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Untargeted metabolomics to evaluate antifungal mechanism:a study of Cophinforma mamane and Candida albicans interaction

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Natural Products and Bioprospecting 2023年第1期13卷 779-787页

作者： Asih Triastuti Marieke Vansteelandt Fatima Barakat Carlos Amasifuen Patricia Jargeat Mohamed Haddad UMR 152 Pharma Dev IRDUPSUniversitéde Toulouse31400 ToulouseFrance Department of Pharmacy Universitas Islam IndonesiaYogyakarta 55584Indonesia Dirección de Recursos Genéticos y Biotecnología Instituto Nacional de Innovación AgrariaAvenida La Molina 1981La MolinaLima 15024Peru Laboratoire Evolution et DiversitéBiologique UMR 5174 CNRSIRDUPSUniversitéde Toulouse31062 ToulouseFrance

Microbial interactions between filamentous fungi and yeast are still not fully *** evaluate a potential anti-fungal activity of a filamentous fungus while highlighting metabolomic changes,co-cultures between an endophytic strain of Cophinforma mamane(CM)and Candida albicans(CA)were *** liquid cultures were incubated under static conditions and metabolite alterations during the course were investigated by ultra-performance liquid chromatography-tandem mass spectrophotometry(UPLC-MS/MS).Results were analyzed using MS-DIAL,MS-FINDER,METLIN,Xcalibur,SciFinder,and MetaboAnalyst metabolomics *** metabolites associated with catabolic processes,including the metabolism of branched-chain amino acids,carnitine,and phospholipids were upregulated both in the mono and co-cultures,indicating fungal adaptability to environmental *** metab-olites,including C20 sphinganine 1-phosphate,myo-inositol,farnesol,gamma-undecalactone,folinic acid,palmitoleic acid,and MG(12:/0:0/0:0)were not produced by CA during co-culture with CM,demonstrating the antifungal mecha-nism of *** results highlight the crucial roles of metabolomics studies to provide essential information regarding the antifungal mechanism of *** against ***,especially when the lost/undetected metabolites are involved in fungal survival and pathogenicity.

关键词： Metabolomics Fungal co-culture Anti-fungal Virulence

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Proteomic analysis of adipose tissue during the last weeks of gestation in pure and crossbred Large White or Meishan fetuses gestated by sows of either breed

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Journal of Animal Science and Biotechnology 2018年第3期9卷 558-573页

作者： F.Gondret B.Guével M.C.Père H.Quesnel Y.Billon *** L.Canario I.Louveau L.Liaubet PEGASE Agrocampus OuestINRA Protim Inserm U1085 Irset Université Rennes 1 Campus de Beaulieu Gen ESI INRA Le Magneraud Gen Physe INRA INPT INPT-ENV Université de Toulouse

Background: The degree of adipose tissue development at birth may influence neonatal survival and subsequent health outcomes. Despite their lower birth weights, piglets from Meishan sows(a fat breed with excellent maternal ability) have a higher survival rate than piglets from Large White sows(a lean breed). To identify the main pathways involved in subcutaneous adipose tissue maturation during the last month of gestation, we compared the proteome and the expression levels of some genes at d 90 and d 110 of gestation in purebred and crossbred Large White or Meishan fetuses gestated by sows of either ***: A total of 52 proteins in fetal subcutaneous adipose tissue were identified as differential y expressed over the course of gestation. Many proteins involved in energy metabolism were more abundant, whereas some proteins participating in cytoskeleton organization were reduced in abundance on d 110 compared with d 90. Irrespective of age,24 proteins differed in abundance between fetal genotypes, and an interaction effect between fetal age and genotype was observed for 13 proteins. The abundance levels of proteins known to be responsive to nutrient levels such as aldolase and fatty acid binding proteins, as wel as the expression levels of FASN, a key lipogenic enzyme, and MLXIPL, a pivotal transcriptional mediator of glucose-related stimulation of lipogenic genes, were elevated in the adipose tissue of pure and crossbred fetuses from Meishan sows. These data suggested that the adipose tissue of these fetuses had superior metabolic functionality, whatever their paternal genes. Conversely, proteins participating in redox homeostasis and apoptotic cel clearance had a lower abundance in Meishan than in Large White fetuses. Time-course differences in adipose tissue protein abundance were revealed between fetal genotypes for a few secreted proteins participating in responses to organic substances, such as alpha-2-HS-glycoprotein, transferrin and ***

