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XDEM multi-physics and multi-scale simulation technology: Review of DEM-CFD coupling, methodology and engineering applications

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Particuology 2019年第3期17卷 176-193页

作者： Bernhard Peters Maryam Baniasadi Mehdi Baniasadi Xavier Besseron Alvaro Estupinan Donoso Mohammad Mohseni Gabriele Pozzetti universite du luxembourg 6. rue Coudenhove-Kalergi L-1359 Luxembourg

The extended discrete element method (XDEM) multi-physics and multi-scale simulation platform is being developed at the Institute of Computational Engineering, the University of luxembourg. The platform is an advanced multi-physics simulation technology that combines flexibility and versatility to establish the next generation of multi-physics and multi-scale simulation tools. For this purpose, the simulation framework relies on coupling various predictive tools based on an Eulerian and Lagrangian approach. The Euleria n approach represents the wide field of con tinuum models;the Lagra ngian approach is perfect for characterising discrete phases. Continuum models thus include classical simulation tools, such as computational fluid dynamics simulation and finite element analysis, while an extended configuration of the classical discrete element method addresses the discrete (e.g., particulate) phase. Apart from predicting the trajectories of in dividual particles, XDEM-suite extends the application of the XDEM to estimating the thermodynamic state of each particle using advanced and optimised algorithms. The thermodynamic state may include temperature and species distributions due to chemical reaction and external heat sources. Hence, coupling these extended features with either computational fluid dynamics simulation or finite element analysis opens a wide range of applications as diverse as pharmaceuticals, agriculture, food processing, mining, construction and agricultural machinery, metals manufacturing, energy production and systems biology.

关键词： Multi-phase modelling Coupled computational fluid dynamics-discrete element method

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Adaptive genetic algorithms guided by decomposition for PCSPs： application to frequency assignment problems

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Frontiers of Computer Science 2016年第6期10卷 1012-1025页

作者： Lamia SADEG-BELKACEM Zineb HABBAS Wassila AGGOUNE-MTALAA Ecole Militaire Polytechnique Algiers 16111 Algeria Ecole nationale Superieure d' Informatique Algiers 16309 Algeria universite de Lorraine Metz 57045 France luxembourg Institute of Science and Technology Luxembourg L-4362 Luxembourg

This paper proposes Adaptive Genetic Algorithms Guided by structural knowledges coming from decomposition methods, for solving PCSPs. The family of algorithms called AGAGD_x_y is designed to be doubly genetic, meaning that any decomposition method and different heuristics for the genetic operators can be considered. To validate the approach, the decomposition algorithm due to Newman was used and several crossover operators based on structural knowledge such as the cluster, separator and the cut were tested. The experimental results obtained on the most challenging Minimum Interference-FAP problems of CALMA instances are very promising and lead to interesting perspectives to be explored in the future.

关键词： optimization problems partial constraint satisfaction problems frequency assignment problems graph decomposition adaptive genetic algorithm (AGA) AGA guided by decomposition (AGAGD).

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A Stein deficit for the logarithmic Sobolev inequality

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Science China Mathematics 2017年第7期60卷 1163-1180页

作者： LEDOUX Michel NOURDIN Ivan PECCATI Giovanni Institut de Mathematiques de Toulouse Universite de Toulouse-Paul-Sabatier Toulouse F-31062 France Institut Universitaire de France UR en Mathematiques-FSTC Luxembourg University Luxembourg City L-1359 Luxembourg

We provide some lower bounds on the deficit in the Gaussian logarithmic Sobolev inequality in terms of the so-called Stein characterization of the Gaussian *** techniques are based on the representation of the relative Fisher information along the Ornstein-Uhlenbeck semigroup by the Minimum Mean-Square Error from information theory.

关键词： deficit logarithmic Sobolev inequality Ornstein-Uhlenbeck semigroup minimum mean-square error Stein kernel

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Bridging the gap with multispecific immune cell engagers in cancer and infectious diseases

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Cellular & Molecular Immunology 2024年第7期21卷 643-661页

作者： Camille Rolin Jacques Zimmer Carole Seguin-Devaux Department of Infection and Immunity Luxembourg Institute of Health29 Rue Henri KochL-4354 Esch-Sur-AlzetteLuxembourg.2University of Luxembourg Place de I'universiteé L-4365 Esch-sur-AlzetteLuxembour

By binding to multiple antigens simultaneously,multispecific antibodies are expected to substantially improve both the activity and long-term efficacy of antibody-based *** cell engagers,a subclass of antibody-based constructs,consist of engineered structures designed to bridge immune effector cells to their target,thereby redirecting the immune response toward the tumor cells or infected *** increasing number of recent clinical trials evaluating immune cell engagers reflects the important role of these molecules in new therapeutic approaches for cancer and *** this review,we discuss how different immune cell types(T and natural killer lymphocytes,as well as myeloid cells)can be bound by immune cell engagers in immunotherapy for cancer and infectious ***,we explore the preclinical and clinical advancements of these constructs,and we discuss the challenges in translating the current knowledge from cancer to the virology ***,we speculate on the promising future directions that immune cell engagers may take in cancer treatment and antiviral therapy.

