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AFF3:a new player in maintaining XIST monoallelic expression

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Journal of Molecular Cell Biology 2019年第9期11卷 723-724页

作者： Reiner A.Veitia Institut Jacques Monod Universite Paris DiderotParisFrance universite paris-diderot ParisFrance

The existence of highly differentiated X and Y chromosomes in mammals raises the issue of X-linked gene dosage compensation between XX females and XY males to avoid what would be similar to a monosomy X in males(Veitia et al.,2015).Inactivation of one copy of the X chromosomes in females provides a dosage-compensation mechanism equalizing the expression of X-linked genes in males and females(Ohno et al.,1959;Lyon,1961).

关键词： dosage al. differentiated

Barium isotope cosmochemistry and geochemistry

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Science Bulletin 2018年第6期63卷 385-394页

作者： Quentin Charbonnier Frederic Moynier Julien Bouchez Institut de Physique du Globe de paris Universite Paris Diderot Sorbonne Paris Cite CNRS UMR 71541rue Jussieu 75238 Paris France Institut Universitaire de France and universite paris diderot 75231 Paris France

While the isotopic variations of barium were reported for the first time fourty years ago, the number of studies on barium isotopes significantly increased only after 2010. Barium isotope anomalies in meteorites have been successfully used to provide constraints about the origin of presolar Si C grains. In carbonaceous chondrites Ba isotope anomalies are indicative of the heterogeneity of the early solar system, possibly resulting from of a later injection of material after the cooling of solar system. Barium isotope fractionation in the same carbonaceous chondrites suggests that a strong magnetic field was present in the innermost part of the early solar system. Barium mass-dependent isotope fractionation has also been detected throughout Earth surface materials. While igneous rocks show limited Ba isotopic variations, relatively large isotopic variations are observed amongst and within soils, rivers, and biological materials. Indeed, plants seem to fractionate Ba isotopes during Ba uptake from soil ***, Ba isotope signatures have the potential to provide clues on the biological cycling of Ba at the Earth surface. In seawater, Ba isotopic variations have been mapped out, and are mainly related to barite precipitation, which is in turn related to organic matter remineralization in the water *** makes Ba isotopes a potentially powerful tool to reconstruct past ocean productivity, although constraints are still lacking regarding the inputs of dissolved Ba to the oceans by rivers or hydrothermalism.

关键词： Barium Meteorites Earth surface Critical zone

Dysfunctions of the Iga system:a common link between intestinal and renal diseases

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Cellular & Molecular Immunology 2011年第2期8卷 126-134页

作者： Christina Papista Laureline Berthelot Renato C Monteiro NSERM U699 Paris 75018France universite´paris diderot Paris 75018France

Immunoglobulin A(Iga)-isotype antibodies play an important role in immunity owing to their structure,glycosylation,localization and receptor *** in this system can lead to multiple types of *** review describes the characteristics of Iga and discusses the involvement of abnormalities in the Iga system on the development of celiac disease and Iga nephropathy.

关键词： celiac disease Iga nephropathy immunoglobulin A receptors

Egg CD9 protein tides correlated with sperm oscillations tune the gamete fusion ability in mammal

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Journal of Molecular Cell Biology 2018年第6期10卷 494-502页

作者： Benjamin Ravaux Sophie Favier Eric Perez and Christine Gourier Laboratoire de Physique Statistique Ecole Normale Superieure/PSL Research UniversityUPMC Univ Paris 06Universite Paris DiderotCNRS75005 ParisFrance

Mammalian fertilization involves membrane events-adhesion,fusion,sperm engulfment,membrane block to polyspermy-whose causes remain largely ***,specific oscillations of the sperm in contact with the egg were shown to be necessary for *** a microfluidic chip to impose the venue for the encounter of two gametes allowed real-time observation of the membrane remodelling occurring at the sperm/egg *** spatiotemporal mapping of egg CD9 revealed that this protein concentrates at the egg/sperm interface as a result of sperm oscillations,until a CDg-rich platform is nucleated on which fusion immediately takes *** 2-5 min after fusion,most of the CD9 leaves the egg for the external aqueous *** an egg membrane wave engulfs the sperm head in^25 *** results show that sperm oscillations initiate the CD9 recruitment that causes gamete fusion after which CD9 and associated proteins leave the membrane in a process likely to contribute to block *** highlight that the gamete fusion story in mammals is an unexpected interplay between mechanical constraints and proteins.

