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Pregnancy Air Exposure: An R Package for Estimation of Exposure to Air Pollution during Critical Windows of Pregnancy

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Open Journal of Statistics 2017年第3期7卷 422-433页

作者： Séverine deguen Laure Nicollet Morgane Gilles Arlette Danzon Olivier Blanchard Géraldine Le Nir denis Zmirou-Navier Wahida Kihal-Talantikite EHESP School of Public Health Rennes France Maternal and Infant Preventive Institute (PMI) Paris France Air Quality Monitoring Associations (AASQA) Airparif Paris France INSERM U1085 IRSET (Research Institute in Environmental and Occupational Health) Rennes France Lorraine university Medical School Nancy France university of strasbourg CNRS LIVE UMR 7362 Strasbourg France

Today, it is well known that ambient air pollution exposures may be related with different health outcomes including adverse birth outcomes (for instance, low birth weight and preterm birth). Then, researchers must estimate exposure to air pollution during different critical windows of exposure across pregnancy. In the literature, the most commonly examined critical windows of exposure are the first, second, and third trimesters of pregnancy, although the entire pregnancy is also studied. In this context, we developed an automatic procedure which estimates individual exposures by trimester. We illustrate usage of the Pregnancy Air Exposure package for all births within the city of Paris in 2011. Nitrogen dioxide data from monitoring stations and data modeled at the census block level were available from the air quality monitoring networks of Ile de France Region. Nitrogen dioxide, NO2, has been chosen as an indicator of traffic-generated pollution. Newborn health data are available from the first birth certificate registered by the Maternal and Child Care department of Paris;more specifically, we used the date of birth and the gestational age to individually determine the beginning and the end of each trimester. The Pregnancy Air Exposure R package was created to simplify application of the procedure for non-specialists, and is freely available from the Equit’Area project website: (***/documents/package_Exposure). The package contains two functions as well as the help files needed to run the procedure and yields air pollution exposure estimates by pregnancy trimester. The two functions can be used successively or independently according to the available input data.

关键词： Air Pollution Exposure Pregnant Women Critical Window of Exposure R Software

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机载激光雷达数据的误差分析及校正

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遥感学报 2007年第3期11卷 390-397页

作者：王成 Menenti M StollM P 李传荣唐伶俐中国科学院光电研究院北京100080 法国strasbourg I大学LSIIT实验室

数据质量分析是遥感机理/应用研究(尤其是定量遥感)首要和关键的一步,直接影响遥感反演的精度和遥感应用的效果。激光雷达(Light detection and Ranging,LiDAR)是一种新兴的主动遥感技术,对数据后处理算法的研究还有待进一步加强,尤其... 详细信息

数据质量分析是遥感机理/应用研究(尤其是定量遥感)首要和关键的一步,直接影响遥感反演的精度和遥感应用的效果。激光雷达(Light detection and Ranging,LiDAR)是一种新兴的主动遥感技术,对数据后处理算法的研究还有待进一步加强,尤其对激光雷达数据的质量分析显得十分迫切。采用了一种基于扫描航带间重叠区数据分析的方法对LiDAR数据质量进行评价,分析误差来源,计算误差的大小,并分别对数据的随机和系统误差进行校正。以机载激光雷达数据为例来进行验证,实验结果表明,这种方法能有效地减少数据误差,达到提高数据质量的目的。

关键词：激光雷达数据数据误差分析误差校正

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19-去甲孕酮衍生物—诺美孕酮对乳腺的作用

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世界核心医学期刊文摘（妇产科学分册） 2005年第6期1卷 58-60页