关键词： Immune cell engagers Multispecific antibodies Cancer Virus Immunotherapy

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An Algebraic Detection Approach for Control Systems under Multiple Stochastic Cyber-attacks

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IEEE/CAA Journal of Automatica Sinica 2015年第3期2卷 258-266页

作者： Yumei Li Holger Voos Mohamed Darouach Changchun Hua the Interdisciplinary Centre for Security Reliability and Trust(SnT) University of Luxembourg the Centre de la Recherche en Automatique de Nancy(CRAN) Universite de Lorraine the Institute of Electrical Engineering Yanshan University

In order to compromise a target control system successfully, hackers possibly attempt to launch multiple cyberattacks aiming at multiple communication channels of the control system. However, the problem of detecting multiple cyber-attacks has been hardly investigated so far. Therefore, this paper deals with the detection of multiple stochastic cyber-attacks aiming at multiple communication channels of a control system. Our goal is to design a detector for the control system under multiple cyberattacks. Based on frequency-domain transformation technique and auxiliary detection tools, an algebraic detection approach is proposed. By applying the presented approach, residual information caused by different attacks is obtained respectively and anomalies in the control system are detected. Sufficient and necessary conditions guaranteeing the detectability of the multiple stochastic cyber-attacks are obtained. The presented detection approach is simple and straightforward. Finally, two simulation examples are provided, and the simulation results show that the detection approach is effective and feasible. © 2014 Chinese Association of Automation.

关键词： Algebra Communication channels (information theory) Control systems Crime Frequency domain analysis Personal computing Stochastic systems

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Interfacial charge transfer and photocatalytic activity in a reverse designed Bi_(2)O_(3)/TiO_(2)core-shell

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Frontiers in Energy 2021年第3期15卷 732-743页

作者： Sabina Ait ABDELKADER Zhenpeng CUI Abdelghani LAACHACHI Christophe COLBEAU-JUSTIN Mohamed Nawfal GHAZZAL UniversitéParis-Saclay UMR 8000CNRSInstitut de Chimie PhysiqueOrsay 91405France Materials Research and Technology Department(MRT) Luxembourg Institute of Science and Technology(LIST)Käerjeng 4940Luxembourg

In this study,the electronic and photocatalytic properties of core-shell heterojunctions photocatalysts with reversible configuration of TiO_(2)and Bi_(2)O_(3)layers were *** core-shell nanostructure,obtained by efficient control of the sol-gel polymerization and impregnation method of variable precursors of semiconductors,makes it possible to study selectively the role of the interfacial charge transfer in each *** morphological,optical,and chemical composition of the core-shell nanostructures were characterized by high-resolution transmission electron microscopy,UV-visible spectroscopy and X-ray photoelectron *** results show the formation of homogenous TiO_(2)anatase and Bi_(2)O_(3)layers with a thickness of around 10 and 8 nm,*** interfacial charge carrier dynamic was tracked using time resolved microwave conductivity and transition photocurrent *** charge transfer,their density,and lifetime were found to rely on the layout layers in the core-shell *** optimal core-shell design,Bi_(2)O_(3)collects holes from TiO_(2),leaving electrons free to react and increase by 5 times the photocatalytic efficiency toward H2 *** study provides new insight into the importance of the design and elaboration of optimal heterojunction based on the photocatalyst system to improve the photocatalytic activity.

关键词： photocatalysis core-shell heterojunction H2 TiO_(2) Bi_(2)O_(3)

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Chromatin Remodeling in Stem Cell Maintenance in Arabidopsis thaliana

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Molecular Plant 2009年第4期2卷 600-609页

作者： Wen-Hui Shen Lin Xu Institut de Biologie Moleculaire des Plantes (IBMP) du CNRS Universite de Strasbourg (UdS) 12 rue du General Zimmer 67084 Strasbourg Cedex France Present address: National Key Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai 200032 China

Pluripotent stem cells are able to both self-renew and generate undifferentiated cells for the formation of new tissues and organs. In higher plants, stem cells found in the shoot apical meristem （SAM） and the root apical meristem （RAM） are origins of organogenesis occurring post-embryonically. It is important to understand how the regulation of stem cell fate is coordinated to enable the meristem to constantly generate different types of lateral organs. Much knowledge has accumulated on specific transcription factors controlling SAM and RAM activity. Here, we review recent evidences for a role of chromatin remodeling in the maintenance of stable expression states of transcription factor genes and the control of stem cell activity in Arabidopsis.

关键词： chromatin structure and remodeling epigenetics meristem development histone chaperone histone modification.

