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World Journal of Gastroenterology 2024年第15期30卷 2081-2086页

作者： Michele Nardolillo Fabiola Rescigno Mario Bartiromo Dario Piatto Stefano Guarino Pierluigi Marzuillo Emanuele Miraglia del Giudice Anna Di Sessa Department of Woman Child and of General and Specialized SurgeryUniversitàdegli Studi della Campania“Luigi Vanvitelli”Naples 80138Italy

Over recent years,the nomenclature of non-alcoholic fatty liver disease has undergone significant ***,in 2020,an expert consensus panel proposed the term“Metabolic(dysfunction)associated fatty liver disease”(MAFLD)to underscore the close association of fatty liver with metabolic abnormalities,thereby highlighting the cardiometabolic risks(such as metabolic syndrome,type 2 diabetes,insulin resistance,and cardiovascular disease)faced by these patients since *** recently,this term has been further replaced with metabolic associated steatotic liver *** is worth noting that emerging evidence not only supports a close and independent association of MAFLD with chronic kidney disease in adults but also indicates its interplay with metabolic ***,comparable pediatric data remain *** the progressive and chronic nature of both diseases and their prognostic cardiometabolic implications,this editorial aims to provide a pediatric perspective on the intriguing relationship between MAFLD and renal function in childhood.

关键词： Metabolic(dysfunction)associated fatty liver disease Renal Function Children Obesity

Toward scalable docker-based emulations of blockchain networks for research and development

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Blockchain(Research and Applications) 2024年第3期5卷 168-183页

作者： Diego Pennino Maurizio Pizzonia universitàdegli studi della Tuscia Dipartimento di EconomiaIngegneriaSocietàe Impresa01100 ViterboItaly universitàdegli studi Roma Tre Dipartimento di Ingegneria CivileInformatica e delle Tecnologie Aeronautiche00146 RomeItaly

Blockchain,like any other complex technology,needs a strong testing methodology to support its evolution in both research and development *** up meaningful tests for permissionless blockchain technology is a notoriously complex task for several reasons:software is complex,a large number of nodes are involved,the network is non-ideal,*** usually adopt small virtual laboratories or costly real devnets based on real *** usually prefer simulations of a large number of nodes based on simplified *** this paper,we aim to obtain the advantages of both approaches,i.e.,performing large,realistic,inexpensive,and flexible experiments,using real blockchain software within a virtual *** do that,we address the challenge of running large blockchain networks in a single physical machine,leveraging Linux and *** analyze a number of problems that arise when large blockchain networks are emulated,and we provide technical solutions for all of ***,we describe two experiences of emulating fairly large blockchain networks on a single machine:adopting both research-oriented and production-oriented software and involving more than 3000 containers.

关键词： Blockchain Blockchain emulation Scalability Docker Research and development experiments

Novel emphasis on somatostatinergic system in retinal ganglion cell neuroresilience

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Neural Regeneration Research 2024年第1期19卷 148-149页

作者： Elisabetta Catalani Davide Cervia Department for Innovation in Biological Agro-food and Forest Systems(DIBAF)Universitàdegli Studi della Tuscialargo dell’UniversitàsncViterboItaly

The neuromodulatory peptide somatostatin(somatotropin release inhibiting factor,SRIF)-14 acts at multiple levels through five SRIF receptor subtypes(sst1 to sst5).SRIF-28 is also derived from a common propeptide translated from a single SRIF gene,although SRIF-14 is the predominant form in the mammalian nervous *** to its short half-life,synthetic SRIF analogs have been developed over the years and are available for therapeutic approaches.