关键词： mammalian fertilization membrane dynamics real-time imaging CDg sperm oscillations gamete fusion

Simulation study on cosmic ray background at large zenith angle based on GRANDProto35 coincidence array experiment

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Nuclear Science and Techniques 2021年第1期32卷 35-45页

作者： Xiang-Li Qian Xu Wang Hui-Ying Sun Zhen Wang Olivier Martineau-Huynh School of Intelligent Engineering Shandong Management UniversityJinan 250357China Tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghai 200240China Sorbonne paris Cite CNRS/IN2P3LPNHESorbonne UniversiteUniversite Paris DiderotParisFrance

Neutrino detection in the 100 PeV energy region is the ultimate means of studying the origin of ultra-highenergy cosmic rays,in which the large radio detection array giant radio array for neutrino detection(GRAND)project aims to use to decipher this century-old *** GRANDProto35 compact array is a microform of 35 radio prototype detectors for the GRAND experiment,which verifies the reliability of GRAND performance through operation,and data analysis of the prototype *** radio detectors are a novel development in recent years,and their indexes need to be verified by traditional detectors,the GRAND Cooperation Group designed and constructed the GRANDProto35 coincidence array composed of radio detectors and scintillation *** study simulated the changes in detection efficiency,effective area,and event rate of cosmic rays with zenith angle based on this coincidence *** study found that the 1017 eV energy region is sensitive to GRANDProto35 *** the energy exceeded 1017 eV,the array detection efficiency could reach more than 95%and the effective area was up to*29106 m2.A simulation study on cosmic ray events with large zenith angles showed that the event rate detected by the array decreased significantly with increasing zenith angle,and the event rate of cosmic rays was approximately 0.1 per day for a zenith angle of 75.This serves as the background pollution rate for neutrino observation caused by largeangle cosmic-ray events,providing an important reference for further *** study results will be verified after the joint operation of the coincidence array.

关键词： GRANDProto35 GEANT4 Scintillation detector Cosmic ray

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Chinese Annals of Mathematics,Series B 2002年第2期23卷 149-164页

作者： C.BARDOS Y.GUO W.STRAUSS universite DivisionDepartment Denis Diderot and LAN Universite Pierre et Marie CurieParisFrance.of Applied MathematicsBrown UniversityProvidenceRhode Island 02912U?

The authors investigate the stability of a steady ideal plane flow in an arbitrary domain in terms of the L^2 norm of the vorticity. Linear stability implies nonlinear instability provided the growth rate of the linearized system exceeds the Liapunov exponent of the flow. In contrast,a maximizer of the entropy subject to constant energy and mass is stable. This implies the stability of certain solutions of the mean field equation.

关键词： Stable ideal plane flows Unstable ideal plane flows Liapunov exponent

Simulation study on performance optimization of a prototype scintillation detector for the GRANDProto35 experiment

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Nuclear Science and Techniques 2021年第5期32卷 71-83页

作者： Xiang-Li Qian Hui-Ying Sun Cheng Liu Xu Wang Olivier Martineau-Huynh School of Intelligent Engineering Shandong Management UniversityJinan 250357China Key Laboratory of Particle Astrophysics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Sorbonne universite Universite Paris DiderotSorbonne Paris CiteCNRS/IN2P3LPNHEParisFrance

As a proposed detector,the giant radio array for neutrino detection(GRAND)is primarily designed to discover and study the origin of ultra-high-energy cosmic rays,with ultra-high-energy neutrinos presenting the main method for detecting ultra-high-energy cosmic rays and their *** main principle is to detect radio emissions generated by ultra-high-energy neutrinos interacting with the atmosphere as they *** is the largest neutrino detection array to be built in ***35,as the first stage of the GRAND experiment,is a coincidence array composed of radio antennas and a scintillation detector,the latter of which,as a traditional detector,is used to perform cross-validation with radio detection,thus verifying the radio detection efficiency and enabling study of the background exclusion *** study focused on the implementation of the optimization simulation and experimental testing of the performance of the prototype scintillation detector used in GRANDProto35.A package based on GEANT4 was used to simulate the details of the scintillation detector,including the optical properties of its materials,the height of the light guide box,and position *** surface of the scintillator and the reflective materials used in the detector was optimized,and the influence of light guide heights and position inhomogeneity on the energy and time resolutions of the detector was *** to the simulation study,the number of scintillator photoelectrons increased when changing from the polished surface to the ground surface,with the appropriate design height for the light guide box being 50 cm and the appropriate design area for the scintillator being 0.5 m^(2).The performance of the detector was tested in detail through a coincidence experiment,and the test results showed that the number of photoelectrons collected in the detector was$84 with a time resolution of~1 ns,indicating good *** simulation results were consistent with