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dual inhibition of sirtuins 1 and 2:reprogramming metabolic energy dynamics in chronicmyeloid leukemia as an immunogenic anticancer strategy

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Cancer Communications 2024年第8期44卷 921-925页

作者： Michael Schnekenburger Anne Lorant Sruthi Reddy Gajulapalli Ridhika Rajora Jin-Young Lee Aloran Mazumder Haeun Yang Christo Christov Hyoung Jin Kang Bernard Pirotte Marc Diederich Laboratoire de Biologie Moleculaire et Cellulaire du Cancer LuxembourgLuxembourg Research Institute of Pharmaceutical Sciences&Natural Products Research Institute College of PharmacySeoul National UniversitySeoulRepublic of Korea Faculte de Medecine Universite de LorraineVandoeuvre-les-NancyFrance Department of Pediatrics Seoul National University College of MedicineSeoul National University Cancer Research InstituteSeoul National University Children’s HospitalSeoulRepublic of Korea Laboratory of Medicinal Chemistry Center for Interdisciplinary Research on Medicines(CIRM)University of LiegeLiegeBelgium

Chronicmyeloid leukemia(CML)is a lethal hematopoietic malignancy with a global incidence primarily attributed to the breakpoint cluster region-Abelson(BCR-ABL1)fusion oncogene in over 95%of *** introduction of tyrosine kinase inhibitors(TKIs)has revolutionized CML management;however,a subset of patients encounters challenges such as resistance and relapse,hindering the achievement of complete *** these challenges in CML also requires addressing persistent leukemia stem cells(LSCs)with inherent resistance *** regulators of LSC metabolism,proliferation,and survival,as well as genetic and epigenetic alterations,provide potential targets[1].

关键词： metabolism myeloid alterations

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Transcriptional output, cell-type densities, and normalization in spatial transcriptomics

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Journal of Molecular Cell Biology 2020年第11期12卷 906-908页

作者： Manuel Saiseletlft Joel Rodrigues-Vitoria Adrien Tourneur Ligia Craciun Alex Spinette Denis Larsimont Guy Andry Joakim Lundeberg Carine Maenhaut Vincent Detours IRIBHM Universite Libre de Bruxelles(ULB)1070 BrusselsBelgium Department of Pathology jules Bordet InstituteUniversite Libre de Bruxelles(ULB)1000 BrusselsBelgium Department of Head&Neck and Thoracic Surgery Jules Bordet InstituteUniversite Libre de Bruxelles(ULB)1000 BrusselsBelgium Science for Life Laboratory Department of Gene TechnologyKTH Royal Institute of TechnologySE-10691 StockholmSweden Department of Bioengineering Stanford UniversityStanfordCA 94305-4245USA

Dear Editor,Spatial transcriptomics(ST)makes it possible to perform RNA-seq at hundreds of precisely located spots on the surface of a histological slice(Stahl et al.,2016).Since mRNA diffusion is minimal during tissues permeabilization and mRNA capture,the transcriptome of each spot is thought to aggregate the transcriptomes of the cells it contains.

关键词： al. histological hundreds

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Wireless communications empowered by reconfigurable intelligent surfaces: Model-based vs model-free channel estimation

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Journal of Information and Intelligence 2023年第3期1卷 253-266页

作者： Li Wei Chongwen Huang George C.Alexandropoulos Ahmet M.Elbir Zhaohui Yang Zhaoyang Zhang Marco Di Renzo Merouane Debbah Chau Yuen Engineering Product Development Pillar Singapore University of Technology and DesignSingapore 487372Singapore College of Information Science and Electronic Engineering Zhejiang UniversityHangzhou 310027China Department of Informatics and Telecommunications National and Kapodistrian University of Athens15784 AthensGreece Interdisciplinary Centre for Security Reliability and TrustUniversity of LuxembourgL-4365 Esch-sur-AlzetteLuxembourgand Duzce UniversityDuzce 81620Turkey universite Paris-Saclay CNRSCentraleSupelecLaboratoire des Signaux et Systemes91192France Khalifa University of Science and Technology Abu DhabiUnited Arab Emirates School of Electrical and Electronics Engineering Nanyang Technological UniversitySingapore 639798Singapore

Reconfigurable intelligent surfaces(RISs)are lately being attractive for their great potential in future sixth generation wireless communications(6G),which is attributed to their affordable energy consumption and easy ***,the large numbers of low-cost reflecting elements comprising RISs impose challenges for channel acquisition in various RIS-based wireless applications,such as RIS-enhanced orthogonal frequency-division multiplexing and multi-user multipleinput multiple-output *** this article,we first overview the state-of-the-art RIS hardware architectures designed to assist channel estimation for RIS-empowered wireless communication *** also overview existing channel estimation approaches,which are categorized into model-based and model-free techniques,and discuss their advantages and limitations depending on the RIS *** challenges with RIS-empowered systems in terms of hardware and other parameter limitations are presented,together with future research directions for channel estimation in RIS-based wireless systems,such as RISs with extremely large numbers of elements,multi-hop communications with RISs,and frequency division duplexing for high mobility systems.

关键词： Reconfigurable intelligent surfaces Channel estimation Model-based methods Model-free methods

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