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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

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Lighting the shades of hidden pain:a role for spinal cord neurons and microglia in vestibulodynia

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Neural Regeneration Research 2025年第10期20卷 2898-2900页

作者： Rosmara Infantino Francesca Gargano Serena Boccella Carmela Belardo Andrea Maria Morace Francesca Guida Sabatino Maione Livio Luongo Department of Experimental Medicine Division of PharmacologyUniversitàdegli Studi della Campania“L.Vanvitelli”Italy UniversitàCampus Bio-medico di Roma RomeItaly

Vulvodynia,a chronic pain disorder affecting the vulvar region,represents a significant challenge in both diagnosis and treatment within the field of women’s *** condition is characterized by chronic pain that significantly affects the quality of life of afflicted *** present perspective paper examines the role of spinal sensitization and microglial activation in vulvodynia.

关键词： pain diagnosis activation

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Genetic and phenotypic analyses reveal major quantitative loci associated to fruit size and shape traits in a non-flat peach collection ( P. persica L. Batsch)

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Horticulture Research 2021年第1期8卷 3211-3227页

作者： Marco Cirilli Irina Baccichet Remo Chiozzotto Cristian Silvestri Laura Rossini Daniele Bassini universita degli studi di Milano-DiSAA MilanoItaly universita degli studi della Tuscia-DAFNE ViterboItaly

Fruit size and shape are critical agronomical and pomological attributes and prime targets in peach breeding *** from the flat peach type,a Mendelian trait well-characterized at the genetic level,ample diversity of fruit size and shapes is present across peach ***,knowledge of the underlying genomic loci remains *** this work,fruit size and shape were assessed in a collection of non-flat peach accessions and selections,under controlled fruit load *** architecture of these traits was then dissected by combining association and linkage mapping,revealing a major locus on the proximal end of chromosome 6(qSHL/Fs6.1)explaining a large proportion of phenotypic variability for longitudinal shape and also affecting fruit size.A second major locus for fruit longitudinal shape(qSHL5.1),probably also affecting fruit size,was found co-localizing at locus G,suggesting pleiotropic effects of peach/nectarine *** additional QTL for fruit longitudinal shape(qSHL6.2)was identi fied in the distal end of chromosome 6 in a cross with an ornamental double-flower peach and co-localized with the Di2 locus,controlling flower *** assisting breeding activities,knowledge of loci controlling fruit size and shape paves the way for more in-depth studies aimed at the identification of underlying genetic variant(s).

关键词： shape size breeding

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Model-driven engineering for multi-party business processes on multiple blockchains

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Blockchain(Research and Applications) 2021年第3期2卷 31-45页

作者： Flavio Corradini Alessandro Marcelletti Andrea Morichetta Andrea Polini Barbara Re Emanuele Scala Francesco Tiezzi universita degli studi di Camerino Camerino62032Italy

As a disruptive technology,the blockchain is continuously finding novel application contexts,bringing new opportunities and radical *** this paper,we use blockchain as a communication infrastructure to support multi-party business *** particular,through smart contracts specifically generated by the mentioned business process,it is possible to derive a trustable infrastructure enabling the interaction among ***,the emergence of different blockchain technologies,satisfying different characteristics,gives the possibility to support the same business process dealing with different non-functional *** this paper,we propose a novel engineering methodology supported by a practical framework called *** permits to derive,using a model-driven strategy,a blockchain-based infrastructure,that can be deployed over a specific blockchain technology(e.g.,Ethereum or Hyperledger Fabric).The objective is to permit the single definition and multiple deployments of the business process,to deliver the same functionalities,but satisfying different nonfunctional *** such a way,organisations willing to cooperate can select the multi-party business process and the blockchain technology they would like to use to satisfy their *** Multi-Chain,they will be able to automatically derive from a Business Process Modelling Notation(BPMN)choreography diagram a blockchain infrastructure ready to be *** overcomes the need to get acquainted with many details of the specific technology.

