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Jasmonic Acid Oxidase 2 Hydroxylates Jasmonic Acid and Represses Basal defense and Resistance Responses against Botrytis cinerea Infection

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Molecular Plant 2017年第9期10卷 1159-1173页

作者： Ekaterina Smirnova Institut de Biologie Moléculaire des Plantes CNRS Université de Strasbourg Strasbourg France Laboratoire de Chimie Organique Synthétique Institut de Chimie Université de Strasbourg CNRS Strasbourg France Institut de Biologie Moléculaire des Plantes CNRS Université de Strasbourg Strasbourg Franc

Jasmonates （JAs） orchestrate immune responses upon wound/herbivore injury or infection by necrotro- phic pathogens. Elucidation of catabolic routes has revealed new complexity in jasmonate metabolism. Two integrated pathways attenuate signaling by turning over the active hormone jasmonoyl-isoleucine （JA-Ile） through w-oxidation or deconjugation, and define an indirect route forming the derivative 12OH-JA. Here, we provide evidence for a second 12OH-JA formation pathway by direct jasmonic acid （JA） oxidation. Three jasmonic acid oxidases （JAOs） of the 2-oxoglutarate dioxygenase family catalyze spe- cific oxidation of JA to 12OH-JA, and their genes are induced by wounding or infection by the fungus Botrytis cinerea. JA02 exhibits the highest basal expression, and its deficiency in jao2 mutants strongly enhanced antifungal resistance. The resistance phenotype resulted from constitutive expression of antimi- crobial markers rather than from their higher induction in infected jao2 plants and could be reversed by ectopic expression of any of the three JAOs injao2. Elevated defense injao2 was dependent on the activity of JASMONATE RESPONSE 1 （JAR1） and CORONATINE-INSENSITIVE 1 （COI1） but was not correlated with erihanced JA-Ile accumulation. Instead, jao2 mutant lines displayed altered accumulation of several JA species in healthy and challenged plants, suggesting elevated metabolic flux through JA-Ile. Collectively, these data identify the missing enzymes hydroxylating JA and uncover an important metabolic diversion mechanism for repressing basal JA defense responses.

关键词： 2-oxoglutarate oxygenase jasmonic acid defense regulation hormone metabolism Botrytis

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Extending the functions of the homeotic transcription factor Cdx2 in the digestive system through nontranscriptional activities

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World Journal of Gastroenterology 2015年第5期21卷 1436-1443页

作者： Jean-Noel Freund Isabelle Duluc Jean-Marie Reimund Isabelle Gross Claire Domon-dell INSERM UMR_S1113 Université de StrasbourgFMTS67200 StrasbourgFrance Centre Hospitalier universitaire de strasbourg 67200 StrasbourgFrance

The homeoprotein encoded by the intestinal-specific Cdx2 gene is a major regulator of gut development and homeostasis,also involved in colon cancer as well as in intestinal-type metaplasias when it is abnormally expressed outside the gut.At the molecular level,structure/function studies have demonstrated that the Cdx2 protein is a transcription factor containing a conserved homeotic DNA-binding domain made ofthree alpha helixes arranged in a helix-turn-helix motif,preceded by a transcriptional domain and followed by a regulatory domain.The protein interacts with several thousand sites on the chromatin and widely regulates intestinal functions in stem/progenitor cells as well as in mature differentiated cells.Yet,this transcription factor also acts trough original nontranscriptional mechanisms.Indeed,the identification of novel protein partners of Cdx2 and also of a splicing variant revealed unexpected functions in the control of signaling pathways like the Wnt and NF-k B pathways,in double-strand break DNA repair and in premessenger RNA splicing.These novel functions of Cdx2 must be considered to fully understand the complexity of the role of Cdx2 in the healthy intestine and in diseases.

关键词： Homeobox Transcription Signaling DNA repair RNA splicing Intestine development Cancer Homeostasis

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Biobased polyurethanes for biomedical applications

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Bioactive Materials 2021年第4期6卷 1083-1106页

作者： Sophie Wendels Luc Av´erous BioTeam/ICPEES-ECPM UMR CNRS 7515Universit´e de Strasbourg25 Rue Becquerel67087Strasbourg Cedex 2France

Polyurethanes(PUs)are a major family of polymers displaying a wide spectrum of physico-chemical,mechanical and structural properties for a large range of fields.They have shown suitable for biomedical applications and are used in this domain since decades.The current variety of biomass available has extended the diversity of starting materials for the elaboration of new biobased macromolecular architectures,allowing the development of biobased PUs with advanced properties such as controlled biotic and abiotic degradation.In this frame,new tunable biomedical devices have been successfully designed.PU structures with precise tissue biomimicking can be obtained and are adequate for adhesion,proliferation and differentiation of many cell’s types.Moreover,new smart shape-memory PUs with adjustable shape-recovery properties have demonstrated promising results for biomedical applications such as wound healing.The fossil-based starting materials substitution for biomedical implants is slowly improving,nonetheless better renewable contents need to be achieved for most PUs to obtain biobased certifications.After a presentation of some PU generalities and an understanding of a biomaterial structure-biocompatibility relationship,recent developments of biobased PUs for non-implantable devices as well as short-and long-term implants are described in detail in this review and compared to more conventional PU structures.

