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Short-and long-term effects of an extreme case of autotomy:does“tail”loss and subsequent constipation decrease the locomotor performance of male and female scorpions?

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Integrative Zoology 2022年第5期17卷 672-688页

作者： Solimary GARCÍA-HERNÁNdeZ Glauco MACHAdo Programa de Pós-graduação em Ecologia Instituto de BiociênciasUniversidade de São PauloSão PauloBrazil LAGE do departamento de Ecologia Instituto de BiociênciasUniversidade de São PauloSão PauloBrazil

In many taxa,individuals voluntarily detach a body part as a form to increase their chances of escaping *** defense mechanism,known as autotomy,has several consequences,such as changes in locomotor performance that may affectﬁ*** of the genus Ananteris autotomize the“tail”,which in fact corresponds to the last abdominal *** autotomy,individuals lose nearly 25%of their body mass and the last portion of the digestive tract,including the anus,which prevents defecation and leads to constipation,because regeneration does not ***,we experimentally investigated the short-and long-term effects of tail loss on the locomotor performance of Ananteris *** a short-term experiment,the maximum running speed(MRS)of males and females did not change after ***,the relative mass of the lost tail did not affect the change in MRS after *** a long-term experiment,autotomy had a negative effect on the MRS of males,but not of *** over-fed individuals suffered from severe constipation but were not slower than autotomized normally fed *** conclusion,tail loss has no immediate effect on the locomotor performance of *** long-term decrease in the locomotor performance of autotomized males may impair mate ***,because death by constipation takes several months,males have a long time toﬁnd mates and ***,the prolonged period between autotomy and death by constipation is crucial for understanding the evolution of one of the most extreme cases of autotomy in nature.

关键词： ﬁtness costs maximum running speed sex differences tail loss weight loss

U-Pb provenance fingerprints of metavolcanic-sedimentary successions of the Mineiro belt:Proxies for the continuity of plate tectonics through the Paleoproterozoic

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Geoscience Frontiers 2022年第5期13卷 309-335页

作者： W.Teixeira C.A.Ávila I.A.Dussin E.Bongiolo instituto de Geociências Universidade de São PauloBrazil Museu Nacional Universidade Federal do Rio de JaneiroBrazil Faculdade de Geologia Universidade do Estado do Rio de JaneiroBrazil Programa de Pós-graduação em Geociências Instituto de GeociênciasUniversidade Federal do Rio Grande do SulBrazil

We document new U-Pb detrital zircon LA-MC-ICP-MS data for seven metavolcanic-sedimentary successions and metasedimentary sequences and reassess additional dates of five siliciclastic samples toward their tectonic significance in the context of the Mineiro belt,Southern São Francisco *** belt represents a crustal segment of the 2.47–2.00 Ga Minas orogen,classically known by its Siderian and Rhyacian juvenile rocks with important implications in the Earth’s *** new and compiled detrital provenance constraints unravel the long-lived magmatic and sedimentary history of the studied basins,lasting ca.230–220 *** maximum depositional dates around 2.1 Ga reflect the renewed sediment budget with the subsequent metamorphic episode ca.2.0 *** of the unmixed relative probability diagrams are consistent with sourcing from the Siderian and Rhyacian arcs of the Mineiro belt,determining a detrital provenance change in time and space for the precursor *** potential sources could be the youngest rocks of the Mantiqueira and Juiz de Fora terranes that constitute the other segments of the Minas orogen,given the age *** overall detrital fingerprints determine the study basins resumed mainly in Rhyacian fore-arc and/or back-arc settings,i.e.,akin to a subductionrelated system that evolved to a collisional(foreland)*** samples show fingerprints of primary extensional settings,determined by major Archean detrital populations sourced from areas outside the Mineiro belt beside the Paleoproterozoic *** working model considers the collage between the Mineiro belt and the ancient foreland around 2.10 Ga and eventual interaction with other crustal segments of the Minas orogen,generating the ca.2.0 Ga metamorphism over the metasedimentary *** more complete isotopic repository in detrital and igneous zircon grains for the studied supracrustal successions and the associated rocks allows new insights into the Rhyacian–oro

关键词： Paleoproterozoic São Francisco Craton detrital zircon geochronology Metavolcanic-sedimentary basin

