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Osteocyte pericellular and perilacunar matrices as markers of bone-implant mechanical integrity

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BIOCELL 2022年第10期46卷 2209-2216页

作者： ReMY GAUTHIER HeLÈNE FOLLET ANA-MARIA TRUNFIO-SFARGHIU DELPHINE FARLAY NINA ATTIK SYLVAIN MEILLE JeRÔME CHEVALIER DAVID MITTON universite de lyon CNRSINSA de LyonUniversite Claude Bernard Lyon 1MATEISUMR5510VilleurbanneF-69621France universite de lyon Universite Claude Bernard Lyon 1INSERMLYOS UMR 1033LyonF-69008France universite de lyon INSA-LyonCNRS UMR5259LaMCoSVilleurbanneF-69621France universite de lyon Universite Claude Bernard Lyon 1UMR CNRS 5615Laboratoire des Multimateriaux et InterfacesVilleurbanneF-69622France universite de lyon Universite Claude Bernard Lyon 1Faculte d’OdontologieLyonF-69008France universite de lyon Universite Gustave EiffelUniv Claude Bernard Lyon 1LBMC UMR_T 9406LyonF-69622France

To develop durable bone healing strategies through improved control of bone repair,it is of critical importance to understand the mechanisms of bone mechanical integrity when in contact with biomaterials and *** mechanical integrity is defined here as the adaptation of structural properties of remodeled bone in regard to an applied mechanical ***,the authors present why future investigations in bone repair and regeneration should emphasize on the matrix surrounding the *** are mechanosensitive cells considered as the orchestrators of bone remodeling,which is the biological process involved in bone *** bone cells are trapped in an interconnected porous network,the lacunocanalicular network,which is embedded in a bone mineralized extracellular *** a consequence of an applied mechanical loading,the bone deformation results in the deformation of this lacunocanalicular network inducing a shift in interstitial fluid pressure and velocity,thus resulting in osteocyte *** material environment surrounding each osteocyte,the so called perilacunar and pericellular matrices properties,define its *** this mechanical stimulation pathway is well known,the laws used to predict bone remodeling are based on strains developing at a tissue scale,suggesting that these strains are related to the shift in fluid pressure and velocity at the lacunocanalicular *** this relationship has been validated through observation in healthy bone,the fluid behavior at the bone-implant interface is more *** presence of the implant modifies fluid behavior,so that for the same strain at a tissue scale,the shift in fluid pressure and velocity will be different than in a healthy bone *** that context,new markers for bone mechanical integrity,considering fluid behavior,have to be *** viewpoint exposed by the authors indicates that the properties of the pericellular and the perilacunar

关键词： Bone mechanical integrity Osteocytes Pericellular Perilacunar Mechanosensitivity

Discrimination of conspecifics from heterospecifics in a hybrid zone: Behavioral and chemical cues in ants

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Insect Science 2022年第1期29卷 276-288页

作者： Marion Cordonnier bernard Kaufmann Laurent Simon Gilles Escarguel Nathalie Mondy Univ lyon Universite Claude Bernard Lyon 1CNRSENTPEUMR 5023 LEHNAF-69622VilleurbanneFrance

Species and nestmate recognition in social insects occurs mostly through cuticular hydrocarbons acting as chemical cues. These compounds generate a colony-specific odor profile depending on genetic and environmental factors. Species and nestmate recognition results in specific behavioral responses, regulating the level of aggression toward other individuals during an interaction. Although species discrimination and recognition cues have been poorly studied in the context of interspecific hybridization, such systems offer an opportunity to further investigate the influence of heritable and environmental factors on recognition. We explored the strength of discrimination in a hybrid zone between two ant species—Tetramorium immigrans and T. caespitum—by comparing cuticular hydrocarbon profiles and measuring intra- and interspecific worker aggression in both areas of sympatry and areas of allopatry among species. Species cuticular hydrocarbon profiles were well-differentiated and interspecific aggression was high, revealing highly discriminating species recognition cues. Hybrids’ cuticular hydrocarbon profiles consisted of a mixture of the parental bouquets, but also exhibited hybrid-specific patterns. Behavioral assays showed that T. immigrans is as aggressive toward hybrids as toward heterospecifics. Finally, aggression between heterospecific workers was lower when interacting individuals came from areas of sympatry among species than from areas of allopatry. Taken as a whole, these findings paint a particularly complex picture of the recognition system in T. immigrans, T. caespitum, and their hybrids, and highlight that hybrid zones afford a still underexplored opportunity for investigating recognition mechanisms and discrimination between species.