关键词： Polyurethanes Biobased Biomedical Bioactive Tissue engineering Biocompatibility Scaffold

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High-resolution and instantaneous imaging of latent fingerprints

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Chinese Chemical Letters 2023年第4期34卷 1-2页

作者： Ming Cheng Juli Jiang Jean-Claude Chambron Leyong Wang Key Laboratory of Mesoscopic Chemistry of MOE Jiangsu Key Laboratory of Advanced Organic MaterialsSchool of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210023China Institut de Chimie de strasbourg UMR 7177CNRSUniversitéde StrasbourgStrasbourg Cedex 67008France

Fingerprints can serve as an information storage platform for individuals and play an important role in forensic investigation and security[1].Most of them are invisible to the naked eye and are called latent fingerprints(LFPs).Conventional imaging techniques suffer from limitations like low resolution and sensitivity[2],restricting the recognition of LFPs to macroscopic features,such as shape,core,ending,bifurcation,island,pores,and so on,which correspond to levels 1 and 2.Features of level 3 including ridges and their edges,are challenging to recognize.

关键词： latent resolution restrict

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Upper gastrointestinal bleeding due to left side portal hypertension after pancreatic surgery

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Hepatobiliary & Pancreatic Diseases International 2023年第1期22卷 81-84页

作者： Pierre Mayer Emanuele Felli Iulian Enescu François Habersetzer Simona Tripon department of Hepatology and Gastroenterology Pôle Hépato-digestifNouvel Hôpital CivilHôpitaux Universitaires de Strasbourg(HUS)StrasbourgFrance Institut Hospitalo-universitaire(IHU)de strasbourg Pôle Hépato-digestifStrasbourgFrance department of Hepato-biliary and Pancreatic surgery Pôle Hépato-digestifNouvel Hôpital CivilHUSStrasbourgFrance Institut des Maladies Virales et Hépatiques Inserm U1110Universitéde StrasbourgFacultéde MédecineStrasbourgFrance department of Interventional Radiology Pôle d’imagerieNouvel Hôpital CivilHUSStrasbourgFrance

Left-side portal hypertension(LSPH)is a rare cause of intraabdominal venous hypertension.In most of cases,LSPH is due to pancreatic diseases,especially chronic pancreatitis,but it is also described in other abdominal diseases(i.e.,retroperitoneal fibrosis or perineal abscess)after abdominal surgery(i.e.,pancreatic surgery,liver transplantation)or endovascular procedures[1–4].

关键词： hypertension surgery diseases

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关于具间接阻尼的强耦合波动方程组的边界耗散传输的敏感性

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中国科学：数学 2017年第10期47卷 1277-1302页

作者：饶伯鹏 Institut de Recherche Mathématique Avancée Université de Strasbourg

本文考察由两个强耦合的波动方程组成的间接边界阻尼反馈系统的稳定性,阐明此类系统的稳定性依赖于耦合的类型、无阻尼系统是否有隐含正则性、以及边界耗散的阶数和无阻尼边界条件间的匹配等诸多因素.首先证明,当无阻尼边界为Dirichlet... 详细信息

本文考察由两个强耦合的波动方程组成的间接边界阻尼反馈系统的稳定性,阐明此类系统的稳定性依赖于耦合的类型、无阻尼系统是否有隐含正则性、以及边界耗散的阶数和无阻尼边界条件间的匹配等诸多因素.首先证明,当无阻尼边界为Dirichlet边界条件时,系统是一致指数稳定的;而当其为Neumann边界条件时,只能建立系统的多项式稳定性.其次,通过谱分析的方法,揭示间接边界阻尼反馈系统的能量在方程间的传递与无阻尼边界条件之间的内在联系.

关键词：波动方程间接阻尼耗散的传递指数稳定性多项式稳定性

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Ring-opening Copolymerization of ε-Caprolactone and δ-Valerolactone Catalyzed by a 2,6-Bis(amino)phenol Zinc Complex

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Chinese Journal of Polymer Science 2020年第3期38卷 240-247,I0006页

作者： Qian Hu Su-Yun Jie Pierre Braunstein Bo-Geng Li State Key Laboratory of Chemical Engineering College of Chemical and Biological EngineeringZhejiang UniversityHangzhou 310027China Universitéde Strasbourg CNRSCHIMIE UMR 7177Laboratoire de Chimie de Coordination67081 Strasbourg CedexFrance

In combination with methyllithium,a 2,6-bis(amino)phenol zinc complex 1 was used in the ring-opening polymerization ofδ-valerolactone in the absence or presence of benzyl alcohol and showed high efficiency,mainly producing cyclic and linear polyvalerolactones,respectively.On the basis of homopolymerization,the ring-opening copolymerization ofε-caprolactone andδ-valerolactone was investigated.The P(CL-co-VL)random copolymers,PCL-b-PVL and PVL-b-PCL diblock copolymers,were prepared by varying the feeding strategy(premixing or sequential feeding).The copolymer composition was adjusted by varying the feeding ratio of two monomers.The structure and thermal properties of obtained polymers were characterized by GPC,1 H-NMR,13 C-NMR,MALDI-TOF mass spectroscopy,and DSC,respectively.