Totally intracorporeal robot-assisted urinary diversion for bladder cancer(Part 1).Review and detailed characterization of ileal conduit and modified Indiana pouch

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Asian Journal of Urology 2021年第1期8卷 50-62页

作者： Hugo otaola-Arca Rafael Coelho Vipul R.Patel Marcelo orvieto department of Urology Clı´nica AlemanaSantiagoChile School of Medicine Clı´nica Alemana-Universidad del DesarrolloSantiagoChile universidade de sa˜o paulo instituto do caˆncer do estado de sa˜o paulo Brazil department of Urology AdventHealth Global Robotics InstituteCelebrationFLUnited States

objective:To review the most used robot-assisted cutaneous urinary diversion(CUD)after radical cystectomy for bladder cancer and create a unified compendium of the different alternatives,including new consistent images Methods:A non-systematic review of the literature with the keywords“bladder cancer”,“cutaneous urinary diversion”,and“radical cystectomy”was ***:Twenty-four studies of intracorporeal ileal conduit(ICIC)and two of intracorporeal Indiana pouch(ICIP)were included in the *** ICIC,the patients’age ranged from 60 to 76 *** operative time to perform a urinary diversion ranged from 60 to 133 *** total estimated blood loss ranged from 200 to 1117 *** rate of positive surgical margins ranged from 0%to 14.3%.Early minor and major complication rates ranged from 0%to 71.4%and from 0%to 53.4%,*** minor and major complication rates ranged from 0%to 66%and from 0%to 32%,*** ICIP data are limited to one case report and one clinical ***:The most frequent type of CUD is *** studies comparing the performance of the different types of CUD,the performance in an intra-or extracorporeal manner,or the performance of a CUD versus orthotopic ileal neobladder are lacking in the *** this day,there are not enough quality data to determine the supremacy of one *** manuscript represents a compendium of the most used CUD with detailed descriptions of the technical aspects,operative and perioperative outcomes,and new consistent images for each technique.

关键词： Bladder cancer Ileal conduit Indiana pouch Intracorporeal urinary diversion Robot-assisted radical cystectomy Surgical technique

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Expression profiles of gastric cancer molecular subtypes in remnant tumors

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World Journal of Gastrointestinal oncology 2021年第4期13卷 265-278页

作者： Marcus Fernando Kodama Pertille Ramos Marina Alessandra Pereira Leonardo cardili Evandro Sobroza de Mello Ulysses Ribeiro Jr Bruno Zilberstein Ivan Cecconello department of Gastroenterology Instituto do CancerHospital das ClinicasHCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01249000São PauloBrazil department of Pathology Instituto do CancerHospital das Clinicas HCFMUSPFaculdade de MedicinaUniversidade de São PauloSão Paulo 01249000São PauloBrazil

BACKGRoUND Remnant gastric cancer(RGC)is a carcinoma arising in the stomach remnant after previous gastric *** is frequently reported as a tumor with a poor prognosis and distinct biological features from primary gastric cancer(PGC).However,as it is less frequent,its profile regarding the current molecular classifications of gastric cancer has not been *** To evaluate a cohort of RGC according to molecular subtypes of GC using a panel of immunohistochemistry and in situ hybridization to determine whether the expression profile is different between PGC and *** Consecutive RGC patients who underwent gastrectomy between 2009 and 2019 were assessed using seven GC panels:Epstein-Barr virus in situ hybridization,immunohistochemistry for mismatch repair proteins(MutL homolog 1,MutS homolog 2,MutS homolog 6,and PMS1 homolog 2),p53 protein,and E-cadherin *** characteristics and survival of these patients were compared to 284 PGC *** A total of 40 RGC patients were enrolled in this *** to PGC,older age(Power body mass index(P=0.010),and lower hemoglobin level(Pociated with RGC *** difference was observed regarding Lauren’s type and pathologic Tumor Node Metastasis stage between the *** the profiles evaluated,EBV-positive tumors were higher in RGC compared to PGC(P=0.039).The frequency of microsatellite instability,aberrant p53 immunostaining,and loss of E-cadherin expression were similar between RGC and *** rates of simultaneous alterations in two or more profiles were observed in RGC compared to PGC(Pording to the molecular classification,the subtypes were defined as EBV in nine(22.5%)cases,microsatellite instability in nine(22.5%)cases,genomically stable in one(2.5%)case,and chromosomal instability in 21(52.5%)*** was no significant difference in survival between molecular subtypes in RGC *** RGC w

