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Olfactory receptors in neural regeneration in the central nervous system

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Neural Regeneration Research 2025年第9期20卷 2480-2494页

作者： Rafael Franco Claudia Garrigós Toni Capó Joan Serrano-Marín Rafael Rivas-Santisteban Jaume Lillo Molecular Neurobiology Laboratory Department of Biochemistry and Molecular BiomedicineFacultat de BiologiaUniversitat de BarcelonaBarcelonaSpain CiberNed Network Center for Biomedical Research in Neurodegenerative Diseases Spanish National Health Institute Carlos ⅢMadridSpain School of Chemistry Universitat de BarcelonaBarcelonaSpain Department of Biochemistry and Physiology School of Pharmacy and Food SciencesUniversitat de BarcelonaBarcelonaSpain Laboratory of Computational Medicine Biostatistics UnitFaculty of MedicineAutonomous University of BarcelonaCampus BellaterraBarcelonaSpain

Olfactory receptors are crucial for detecting odors and play a vital role in our sense of smell,influencing behaviors from food choices to emotional *** receptors also contribute to our perception of flavor and have potential applications in medical diagnostics and environmental *** ability of the olfactory system to regenerate its sensory neurons provides a unique model to study neural regeneration,a phenomenon largely absent in the central nervous *** gained from how olfactory neurons continuously replace themselves and reestablish functional connections can provide strategies to promote similar regenerative processes in the central nervous system,where damage often results in permanent *** the molecular and cellular mechanisms underpinning olfactory neuron regeneration could pave the way for developing therapeutic approaches to treat spinal co rd injuries and neurodegenerative diseases like Alzheimer's *** ctory receptors are found in almost any cell of eve ry orga n/tissue of the mammalian *** ectopic expression provides insights into the chemical structures that can activate olfactory *** addition to odors,olfactory receptors in ectopic expression may respond to endogenous compounds and molecules produced by mucosal colonizing *** analysis of the function of olfactory receptors in ectopic expression provides valuable information on the signaling pathway engaged upon receptor activation and the receptor's role in proliferation and cell differentiation *** review explo res the ectopic expression of olfa ctory receptors and the role they may play in neural regeneration within the central nervous system,with particular attention to compounds that can activate these receptors to initiate regenerative *** suggests that olfactory receptors could serve as potential therapeutic targets for enhancing neural repair and recovery following central nervous syste

关键词： adenosine receptors adrenergic receptors ectopic expression G proteincoupled receptors glia neurons

Design and redesign journey of a drug for transthyretin amyloidosis

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Neural Regeneration Research 2025年第4期20卷 1096-1097页

作者： Francisca Pinheiro Salvador Ventura Institut de Biotecnologia i Biomedicina Departament de Bioquímica i Biologia MolecularUniversitat Autònoma de BarcelonaBellaterraSpain

The misfolding and subsequent aggregation of proteins into amyloid fibrils underlie the onset of a variety of human disorders collectively known as ***(TTR)is one of the>30 amyloidogenic proteins identified to date and is associated with a group of highly debilitating and life-threatening disorders called TTR amyloidosis(ATTR).ATTR comprises senile systemic amyloidosis,which is linked to wild-type(WT)TTR aggregation,and hereditary ATTR,a dominantly inherited disorder caused by the deposition of one of over 130 TTR genetic *** systemic amyloidosis is a prevalent age-related amyloidosis,affecting up to 25%of the population over 80 years of age,and is characterized by the build-up of TTR fibrils in the *** hereditary ATTR,the clinical presentation is highly heterogeneous,primarily affecting the peripheral nervous system(familial amyloid polyneuropathy-FAP)or the heart(familial amyloid cardiomyopathy).In rare cases,aggregation develops in the central nervous system,giving rise to a phenotype known as familial leptomeningeal amyloidosis(Carroll et al.,2022).