作者： G. André 杨晓梅 15 rue Ohmacht 67000 Strasbourg France

As the biological effects of progestins vary according to their molecular structure, it becomes essential to differentiate the various types of progestins, particularly with regard to the breast. Objective. The purpose of this review was to gather published data on the effects of a 19- norprogesterone derivative, nomegestrol acetate, on the breast. Materials and methods. All experimental and clinical published studies reporting data in the literature on nomegestrol acetate and breast were reviewed. Results. In experiments on steroid receptors, it was shown that nomegestrol acetate presents a high binding specificity and affinity for progesterone receptors, notably in normal and cancerous human breast tissues. It sharply inhibits synthesis of progesterone receptors in hormone- dependent T- 47D human breast cancer cells grown in an estrogenic culture medium, thereby demonstrating its strong progestational activity. On the other hand, it does not bind to estrogen receptors and lacks any estrogenic potential, confirmed by the lack of induction of alkaline phosphatase activity of endometrial Ishikawa cells. Estrogen- induced synthesis of estrogen receptors is also inhibited by nomegestrol acetate, a major determinant of its strong intrinsic anti- estrogenic activity. Unlike androgenic progestins (e.g. 19- nortestosterone derivatives and medroxyprogesterone acetate) which may act indirectly on the breast by inducing modifications of sex hormone binding globulin (SHBG) and insulin- like growth factor- I (IGF- I), nomegestrol acetate is devoid of any androgenic activity. In studies carried out on the effects of progestins on enzyme activities involved in estradiol (E2) formation in breast tissue, nomegestrol acetate can control E2 levels in breast cancer tissue in vitro: it inhibits estrone sulfatase activity that converts estrone sulfate (E1S)- to estrone (E1) and inhibits 17β - hydroxysteroid dehydrogenase type 1 activity that converts E1 to E2, resulting in blockade of E

关键词：诺美孕酮甲孕酮人乳腺癌细胞孕酮受体正常乳腺组织临床试验结果雌酮硫酸酯激素替代治疗类固醇受体激素依赖性

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Numerical and Experimental Modelling of Human Head under Impact - New Tolerance limits and experimental injury criteria

Numerical and Experimental Modelling of Human Head under Imp...

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The 3rd International Forum of Automotive Traffic Safety

作者： Rémy Willinger Daniel Baumgartner Louis Pasteur university （ULP）-Institute of Fluid and Solid Mechanics-CNRS 7507 2 rue Boussingault 67000 strasbourg France

Head injuries are frequent and severe injuries in almost all types of traffic accidents with height societal and economic costs. Therefore, head injury reduction is a high priority for traffic safety improvement. After a review of the state of the art of human head modelling, the present paper presents original physical and numerical human head models followed by there modal and temporal validation against human head vibration analysis in vivo and cadaver impact tests. The human head finite element model developed by ULP at strasbourg university presents two particularities : one at the brain-skull interface level were fluid-structure interaction is taken into account, the other at the skull modelling level by integrating the bone fracture simulation. Validation shows that the model correlated well with a number of experimental cadaver tests and predicted intra-cranial pressure accurately. However, for long duration impacts the model reaches its limits. The skull stiffness and fracture force were accurately predicted when compared with experimental values from the literature. In a second step a new dummy head prototype named Bimass 150 is presented. It has been constructed using a Hybrid III headform and comprises two masses : a skull and a mass to represent the brain attached to the skull with a damped spring system. The novel feature of this device is that it can simulate the brain - skull relative displacement at a frequency close to 150 Hz as recorded under vibration analysis in vivo. This numerical and physical improved human head surrogates have then be used for experimental and numerical real world accident reconstruction. Helmet damage from thirteen motorcycle accidents was replicated in drop tests in order to define the head’s loading conditions. A total of twenty two well documented American football head trauma have been reconstructed as well as twenty eight pedestrian head impacts. By correlating head injury type and location with intra-cerebral mechanic

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Alternative splicing of FMRl gene in fetal and adult human brain

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Progress in Natural Science:Materials International 1998年第6期 61-66页

作者：黄涛,李兰英,范钰,VICAIRE Serge,庞智玲,MANdeL Jean-Louis,吴冠芸,沈岩 State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China Institute of Endocrinology Tianjin Medical university Tianjin 300070 China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China Institut de Genetique et de Biologie Moleculaire Cellulaire CNRS INSERM ULP BP 163 67404 Illkirch Cedex C.U. de strasbourg France Institute of Endocrinology Tianjin Medical university Tianjin 300070 China Institut de Genetique et de Biologie Moleculaire Cellulaire CNRS INSERM ULP BP 163 67404 Illkirch Cedex C.U. de strasbourg France State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Peking Union Medical College Chinese Academy of Medical Sciences Beijing 100005 China

Fragile X syndrome can be caused by lack of expression of the FMRl gene, which encodes an RNA binding protein. Extensive alternative splicing of the FMRl gene has been observed in human and mice. Five regions of the FMRl gene have been reported to be alternatively spliced. To determine whether such alternative splicing might be developmentally regulated, RT-PCR was used to analyze poly(A) RNA transcripts of the FMRl gene in adult and fetal human brain. A new alternative acceptor site in exon 17 that may lead to a truncation of the last 53 ammo acids of the FMRl protein was described. This acceptor site was used in several regions of fetal brain but not in adult cortex. The results suggest that alternative splicing of the FMRl gene may be subject to developmental switching

关键词： FMR1 gene alternative splicing Fragile X.