关键词： Blockchain Model-driven Multi-party Choreography

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LOW MACH NUMBER LIMIT ON EXTERIOR DOMAINS

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Acta Mathematica Scientia 2012年第1期32卷 164-176页

作者： Donatella Donatelli Pierangelo Marcati Dipartimento di Matematica Pura ed Applicata Universita degli Studi dell'Aquila

This paper is concerned with the low Mach number limit for the compressible Navier-Stokes equations in an exterior domain. We present here an approach based on Strichartz estimate defined on a non trapping exterior do... 详细信息

关键词： exterior domain compressible and incompressible Navier-Stokes equation low Mach number limit hyperbolic equations wave equations rescaling dispersive estimates Strichartz estimates

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Updating the orbital ephemeris of the dipping source XB 1254–690 and the distance to the source

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Research in Astronomy and Astrophysics 2017年第10期17卷 97-108页

作者： Angelo F.Gambino Rosario Iaria Tiziana Di Salvo Marco Matranga Luciano Burderi Fabio Pintore Alessandro Riggio Andrea Sanna universita degli studi di Palermo Dipartimento di Fisica e Chimica universita degli studi di Cagliari Dipartimento di Fisica INAF-Istituto di Astrofisica Spaziale e Fisica Cosmica - Milano

XB 1254-690 is a dipping low mass X-ray binary system hosting a neutron star and showing type I X-ray bursts. We aim at obtaining a more accurate orbital ephemeris and at constraining the orbital period derivative of the system for the first time. In addition, we want to better constrain the distance to the source in order to locate the system in a well defined evolutive scenario. We apply, for the first time, an orbital timing technique to XB 1254-690, using the arrival times of the dips present in the light curves that have been collected during 26 yr of X-ray pointed observations acquired from different space missions. We estimate the dip arrival times using a statistical method that weights the count-rate inside the dip with respect to the level of persistent emission outside the dip. We fit the obtained delays as a function of the orbital cycles both with a linear and a quadratic function. We infer the orbital ephemeris of XB 1254-690, improving the accuracy of the orbital period with respect to previous estimates. We infer a mass of M2 = 0.42 ± 0.04 M for the donor star, in agreement with estimations already present in literature, assuming that the star is in thermal equilibrium while it transfers part of its mass via the inner Lagrangian point, and assuming a neutron star mass of 1.4 Mo. Using these assumptions, we also constrain the distance to the source, finding a value of 7.6±0.8 kpc. Finally, we discuss the evolution of the system, suggesting that it is compatible with a conservative mass transfer driven by magnetic braking.

关键词： stars: neutron -- stars: individual (XB 1254-690) -- X-rays: binaries -- X-rays: stars --Astrometry and celestial mechanics: ephemerides

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An Integrated Approach for Optimal Design of Micro Gas Turbine Combustors

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Journal of Thermal Science 2009年第2期18卷 173-184页

作者： Luca Fuligno Diego Micheli Carlo Poloni EnginSoft s.p.a. Dipartimento di Ingegneria Meccanica Universita degli Studi di Trieste Dipartimento

The present work presents an approach for the optimized design of small gas turbine combustors, that integrates a0-D code, CFD analyses and an advanced game theory multi-objective optimization algorithm. The output of the0-D code is a baseline design of the combustor, given the required fuel characteristics, the basic geometry (tubularor annular) and the combustion concept (i.e. lean premixed primary zone or diffusive processes). For the optimizationof the baseline design a simplified parametric CAD/mesher model is then defined and submitted to a CFDcode. Free parameters of the optimization process are position and size of the liner hole arrays, their total area andthe shape of the exit duct, while different objectives are the minimization of NOx emissions, pressure losses andcombustor exit Pattern Factor. A 3D simulation of the optimized geometry completes the design procedure. As afirst demonstrative example, the integrated design process was applied to a tubular combustion chamber with alean premixed primary zone for a recuperative methane-fuelled small gas turbine of the 100 kW class.