关键词： amyloid aggregation senile

Brain-derived neurotrophic factor signaling in the neuromuscular junction during developmental axonal competition and synapse elimination

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Neural Regeneration Research 2025年第2期20卷 394-401页

作者： Josep Tomàs Víctor Cilleros-Mañé Laia Just-Borràs Marta Balanyà-Segura Aleksandra Polishchuk Laura Nadal Marta Tomàs Carolina Silvera-Simón Manel M.Santafé Maria A.Lanuza Unitat d’Histologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the development of the nervous system,there is an overproduction of neurons and *** competition between neighboring nerve endings and synapses performing different activity levels leads to their elimination or *** have extensively studied the involvement of the brain-derived neurotrophic factor-Tropomyosin-related kinase B receptor neurotrophic retrograde pathway,at the neuromuscular junction,in the axonal development and synapse elimination process versus the synapse *** purpose of this review is to describe the neurotrophic influence on developmental synapse elimination,in relation to other molecular pathways that we and others have found to regulate this *** particular,we summarize our published results based on transmitter release analysis and axonal counts to show the different involvement of the presynaptic acetylcholine muscarinic autoreceptors,coupled to downstream serine-threonine protein kinases A and C(PKA and PKC)and voltage-gated calcium channels,at different nerve endings in developmental *** dynamic changes that occur simultaneously in several nerve terminals and synapses converge across a postsynaptic site,influence each other,and require careful studies to individualize the mechanisms of specific *** describe an activity-dependent balance(related to the extent of transmitter release)between the presynaptic muscarinic subtypes and the neurotrophin-mediated TrkB/p75NTR pathways that can influence the timing and fate of the competitive interactions between the different axon *** downstream displacement of the PKA/PKC activity ratio to lower values,both in competing nerve terminals and at postsynaptic sites,plays a relevant role in controlling the elimination of supernumerary ***,calcium entry through L-and P/Q-subtypes of voltage-gated calcium channels(both channels are present,together with the N-type channel in developing nerve terminals)contributes to red

关键词： acetylcholine release adenosine receptors axonal competition brain-derived neurotrophic factor calcium channels motor end-plate muscarinic acetylcholine receptors postnatal synapse elimination serine kinases tropomyosin-related kinase receptorB

Beyond neurodegeneration:engineering amyloids for biocatalysis

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Neural Regeneration Research 2025年第10期20卷 2915-2916页

作者： Andrea Bartolomé-Nafría Javier García-Pardo Salvador Ventura Institut de Biotecnologia i de Biomedicina(IBB)and Departament de Bioquímica i Biologia Molecular Universitat Autònoma de BarcelonaBellaterraBarcelonaSpain Hospital Universitari Parc Taulí Institut d’Investigaciói InnovacióParc Taulí(I3PT-CERCA)Universitat Autònoma de BarcelonaSabadellSpain

Amyloid fibrils are highly organized protein or peptide aggregates,often characterized by a distinctive supramolecular cross-β-sheet *** formation and accumulation of these structures have been traditionally associated with neural or systemic human diseases,such as Alzheimer’s disease,Parkinson’s disease,type-2 diabetes,or amyotrophic lateral sclerosis(Wei et al.,2017;Wittung-Stafshede,2023).

关键词： structure amyloid

Dynamic Scaling and Universality of the Two-Dimensional Random-Bond Potts Model

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Chinese Physics Letters 2001年第10期18卷 1404-1407页

作者： YING He-Ping BIAN Bao-jun JI Da-Ren Lothar Schiilke Zhejiang Institutte of Modern Physics Zhejiang UniversityHangzhou 310027 Fachbereich Physik Universitat SiegenD-57068 SiegenGermany Department of Mathematics Zhejiang UniversityHangzhou 310027

Short-time dynamics and universality are investigated for the random-bond Potts model with a trinary distribu tion of quenched randomness on a two-dimensional triangular lattice. The universal power-law scaling behaviour is applied to estimate the exponents z and β/v. Emphasis is placed on dynamic Monte Carlo evolutions for different multi-disorder amplitudes. Our results indicate that the quenched impurities cause a change of the critical universality.

关键词： behaviour scaling triangular

Negotiating ＂Airy Curtains＂ Throughout the Cold War

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International Relations and Diplomacy 2014年第1期2卷 16-24页

作者： Christian Henrich-Franke universitat siegen Siegen Germany

This paper analyzes in a long-term perspective the evolution of the international system between the 1920s and the 1980s in the particular case of broadcasting frequency regulation. It addresses the constructing of ＂Airy Curtains＂--the immaterial equivalent to the Iron Curtain-along ideological frontiers by focusing on the International Telecommunication Union＇s frequency allocation conferences throughout the ＂Cold War＂. The question is raised： Which changes in the construction of ＂Airy Curtains＂ and the international system are observable in a long term perspective？ The paper answers this question by telling a story of specialization and differentiation of the international system. At the core of the paper the tensions between experts and diplomats in the negotiations on international regulations are discussed. The paper argues that in three periods the governance changed from an expert matter over a conflictual diplomatic period into a system where ＇Cold War engineers＇ and the ＇Engineering diplomats＇ took a pragmatic approach to the ideological conflicts and the political demand for Cold War broadcasting by a decoupling of politics and technology. In that context decision-making changed from ＂conference diplomacy＂ in the beginning to a complex process where many problems were solved outside the conferences themselves.

