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Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

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Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita O.Teodoro Mafalda Ribeiro Ramos Lara Carvalho iNOVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

Impact of Zika virus non-structural protein mutations on hippocampal damage

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Neural Regeneration Research 2025年第8期20卷 2307-2308页

作者： Larissa M.G.Cassiano Roney S.Coimbra Neurogenômica/Imunopatologia Instituto RenéRachouFiocruzBelo HorizonteBrazil Departamento de Bioquímica e Imunologia Instituto de Ciências BiológicasUniversidade Federal de Minas GeraisBelo HorizonteBrazil

The Zika virus(ZIKV),a member of the Flaviviridae family,attracted worldwide attention for its connection to severe neurological effects,notably microcephaly in newborns,first reported during the 2015 epidemic in ***,its impact goes beyond fetal and neonatal abnormalities,also affecting the central nervous system(CNS)in both children and adults,leading to enduring cognitive and behavioral impairments.

关键词： damage fetal neonatal

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Chinese Annals of Mathematics,Series B 2002年第2期23卷 253-266页

作者： J.F.RODRIGUES CMAF/universidade

This paper presents new results for strong solutions and their coincidence sets of the obstacle problem for linear hyperbolic operators of first order. An inequality similar to the LewyStampacchia ones for elliptic and parabolic problems is shown. Under nondegeneracy conditions the stability of the coincidence set is shown with respect to the variation of the data and with respect to approximation by semilinear hyperbolic problems. These results are applied to the asymptotic stability of the evolution problem with respect to the stationary coercive problem with obstacle.

关键词： Hyperbolic obstacle problem Linear hyperbolic operator Strong solution

The effect of ethanol fuel dilution on oil performance and MoDTC tribofilms formation and composition

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Friction 2024年第9期12卷 2108-2125页

作者： Juan RUIZ-ACERO Felipe KESSLER Henara COSTA Tiago COUSSEAU Polytechnic School Universidade de São PauloSão Paulo 05508-030Brazil School of Food and Chemistry Universidade Federal do Rio GrandeRio Grande 96203-000Brazil School of Engineering Universidade Federal do Rio GrandeRio Grande 96203-900Brazil Mechanical Engineering Department Univ.Tecnológica Federal do ParanáCuritiba 81280-340Brazil University of Newcastle CallaghanSW 2308Australia

Ethanol has emerged as a promising alternative to fossil fuels,but its use can lead to significant dilution in lubricants,particularly during cold start or heavy *** dilution can affect the performance of additives,including friction modifiers like molybdenum dithiocarbamate(MoDTC),which are designed to reduce friction under extreme contact *** research suggests that ethanol may impact the performance of MoDTC,prompting this study’s goal to investigate the effects of ethanol on MoDTC tribofilms and their friction response under boundary lubrication ***,reciprocating tribological tests were performed with fully formulated lubricants containing MoDTC with varying ethanol *** results indicate that a critical ethanol dilution level inhibits friction reduction by MoDTC activation,resulting in friction coefficients(COFs)similar to the base *** tested with simple mixtures of polyalphaolefin(PAO)+MoDTC showed increased COFs with added *** of tested surfaces using Raman spectroscopy,X-ray photoelectron spectroscopy(XPS),and X-ray absorption spectroscopy near the edge structure(XANES)revealed the presence of sulfates,MoO_(3),MoS_(2),and MoS_(x)O_(y)compounds in the tribofilms formed on the surfaces,with and without ethanol diluted in the ***,the addition of ethanol increased the sulfates and MoO_(3)content of the tribofilms at the expense of friction-reducing compounds such as MoS_(2)and MoS_(x)O_(y).These findings suggest that ethanol dilution in lubricants containing MoDTC creates an oxygen-rich interfacial medium that favors the formation of compounds with insufficient friction-reducing capabilities.

关键词： molybdenum dithiocarbamate(MoDTC) ethanol tribofilm friction modifier additive lubricant

A stability-indicating high performance liquid chromatography method to determine apocynin in nanoparticles

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Journal of Pharmaceutical Analysis 2017年第2期7卷 129-133页

作者： Juliana Kovalczuk de Oliveira Débora Fernanda Veres Ronik Jociani Ascari Rubiana Mara Mainardes Najeh Maissar Khalil Department of Pharmacy Laboratory of Pharmaceutical NanotechnologyUniversidade Estadual do Centro-OesteRua Simeao Camargo Varelade Sá.85040-080 GuarapuavaBrazil Department of Biological Sciences Universidade Tecnológica Federal do ParanáRua Cerejeiras S/N85892-000 Santa HelenaPRBrazil

In this study, we developed and validated a fast, specific, sensitive, precise and stability-indicating high performance liquid chromatography（HPLC） method to determine the drug apocynin in bovine serum albumin（BSA） nanoparticles. Chromatographic analyses were performed on an RP C18 column and using a photodiode array detector at a wavelength of 276 nm. Mobile phase consisted of a mixture of acetonitrile and 1% acetic acid（60：40, v/v）, and it was eluted isocratically at a flow rate of 0.8 mL/min. The retention time of apocynin chromatographic peak was 1.65 min. The method was linear, precise, accurate and specific in the range of 5–100 μg/mL. The intra-and inter-day precisions presented relative standard deviation（RSD） values lower than 2%. The method was robust regarding changes in mobile phase proportion, but not for flow rate. Limits of detection and quantitation were 78 ng/mL and 238 ng/mL, respectively. Apocynin was exposed to acid and alkali hydrolysis, oxidation and visible light. The drug suffered mild degradation under acid and oxidation conditions and great degradation under alkali conditions. Light exposure did not degrade the drug. The method was successfully applied to determine the encapsulation efficiency of apocynin in BSA nanoparticles.