关键词： Stomach neoplasms Gastric remnant Gastric remnant cancer Adenocarcinoma Immunohistochemistry

Physiology and health assessment,risk balance,and model for endstage liver disease scores:Postoperative outcome of liver transplantation

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World Journal of Transplantation 2025年第1期15卷 86-94页

作者： Raquel Hohenreuther Andresa ThoméSilveira Edison Moraes Rodrigues Filho Anderson Garcez Bruna Goularth Lacerda sabrina Alves Fernandes Claudio Augusto Marroni Postgraduate Program in Hepatology Universidade Federal de Ciências da Saúde de Porto AlegrePorto Alegre 90050-170Brazil department of Intensive Medicine Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Brazil department of Public Health University of Vale do Rio dos SinosSao Leopoldo 93022-750Brazil

BACKGRoUND Liver transplantation aims to increase the survival of patients with end-stage liver diseases and improve their quality of *** number of organs available for transplantation is lower than the *** provide fair organ distribution,predictive mortality scores have been *** To compare the Acute Physiology and Chronic Health Evaluation IV(APACHE IV),balance of risk(BAR),and model for end-stage liver disease(MELD)scores as predictors of *** Retrospective cohort study,which included 283 adult patients in the postoperative period of deceased donor liver transplantation from 2014 to *** The transplant recipients were mainly male,with a mean age of 58.1 *** were mostly male,with a mean age of 41.6 *** median cold ischemia time was 3.1 hours,and the median intensive care unit stay was 5 *** APACHE IV,a mean of 59.6 was found,BAR 10.7,and MELD *** 28-day mortality rate was 9.5%,and at 90 days,it was 3.5%.The 28-day mortality prediction for APACHE IV was very good[area under the curve(AUC):0.85,Por APACHE IV were very good(AUC:0.80,Poderate for BAR and MELD,respectively,(AUC:0.66,Powed good discrimination between deaths and *** for the best value for liver transplantation,it was significant only for APACHE IV(PoNCLUSIoN The APACHE IV assessment score was more accurate than BAR and MELD in predicting mortality in deceased donor liver transplant recipients.

关键词： Liver transplantation Acute physiology and chronic health evaluation IV Balance of risk Model for end-stage liver disease Mortality Intensive care unit

Assessment of programmed death-ligand 1 expression in primary tumors and paired lymph node metastases of gastric adenocarcinoma

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World Journal of Gastrointestinal oncology 2024年第3期16卷 883-893页

作者： Brendha cação Coimbra Marina Alessandra Pereira Leonardo cardili Venancio Avancini Ferreira Alves Evandro Sobroza de Mello Ulysses Ribeiro Jr Marcus Fernando Kodama Pertille Ramos department of Gastroenterology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloFaculdade de MedicinaUniversidade de São PauloSão Paulo 01246000Brazil department of Pathology Instituto do CancerHospital das Clínicas da Faculdade de Medicina da Universidade de São PauloSão Paulo 01246000Brazil

BACKGRoUND Anti-programmed death-1/programmed death-ligand 1(PD-1/PD-L1)immuno-therapy has demonstrated promising results on gastric cancer(GC).However,PD-L1 can express differently between metastatic sites and primary tumors(PT).AIM To compare PD-L1 status in PT and matched lymph node metastases(LNM)of GC patients and to determine the correlation between the PD-L1 status and clinicopathological *** We retrospectively reviewed 284 GC patients who underwent ***-L1 was evaluated by immunohistochemistry(clone SP142)using the com-bined positive *** PD-L1+PT staged as pN+were also tested for PD-L1 expression in their ***-L1(-)GC with pN+served as the comparison *** Among 284 GC patients included,45 had PD-L1+PT and 24 of them had pN+.For comparison,44 PD-L1(-)cases with pN+were included(sample loss of 4 cases).of the PD-L1+PT,54.2%(13/24 cases)were also PD-L1+in the *** PD-L1(-)PT,9.1%(4/44)had PD-L1+in the *** agreement between PT and LNM had a kappa value of *** tumor size and moderate/severe peritumoral inflammatory response were associated with PD-L1 positivity in both *** was no statistical difference in overall survival for PT and LNM according to the PD-L1 status(P=0.166 and P=0.837,respectively).CoNCLUSIoN Intra-patient heterogeneity in PD-L1 expression was observed between the PT and matched *** disagreement in PD-L1 status may emphasize the importance of considering different tumor sites for analyses to select patients for immunotherapy.