关键词： aggressive behavior ants cuticular hydrocarbons hybrid zone recognition cues Tetramorium

Pharmacological attenuation of blood pressure variability

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Acta Pharmacologica Sinica 2005年第11期26卷 1288-1289页

作者： claude JULIEN France Laboratoire de Physiologie Faculte de Pharmacie lyon 69373 universite claude bernard lyon 1

Over the past few years, the research team of ProfessorDing-feng SU has reported an impressive quantity of experimental data about the relationships between blood pressurevariability (BPV) and end-organ damage, a topic of obviousclinical interest. This research work has been summarized ina paper that appeared in the August issue of the renownedjournal Trends in Pharmacological Sciences[1]. The studiesby Su et al provide convincing evidence that BPV is an independent cardiovascular risk factor that should be considered as such and, therefore, might become an important target for therapeutic interventions. Besides these exciting perspectives in the prevention and treatment of cardiovascular

关键词： BPV Pharmacological attenuation of blood pressure variability

Tertiary lymphoid structures in cancer – considerations for patient prognosis

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Cellular & Molecular Immunology 2020年第6期17卷 570-575页

作者： Luis Munoz-Erazo Janet L.Rhodes Valentine C.Marion Roslyn A.Kemp Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Ecole Normale Superieure de lyon LyonFrance and Universite Claude Bernard Lyon 1LyonFrance

Tertiary lymphoid structures(TLS)are ectopic lymphoid formations that form within nonlymphoid *** share structural and functional characteristics with secondary lymphoid structures such as lymph nodes and can contain B-cell follicles and germinal centers surrounded by a T-cell *** have been described in several types of cancers and are usually associated with positive patient ***,TLS differ vastly in cellular composition and location within tissue *** this review,we discuss factors confounding the interpretation of the evidence for a prognostic role for TLS in cancer and frame these factors in the context of translation to regular clinical use.

关键词： tertiary lymphoid structure prognosis cancer tissue

Energy Filtering and Coaxial Detection of the Backscattered Electrons in Scanning Electron Microscope

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Chinese Physics Letters 2000年第9期17卷 637-639页

作者： JIANG Chang-Zhong P.Morin N.Rosenberg Department of Physics Wuhan UniversityWuhan 430072 Departement de Physique des Materiaux Universite Claude Bernard Lyon I69622 Villeurbanne CedexFrance

A new detection system in scanning electron microscope,which filters in energy and detects the backscattered electrons close to the microscope axis,is *** technique ameliorates the dependence of the *** tering coefficient on atomic number,and suppresses effectively the relief contrast at the same *** this new method is very suitable to the composition analysis.

关键词： Electron scattered system

Atmospheric photochemistry and secondary aerosol formation of urban air in lyon,France

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Journal of Environmental Sciences 2021年第1期33卷 311-323页

作者： Salah Eddine Sbai Chunlin Li Antoinette Boreave Nicolas Charbonnel Sebastien Perrier Philippe Vernoux Farida Bentayeb Christian George Sonia Gil Department of physics Laboratoires de physique des hauts Energies Modelisation et SimulationMohammed V Uniuersity in RabatRabatMorocco universite lyon Universite Claude Bernard Lyon 1CNRSIRCELYON2 Auenue Albert Einstein69100 LyonFrance Department of Earth and Planetary Sciences Weizmann Institute of Science76100 RehovotIsrael

Photochemical aging of volatile organic compounds(VOCs)in the atmosphere is an important source of secondary organic aerosol(SOA).To evaluate the formation potential of SOA at an urban site in lyon(France),an outdoor experiment using a Potential Aerosol Mass(PAM)oxidation flow reactor(OFR)was conducted throughout entire days during JanuaryFebruary *** variation of SOA formations and their correlation with OH radical exposure(OHexp),ambient pollutants(VOCs and particulate matters,PM),Relative Humidity(RH),and temperature were explored in this *** urban air was exposed to high concentration of OH radicals with OHexp in range of(0.2-1.2)×10^12 molecule/(cm^3·sec),corresponding to several days to weeks of equivalent atmospheric photochemical *** results informed that urban air at lyon has high potency to contribute to SOA,and these SOA productions were favored from OH radical photochemical oxidation rather than via *** SOA formation(36μg/m^3)was obtained at OHexp of about 7.4×10^11 molecule/(cm^3·sec),equivalent to approximately 5 days of atmospheric *** correlation between SOA formation and ambient environment conditions(RH&temperature,VOCs and PM)was *** was the first time to estimate SOA formation potential from ambient air over a long period in urban environment of lyon.