关键词： Adipose tissue Fetus Genetics Maturity grade Proteome

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Experiment/simulation correlation-based methodology for metallic ballistic protection solutions

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Defence Technology（防务技术） 2023年第11期29卷 24-38页

作者： Yohan Cosquer Patrice Longère Olivier Pantalé Claude Gailhac DGA-Techniques Aéronautiques 31130BalmaFrance Institut Clement Ader Universite de ToulouseISAE-SUPAEROIMT Mines AlbiUPSINSACNRS3RueCarolineAigle31400ToulouseFrance Laboratoire Genie de Production INP/ENITUniversitéde Toulouse47Avenued’AzereixF-65016TarbesFrance CNIM Systemes Industriels 83500 La Seyne-sur-MerFrance

A methodology is developed based on the coupling of a finite element code with an optimisation module for the design of land vehicle armouring composed of lightweight aluminium alloy and high strength steel *** an experiment/simulation correlation,a numerical model has been built and calibrated considering monolithic plates and then verified considering a bi-metal protection against tungsten carbide projectile mimicking the core of a 7.62×51 AP8 *** addition,a method is proposed to obtain the v_(res)-v_(i) curve for the full 7.62×51 AP8 bullet from the v_(res)-v_(i) curve obtained from the core only.

关键词： Impact Terminal ballistics Ballistic limit MARS380 Aluminium alloy 7.62×51 AP8

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Private Label Positioning and Product Line

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Frontiers of Economics in China-Selected Publications from Chinese universities 2017年第3期12卷 480-513页

作者： Stephane Caprice toulouse School of Economics INRA University of Toulouse Capitole Toulouse France

This article examines （i） how retailers position private label products, （ii） why private labels are sold in some product categories but not in others, and why some national brand products may have difficulty in accessing retailers＇ shelves, （iii） why some private label products are positioned as ＂premium＂ brands, and （iv） how consumers＇ surplus and total welfare are affected by private labels. We find that private label positioning leads to less differentiation in product category, which structurally changes a retailer＇s product line in return. Consumer welfare and total welfare are lower

关键词： private label national brand product line

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High-sensitivity integrated SiN rib-waveguide long period grating refractometer

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Photonics Research 2022年第2期10卷 564-573页

作者： Clement Deleau Han Cheng Seat Olivier Bernal Frederic Surre LAAS-CNRS Université de ToulouseCNRSINPToulouseFrance James Watt School of Engineering University of GlasgowGlasgowUK

In this research, we demonstrate a high-sensitivity integrated silicon nitride long period grating(LPG) refractometer based on a rib waveguide with sinusoidally modulated width. While integrated LPG architectures typically achieve ultrahigh sensitivity only over a narrow optical bandwidth using a phase-matching turning-point optimization technique, our sensor exhibits a very high refractometric sensitivity that was designed to remain constant over a broad operational optical spectral bandwidth. The proposed design method relies on multi-modal dispersion tailoring that consists of homogenizing the spectral behaviors of both group and effective indices of the coupling modes. Experimental results are in agreement with numerical simulations, demonstrating not only a sensitivity reaching 11,500 nm/RIU but, more significantly, also that this sensitivity remains almost constant over a broad spectral range of at least 100 nm around 1550 nm. Additional advantages of the proposed sensor architecture encompass a low temperature sensitivity, down to -0.15 nm/K, and simplicity of the fabrication *** results demonstrate the feasibility of chip-scale photonic integration to achieve both high sensitivity and large dynamic range of the proposed refractometer.

关键词： waveguide simplicity turning

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Electrochemical ageing study of mixed lanthanum/praseodymium nickelates La2-xPrxNiO4+δ as oxygen electrodes for solid oxide fuel or electrolysis cells

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Journal of Energy Chemistry 2020年第7期29卷 62-70,I0003页

作者： Vaibhav Vibhu Aurélien Flura Aline Rougier Clément Nicollet Sébastien Fourcade Teresa Hungria Jean-Claude Grenier Jean-Marc Bassat CNRS Univ.BordeauxBordeaux INPICMCBUMR 5026F-33600 PessacFrance Centre de Microcaractérisation Raimond CASTAING Universitéde ToulouseCNRSUT3–Paul SabatierINPINSAEspace Clément Ader3 rue Caroline AigleToulouse 31400France

