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Subclinical proximal tubulopathy in hepatitis B:The roles of nucleot(s)ide analogue treatment and the hepatitis B virus

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World Journal of Hepatology 2020年第12期12卷 1326-1340页

作者： Anais Brayette Marie Essig Paul Carrier Marilyne debette-Gratien Anais Labrunie Sophie Alain Marianne Maynard Nathalie Ganne-Carrie Eric Nguyen-Khac Pauline Pinet Victor de Ledinghen Christophe Renou Philippe Mathurin Claire Vanlemmens Vincent Di Martino Anne Gervais Juliette Foucher Fouchard-Hubert Isabelle Julien Vergniol Isabelle Hourmand-Ollivier Daniel Cohen Xavier Duval Thierry Poynard Marc Bardou Armand Abergel Manh-Thong Dao Thierry Thevenot Jean-Baptiste Hiriart Valerie Canva Guillaume Lassailly Christine Aurières Nathalie Boyer Dominique Thabut Pierre-Henri Bernard Matthieu Schnee Dominique Larrey Bertrand Hanslik Severine Hommel Jeremie Jacques Veronique Loustaud-Ratti U1248 INSERM Department of Hepatology and GastroenterologyUniv.LimogesCHU LimogesLimoges F-87000France U1248 INSERM Department of Nephrology and TransplantationCHU LimogesLimoges F-87000France department of Center of Epidemiology Biostatistics and Research MethodologyCHU LimogesLimoges F-87000France U1092 INSERM Department of VirologyCHU LimogesLimoges F-87000France department of Hepatology Croix-Rousse University Hospital of LyonLyon 69004France department of Hepatology Jean Verdier University Hospital of BondyBondy 93140France department of Hepato-Gastroenterology Amiens University HospitalAmiens 80054France department of Infectious Diseases CHU LimogesLimoges F-87000France department of Hepatology Haut Leveque HospitalBordeaux University HospitalPessac 33604France department of Gastroenterology Hyeres HospitalHyeres 83407France department of Hepato-Gastroenterology Claude Huriez University HospitalLille 59037France department of Hepatology Jean Minjoz University HospitalBesançon 25030France department of Infectious Diseases Bichat University HospitalParis 75018France department of Hepatology University Hospital of AngersAngers 49933France department of Hepato-Gastroenterology and Nutrition University Hospital of CaenCaen 14033France department of General Medecine University Hospital of CaenCaen 14000France department of Hepatology La Pitié-Salpêtrière University HospitalParis 75651France department of Hepatology and Gastroenterology Dijon University HospitalDijon 21079France department of Hepatology and Gastroenterology Estaing University HospitalClermont Ferrand 63003France department of Hepatology Beaujon University HospitalClichy 92110France department of Hepatology Saint-AndréUniversity HospitalBordeaux 33000France department of Hepatology and Gastroenterology La Roche-Sur-Yon Hospital CenterLa Roche-Sur-Yon 85000France department of Hepatology and Gastroenterology University Hospital of MontpellierMontpellier 34295France department of Addictology Hospita

BACKGROUND The recommended monitoring tools for evaluating nucleot(s)ide analogue renal toxicity,such as estimated glomerular filtration rate(eGFR)and phosphatemia,are late markers of proximal *** early markers are available,but no consensus exists on their *** To determine the 24 mo prevalence of subclinical proximal tubulopathy(SPT),as defined with early biomarkers,in treated vs untreated hepatitis B virus(HBV)-monoinfected *** A prospective,non-randomized,multicenter study of HBV-monoinfected patients with a low number of renal comorbidities was *** patients were separated into three groups:Naïve,starting entecavir(ETV)treatment,or starting tenofovir disoproxil(TDF)*** on the early markers of SPT,the eGFR and phosphatemia,were collected *** was defined as a maximal tubular reabsorption of phosphate/eGFR below 0.8 mmoL/L and/or uric acid fractional excretion above 10%.The prevalence and cumulative incidence of SPT at month 24(M24)were *** data were analyzed using analyses of variance or Kruskal-Wallis tests,whereas chi-squared or Fisher’s exact tests were used to analyze qualitative *** analyses were used to adjust for any potential confounding *** Of the 196 patients analyzed,138(84 naïve,28 starting ETV,and 26 starting TDF)had no SPT at *** M24,the prevalence of SPT was not statistically different between naïve and either treated group(21.1%vs 30.7%,Pdentified after *** cumulative incidence of SPT over 24 mo(25.5%,13.3%,and 52.9%in the naïve,ETV,and TDF groups,respectively)tended to be higher in the TDF group vs the naïve group(hazard ratio:2.283,P=0.05).SPT-free survival at M24 was 57.6%,68.8%,and 23.5%for the naïve,ETV,and TD

关键词： Hepatitis B virus Proximal tubulopathy Biomarkers Renal insufficiency Nucleoside analogues

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迎接国土空间规划的新挑战——中法专题研讨会

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China City Planning Review 2020年第2期29卷 6-23页