关键词： Urban air Oxidation Flow Reactor(OFR) Secondary Organic Aerosol(SOA) Volatile Organic Compounds(VOC) Photochemistry lyon

Lorentz Force Electrical Impedance Detection Using Step Frequency Technique

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Chinese Physics Letters 2018年第1期35卷 46-50页

作者： Zhi-Shen Sun Guo-qiang Liu Hui Xia Institute of Electrical Engineering Chinese Academy of SciencesBeijing 100190 University of Chinese Academy of Sciences Beijing 100049 Univ lyon Universite Claude Bernard Lyon 1Centre Leon BerardINSERMLabTAU UMR1032LYON F-69003France

Lorentz force electrical impedance tomography(LFEIT)inherits the merit of high resolution by ultrasound stimulation and the merit of high contrast through electromagnetic field *** reduce the instantaneous peak power of the stimulating signal to the transducer,the sinusoidal pulse and step-frequency technique is investigated in *** theory of application of step-frequency technique in LFEIT is formulated with the direct demodulation method and the in-phase quadrature demodulation *** with the in-phase quadrature demodulation method,the direct demodulation method has simple experimental setup but could only detect half of the *** carried out with copper foils confirmed that LFEIT using the step-frequency technique could detect the electrical conductivity variations precisely,which suggests an alternative method of realization of LFEIT.

关键词： Electric impedance measurement

Preparation and Characterization of Sol-Gel Derived Au Nanoparticle Dispersed Y_2O_3∶Eu Films

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Journal of Rare Earths 2005年第5期23卷 600-606页

作者：郭海张慰萍董宁楼立人尹民 Tillement O Mugnier J Bernstein E Brevet P F Structure Research Laboratory University of Science and Technology of China Academia Sinica Hefei 230026 China Department of Physics University of Science and Technology of China Hefei 230026 China Department of Physics University of Science and Technology of China Hefei 230026 China Laboratoire de Physico-Chimie des Materiaux Luminescents CNRS-UMR 5620 Universite Claude Bernard Lyon I 43 Boulevard du 11 Novembre 1918 69622 Villeurbanne Cedex France Laboratoire de Spectrometrie Ionieque et Moleculaire CNRS-UMR 5579 Universite Claude Bernard Lyon I 43 Boulevard du 11 Novembre 1918 69622 Villeurbanne Cedex France Department de Physique des Materiaux CNRS-UMR 5586 Universite Claude Bernard Lyon I 43 Boulevard du 11 Novembre 1918 69622 Villeurbanne Cedex France Laboratoire de Spectrometrie Ionieque et Moleculaire CNRS-UMR 5579 Universite Claude Bernard Lyon I 43 Boulevard du 11 Novembre 1918 69622 Villeurbanne Cedex France)

Gold nanoparticles dispersed Y2O3 films were prepared through a sol-gel method by using yttrium acetate and Au nanoparticles colloid as precursors. The films were characterized by X-ray diffraction （XRD）, transmission electron microscopy （TEM） and UV-VIS absorption spectra. XRD patterns and TEM images of Y2O3 ＋ Au films give the same resuits on structure and particle size as that of pure Y2O3 films. The surface plasma resonance （SPR） of Au nanoparticles in Y2O3 ＋ Au film was observed around 550 nm in the absorption spectrum and its position shifts to red with increasing annealing temperature is caused by the increase of dielectric constant of Y2O3 matrix and the size of Au nanoparticles. The second and third order nonlinear optical effects of Y2O3 ＋ Au films were also observed. The photoluminescent properties of Y2O3 ： Eu ＋ Au films were investigated and results indicate that there exist an energy transfer from Eu^3 ＋ to Au nanoparticles and this energy transfer decreases the emission of Eu^3 ＋ in Y2O3 ： Eu ＋ Au film.

关键词： sol-gel Y2O3 + Au films nanocomposite photoluminescence rare earths

Inhibitive Determination of Heavy Metal Ions by Conductometric Nitrate Reductase Biosensor

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Chemical Research in Chinese Universities 2009年第4期25卷 443-445页

作者： WANG Xue-jiang XIA Si-qing ZHAO Jian-fu ZHAO Hong-ning RENAULT Nicole Jaffrezic State Key Laboratory of Pollution Control and Resources Reuse Tongji University Shanghai 200092 P R. China Laboratoire de Sciences Analytiques（UMR CNRS 5180） Universite Claude Bernard Lyon 1 Universite ＇de Lyon Villeurbanne Cedex 69622 France

A conductometric nitrate biosensor based on methyl viologen/Nafion/nitrate reductase（NR） interdigitated electrode for heavy metal determination was *** activity of NR（EC 1.***.6.2） from Asper gillusniger（***） was assayed as a function of metal concentration in the presence of Cu^2＋,Zn^2＋,Cd^2＋ and Pb^2＋.Parameters influencing the performance of the biosensor were optimized for the application of it in the inhibition determination of heavy metal *** limits for Cu^2＋,Zn^2＋,Cd^2＋ and Pb^2＋ were about 0.05,0.5,0.1 and 1.0 μmol/L,*** results show that NR activity could not be regained after exposure to Cu^2＋,but could be partially recovered after exposure to Zn^2＋,Pb^2＋ and Cd^2＋.

关键词： Conductometric biosensor Heavy metal Nitrate reductase