The chemical and electrochemical stability of lanthanide nickelates La2 NiO4+δ(LNO),Pr2 NiO4+δ(PNO)and their mixed compounds La(2-x)PrxNiO4+δ(LPNOs)with x=0.5,1 or 1.5 is *** aim is to promote these materials as efficient electrodes for solid oxide fuel cell(SOFC)and/or solid oxide electrolysis cell(SOEC).La2 NiO4+δand La1.5Pr0.5NiO4+δcompounds are chemically very stable as powders over one month in the temperature range 600-800℃,while the other materials rich in praseodymium progressively decompose into various perovskite-deriving components with additional Pr6 *** their uneven properties,all these materials are quite efficient and sustainable as electrodes on top of gadolinium doped ceria(GDCBL)//yttrium doped zirconia(8 YSZ)electrolyte,for one month at 700℃without *** polarization(300 mA·cm-2),the electrochemical performances of LNO,PNO and La1.5Pr0.5NiO4+δ(LP5 NO)quickly degrade in SOFC mode,*** the oxygen reduction reaction,while they show durability in SOEC mode,*** the oxide oxidation reaction.

关键词： Lanthanide nickelates SOFC cathode SOEC anode Stability Inductive loop Degradation

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The Drought of Amazonia in 2023-2024

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American Journal of Climate Change 2024年第3期13卷 567-597页

作者： Jose A. Marengo Ana P. Cunha Jhan-Carlo Espinoza Rong Fu Jochen Schöngart Juan C. Jimenez Mabel C. Costa Joao M. Ribeiro Sly Wongchuig Siyu Zhao National Center for Monitoring and Early Warning of Natural Disasters/CEMADEN So Jos dos Campos Brazil UNESP/CEMADEN So Jos dos Campos Brazil Graduate School of International Studies Korea University Seoul South Korea Institut des Gosciences de lEnvironnement (IGE) Institut de Recherche pour le Dvelopement (IRD) Saint Martin dHeres France Instituto de Investigacin sobre la Enseanza de las Matemticas (IREM PUCP) Pontificia Universidad Catlica del Per Lima Peru Department of Atmospheric and Oceanic Sciences University of California Los Angeles Los Angeles CA USA Departament of Environmental Dynamics Instituto Nacional de Pesquisas da Amaznia (INPA) Manaus Brazil Global Change Unit (GCU) of the Image Processing Laboratory (IPL) Universitat de Valncia Estudi General (UVEG) Paterna Spain Laboratoire dEtudes en Gophysique et Ocanographie Spatiales (LEGOS) Universit de Toulouse CNES/CNRS/IRD/UT3 Toulouse France

The Amazon basin has experienced an extreme drought that started in the austral summer of 2022-23 and extends into 2024. This drought started earlier than other previous droughts. Although some rain fell during the austral summer, totals remained below average. Higher temperatures during austral winter and spring 2023, which affected most of Central South America, then aggravated drought conditions. This coincided with an intense El Niño and abnormally warm tropical North Atlantic Ocean temperatures since mid-2023. Decreased rainfall across the Amazon basin, negative anomalies in evapotranspiration (derived from latent heat) and soil moisture indicators, as well as increased temperatures during the dry-to-wet transition season, September-October-November (SON) 2023, combined to delay the onset of the wet season in the hydrological year 2023-24 by nearly two months and caused it to be uncharacteristically weak. SON 2023 registered a precipitation deficit of the order of 50 to 100 mm/month, and temperatures +3˚C higher than usual in Amazonia, leading to reduced evapotranspiration and soil moisture indicators. These processes, in turn, determined an exceptionally late onset and a lengthening of the dry season, affecting the 2023-2024 hydrological year. These changes were aggravated by a heat wave from June to December 2023. Drought-heat compound events and their consequences are the most critical natural threats to society. River levels reached record lows, or dried up completely, affecting Amazonian ecosystems. Increased risk of wildfires is another concern exacerbated by these conditions.

