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Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli Ali Mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

LOG-CONCAVITY OF THE FIRST diRICHLET EIGENFUNCTION OF SOME ELLIPTIC diFFERENTIAL OPERATORS AND CONVEXITY INEQUALITIES FOR THE RELEVANT EIGENVALUE

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Acta Mathematica Scientia 2025年第1期45卷 143-152页

作者： Andrea COLESANTI dipartimento di Matematica&Informdtica‘U.dini’ Universitàdegli Studi di FirenzeViale Morgagni 67/A-50134FirenzeItaly

Given an open bounded subsetΩofℝn we consider the eigenvalue problem{Δu-(■u,■V)=-λvu,u>0inΩ,u=0 onδΩ,where V is a given function defined inΩandλV is the relevant *** determine sufficient conditions on V such that ifΩis convex,the solution u is *** also determine sufficient conditions ensuring thatλV,as a function of the setΩ,verifies a convexity inequality with respect to the Minkowski addition of sets.

关键词： eigenvalue log-concavity elliptic operator Brunn-Minkowski inequality convex body

On the Lebesgue Integral and the Lebesgue Measure: Mathematical Applications in Some Sectors of Chern-Simons Theory and Yang-Mills Gauge Theory and Mathematical Connections with Some Sectors of String Theory and Number Theory

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Journal of Modern Physics 2025年第1期16卷 93-132页

作者： Michele Nardelli dipartimento di Scienze della Terra Universit degli Studi di Napoli Federico II Napoli Italy dipartimento di Matematica ed Applicazioni R. Caccioppoli Universit degli Studi di Napoli Federico II-Polo delle Scienze e delle Tecnologie Napoli Italy

In this paper, in Section 1, we have described some equations and theorems concerning the Lebesgue integral and the Lebesgue measure. In Section 2, we have described the possible mathematical applications, of Lebesgue integration, in some equations concerning various sectors of Chern-Simons theory and Yang-Mills gauge theory, precisely the two dimensional quantum Yang-Mills theory. In conclusion, in Section 3, we have described also the possible mathematical connections with some sectors of String Theory and Number Theory, principally with some equations concerning the Ramanujan’s modular equations that are related to the physical vibrations of the bosonic strings and of the superstrings, some Ramanujan’s identities concerning π and the zeta strings.

关键词： Lebesgue Integral Chern-Simons Theory Yang-Mills Gauge Theory String Theory Number Theory

Turbine Blade Boundary Layer Separation Suppression via Synthetic Jet: an Experimental and Numerical Study

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Journal of Thermal Science 2012年第5期21卷 404-412页

作者： Bernardini C. Carnevale M. Manna M. Martelli F. Simoni D. Zunino P. università degli studi di Firenze Firenze Italy università degli studi di Napoli Federico Ⅱ Napoli Italy università degli studi di Firenze FirenzeItaly università degli studi di Genova Genova Italy

The present paper focuses on the analysis of a synthetic jet device (with a zero net massflow rate) on a separated boundary layer. Separation has been obtained on a flat plate installed within a converging-diverging test section specifically designed to attain a local velocity distribution typical of a high-lift LPT blade. Both experimental and numerical investigations have been carried out. Unsteady RANS results have been compared with experiments in terms of time-averaged velocity and turbulence intensity distributions. Two different Reynolds number cases have been investigated, namely Re = 200,000 and Re = 70,000, which characterize low-pressure turbine operating conditions during take-off/landing and cruise. A range of synthetic jet aerodynamic parameters (Strouhal number and blowing ratio) has been tested in order to analyze the features of control-separated boundary layer interaction for the aforementioned Reynolds numbers.

关键词： Synthetic Jet Separated Flow Active Flow Control Unsteady Flow Ultra High Lift LPT.

Unsteady Inflow Effects on the Wake Shed from a High-Lift LPT Blade Subjected to Boundary Layer Laminar Separation

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Journal of Thermal Science 2012年第2期21卷 97-108页

作者： Francesca Satta Marina Ubaldi Pietro Zunino università degli studi di Genova

An experimental investigation on the near and far wake of a cascade of high-lift low-pressure turbine blades subjected to boundary layer separation over the suction side surface has been carried out, under steady and unsteady inflows. Two Reynolds number conditions, representative of take-off/landing and cruise operating conditions of the real engine, have been tested. The effect of upstream wake-boundary layer interaction on the wake shed from the profile has been investigated in a three-blade large-scale linear turbine cascade. The comparison between the wakes shed under steady and unsteady inflows has been performed through the analysis of mean velocity and Reynolds stress components measured at midspan of the central blade by means of a two-component crossed miniature hot-wire probe. The wake development has been analyzed in the region between 2% and 100% of the blade chord from the central blade trailing edge, aligned with the blade exit direction. Wake integral parameters, half-width and maximum velocity defects have been evaluated from the mean velocity distributions to quantify the modifications induced on the vane wake by the upstream wake. Moreover the thicknesses of the two wake shear layers have been considered separately in order to identify the effects of Reynolds number and incoming flow on the wake shape. The self-preserving state of the wake has been looked at, taking into account the different thicknesses of the two shear layers. The evaluation of the power density spectra of the velocity fluctuations allowed the study of the wake unsteady behavior, and the detection of the effects induced by the different operating conditions on the trailing edge vortex shedding.

