检索结果-南通市图书馆

Elaborate Design of Two Novel Fluorescent Zinc-based Metal-Organic Frameworks for Highly Efficient Tetracycline Antibiotics Detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2024年第3期40卷 499-507页

作者： TAO He JI Chengshan ZHANG Jian YIN Yuanyuan JIA Wenwen JIANG Xin XU Jie YANG Yulin mit Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001P.R.China

The abuse of tetracycline antibiotics has caused great harm to human health and *** inexpensive,convenient and sensitive methods for the detection of tetracycline antibiotics is highly ***,based on the H_(4)ddp ligand[H_(4)ddp=3-(3,5-dicarboxyphenyl)pyridine-2,6-dicarboxylic acid],two novel zinc-based metal-organic frameworks(MOFs){[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn1-ddp)and{[Zn_(3)(ddp)_(2)(H_(2)O)_(4)]·3H_(2)O}n(Zn2-ddp)were successfully designed by delicate structural *** Zn1-ddp and Zn2-ddp exhibited excellent water and chemical stability and showed excellent fluorescence quenching performance for tetracycline ***,the more advanced framework structure and better fluorescent performance make Zn1-ddp more sensitive than Zn2-ddp in fluorescent detection with a detection limit of 0.29µmol/L for tetracycline(TC),0.09µmol/L for doxycycline(DOX),0.10µmol/L for minocycline(MIN)and metacycline(MEL),0.19µmol/L for chlortetracycline(CTC),and 0.67µmol/L for oxytetracycline(OTC)among tetracycline *** fluorescence quenching mechanism of Zn1-ddp and Zn2-ddp for tetracycline antibiotics detection was deeply *** reasons for the superior detection performance of Zn1-ddp over Zn2-ddp were also analyzed in depth through Fourier transform infrared spectrophotometry(FTIR),X-ray photoelectron spectroscopy(XPS)analysis and framework structure *** developed method opens up a new perspective for antibiotics detection based on zinc-based MOFs.

关键词： Water system Metal-organic framework Fluorescent detection Tetracycline antibiotic

Reconstruct recent multi-population migration history by using identical-by-descent sharing

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Genetics and Genomics 2024年第6期51卷 642-651页

作者： Wenxiao Zhang Kai Yuan Ru Wen Haifang Li Xumin Ni School of Mathematics and Statistics Beijing Jiaotong UniversityBeijing 100044China The Stanley Center for Psychiatric Research Broad Institute of MIT and HarvardCambridgeMA 02142USA Baidu Incorporated Beijing 100085China

Identical-by-descent(IBD)is a fundamental genomic characteristic in population genetics and has been widely used for population history ***,limited by the nature of IBD,which could only capture the relationship between two individuals/haplotypes,existing IBD-based history inference is constrained to two *** this study,we propose a framework by leveraging IBD sharing in multipopulation and develop a method,MatrixiBD,to reconstruct recent multi-population migration ***,we employ the structured coalescent theory to precisely model the genealogical process and then estimate the IBD sharing across multiple *** our model,we establish a theoretical connection between migration history and IBD *** method is rigorously evaluated through simulations,revealing its remarkable accuracy and ***,we apply MatrixiBD to Central and South Asia in the Human Genome Diversity Project and successfully reconstruct the recent migration history of three closely related populations in South *** taking into account the IBD sharing across multiple populations simultaneously,MatrixlBD enables us to attain clearer and more comprehensive insights into the history of regions characterized by complex migration dynamics,providing a holistic perspective on intricate patterns embedded within the recent population migration history.

关键词： Population genetics IBD sharing Migration history Structured coalescent theory Gene flow

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四面体超晶格中高温铁磁半导体的预测

Science China Materials 2024年第4期67卷 1225-1230页

作者：王亚奇孙华胜吴世海李盎万逸阚二军黄呈熙 mit Key Laboratory of Semiconductor Microstructure and Quantum Sensing Nanjing University of Science and TechnologyNanjing 10094China

铁磁(FM)半导体兼具半导体(如逻辑器件)和磁性材料(如记忆存储器)的优点,半个多世纪以来一直受到广泛关注.然而,铁磁半导体的发展受到候选材料稀缺以及居里温度低的阻碍.铁磁性通常在具有八面体配位的过渡金属化合物中被发现.而具有较... 详细信息

铁磁(FM)半导体兼具半导体(如逻辑器件)和磁性材料(如记忆存储器)的优点,半个多世纪以来一直受到广泛关注.然而,铁磁半导体的发展受到候选材料稀缺以及居里温度低的阻碍.铁磁性通常在具有八面体配位的过渡金属化合物中被发现.而具有较小晶体场分裂和较弱反铁磁(AFM)直接交换的四面体配位化合物可能是高温铁磁体的潜在候选者,但很少被探索.在这项工作中,我们提出了高温铁磁半导体可以在四面体配位超晶格(SL)中实现.在第一性原理计算的基础上,我们系统地研究了一系列MX/TMX (MX表示12-16,13-15或14-14族四面体半导体,TM表示3d过渡金属,X表示配体)超晶格.其中,SiC/CrC SL是一种稳定的铁磁半导体材料,具有0.363 eV的间接带隙和~935 K的高居里温度.此外,我们还探讨了Cr原子层的分布和层间磁耦合,预测了单轴应变引起了反铁磁到铁磁的相变.这些发现为实现四面体配位超晶格的高温铁磁半导体在未来自旋电子应用中开辟了新的机会.