关键词： life system predominant

A divergent pattern in functional connectivity: a transdiagnostic perspective

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Neural Regeneration Research 2024年第9期19卷 1885-1886页

作者： Lu Zhang Lorenzo Pini Padova Neuroscience Center Universitàdegli Studi di PadovaPadovaItaly

Functional magnetic resonance imaging(fMRI)is a popular tool used to investigate not only how the brain responds to specific stimuli during sensorimotor or cognitive tasks,but also brain activity at *** physics beyond... 详细信息

关键词： pattern connectivity functional

Statistical analysis of physico-mechanical parameters of sandstones occurring in orogenic settings

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Journal of Mountain Science 2024年第4期21卷 1388-1402页

作者： PAPPALARDO Giovanna CARBONE Serafina MONACO Carmelo ZOCCO Giordana MINEO Simone Dipartimento Di Scienze Biologiche Geologiche E AmbientaliUniversitàDegli Studi Di CataniaCorso Italia 5795129 CataniaItaly

In northeastern Sicily(Italy),sandstone rock masses widely crop out as cover deposits over crystalline terrains belonging to the orogenic *** being part of the same geological formation,these sandstones are characterized by highly different features in terms of texture and physico-mechanical *** poses a scientific question on the possibility of tracing these rocks to a single statistical model,which could be representative of their main engineering geological ***,it is worth investigating on the possible reasons of such differences,that should be searched either in the current geographical sandstone distribution or in the rock *** this study,sandstone samples were collected from different sites and were analyzed at both the hand and thin section *** sandstone types were recognized,characterized by a different ***,the laboratory characterization allowed estimating their main physico-mechanical and ultrasonic properties,such as porosity,density,mechanical strength,deformability,and ultrasonic *** rock mechanical strength proved linked to the rock compactness and to the presence of lithic fragments,while pores and a pseudo-matrix between grains represent weakening *** data were also statistically analyzed by grouping the specimens according to a geographical criterion,with respect to their sampling area,but no link was found between location and rock ***,with the aim of achieving mathematical laws that could be used to predict some rock properties from others,useful for practical purposes when dealing with such a high property variability,single and multiple regression analyses were carried *** show that the Uniaxial Compressive Strength,porosity,and P-wave velocity are the best predictors for a quick,indirect estimation of the main physico-mechanical *** methodological approach developed for this research can be taken as reference to study other world

关键词： Sandstone Laboratory test Uniaxial Compressive Strength Porosity Rocks

The potential for an old-growth forest to store carbon in the topsoil:A case study at Sasso Fratino,Italy

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Journal of Forestry Research 2024年第2期35卷 23-32页

作者： Tommaso Chiti Nicola Benilli Giovanni Mastrolonardo Giacomo Certini Dipartimento per la Innovazione nei Sistemi Biologici Agroalimentari e Forestali(DIBAF)Universitàdella TusciaVia San C.de Lellis Snc01100 ViterboItaly Dipartimento di Scienze e Tecnologie Agrarie AlimentariAmbientali e Forestali(DAGRI)Universitàdegli Studi di FirenzeP.le delle Cascine 1850144 FirenzeItaly

There is considerable interest devoted to oldgrowth forests and their capacity to store carbon(C)in biomass and *** of C stocks in old-growth forests are carried out worldwide,although there is a lack of information on their actual potential for C *** further understand this,soil organic carbon(SOC)was measured in one of Italy's best-preserved old-growth forests,the Sasso Fratino Integral Nature *** reserve is on the World Heritage List along with other ancient beech forests of Europe,and it is virtually untouched due to the steepness of the terrain,even before legal constraints were *** the sandstone-derived soils are often shallow,they are rich in organic ***,no quantification had been carried *** systematically sampling the topsoil across the forest,we accurately determined the average amount of SOC(62.0±16.9 Mg ha^(–1))and nitrogen(4.0±1.2 Mg ha^(–1))in the top 20 *** the CENTURY model,future dynamics of SOC stocks were predicted to 2050 according to two climate scenarios,A1F1 and B2,the first of high concern and the second more *** model projected an increase of 0.2 and 0.3 Mg ha^(–1)a^(–1)by 2030 under the A1F1 and B2 scenarios,respectively,suggesting that the topsoil in old-growth forests does not reach equilibrium but continues accumulating ***,from 2030 to 2050,a decline in SOC accumulation is predicted,indicating SOC net loss at high altitudes under the worst-case *** study confirms that soils in oldgrowth forests play a significant role in carbon *** also suggests that climate change may affect the potential of these forests to store SOC not only in the long term but also in the coming years.

