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格林-巴利综合征伴幻觉与onirism:被低估的伴随症状(法国)

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世界核心医学期刊文摘（神经病学分册） 2005年第5期1卷 55-55页

作者： Le Rhun E. de Sèze J. Stojkovic T. 王晓琳 Clinique Neurologique Hpital Roger Salengro CHRU de Lille 59037 Lille Cedex France

Introduction. Guillain-Barré Syndrome (GBS) is generally related to perip heral nervous system involvement, but certain variants with central nervous syst em manifestations have been described. Case report. In the present study we repo rt 2 patients with GBS associated with hallucinations and onirism. Two men (age 64 and 49 years) presented GBS without proven infectious origin who required int ensive care because of respiratory problems. The disease progressed and manifest ations of encephalitis (hallucinations and onirism) appeared. The sensorimotor s igns and encephalitis manifestations evolved in parallel with full recovery in t he first patient and death after 11 months of intensive care in the second. Conc lusion. GBS may be associated with stereotypic central nervous system symptoms, mimicking delirium tremens. The manifestations would be related to the severity of the initial period, but not to long-term prognosis.

关键词： onirism 精神错乱中枢系统重症监护感觉运动完全康复中枢神经系统进展过程周围神经系统感染源

盆腔脱垂修补术后经阴道途径的修补增强(法)

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世界核心医学期刊文摘（妇产科学分册） 2006年第5期2卷 60-60页

作者： Belot F Collinet P debodinance P 党慧敏 Service de Gyné cologie Obsté trique Clinique de Chirurgie Gyné cologique CHRU de Lille 2 avenue Oscar-Lambret 59037 Lille Cedex

Introduction. Prosthetic reinforcement by the vaginal approach for surgical repair of pelvic prolapse is experiencing increasing popularity despite problems with tolerance. The most frequently described complication is prosthesis exposure, also known as erosion or granuloma. The mechanism is associated with defective vaginal healing and is independent of major infection such as pelvic cellulitis. The purpose of our study was to define the course of this complication and the best therapeutic strategy for patients with prosthesis exposure. Materials and method. Our continuous and retrospective study conducted over a period of 24 months between January 2002 and december 2003 recorded 34 files. These patients underwent prosthetic treatment via the vaginal approach of genital prolapse associated with prosthesis exposure. The procedure, known as TVM (Tension free Vaginal Mesh), involves the insertion without fixing of a synthetic prosthesis in areas of bladder-vagina and rectum-vagina detachment. Results. In 33 cases out of 34, the exposure site was located on the anterior colpotomy scar (97% ). These prosthesis exposures were managed in two stages, using antiseptic treatment first. This treatment cured 9 patients (26.47% ). In the event of failure, a procedure was carried out under brief general anesthesia on an outpatient basis or during a 24- hour hospital stay. This single resection was sufficient for 20 patients (88% ). Two patients nevertheless required a second removal procedure (8% ) and one patient a third procedure (4% ). To notice, one patient presented with a bladder-vagina fistula after resection. This observation of a bladder-vagina fistula following partial removal led us to recommend a blue test and/or cystoscopy as routine practice for each procedure. Conclusion. With this new vaginal approach for prolapse repair, it is important to monitor prosthesis exposure. To manage exposures, it is necessary to begin with antiseptic or estrogenic treatment. In the e

关键词：生殖器脱垂雌激素治疗蜂窝织炎切除术病历记录发病机制防腐处理

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多发性硬化急性复发引起双侧第3脑神经麻痹

世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 8-8页

作者： Marcel-Viallet M. de Seze J. defoort-Dhellemmes S. 邢咏新 Clini que Neurologique Hopital Roger-Salengro CHRU de Lille 59037 Lille Cedex France

Introduction. We report a case of bilateral third cranial nerve palsy in a pat ient with a secondary progressive multiple sclerosis. Observation. MRI revealed a large hyperintense lesion in T2-weighted images in the mesencephalic area. Th e clinical and radiological outcome was good after intravenous methylprednisolon e. The oculomotor signs were probably caused by this mesencephalic lesion. Concl usion. This case of bilateral third cranial nerve palsy is, to our knowledge, th e first one occurring in a patient with multiple sclerosis.