关键词： GRANDProto35 GEANT4 Scintillation detector Light guide height Photoelectrons

X chromosome inactivation and active X upregulation in therian mammals: facts, questions, and hypotheses

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Journal of Molecular Cell Biology 2015年第1期7卷 2-11页

作者： Reiner A.Veitia Frederic Veyrunes Samuel Bottani James A.Birchler Institut Jacques Monod ParisFrance universite paris diderot ParisFrance Institut des Sciences de l’Evolution de Montpellier CNRS/Universite Montpellier IIMontpellierFrance Matiere et Systemes Complexes ParisFrance Division of Biological Sciences University of MissouriColumbiaMOUSA

X chromosome inactivation is a mechanism that modulates the expression of X-linked genes in eutherian females(XX).Ohno proposed that to achieve a proper balance between X-linked and autosomal genes,those on the active X should also undergo a 2-fold *** some support for Ohno's hypothesis has been provided through the years,recent genomic studies testing this hypoth-esis have brought contradictory results and fueled *** far,there are as many results in favor as against Ohno's hypothesis,depending on the nature of the datasets and the various assumptions and thresholds involved in the ***,they have con-firmed the importance of dosage balance between X-linked and autosomal genes involved in stoichiometric *** facts as well as questions and hypotheses are discussed below.

关键词： X inactivation X chromosome upregulation monoallelic expression imprinting dosage balance

Laboratory radiative accretion shocks on GEKKO XⅡlaser facility for POLAR project

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High Power Laser Science and Engineering 2018年第2期6卷 181-188页

作者： L.Van Box Som E.Falize M.Koenig Y.Sakawa B.Albertazzi E Barroso J.-***-Bidaud C.Busschaert A.Ciardi Y.Hara N.Katsuki R.Kumar E Lefevre C.Michaut Th.Michel T.Miura T.Morita M.Mouchet G.Rigon T.Sano S.Shiiba H.Shimogawara S.Tomiya CEA-DAM-DIF F-91297 ArpajonFrance LERMA Sorbonne UniversiteObservatoire de ParisUniversite PSLCNRSF-75005 ParisFrance CEA Saclay DSM/Irfu/Service d'AstrophysiqueF-91191 Gif-sur-YvetteFrance LULI-CNRS Ecole PolytechniqueCEA:Universite Paris-Saclay UPMC Univ paris 06:Sorbonne universite-F-91128 Palaiseau Cedex France Graduate School of Engineering Osaka UniversitySuitaOsaka 565-0871Japan Institute of Laser Engineering Osaka UniversitySuitaOsaka 565-0871Japan Faculty of Engineering Sciences Kyushu University6-1 Kasuga-KoenKasugaFukuoka 816-8580Japan Aoyama Gakuin University Japan GEPI Observatoire de ParisPSL Research UniversityCNRSUniversite Paris DiderotSorbonne Paris CiteF-75014 ParisFrance LUTH Observatoire de ParisPSL Research UniversityCNRSUniversite Paris DiderotSorbonne Paris CiteF-92195 MeudonFrance

A new target design is presented to model high-energy radiative accretion shocks in polars. In this paper, we present the experimental results obtained on the GEKKO XII laser facility for the POLAR project. The experimental results are compared with 2 D FCI2 simulations to characterize the dynamics and the structure of plasma flow before and after the collision. The good agreement between simulations and experimental data confirms the formation of a reverse shock where cooling losses start modifying the post-shock region. With the multi-material structure of the target,a hydrodynamic collimation is exhibited and a radiative structure coupled with the reverse shock is highlighted in both experimental data and simulations. The flexibility of the laser energy produced on GEKKO XII allowed us to produce high-velocity flows and study new and interesting radiation hydrodynamic regimes between those obtained on the LULI2000 and Orion laser facilities.

关键词： accretion processes high power laser hydrodynamics laboratory astrophysics