关键词： El Niño SST in the Tropical Atlantic Amazon Drought River Levels Heatwave Dry Season Length

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Directional H^(2) Compression Algorithm: Optimisations and Application to a Discontinuous Galerkin BEM for the Helmholtz Equation

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Communications in Computational Physics 2022年第5期31卷 1585-1635页

作者： Nadir-Alexandre Messaï Sebastien Pernet Abdesselam Bouguerra ONERA/DTIS Universitéfédérale de Toulouse F-31000 Toulouse France Laboratoire de Physique de la Matière et du Rayonnement(LPMR) Département de Sciences de la MatièreUniversitéde Souk-AhrasBP 155341000 Souk-AhrasAlgeria

This study aimed to specialise a directional H^(2)(DH^(2))compression to matrices arising from the discontinuous Galerkin(DG)discretisation of the hypersingular equation in *** significantfinding is an algorithm that takes a DG stiffness matrix andfinds a near-optimal DH^(2) approximation for low and high-frequency *** introduced the necessary special optimisations to make this algorithm more efficient in the case of a DG stiffness ***,an automatic parameter tuning strategy makes it easy to use and *** comparisons with a classical Boundary Element Method(BEM)show that a DG scheme combined with a DH^(2) gives better computational efficiency than a classical BEM in the case of high-order finite elements and hp heterogeneous *** results indicate that DG is suitable for an auto-adaptive context in integral equations.

关键词： Integral equation boundary element method Helmholtz equation discontinuous Galerkin directional H^(2)-matrix low-rank approximation all frequency compression algorithm

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Conservative Discontinuous Galerkin/Hermite Spectral Method for the Vlasov-Poisson System

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Communications on Applied Mathematics and Computation 2022年第1期4卷 34-59页

作者： Francis Filbet Tao Xiong Institut de Mathématiques de toulouse UniversitéPaul SabatierToulouse 31062France School of Mathematical Sciences and Fujian Provincial Key Laboratory of Mathematical Modeling and High-Performance Scientific Computing Xiamen UniversityXiamen 361005Fujian ProvinceChina

We propose a class of conservative discontinuous Galerkin methods for the Vlasov-Pois-son system written as a hyperbolic system using Hermite polynomials in the velocity *** schemes are designed to be systematically as accurate as one wants with prov-able conservation of mass and possibly total *** properties in general are hard to achieve within other numerical method frameworks for simulating the Vlasov-Poisson *** proposed scheme employs the discontinuous Galerkin discretization for both the Vlasov and the Poisson equations,resulting in a consistent description of the distribu-tion function and the electric *** simulations are performed to verify the order of the accuracy and conservation properties.

关键词： Energy conserving Discontinuous Galerkin method Hermite spectral method Vlasov-Poisson

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Segmentations of foreland belts and their tectonic mechanism in the Southwest Tarim Basin

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Science China Earth Sciences 2005年第10期48卷 1585-1598页

作者： J. Canerot J. Deramond Lab. de Bassin Dynamique Sedimentaire Universite Paul Sabatier Toulouse III 39 Allee Jules-Guesde 31062 Toulouse FranceLab. de Bassin Dynamique Sedimentaire Universite Paul Sabatier Toulouse III 39 Allee Jules-Guesde 31062 Toulouse France

Based on lots of field investigations and comprehensive interpretations of seismic profiles with outcrop cross-sections, this paper shows that the foreland belts surrounding the Southwest Tarim Foreland Basin have the regularity of segmentation along the strike of foreland belts. There are many thin-skinned thrusting systems thrusting from mountains to the basin and the arcuate back-thrusting systems to the mountains distributed at intervals in the front of West Kunlun-Pamir and Southern Tianshan. Between thrusting and back-thrusting systems, the strike-slip faults developed. The northeast uplifts and depressions of Southwest Tarim Basin correspond with the segmentation of foreland basin. The thin-skinned thrusting system is formed in the case that the thickness of sedimentary covers is less than 10 km in depth where the basement is an uplift belt in general. The back-thrusting systems and triangle zones are formed in the case that the thickness of sedimentary covers is larger than 8 km in depth where the basement is a depression zone. The main mechanics of segmentation of foreland basin are the difference of mountain uplift and deformation rate along the longitude of the mountains, the huge sedimentary rocks in different depression centers, the uplift belts and depression zones in the basement rocks, and multi-displaced weak layers in the foreland basin. The segmentation of Southwest Tarim Foreland Basin is due to the intra-plate deformation of re-orogenies of West Kunlun-Pamir and Southwest Tianshan and the co-related deformation between mountains and basement of basin since Neocene.

关键词： Southwest Tarim Basin, foreland basin,West Kunlun-Pamir and Tianshan, tectonic segmentation,structure of basement.

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