关键词：过渡金属化合物高居里温度自旋电子晶体场分裂超晶格逻辑器件八面体配位候选者

在线全文

学校读者我要写书评

暂无评论

角膜接触镜用于眼球穿通伤术后视力的恢复

世界核心医学期刊文摘（眼科学分册） 2005年第2期1卷 40-41页

作者： Grunauer-Kloevekorn C. Habermann A. Wilhelm F. 肖颖 universitatsaugenklin. mit poliklin. Martin-Luther-Univ. Halle-Witte n berg Ernst-Grube-Strasse 40 06097 Halle Germany Dr.

Introduction: Visual rehabilitation after open globe injury may be a challengi ng process because of ametropia following aphakia, corneal scarring with high or irregular corneal astigmatism or loss of contrast sensitivity due to traumatic aniridia. We report on contact lens fitting for visual rehabilitation in patient s after open globe injury. Patients: From 2000 to 2003, contact lenses were fitt ed unilaterally for the visual rehabilitation in 13 patients after open globe in jury. In three patients we found unilateral aphakia, in 8 patients a high or irr egular astigmatism after penetrating or autorotation keratoplasty and in two pat ients a traumatic aniridia, in one case combined with aphakia. Results: 11 rigid contact lenses were fitted with different designs of the front and back surface as well as two iris-print lenses. In 11 patients (86%) a good visual rehabili tation was achieved with an increase of visual acuity up to 9 lines while obtain ing a good contact lens tolerance. One patient wearing an iris-print contact le ns was unable to tolerate the contact lens due to its thickness and its weight. In another patient fitting of a contact lens was not possible because of the com plicated corneal condition. We did not observed severe contact lens complication s at any time. Conclusions: In addition to operative procedures for visual rehab ilitation after open globe injuries, the use of contact lenses is another possib le procedure for refractive correction. Different problems such as ametropia fol lowing aphakia, irregular or high astigmatism or aniridia can be solved with goo d visual results, good tolerance and less complications.

关键词：眼球穿通伤术后视力外伤性无虹膜角膜接触镜角膜散光屈光不正角膜瘢痕角膜成形术对比敏感度表面设计

Evaluation of large language models for the classification of medical device software

在线全文

学校读者我要写书评

暂无评论

Bio-Design and Manufacturing 2024年第5期7卷 819-822页

作者： Yu Han Aaron Ceross Florence Bourgeois Paulo Savaget Jeroen H.M.Bergmann Department of Engineering Science University of OxfordOld Road CampusOxford OX37QDUK Harvard-mit Center for Regulatory Science Harvard Medical SchoolBostonMAUSA Computational Health Informatics Program(CHIP) Boston Children’s HospitalBostonMAUSA Department of Technology and Innovation The University of Southern DenmarkOdenseDenmark

Amidst the rapidly expanding integration of large language models(LLMs)across various sectors(ranging from everyday applications to specialized fields demanding stringent regulatory adherence),our investigation seeks to determine how well these models can support medical device software *** device classification functions to systematically categorize devices according to their designated use,associated risk levels,and requisite regulatory oversight,thereby providing a structured framework for ensuring safety and efficacy as mandated by regulatory authorities.

关键词： everyday demanding thereby

Antifouling Properties of Electrospun Polymeric Coatings Induced by Controlled Surface Morphology

在线全文

学校读者我要写书评

暂无评论

ENERGY & ENVIRONMENTAL MATERIALS 2024年第6期7卷 409-419页

作者： Favrin, Fabio L. Zavagna, Lorenzo Sestini, Matteo Esin, Semih Azimi, Bahareh Labardi, Massimiliano Milazzo, Mario Gallone, Giuseppe Batoni, Giovanna Danti, Serena Univ Pisa Dept Civil & Ind Engn Largo Lucio Lazzarino 2 I-56122 Pisa Italy Univ Pisa Dept Translat Res & New Technol Med & Surg Via San Zeno 35-39 I-56123 Pisa Italy Massachusetts Inst Technol mit Dept Civil & Environm Engn Massachusetts Ave 77 Cambridge MA 02139 USA Inst Chem & Phys Proc IPCF Natl Res Council CNR Pisa Res Area Via Moruzzi 1 I-56124 Pisa Italy