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Preparation of highly dispersed supported Ni-Based catalysts and their catalytic performance in low temperature for CO methanation

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Carbon Resources Conversion 2020年第1期3卷 164-172页

作者： Yongbin Yao Jing Xu Xuhong Guo Jiangwei Li Qixia Zhang Jiangbing Li Chao Wang Mengjuan Zhang Bin Dai Feng Yu Sebastien Thomas Anne-Cecile Roger Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan School of Chemistry and Chemical EngineeringShihezi UniversityShihezi 832003PR China State Key Laboratory of Chemical Engineering East China University of Science and TechnologyShanghai 200237PR China Key Laboratory on Resources Chemicals and Materials of Ministry of Education Shenyang University of Chemical TechnologyShenyang 110142PR China Graduate School of Science and Technology Hirosaki University3 Bunkyo-choHirosakiAomori 036-8560Japan Institut de Chimie et Procedes pour l’Energie l’Environnement et la Sante(ICPEESUMR CNRS 7515)25 rue Becquerel67087 StrasbourgFrance

The use of non-noble nickel-based catalysts for low temperature CO methanation has been a challenge in recent ***,MgAl layered double oxides sample with high dispersion synthesized by a facile N-(2-Hydroxyethyl)ethylenediaminetriacetic acid assisted wetness impregnation approach,demonstrates much superior catalytic activity and exceptional stability for CO methanation in comparison with the classical Ni/MgAl-LDO catalyst prepared by the ordinary wetness impregnation *** results showed that N-(2-Hydroxyethyl)ethylenediaminetriacetic acid played a positive role in the dispersion of Ni,as well as Ni-support ***-dispersed Ni particles with a size of about 5 nm were formed in the presence of N-(2-Hydroxyethyl)ethylenediaminetriacetic *** to the Ni/MgAl-LDO prepared by conventional impregnation method,the NH-Ni/MgAl-LDO exhibited superior catalytic performance,especially excellent thermal *** NH-Ni30/MgAl-LDO catalyst was found to keep a 70%CO conversion even at 160◦C which demonstrates its good low temperature *** the in situ FTIR observations,this good performance at low temperatures may be linked to the delocalization of electrons around CO caused by surface hydroxyl groups.

关键词： Complexed-impregnation Layered double oxide CO methanation Low temperature catalyst

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橡胶增韧高聚物的动态断裂(英文)

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宁波大学学报（理工版） 2003年第4期16卷 367-372页

作者： C.FOND R.SCHIRRER Institute Charles Sadmn 6rue BoussingauhF67083 StrasbourgFranceInstitute Charles Sadmn6rue BoussingauhF67083 StrasbourgFrance

采用冲击改性的高聚物对材料的断裂能在近瑞利波速C,时减小的断裂行为进行了研究.设计了基于条带几何形状的实验装置用以探索这些高聚物在快速裂纹传播(RCP)时的脆性行为.发现沿着橡胶增韧聚甲基丙烯酸甲酯(RT-PMMA)的整个试样,尽管有... 详细信息

采用冲击改性的高聚物对材料的断裂能在近瑞利波速C,时减小的断裂行为进行了研究.设计了基于条带几何形状的实验装置用以探索这些高聚物在快速裂纹传播(RCP)时的脆性行为.发现沿着橡胶增韧聚甲基丙烯酸甲酯(RT-PMMA)的整个试样,尽管有的出现裂纹分叉甚至裂纹俘获静止,其宏观裂纹速度几乎恒定.当材料行为趋于加速裂纹时,临近Cr时断裂能减少,而当由于分叉使力学惯性效应趋于限制裂纹传播速率时,宏观裂纹速度稳定在大约amb=0.6 cr,其是RT-PMMA的宏观裂纹分叉速度.因此,对这种材料在宏观裂纹分叉速度时,实验断裂表面能及断裂表面韧性没有单一值.实际上,其宏观断裂表面能值随着失稳形态数目或无效裂纹分叉而增加.