作者：施卫良 Eric Huybrechts 尹稚 Simon Teyssou Zheng Xiaojin Laurent Coudroy de lille Wu Tinghai Olivier Chadoin Li Min Qian Fang Beijing Municipal Commission of Planning and Natural Resources International Affairs Institute Paris Region Institute for China Sustainable Urbanization Tsinghua University Institute for Urban Governance and Sustainable development Tsinghua University School of Architecture Tsinghua University the National Graduate School of Architecture Clermont-Ferrand Beijing Tsinghua Tongheng Urban Planning and design Institutev the Academic Committee of Master Planning Urban Planning Society of China Ecole d’urbanisme de ParisLab’urba(UPEC) department of Urban Planning and design School of ArchitectureTsinghua University ENSAP Bordeaux PAVE–Centre Emile Durkheim(CNRS 5116) 不详

Introduction Both China and France have a long history of urban and rural planning and governance, and lately the topics, such as urban and rural living quality, natural resources management, and natural and cultural heritage, have become the focuses of public policy that emphasizes improving people’s living conditions and promoting regional harmonious development. Moreover, the above topics have been regarded as the most important points in the bilateral cooperation agreements between China and France concerning sustainable urban development. On Oct. 13, 2019, the SinoFrench Seminar on "Meeting the New Challenges of Territorial and City Planning" was jointly held by the department of Urban Planning, School of Architecture, Tsinghua university and the Cultural and Educational Cooperation Section, French Embassy–French Cultural Center in Beijing at the School of Architecture, Tsinghua university. About 20 experts from the political, academic, and professional fields of urban planning in China and France were invited to carry out discussion on four primary themes, which are "New Urban Planning Strategy,""New Territorial and City Planning Policy,""New Exploration in Urban Planning," and "New Talents Cultivation Pattern." As a medium support to the seminar, we collected some of the speeches and share them with readers in this issue.

关键词： jointly Seminar urban

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Impact of previous cyst-enterostomy on patients' outcome following resection of bile duct cysts

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World Journal of Gastrointestinal Surgery 2016年第6期8卷 427-435页

作者： Mehdi Ouaissi Reza Kianmanesh Emilia Ragot Jacques Belghiti Pietro Majno Gennaro Nuzzo Remi Dubois Yann Revillon Daniel Cherqui Daniel Azoulay Christian Letoublon Frane is-Rene Pruvot Francois Paye Patrick Rat Karim Boudjema Adeline Roux Jean-Yves Mabrut Jean-Francois Gigot department of General and Digestive Surgery La Timone Hospital 13009 Marseille France department of Digestive and Endocrine Surgery Robert Debré Hospital 51090 Reims France department of HPB Surgery Beaujon Hospital 92110 Clichy France department of Digestive Surgery Geneva University Hospital 1205 Geneva Switzerland department of HPB Surgery Gemelli University Hospital 00168 Roma Italy department of Pediatric Surgery Mother and Children Hospital 69677 Bron France department of Pediatric Digestive Surgery Necker Hospital 75175 Paris France department of Digestive and HPB Surgery Paul Brousse Hospital 94800 Villejuif France department of Digestive and HPB Surgery Henri Mondor Hospital 94000 Creteil France department of Digestive and HPB Surgery Henri Mondor Hospital 94000 Creteil France department of Digestive surgery and Transplantation Claude Huriez Hospital 59037 Lille France department of Digestive Surgery Saint Antoine Hospital 75012 Paris France department of Digestive Surgery Dijon University Hospital 21000 Dijon France department of HPB Surgery Pontchaillou Hospital 35033 Rennes France Pole Information Medicale Evaluation Recherche Unité de Recherche Clinique 69317 Lyon France department of Digestive Surgery and Hepatic Transplantation La Croix-Rousse Hospital 69317 Lyon France department of Abdominal Surgery and Transplantation Division of Hepato-Biliary and Pancreatic Surgery Cliniques universitaires Saint-Luc 1200 Brussels Belgium

AIM:To analyze the impact of previous cyst-enterostomy of patients underwent congenital bile duct cysts(BDC) ***:A multicenter European retrospective study between 1974 and 2011 were conducted by the French Surgical *** Todani subtypes I and IVb were *** imaging studies and operative and pathology reports underwent central *** with and without a previous history of cystenterostomy(CE) were ***:Among 243 patients with Todani types I and IVb BDC,16 had undergone previous CE(6.5%).Patients with a prior history of CE experienced a greater incidence of preoperative cholangitis(75% vs 22.9%,P < 0.0001),had more complicated presentations(75% vs 40.5%,P = 0.007),and were more likely to have synchronous biliary cancer(31.3% vs 6.2%,P = 0.004) than patients without a prior *** morbidity(75% vs 33.5%;P < 0.0008),severe complications(43.8% vs 11.9%;P = 0.0026) and reoperation rates(37.5% vs 8.8%;P = 0.0032) were also significantly greater in patients with previous CE,and their Mayo Risk Score,during a median follow-up of 37.5 mo(range:4-372 mo) indicated significantly more patients with fair and poor results(46.1% vs 15.6%;P = 0.0136).CONCLUSION:This is the large series to show that previous CE is associated with poorer short-and longterm results after Todani types I and IVb BDC resection.

关键词： Bile duct cyst Congenital Biliary disease Cyst-enterostomy Long-term outcome

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