关键词：多发性硬化脑神经麻痹脑病变眼球运动加权像放射检查

视网膜电图及解剖学异常提示Lewy体痴呆患者的视网膜病变

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世界核心医学期刊文摘(神经病学分册) 2006年第2期 48-49页

作者： devos D. Tir M. Maurage C.A. 樊慧婷 Clinique Neurologique Hpital R. Salengro CHU F-59037 Lille Cedex France.Dr

The authors used flash electroretinography to demonstrate dysfunction of the photopic and scotopic retina in patients with dementia with Lewy bodies and visual hallucinations (VHs)-compared with patients with Parkinson disease, patients without VHs, and controls. The retinal dysfunction may be related to slight alteration of the photoreceptors and numerous pale inclusions in the outer plexiform layer found at the post mortem examination, suggesting a specific retinopathy.

关键词：视网膜电图眼科检查痴呆患者 Lewy 病变

动脉导管未闭严重程度的检测:不同检查指标的比较研究

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 8-8页

作者： El Hajjar M. Vaksmann G. Rakza T. L. Storme 张振 Service de Médecine Néonatale Hpital Jea-nne de Flandre CHRU de Lille Lille Cédex 59037 France Dr.

Background: When the ductus arteriosus (DA) is patent, the ductal shunt is proportional to the ratio of left ventricular output (LVO) to systemic blood flow. Systemic blood flow can be estimated by measuring flow in the superior vena cava (SVC). Objective: To re-evaluate the accuracy of standard echocardiographic markers of patent ductus arteriosus (PDA) using LVO/SVC flow ratio. Methods: Prospective study. Preterm infants of 24-30 weeks gestational age and postnatal age less than 48 hours. The following echocardiographic criteria were measured: left atrial to aortic root ratio (LA/Ao); DA diameter by B mode and colour Doppler; mean and end diastolic flow velocity of the left pulmonary artery (LPA); LVO; SVC flow. Results: Twenty three preterm infants were enrolled (median gestational age 28 weeks (range 24-30), median birth weight 840 g (500-1440)). The DA was closed in eight (mean (SD)-LVO/SVC 2.4 (0.3)) and open in 15 (mean (SD) LVO/SVC 4.5 (0.6)). An LA/Ao ratio ≥ 1.4, a DA diameter ≥ 1.4 mm/kg, and a mean and end diastolic flow velocity of LPA respectively ≥ 0.42 and ≥ 0.20 m/s identified an LVO/SVC ≥ 4 with a sensitivity and a specificity above 90% . Conclusion: This study indicates that LA/Ao ratio, DA diameter, and mean and end diastolic flow velocity of the LPA are accurate markers of PDA. These standard echocardiographic variables are easy to measure and need less skill and resources than direct measurements of ductal shunt.

关键词：动脉导管未闭合检测指标检查指标严重程度超声心动图早产新生儿血流速率前瞻性研究主动脉根部彩色多普勒

Association of gene variants with susceptibility to type 2 diabetes among Omanis

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World Journal of Diabetes 2015年第2期6卷 358-366页

作者： Sawsan Al-Sinani Nicolas Woodhouse Ali Al-Mamari Omaima Al-Shafie Mohammed Al-Shafaee Said Al-Yahyaee Mohammed Hassan deepali Jaju Khamis Al-Hashmi Mohammed Al-Abri Khalid Al-Rassadi Syed Rizvi Yengo Loic Philippe Froguel Riad Bayoumi department of Biochemistry College of Medicine and Health SciencesSultan Qaboos University Genomics and Metabolic Disease Institute Pasteur of lille Lille2 University

AIM:To investigate the association of 10 known common gene variants with susceptibility to type 2diabetes mellitus(T2D)among ***:Using case-control design,a total of992 diabetic patients and 294 normoglycemic Omani Arabs were genotyped,by an allelic discrimination assay-by-design TaqMan method on fast real time polymerase chain reaction system,for the following gene variants:KCNJ11(rs5219),TCF7L2(rs7903146),CDKAL1(rs10946398),CDKN2A/B(rs10811661),FTO(rs9939609 and rs8050136),IGF2BP2(rs4402960),SLC30A8(rs13266634)CAPN10(rs3792267)and HHEX(rs1111875).T2D patients were recruited from the Diabetes Clinic(n=243)and inpatients(n=749)at Sultan Qaboos Univesity Hospital(SQUH),Muscat,*** control participants(n=294)were volunteers from the community and from those visiting Family Medicine Clinic at SQU,for regular medical *** difficulty in recruiting Omani participants with no family history of diabetes was the main reason behind the small number of control participants in this *** all volunteers questioned had a relativewith diabetes *** of the small number of normoglycemic controls in this study,this sample was sufficient for detection of genes and loci for common alleles influencing T2D with an odds ratio of≥1.3reaching at least 80%*** was collected from June 2010 to February ***:Using binary logistic regression analysis,four gene variants showed significant association with T2D risk:KCNJ11(rs5219,P=5.8×10^(-6),OR=1.74),TCF7L2(rs7903146,P=0.001,OR=1.46),CDKAL1(rs10946398,P=0.002,OR=1.44)and CDKN2A/B(rs10811661,P=0.020,OR=1.40).The fixation index analysis of these four gene variants indicated significant genetic differentiation between diabetics and controls{[KCNJ11(rs5219),Pdetect an as