关键词：动态断裂橡胶增韧高聚物裂纹传播速率裂纹分叉速度冲击改性断裂能

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ERK1/2信号通路在Jurkat T细胞增殖调控中的作用

ERK1/2信号通路在Jurkat T细胞增殖调控中的作用

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遗传学进步与人口健康高峰论坛

作者：邢飞跃滕振平 Christian Bronner 方志远郭中峰于哲陈笛陈玲王炯坤潘山郝文婷李玉婷樊振华刘娜陈国良陈振珵龙宇天毛成全暨南大学组织移植与免疫中心 Institut National de la Sante et de la Recherche Medicale/universite Louis Pasteur strasbourg France 67404

为探讨 ERK1/2信号通路在 Jurkat T 细胞增殖调控中的作用,采用共聚焦显微镜和 MTT 法检测不同浓度 PD98059 对 Jurkat T 细胞集落形成和增殖指数的影响,PI 染色结合流式细胞术分析不同浓度 PD98059对 Jurkat T 细胞细胞周期的影响．利...

为探讨 ERK1/2信号通路在 Jurkat T 细胞增殖调控中的作用,采用共聚焦显微镜和 MTT 法检测不同浓度 PD98059 对 Jurkat T 细胞集落形成和增殖指数的影响,PI 染色结合流式细胞术分析不同浓度 PD98059对 Jurkat T 细胞细胞周期的影响．利用不同浓度、不同信号通路特异性阻断剂 LY294002、AG490、GF109203X 和 Genistein 以及 LY294002联合 ACA90 处理 Jurkat T 细胞,观察它们对 Jurkat T 细胞集落形成和增殖指数的影响．选用最佳浓度 PD98059、LY294002、AG490、 GF109203X 和 Genistein,通过 Western Blot 检测它们对 Jurkat T 细胞中 ERK1/2、P-ERK1/2和反向 CCAAT 盒结合蛋白

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Measurement of the integrated luminosity of the Phase 2 data of the Belle Ⅱ experiment

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Chinese Physics C 2020年第2期44卷 1-12页

