysis. Results: Of the 728 new hospital admissions for the period January 2000-December 2009 for stroke, 369 (50.7%) were males and 359 (49.3%) were females. 59.8% were South-East Asian;30.5% were African and 9.7% were mixed ethnicity. The predominant age group was 60 - 69 years (n = 215, 29.5%) while less than 1% were under 30. Ischemic stroke accounted for 352 (48.4%) of all new cases for the period;Hemorrhagic stroke accounted for 14.6% (n = 107), with 37% (n = 269) classified as other unspecified condition (including unknown). Of the 728 cases examined, 171 patients died before being discharged and 552 were treated and discharged. Information of 5 cases was not available. Using this data, the overall case fatality ratio was calculated as 23.5%, with the case fatality ratio for males being 23.2% and the equivalent ratio for females being 22.9%. Using a standard classification, the majority, (n = 389, 53.4%), of cases were classified as mild;246 (33.8%) were deemed moderate, and 93 (12.8%) were severe cases. Hypertension was clinically diagnosed in 80.9% of the cases;56.3% were diabetic, and 21.7% were classified as smokers having been either past or current smokers. Other lifestyle risk factors such as obesity and exercise were not examined due to the lack of the relevant data. The most frequent cardiovascular risk factor was chamber enlargement being present in 33.2%, while the second most frequent

关键词： Stroke Epidemiology Hypertension