关键词： Zn complex Copolymerization Block copolymer Random copolymer

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Geochemical tracing and modeling of surface and deep water–rock interactions in elementary granitic watersheds(Strengbach and Ringelbach CZOs, France)

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Acta Geochimica 2017年第3期36卷 363-366页

作者： F.Chabaux D.Viville Y.Lucas J.Ackerer C.Ranchoux C.Bosia M.C.Pierret T.Labasque L.Aquilina R.Wyns C.Lerouge C.dezaye P.Négreol Laboratoire D'Hydrologie et de Géochimie de strasbourg (LHyGeS) CNRS Université de Strasbourg 1 Rue Blessig 67084 Strasbourg Cedex France CNRS Géosciences Rennes UMR 6118 Université de Rennesl Campus de Beaulieu 35042 Rennes Cedex France BRGM 3 Avenue Claude Guillemin 45060 Orléans France

From the study of the Strengbach and Ringelbach watersheds we propose to illustrate the interest of combining the geochemical tracing and geochemical modeling approaches on surface and deep borehole waters,to decipher the diversity of the water flow and the associated water–rock interactions in such elementary mountainous catchments. The results point to a clear geochemical typology of waters depending on the water circulations(deep vs. hypodermic) within the substratum.

关键词：地球化学示踪山区小流域相互作用模型深层水花岗岩表层法国水岩相互作用

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HIV reservoir: antiviral immune responses and immune interventions for curing HIV infection

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Chinese Medical Journal 2022年第22期135卷 2667-2676页

作者： Shuang Li Christiane Moog Tong Zhang Bin Su Beijing Key Laboratory for HIV/AIDS Research Sino-French Joint Laboratory for Research on Humoral Immune Response to HIV InfectionClinical and Research Center for Infectious DiseasesBeijing Youan HospitalCapital Medical UniversityBeijing 100069China Laboratoire d’ImmunoRhumatologie Moléculaire Institut national de la santéet de la recherche médicale(INSERM)UMR_S 1109Institut thématique interdisciplinaire(ITI)de Médecine de Précision de StrasbourgTransplantex NGFacultéde MédecineFédération Hospitalo-Universitaire OMICAREFédération de Médecine Translationnelle de Strasbourg(FMTS)Universitéde StrasbourgStrasbourg 67000France

Antiretroviral therapy against human immunodeficiency virus (HIV) is effective in controlling viral replication but cannot completely eliminate HIV due to the persistence of the HIV reservoir. Innate and adaptive immune responses have been proposed to contribute to preventing HIV acquisition, controlling HIV replication and eliminating HIV-infected cells. However, the immune responses naturally induced in HIV-infected individuals rarely eradicate HIV infection, which may be caused by immune escape, an inadequate magnitude and breadth of immune responses, and immune exhaustion. Optimizing these immune responses may solve the problems of epitope escape and insufficient sustained memory responses. Moreover, immune interventions aimed at improving host immune response can reduce HIV reservoirs, which have become one focus in the development of innovative strategies to eliminate HIV reservoirs. In this review, we focus on the immune response against HIV and how antiviral immune responses affect HIV reservoirs. We also discuss the development of innovative strategies aiming to eliminate HIV reservoirs and promoting functional cure of HIV infection.

关键词： Antiviral immune response Functional HIV cure HIV reservoir Human immunodeficiency virus Immune interventions

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3D printing of optical materials by processes based on photopolymerization:materials,technologies,and recent advances

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Photonics Research 2022年第6期10卷 1344-1360页

作者： EMMA GEISLER MAXIME LECOMPèRE OLIVIER SOPPERA universitéde Haute-Alsace CNRSIS2M UMR 7361F-68100 MulhouseFrance Universitéde Strasbourg F-67000 StrasbourgFrance Essilor International 94000 CréteilFrance

3D printing technologies have expanded beyond the research laboratories where they were used solely for prototyping and have become widely used in several industries.The production of custom 3D objects has significant potential in optical applications.However,this necessitates extremely specific material properties,such as transparency,homogeneity,birefringence,and surface finish.Currently,the majority of optical objects are manufactured using plastics.Moreover,the 3D printing processes using polymers to produce optical objects have significant advantages,such as limited wastage,short manufacturing time,and easy customization.However,despite extensive efforts,no technology has achieved the production of objects perfectly suited for optical applications.The objective of this review is to summarize recent advances in the field of 3D printing for optics,with an emphasis on specific developments for dedicated applications,and to explore new candidate processes.

关键词： printing expanded transparency

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