关键词： Gastric cancer Lymph node Programmed death ligand 1 Stomach neoplasms Immunohistochemistry Metastasis

New exotic charmonium states

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Chinese Physics C 2010年第9期34卷 1157-1162页

作者： M.Nielsen instituto de Física Universidade de So Paulo

In the last years many states in the charmonium mass region were discovery by BABAR,Belle and CDF collaborations.I discuss some of these discoveries,and how the QCD Sum Rule approach can be used to understand the stru... 详细信息

关键词： non-perturbative methods heavy mesons spectroscopy exotic mesons

Age and origin of the Cu（Au—Mo—Ag）salobo 3A ore deposit,carajás Mineral Province,Amazonian Craton,northern Brazil

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Episodes 2003年第1期26卷 2-9页

作者： Tassinari, Colombo Celso Gaeta Mellito, Kátia Maria Babinski, Marly Centro de Pesquisas Geocronogicas Instituto de Geociências Universidade de São Paulo São Paulo CEP 05588-080 Rua do Lago 562 Brazil

The salobo 3A polymetallic Cu (Au-Mo-Ag) deposit, located in the southeastern part of the Amazonian Craton, northern Brazil, is hosted by an Archean metavolcano-sedimentary sequence of salobo Group. The copper mineralization consists of bornite-chalcocite and bornite-chalcopyrite disseminated with magnetite. In this paper we attempt to date the mineralization episodes and to characterize the fluid sources. The stepwise Pb leaching technique applied to chalcocite, tourmaline, chalcopyrite and magnetite yielded 207Pb-206Pb ages of 2705 ± 42 Ma, 2587 ± 150 Ma, 2427 ± 130 Ma, and 2112 ± 12 Ma, respectively. The older age is interpreted as the timing of primary mineralization. Ages of 2.58 Ga and 2.42 Ga are considered to be related to tectonic reactivation of the Itacaiúnas Belt, and the younger age, obtained on late magnetite crystals, suggests the presence of Paleoproterozoic hydrothermal episode. Sm-Nd and Rb-Sr ages of 2.4 and 2.1 Ga were obtained for schists from the salobo Group and chloritized gneisses of the Xingú Complex, respectively. The strong radiogenic Pb isotopic compositions of all analyzed minerals suggest a continental environment for the mineralizations. our geochronological results are in agreement with a primary syngenetic origin for the salobo mineralization, with late remobilization into brittle-ductile structures during a policyclic evolution of the carajás-Cinzento strike-slip system. Low-grade metamorphism and anorogenic granitic plutonism affected the area at ca. 2.1 and 1.8 Ga, respectively.

关键词：铜矿床巴西亚马逊克拉通地块成矿时代成矿作用金钼银矿床

Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer

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Chinese Journal of cancer Research 2022年第6期34卷 612-622页

作者： Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr department of Gastroenterology Instituto do Cancer do Estado de Sao PauloHospital das ClinicasFaculdade de MedicinaUniversidade de Sao Paulo(ICESP-HCFMUSP)Sao PauloSP 01246-000Brazil department of Pathology Instituto do Cancer do Estado de Sao PauloHospital das ClinicasFaculdade de MedicinaUniversidade de Sao Paulo(ICESP-HCFMUSP)Sao PauloSP 01246-000Brazil

objective:Remnant gastric cancer(RGC)is usually associated with a worse *** they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for *** study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated ***:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively *** resections with histological diagnosis of gastric adenocarcinoma were enrolled in the *** risk score based on immune parameters was developed using binary logistic regression *** were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune *** markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the *** score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR *** were no differences in clinicopathological and surgical characteristics between the three *** survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR *** the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse ***:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with ***,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic bi

关键词： Stomach neoplasms gastric remnant tumor-infiltrating lymphocytes immune microenvironment