关键词： Carbon sequestration CENTURY model Climate change Forest soil Soil nitrogen

Application of flame-formed carbon nanoparticle films for ethanol sensing Author links open overlay panel

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Particuology 2024年第8期91卷 202-210页

作者： Pegah Darvehi Luca Basta Mario Commodo Patrizia Minutolo Andrea D'Anna Istituto di Scienze e Tecnologie per l’Energia e la MobilitàSostenibili Consiglio Nazionale delle RicercheP.le Tecchio 8080125NapoliItaly Dipartimento di Ingegneria Chimica dei Materiali e della Produzione IndustrialeUniversitàdegli Studi di Napoli Federico IIP.le Tecchio 8080125NapoliItaly

Carbon nanoparticles(CNPs)have received considerable attention due to their exceptional qualities and *** unique physical and chemical characteristics make them extremely intriguing as materials for numerous high-potential applications,such as electronics and gas *** study focused on producing carbon-based nanomaterial devices by deposition of flame-formed carbon nanoparticles on a suitable substrate and investigating their gas-sensing *** were produced in a fuel-rich laminar premixed ethylene/air flame and the collected CNP film was morphologically and electrically *** electrical conductivity of the film was investigated as a function of ethanol concentration and amount of deposited ***,CNP films exhibited high sensitivity to ambient ethanol gas concentrations,and rapid recovery times at room temperature,and showed a sensitivity increasing with the amount of deposited material and the surface *** findings demonstrate the high potential of combustion-generated CNPs as building materials for low-cost and portable ethanol sensors.

关键词： Flame synthesis Carbon nanoparticles Soot Nanostructured thin film Optical and electrical characterization Atomic force microscopy Sensors

Advancing immunosuppression in liver transplantation: A narrative review

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Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 441-448页

作者： Samuele Iesari Francesca Laura Nava Ilaria Elena Zais Laurent Coubeau Mariano Ferraresso Evaldo Favi Jan Lerut General Surgery and Kidney Transplantation Fondazione IRCCS Ca’Granda Ospedale Maggiore Policlinico15 Via della Commenda20122 MilanItaly Institut de Recherche Expérimentale et Clinique Universitécatholique de Louvain10 Avenue Hippocrate1200 BrusselsBelgium Service de Chirurgie et Transplantation Abdominale Cliniques Universitaires Saint-Luc55 Avenue Hippocrate1200 BrusselsBelgium Department of Clinical Sciences and Community Health Universitàdegli Studi di Milano19 Via della Commenda20122 MilanItaly

Immunosuppression is essential to ensure recipient and graft survivals after liver transplantation(LT). However, our understanding and management of the immune system remain suboptimal. Current immunosuppressive therapy cannot selectively inhibit the graft-specific immune response and entails a significant risk of serious side effects, i.e., among others, de novo cancers, infections, cardiovascular events, renal failure, metabolic syndrome, and late graft fibrosis, with progressive loss of graft function. Pharmacological research, aimed to develop alternative immunosuppressive agents in LT, is behind other solidorgan transplantation subspecialties, and, therefore, the development of new compounds and strategies should get priority in LT. The research trajectories cover mechanisms to induce T-cell exhaustion, to inhibit co-stimulation, to mitigate non-antigen-specific inflammatory response, and, lastly, to minimize the development and action of donor-specific antibodies. Moreover, while cellular modulation techniques are complex, active research is underway to foster the action of T-regulatory cells, to induce tolerogenic dendritic cells, and to promote the function of B-regulatory cells. We herein discuss current lines of research in clinical immunosuppression, particularly focusing on possible applications in the LT setting.

关键词： Liver transplantation Immunosuppression Drug development Long-term results Clinical operational tolerance

Long COVID and gut candidiasis:What is the existing relationship?