关键词： Wake-wake unsteady interaction high-lift blade profiles low-pressure turbine blade wake.

Correlation of powder flow properties to interparticle interactions at ambient and high temperatures

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Particuology 2014年第1期12卷 90-99页

作者： Igino Tomasetta diego Barletta Massimo Poletto dipartimento di Ingegneria Industriale Università degli Studi di Salerno

A combination of a continuum approach and a particleparticle approach to describe the multiscale nature of the mechanical properties of bulk solids may be beneficial to scientific and engineering applica tions. In this paper, a procedure is proposed to estimate the interparticle forces beginning with the bulk flow properties as measured with standardized techniques. In particular, the relationship between inter particle forces and bulk solid tensile strength is adopted based on the microscale approaches of Rumpf （1970） and Molerus （1975）. The flow properties of fluid cracking catalyst （FCC）, corundum and glass bead powders were all characterized with a modified Schulze ring shear cell capable of operating at tempera tures up to 500 ~C. The powder test conditions were selected such that the van der Waals forces were the most significant particleparticle interactions. The model equations describe two cases, in which either elastic or plastic deformation of the contact points is assumed. The results indicate that the model pro vides the correct order of magnitude for the values of the tensile strength when proper values for the mean curvature radius at the contact points are taken into account. A sensitivity analysis for the main parameters in the model was performed. This analysis indicated that the assumption of plastic deforma tion at contact surfaces coupled with a decrease in porosity justified an increase of the tensile strength with consolidation stress. Furthermore, the effect of temperature on the measured flow behavior can be explained as a change in the strength of the material.

关键词： Shear testingYield locusvan der Waals forcelnterparticle interactionsPowder consolidationHigh temperature

Moment Maps and Equivariant Volumes

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Acta Mathematica Sinica,English Series 2007年第12期23卷 2155-2188页

作者： Alberto DELLA VEDOVA Roberto PAOLETTI dipartimento di Matematica Università degli Studi di Parma Viale dipartimento di Matematica e Applicazioni Università degli Studi di Milano Bicocca

The study of the volume of big line bundles on a complex projective manifold M has been one of the main veins in the recent interest in the asymptotic properties of linear series. In this article, we consider an equiv... 详细信息

关键词： big line bundle asymptotic invariant moment map GIT quotient

The sedimentary dynamics of Sabellaria alveolata bioconstructions (Ostia,Tyrrhenian Sea, central Italy)

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Journal of Palaeogeography 2020年第1期9卷 42-59页

作者： Stefania Nunzia Lisco Pasquale Acquafredda Salvatore Gallicchio Luisa Sabato Andrea Bonifazi Frine Cardone Giuseppe Corriero Maria Flavia Gravina Cataldo Pierri Massimo Moretti dipartimento di Scienze della Terra e Geoambientali Universitàdegli Studi di Bari70124 BariItaly dipartimento di Biologia Universitàdegli Studi di Bari70124 BariItaly dipartimento di Biologia Universitàdi Roma“Tor Vergata”00133 RomeItaly.

Sabellaria alveolata(Linnaeus 1767)is a polychaete able to build bioconstructions of different thickness,size and patchiness,in intertidal and subtidal *** biological features have been the object of numerous studies *** worm reefs are formed by millions of tubes built by sand and shells(whole or in fragments)bonded together with a strong glue produced by the worm ***,Sabellaria alveolata represents a sedimentological asset for the coastal protection,since it contributes to create natural barriers against storm waves and erosion,and supplies the beach with new sandy *** work shows a multidisciplinary approach to studying a bioconstruction of Sabellaria alveolata along the Latium coast(Ostia,Tyrrhenian Sea,central Italy),proposing image analysis as a novel technique to investigate worm reefs,along with classical sedimentological/ecological *** Sabellaria bioconstructions have been analysed at different scales of observation,suggesting the more appropriate strategies to develop a reliable model illustrating the different growth steps of these bioconstructions.

关键词： Sedimentology Sabellaria alveolata Bioconstruction Shallow-marine environment Image analysis Tyrrhenian Sea Latium coast Ostia

Foreword to the International Conference onMaterials and Energy (ICOME 2023)

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Fluid Dynamics & Materials Processing 2025年第2期21卷 253-260页

作者： Biagio Morrone Petronia Carillo Mohammed El Ganaoui Morsli Souad Rachid Bennacer Department of Engineering Universitàdegli studi della Campania“L.Vanvitelli”Aversa81031Italy Department distabif Universitàdegli studi della Campania“L.Vanvitelli”Caserta81100Italy Laboratory for studies and Research onWood Materials(LERMAB) Institut Henri Poincaréde Longwy(IUT)Universitéde LorraineLongwy54400France Laboratory of Study ofMicrostructures Mechanics andMaterial Sciences(LEM3)écoleNationale des Ingénieurs deMetz(ENIM)Universitéde LorraineMetz57070France universitéParis-Saclay ENS Paris-SaclayCNRSLMPSGif-sur-Yvette91190France

1 Foreword The crises produced by the COVID-19 pandemic and the ongoing Russia-Ukraine conflict have starkly highlighted the critical need for scientific innovation and global *** pandemic underscored the urgency of swift,science-driven responses to worldwide health emergencies,while the war has intensified energy shortages and material scarcities,amplifying the demand for sustainable and resilient solutions.

关键词： intensified Foreword Russia