作者： F.Abudinén I.Adachi P.Ahlburg H.Aihara N.Akopov A.Aloisio F.Ameli L.Andricek N.Anh Ky D.M.Asner H.Atmacan T.Aushev V.Aushev T.Aziz K.Azmi V.Babu S.Baehr S.Bahinipati A.M.Bakich P.Bambade Sw.Banerjee S.Bansal V.Bansal M.Barrett J.Baudot A.Beaulieu J.Becker P.K.Behera J.V.Bennett E.Bernieri F.U.Bernlochner M.Bertemes M.Bessner S.Bettarini V.Bhardwaj F.Bianchi T.Bilka S.Bilokin D.Biswas G.Bonvicini A.Bozek M.Bračko P.Branchini N.Braun T.E.Browder A.Budano S.Bussino M.Campajola L.Cao G.Casarosa C.Cecchi D.Červenkov M.-C.Chang P.Chang R.Cheaib V.Chekelian Y.Q.Chen Y.-T.Chen B.G.Cheon K.Chilikin H.-E.Cho K.Cho S.Cho S.-K.Choi S.Choudhury D.Cinabro L.Corona L.M.Cremaldi S.Cunliffe T.Czank F.Dattola E.de La Cruz-Burelo G.de Nardo M.de Nuccio G.de Pietro R.de Sangro M.destefanis S.dey A.de Yta-Hernandez F.Di Capua S.Di Carlo J.Dingfelder Z.Doležal I.Domínguez Jiménez T.V.Dong K.Dort S.Dubey S.Duell S.Eidelman M.Eliachevitch T.Ferber D.Ferlewicz G.Finocchiaro S.Fiore A.Fodor F.Forti A.Frey B.G.Fulsom M.Gabriel E.Ganiev M.Garcia-Hernandez R.Garg A.Garmash V.Gaur A.Gaz U.Gebauer A.Gellrich J.Gemmler T.Geßler R.Giordano A.Giri B.Gobbo R.Godang P.Goldenzweig B.Golob P.Gomis P.Grace W.Gradl E.Graziani D.Greenwald C.Hadjivasiliou S.Halder K.Hara T.Hara O.Hartbrich K.Hayasaka H.Hayashii C.Hearty M.T.Hedges I.Heredia de la Cruz M.Hernández Villanueva A.Hershenhorn T.Higuchi E.C.Hill H.Hirata M.Hoek S.Hollitt T.Hotta C.-L.Hsu Y.Hu K.Huang T.Iijima K.Inami G.Inguglia J.Irakkathil Jabbar A.Ishikawa R.Itoh M.Iwasaki Y.Iwasaki S.Iwata P.Jackson W.W.Jacobs D.E.Jaffe E.-J.Jang H.B.Jeon S.Jia Y.Jin C.Joo J.Kahn H.Kakuno A.B.Kaliyar G.Karyan Y.Kato T.Kawasaki H.Kichimi C.Kiesling B.H.Kim C.-H.Kim D.Y.Kim S.-H.Kim Y.K.Kim Y.Kim T.D.Kimmel K.Kinoshita C.Kleinwort B.Knysh P.Kodyš T.Koga I.Komarov T.Konno S.Korpar D.Kotchetkov N.Kovalchuk T.M.G.Kraetzschmar P.Križan R.Kroeger J.F.Krohn P.Krokovny W.Kuehn T.Kuhr M.Kumar R.Kumar K.Kumara S.Kurz A.Kuzmin Y.-J.Kwon S.Lacaprara Y.-T.Lai C.La Licata K.Lalwani L.Lanceri J.S.Lange K.Lautenbach I.-S.Le Beihang university Beijing 100191 Brookhaven National Laboratory UptonNew York 11973 Budker Institute of Nuclear Physics SB RAS Novosibirsk 630090 Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional Mexico City 07360 Faculty of Mathematics and Physics Charles University12116 Prague Chiba university Chiba 263-8522 Consejo Nacional de Ciencia y Tecnología Mexico City 03940 deutsches Elektronen–Synchrotron 22607 Hamburg Duke university DurhamNorth Carolina 27708 Earthquake Research Institute University of TokyoTokyo 113-0032 Forschungszentrum Jülich 52425 Jülich department of Physics Fu Jen Catholic UniversityTaipei 24205 Key Laboratory of Nuclear Physics and Ion-beam Application(MOE)and Institute of Modern Physics Fudan UniversityShanghai 200443 II.Physikalisches Institut Georg-August-Universität Göttingen37073 Göttingen Gifu university Gifu 501-1193 The Graduate university for Advanced Studies(SOKENDAI) Hayama 240-0193 Gyeongsang National university Jinju 52828 department of Physics and Institute of Natural Sciences Hanyang UniversitySeoul 04763 High Energy Accelerator Research Organization(KEK) Tsukuba 305-0801 J-PARC Branch KEK Theory CenterHigh Energy Accelerator Research Organization(KEK)Tsukuba 305-0801 Indian Institute of Science Education and Research Mohali SAS Nagar140306 Indian Institute of Technology Bhubaneswar Satya Nagar 751007 Indian Institute of Technology Hyderabad Telangana 502285 Indian Institute of Technology Madras Chennai 600036 Indiana university BloomingtonIndiana 47408 Institute for High Energy Physics Protvino 142281 Institute of High Energy Physics Vienna 1050 Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049 Institute of Particle Physics(Canada) VictoriaBritish Columbia V8W 2Y2 Institute of Physics Hanoi Instituto de Fisica Corpuscular Paterna 46980 INFN Laboratori Nazionali di Frascati I-00044 Frascati INFN Sezione di Napoli I-80126 Napoli INFN Sezione di Padova I-35131 Padova INFN Sezione di Perugia I-06123 Perugia

From April to July 2018,a data sample at the peak energy of the T(4 S) resonance was collected with the Belle Ⅱ detector at the SuperKEKB electron-positron *** is the first data sample of the Belle Ⅱ *** Bhabha and digamma events,we measure the integrated luminosity of the data sample to be(496.3±0.3±3.0) pb-1,where the first uncertainty is statistical and the second is *** work provides a basis for future luminosity measurements at Belle Ⅱ.

关键词： luminosity Bhabha digamma Belle II

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多层螺旋CT和锥形束CT:高分辨力颌骨和颅底成像的对比研究

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国际医学放射学杂志 2015年第2期 201-202页

作者： J.P.Dillenseger J.F.Matern C.I.Gros F.Bornert C.Goetz J.M.L.Minor 卢忠飞 Imagerie Préclinique Biophysique et Médecine Nucléaire Hpital de Hautepierre 1 Av. Molière 67098 Strasbourg CedexFrance

摘要目的采用不同的CT扫描系统,定性和定量评估口腔科及耳鼻喉科所需的高分辨力颅骨成像。材料与方法本研究共采用3种多层螺旋CT(MSCT)系统和1种锥体束

关键词：高分辨力高分辨率 CT 几何精度

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