关键词： changing international relations expert governance cold war broadcasting

The Root Cap Determines Ethylene-Dependent Growth and Development in Maize Roots

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Molecular Plant 2008年第2期1卷 359-367页

作者： Achim Hahn Roman Zimmermann Dierk Wanke Klaus Harter Hans G. Edelmann Botanisches Institut Universitfit zu Koin Gyrhofstr. 15 D-50931 Koin Germany Present address: ZMBP Pflanzenphysiologie University TQbingen Auf der Morgenstelle 1 D-72076 TQbingen Germany Institut fur Entwicklungsbiologie Universitat zu Koin Gyrhofstr. 17 D-50931 Koin Germany Institut fur Entwicklungsbiologie Universitat zu Koin Gyrhofstr. 17 D-50931 Koln Germany ZMBP Pflanzenphysiologie Universitat Tubingen Auf der Morgenstelle 1 D-72076 Tubingen Germany Present address: Biologie und ihre Didaktik Universitat Siegen D-57068 Siegen Germany

Besides providing protection against mechanical damage to the root tip, the root cap is involved in the perception and processing of diverse external and internal stimuli resulting in altered growth and development, The transduction of these stimuli includes hormonal signaling pathways such as those of auxin, ethylene and cytokinin. Here, we show that the root cap is essential for the ethylene-induced regulation of elongation growth and root hair formation in maize. Exogenously applied ethylene is no longer able to inhibit elongation growth when the root cap has been surgically removed prior to hormone treatment. Reconstitution of the cap positively correlates with the developing capacity of the roots to respond to ethylene again. In contrast, the removal of the root cap does not per se affect growth inhibition controlled by auxin and cytokinin. Furthermore, our semi-quantitative RT-PCR results support earlier findings that the maize root cap is a site of high gene expression activity with respect to sensing and responding to hormones such as ethylene, From these data, we propose a novel function of the root cap which is the establishment of competence to respond to ethylene in the distal zones of the root.

关键词： AUXIN BIOSYNTHESIS INSENSITIVE MUTANTS CELL ELONGATION

Corrosion of Alumina and Mullite Based Refractories by an Ingot Casting Steel

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China's Refractories 2018年第1期27卷 14-19页

作者： Jens FRUHSTORFER Steffen DUDCZIG Leandro SCHOTTLER Christos G. ANEZIRIS Institute of Ceramic Glass and Construction Materials Technische Universitat Bergakademie Freiberg Freiberg 09599 Germany Deutsche Edelstahlwerke GmbH Siegen 57078 Germany

The corrosion of refractory crucibles by a highly cor- rosive steel （18CrNiMo7-6） with a high aluminum con- tent and casting temperature of 1 580℃ was investiga- ted. The tested refractories were alumina, muUite and alumina doped with zirconia and titania （ AZT）. The samples were decreasingly attacked in the sequence AZT, alumina and mullite with corrosion layers of about 14, 6 and 1 mm, respectively. In the alumina and AZT, compositions corresponding to manganese aluminates and subsequently manganese aluminosilicates formed with manganese and silicon from the steel. In the mullite cru- cible, compositions corresponding to manganese aluminosilicates formed directly with manganese from the steel giving a highly viscous interfacial melt which retarded the further corrosion.

关键词： castable corrosion mullite refractory

A Secure Elliptic Curve-Based RFID Protocol

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Journal of Computer Science & Technology 2009年第2期24卷 309-318页

作者： Santi Martínez Magda Valls Concepció Roig Josep M. Miret Francesc Giné Computer Science Department Universitat de Lleida Mathematics Department Universitat de Lleida

Nowadays, the use of Radio Frequency Identification （RFID） systems in industry and stores has increased Nevertheless, some of these systems present privacy problems that may discourage potential users. Hence, high confidence and efficient privacy protocols are urgently needed. Previous studies in the literature proposed schemes that are proven to be secure, but they have scalability problems. A feasible and scalable protocol to guarantee privacy is presented in this paper. The proposed protocol uses elliptic curve cryptography combined with a zero knowledge-based authentication scheme. An analysis to prove the system secure, and even forward secure is also provided.

关键词： elliptic curve cryptography forward security RFID zero knowledge