Nosocomial infections affect implanted medical devices and greatly challenge their functional outcomes, becoming sometimes life threatening for the patients. Therefore, aggressive antibiotic therapies are administered, which often require the use of last-resort drugs, if the infection is caused by multi-drug-resistant bacteria. Reducing the risk of bacterial contamination of medical devices in the hospitals has thus become an emerging issue. Promising routes to control these infections are based on materials provided with intrinsic bactericidal properties (i.e., chemical action) and on the design of surface coatings able to limit bacteria adhesion and fouling phenomena (i.e., physical action), thus preventing bacterial biofilm formation. Here, we report the development and validation of coatings made of layer-by-layer deposition of electrospun poly(vinylidene fluoride-co-trifluoro ethylene) P(VDF-TrFE) fibers with controlled orientations, which ultimately gave rise to antifouling surfaces. The obtained 10-layer surface morphology with 90 degrees orientation fibers was able to efficiently prevent the adhesion of bacteria, by establishing a superhydrophobic-like behavior compatible with the Cassie-Baxter regimen. Moreover, the results highlighted that surface wettability and bacteria adhesion could be controlled using fibers with diameter comparable to bacteria size (i.e., achievable via electrospinning process), by tuning the intra-fiber spacing, with relevant implications in the future design of biomedical surface coatings.

关键词： additive manufacturing Escherichia coli fibers Poly(vinylidene fluoride-co-trifluoro ethylene) P(VDF-TrFE) Pseudomonas aeruginosa superhydrophobic IN-VITRO MICRO SUPERHYDROPHOBICITY INFECTION RISK NANO

CRISPR-Based Technologies for the Manipulation of Eukaryotic Genomes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

四川生理科学杂志 2024年第1期46卷 160-160页

作者： Alexis C Komor Department of Chemistry and Chemical Biology Harvard University Cambridge MA 02138 USA Howard Hughes Medical Institute Harvard University Cambridge MA 02138 USA Broad Institute of MIT and Harvard Cambridge MA 02141 USA. Department of Chemistry and Chemical Biology Harvard University Cambridge MA 02138 USA Howard Hughes Medical Institute Harvard University Cambridge MA 02138 USA Broad Institute of MIT and Harvard Cambridge MA 02141 USA. Electronic address: drliu@fas.harvard.edu.

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of advances in the life sciences that have grown from the ability to edit genomes within living *** this Review,we summarize CRISPR-based tec... 详细信息

关键词： CRISPR Cas9 Genome

Effect of Strain Rate on Hydrogen Embrittlement Behaviour of Amorphous NiCrFeSiB Alloy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Materials Science & Technology 1996年第2期12卷 105-108页

作者： Zuo, Y Latanision, RM mit CAMBRIDGEMA 02139

The effect of strain rate on hydrogen embrittlement behaviour of amorphous Ni-6.6Cr-2.6Fe-7.8Si-14.5B (at pct) alloy in 0.1 mol/L H2SO4 solution was studied by the methods of slow strain rate test and electrochemical charging. The results show that fracture stress of the alloy decreases with the decrease of strain rate within a certain range. As a tentative explanation, the effect of strain rate on hydrogen embrittlement fracture stress was attributed to the interaction between hydrogen and the excess volume in amorphous alloys.

关键词： Amorphous alloys

A Survey of Language-Based Approaches to Cyber-Physical and Embedded System Development

在线全文

学校读者我要写书评

暂无评论

Tsinghua Science and Technology 2015年第2期20卷 130-141页

作者： Paul Soulier Depeng Li John R. Williams University of Hawaii Massachusetts Institute of Technology(mit)

As computers continue to advance, they are becoming more capable of sensing, interacting, and communicating with the physical and cyber world. Medical devices, electronic braking systems in automotive applications, and industrial control systems are examples of the many Cyber-Physical Systems （CPS） that utilize these computing capabilities. Given the potential consequences of software related failures in such systems, a high degree of safety, security, and reliability is often required. Programming languages are important tools used by programmers to develop CPS. They provide a programmer with the ability to transform designs into machine code. Of equal importance is their ability to detect and avoid programming mistakes. The development of CPS has predominantly been accomplished using the C programming language. Although C is a powerful language, it lacks features present in other languages that facilitate the development of reliable systems. This has prompted research into language-based alternatives for improving program quality through the use of programming languages. This paper presents an overview of the characteristics of embedded and cyber-physical systems and the associated requirements imposed on programming languages. This is followed by a survey of relevant research into language- based methods for creating safe, reliable, and robust software for CPS.

关键词： cyber-physical systems embedded systems programming languages type systems