关键词： Apocynin Nanoparticles Bovine serum albumin HPLC

Characterization of Mould in Masonry in Hospital Environment—Case Study

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Open Journal of Civil Engineering 2016年第4期6卷 618-630页

作者： Washington Batista de Souza Adalberto Matoski universidade tecnológica Federal do Paraná Curitiba Brazil

The objective of this study is the characterization of mould inside and in the surface wall of a hospital. The present research was made on the wall of the Clinical Hospital of the Federal University of Paraná, Brazil. For the methodology the samples were extracted from the surface, mortar and brick. The samples were spread on Petri plates containing Sabouraud dextrose agar and incubated at 25℃ for seven days. The results of the 90 samples collected showed growth of 39% of colonies with the following distribution of microorganisms: Aspergillus (present in 27% of samples), Cladosporium, Absidia, Rhizopus, Rhodotorula, Fusarium, Penicillium and Aspergillus flavus. Within the investigated substrate, three species of different fungi were identified: Aspergillus flavus, Aspergillus fumigatus and Aspergillus niger.

关键词： Walls Brick Mould Mortar Hospital

Nucleon Finite Volume Effect and Nuclear Matter Properties in a Relativistic Mean-Field Theory

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Communications in Theoretical Physics 2006年第6X期46卷 1052-1058页

作者： R. Costa A.J. Santiago H. Rodrigues J. Sa Borges Instituto de Fisica Universidade do Estado do Rio de Janeiro Rio de Janeiro-RJ 20559-900 Brazil Centro Federal de Educ~ao tecnológica Rio de Janeiro Brazil

Effects of excluded volume of nucleons on nuclear matter are studied, and the nuclear properties that follow from different relativistic mean-field model parametrizations are compared. We show that, for all tested parametrizations, the resulting volume energy al and the symmetry energy J are around the acceptable values of 16 MeV and 30 MeV, and the density symmetry L is around 100 MeV. On the other hand, models that consider only linear terms lead to incompressibility Ko much higher than expected. For most parameter sets there exists a critical point （pc, δc）, where the minimum and the maximum of the equation of state are coincident and the incompressibility equals zero. This critical point depends on the excluded volume parameter r. If this parameter is larger than 0.5 fm, there is no critical point and the pure neutron matter is predicted to be bound. The maximum value for neutron star mass is 1.85M⊙, which is in agreement with the mass of the heaviest observed neutron star 4U0900-40 and corresponds to r = 0.72 fm. We also show that the light neutron star mass （1.2M⊙） is obtained for r ≌ 0.9 fro.

关键词： nuclear matter relativistic models nuclear matter aspects of neutron stars

Null Controllability of Some Reaction-Diffusion Systems with Only One Control Force in Moving Domains

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Chinese Annals of Mathematics,Series B 2016年第1期37卷 29-52页

作者： J. LIMACO M. CLARK A. MARINHO S. B. de MENEZES A. T. LOUREDO universidade Federal Fluminense IM RJ Brazil universidade Federal do Piaui DM PI Brazil universidade Federal do Piaui DM PI Brazil universidade Federal do Ceara DM CE Brazil universidade Estadual da Pavaiba DM PB Brazil.

In this article, the authors establish the local null controllability property for semilinear parabolic systems in a domain whose boundary moves in time by a single control force acting on a prescribed subdomain. The proof is based on Kakutani＇s fixed point theorem combined with observability estimates for the associated lineaxized system.

关键词： Kakutani's fixed point theorem Unique continuation Null controllability

Waste Tire Rubber-based Refrigerants for Solid-state Cooling Devices

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Chinese Journal of Polymer Science 2020年第7期38卷 769-775,I0007页

作者： Nicolau Molina Born Erik Oda Usuda Mariana da Silva Gigliotti Denílson JoséMarcolino de Aguiar William Imamura Lucas Soares Paixao Alexandre Magnus Gomes Carvalho Catalan Institute of Nanoscience and Nanotechnology(ICN2) 08860BellaterraBarcelonaSpain The Institute of Photonic Sciences(ICFO) 08193CastelldefelsBarcelonaSpain universidade Federal de Sāo Paulo(UNIFESP) 00972-270DiademaSPBrazil Instituto de Física"Gleb Wataghin" Universidade Estadual de Campinas(UNICAMP)13083-970CampinasSPBrazil universidade tecnológica Federal do Paraná(UTFPR) 84017-220Ponta GrossaPRBrazil Faculdade de Engenharia Mec(a)nica Universidade Estadual de Campinas(UNICAMP)13083-860CampinasSPBrazil Departamento de Engenharia Mec(a)nica Universidade Estadual de Maringá(UEM)870-900MaringáPRBrazil

Management of discarded tires is a compelling environmental issue *** there are several approaches developed to recycle waste tire rubbers,their application in solid-state cooling is still *** the high barocaloric potential verified for elastomers,the use of waste tire rubber(WTR)as a refrigerant in solid-state cooling devices is very ***,we investigated the barocaloric effects in WTR and polymer blends made of vulcanized natural rubber(VNR)and WTR,to evaluate its feasibility for solid-state cooling *** adiabatic temperature changes and the isothermal entropy changes reach giant values,as well as the performance parameters,being comparable or even better than most barocaloric materials in ***,pure WTR and WTR-based samples also present a faster thermal exchange than VNR,consisting of an additional advantage of using these discarded ***,the present findings evidence the encouraging perspectives of employing waste rubbers in solid-state cooling based on barocaloric effects,contributing to both the recycling of polymers and the sustainable energy technology field.

关键词： Waste tire rubber Solid-state cooling Barocaloric effect Tire recycling Sustainable energy