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World Journal of Gastroenterology 2024年第37期30卷 4104-4114页

作者： Filippo Bistagnino Davide Pizzi Filippo Mantovani Jacopo Rosso Antonino Marcos Roberto Tovani-Palone Department of Medical Biotechnology and Translational Medicine International Medical SchoolUniversitàdegli Studi di MilanoMilan 20054Italy Department of Biomedical Sciences for Health Universitàdegli Studi di MilanoMilan 20133Italy Department of Research Analytics Saveetha Dental College and HospitalsSaveetha Institute of Medical and Technical SciencesChennai 600077India

Since the beginning of the coronavirus disease(COVID)2019 pandemic,thou-sands of articles on the topic have been published,and although there is a growing trend of research on another associated condition,long coronavirus disease,important points still remain to be clarified in this *** evidence has suggested a relevant link between new clinical discoveries and molecular mechanisms that could be associated with the manifestations of different signs and symptoms involving cases of long ***,one of the existing gaps that requires further investigation concerns a possible rela-tionship between gut candidiasis and long *** recent studies also suggest an interplay between the occurrence of these two conditions,it is not yet fully clear how this may happen,as well as the specifics regarding the possible pathophysiological mechanisms *** this connection and with the advent of a potential strengthening of the body of evidence supporting the hypothesis of a link between gut candidiasis and long COVID,a better understanding of the clinical presentation,pathophysiology and clinical management of such a relationship should be essential and useful for both,additional advances towards more targeted research and appropriate case *** more about the signs,symptoms,and complications associated with cases of long COVID is essential in order to more effectively mitigate the related burden and provide a higher quality of care and life for the affected *** light of this and the need for better outcomes,here we review and discuss the content on different aspects of long COVID,including its pathophysiology and the existing evidence of a potential relationship between such a condition and gut candidiasis,as well as suggest propositions for future related *** Long coronavirus disease(COVID)is a condition characterized by the emergence of new symptoms or the persistence of existing symptoms for at least two months,

关键词： Post-acute COVID-19 syndrome COVID-19 Candidiasis Gastrointestinal microbiome Pandemics

Assessment of slow deformations and landslide modelling in the urban area through a multi-methodological approach

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Journal of Earth Science 2024年

作者： Fabio Ietto Massimo Conforti Cristiano Tolomei Federico Cella Giuseppe Cianflone università degli studi della calabria， Dipartimento di Biologia， Ecologia e Scienze della Terra (DiBEST)， Via P.Bucci， Cubo 15B， 87036 Consiglio Nazionale Ricerche (CNR)， Istituto di Ricerca per la Protezione Idrogeologica (IRPI)， Via Cavour INGV-Istituto Nazionale di Geofisica e Vulcanologia， Via di Vigna Murata 605 università di Camerino， Scuola di Scienze e Tecnologia， Sez.Geologia， Via Gentile III da Varano 27

Slow-moving landslides are widespread in the Mediterranean area， causing damage to the exposed facilities and economic losses in many countries. The recognition of slow-moving landslides in urban areas is always a difficult task to deal with because the presence of buildings， infrastructures， and human activities usually conceals the morphological signs of these landslide activities. So， in the last decades， numerous researchers have shown new methodologies to deepen the studies of similar instability phenomena. The present research is based on an integrated approach to investigate the landslide boundaries， type of movement， failure surface depth， and vulnerability state of buildings in Rota Greca village (calabria region， southern Italy) affected by a slow-moving landslide. For this purpose， multi-source data were acquired through geological and geomorphological surveys， recognition of landslide-induced damage on the built environment， subsurface investigations (e.g.， continuous drill boreholes， Standard Penetration Test， Rock Quality Designation index and inclinometer monitoring)， laboratory tests (direct shear tests on undisturbed samples)， geophysical survey， and InSAR-derived map of deformation rates. The complete integration of multi-source data allowed for the construction of reliable landslide modelling with relative geotechnical properties. In addition， the cross-comparison between surface deformation data by SAR images and severity damage level collected on the exposed buildings enabled to obtain the vulnerability map of the built area. In particular， the achieved goals highlighted two failure surfaces at about -13 and -25 m depth， causing a high vulnerability value for the buildings allocated in the central portion of the Rota Greca village. The knowledge acquired by the multi-approach can be used to manage and implement appropriate landslide risk mitigation strategies， providing helpful advice and best practices to state-run organisations and stakeholder

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