关键词： micro gas turbine combustor optimized design

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The cold chain and the COVID-19 pandemic:an unusual increase in histamine content in fish samples collected in Southern Italy during lockdown

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Food Quality and Safety 2021年第4期5卷 329-335页

作者： Francesco Giuseppe Gailuzzo Gaetano Cammilleri Antonello Cicero Licia Pantano Andrea Pulvirenti Andrea Macaluso Nicola Cicero Vittorio Calabrese Vincenzo Ferrantelli Istituto Zooprofilattico Sperimentale della Sicilia PalermoItaly Dipartimento di Scienze della Vita Universita degli studi di Modena e Reggio EmiliaModenaItaly Dipartimento SASTAS Universita degli studi di MessinaMessinaItaly Dipartiment'o di Scienze biomediche e biotecnologiche Universita degli studi di CataniaCataniaItaly

Objectives:We analysed 900 samples of fresh(250)and processed(650)fish products collected in Sicily(Southern Italy)in 2020 during the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)pandemic(hereafter:COVID-19).Materials and methods:The samples were divided temporally based on four phases relating to the various restrictions imposed by the Italian government in this *** validated method of ultrahigh-performance liquid chromatography combined with a diode array detector was then employed for the ***:The samples collected during the Phase I lockdown period and after it had ended(Phase II)revealed significant increases in the mean histamine levels:(41.89±87.58)mg/kg and(24.91±76.76)mg/kg,*** 11(1.3%of the total)fresh fish samples that were identified as being non-compliant with Regulation(EC)No.2073/2005 were only found during these two *** the processed samples were always *** histamine values decreased as the restrictions eased,achieving a mean value of(11.16±9.3)mg/kg(Phase III).Conclusions:There was an increase in the incidence offish samples that were non-compliant with Regulation(EC)No.2073/2005 compared to previous surveillance *** results provide a first report on the effect of lockdown measures on food safety and the cold *** findings must cause food safety operators to intensify their controls over fresh fish products in such periods to safeguard consumer *** studies are required to evaluate whether the same trend would be observed with other food contaminants.

关键词： Histamine cold-chain food safety COVID-19

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Heat Loss from Buried Vertical Plate with Assigned Temperature Distribution

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Journal of Thermal Science 2009年第3期18卷 253-255页

作者： L.Fontana A.Quintino Dipartimento di Progettazione e studio dell'Architettura Universita degli Studi"Roma Tre" Dipartimento

Thermal losses for a buried vertical thin plate can be expressed as a function of the assigned temperature distribution,the medium conductivity and the geometrical properties that describe the model. When the geometricalproperties reduce to one, the plate-ground thermal resistance can be expressed regardless of plate dimension, dependingonly on temperature distribution given at surface plate and its temperature difference with medium.

关键词： thermal resistance buried vertical plate

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A comparison between different methods for determining grain distribution in coarse channel beds

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International Journal of Sediment Research 2016年第2期31卷 97-109页

作者： Alessio Cislaghi Enrico Antonio Chiaradia Gian Battista Bischetti Department of Agricultural and Environmental Sciences(DiSAA) Universita degli Studi di Milano

The determination of grain size distribution in alluvial channels plays a crucial role in understanding fluvial dynamics and processes(e.g.,hydraulic resistance,sediment transport and erosion,and habitat suitability).However,to determine an accurate distribution,tremendous field efforts are often ***,the grain size distribution of channel beds have been obtained by manually counting a set of randomly selected stones(the "pebble count").Based on this elementary principle,many authors have proposed different adaptations to overcome weaknesses and problems with the original method;with the development of digital technology,photographic methods have been developed in order to significantly reduce the time spent in the *** of these "image-assisted" methods include Automated Grain Sizing,ACS,and Manual Photo Sieving,*** this study,AGS and MPS were applied under ideal laboratory conditions,to be used as reference,and in two field conditions with different degrees of difficulty in terms of visual determination of the grain size distribution;these included an artificial unlined channel and two natural mountainous *** results were compared with those obtained with the pebble-count *** general,strong agreement between the methods was found when they were applied under favorable conditions( "the laboratory"),and the differences between the imageassisted and pebble count methods were similar to those found in previous *** being more time consuming,MPS was deemed preferable to AGS when conditions are not optimal;in these cases,the time spent on image elaboration significantly increased in the AGS method(approximately three-fold),but the estimation error of the median grain size decreased by approximately 37%.The use of imageassisted analysis has proven to be robust for characterizing sediment in watercourse beds and reducing fieldwork time,but because field conditions can significantly affect the accuracy of results,the method

关键词： Grain size distribution curve Grain size analysis Image analysis Gravel beds Segmentation

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