关键词： Type 2 diabetes Genetics Oman Casecontrol Association Gene Variants

Neural Network Based on SET Inverter Structures: Neuro-Inspired Memory

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World Journal of Nano Science and Engineering 2014年第4期4卷 134-142页

作者： Bilel Hafsi Rabii Elmissaoui Adel Kalboussi IEMN Laboratory University of Lille1 Avenue Poincaré 59652 Villeneuve d’Ascq Cedex France Microelectronics and Instrumentation Laboratory Faculty of Sciences of Monastir University of Monastir Monastir Tunisia Research Unit on Study of Industrial Systems and Renewable Energies National Engineering School of Monastir Monastir Tunisia

This paper presents a basic block for building large-scale single-electron neural networks. This macro block is completely composed of SET inverter circuits. We present and discuss the basic parts of this device. The full design and simulation results were done using MATLAB and SIMON, which are a single-electron tunnel device and circuit simulator based on a Monte Carlo method. Special measures had to be taken in order to simulate this circuit correctly in SIMON and compare results with those of SPICE simulation done before. Moreover, we study part of the network as a memory cell with the idea of combining the extremely low-power properties of the SET and the compact design.

关键词： Single-Electron Neuron Synapse Inverter Neural Network Single-Electron Memory Perceptron MATLAB SIMON

ALS患者CSF中缺氧时VEGF表达的矛盾反应

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世界核心医学期刊文摘（神经病学分册） 2006年第6期2卷 35-36页

作者： Moreau C. devos D. Brunaud-Danel V. 陈孝东 Clinique Nuerologique H.opital R. Salengro CHU F-59037 Lille Cedex France Dr.

Vascular endothelial growth factor (VEGF) is implicated in motor neurone degeneration. In normal individuals, hypoxia is known to induce an overexpression of VEGF, as measured in CSF. We show that patients with ALS do not manifest this VEGF overexpression in the presence of hypoxia. Although VEGF gene expression is mainly stimulated by hypoxia, we have measured lower VEGF levels in cerebrospinal fluid (CSF)from hypoxaemic patients with amyotrophic lateral sclerosis (ALS) than in CSF from normoxaemic patients with ALS. In contrast, hypoxaemic neurological controls displayed higher levels than normoxaemic neurological controls. There was a negative correlation between VEGF levels and the severity of hypoxaemia in patients with ALS, suggesting deregulation of VEGF in ALS.

关键词：肌萎缩侧索硬化(ALS) VEGF表达缺氧患者血管内皮生长因子(VEGF) 矛盾反应 VEGF基因表达运动神经元变性正常受试者

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玉米地组分亮度温度分类变化研究

遥感学报 2005年第1期9卷 16-23页

作者：余涛顾行发田国良 Michel Legrand Jean Franc ois Hanocq Roland Bosseno 蔡红艳中国科学院遥感应用研究所北京100101 法国农科院法国lille大学北京师范大学数学系北京100875

以玉米整个生长期野外热红外辐射观测数据为基础,对两种组分亮温分类方法作了比较,并对玉米地组分亮温的变化特征展开了分析。结果表明,农田亮温组分的数目和数值随测量时间和日期改变。在整个测量期间,在当地时间中午前后,农田呈现出3... 详细信息

以玉米整个生长期野外热红外辐射观测数据为基础,对两种组分亮温分类方法作了比较,并对玉米地组分亮温的变化特征展开了分析。结果表明,农田亮温组分的数目和数值随测量时间和日期改变。在整个测量期间,在当地时间中午前后,农田呈现出3个亮温组分植被、被阳光照到的亮土和植被阴影下的暗土。观测早期,植被亮温分布相对集中;随着农田植被覆盖率的增高,植被亮温分布逐步分散,组分间温差缩小,部分亮温值相互重叠。产生这些现象的原因将在以后的研究中加以探讨。

关键词：玉米地组分亮温分类