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SARS-CoV-2:Air pollution highly correlated to the increase in mortality.The case of guadalajara,Jalisco,Mexico

Infectious Disease Modelling 2023年第2期8卷 445-457页

作者： Elizabeth Torres-Anguiano Itzel Sanchez-Lopez Angeles Garduno-Robles Jorge David Rivas-Carrillo Edgar Alfonso Rivera-Leon Sergio Sanchez-Enríquez Luis Fernando Ornelas-Hernandez Fernando Zazueta Leon-Quintero Eduardo Narciso Salazar Leon-Quintero Guillermo Enrique Juarez-Lopez Fernando Antonio Sanchez-Zubieta Mariana Ochoa-Bru Abraham Zepeda-Moreno Onkogenetik/Mexicana de Investigacion y Biotectogía S.A.de C.V GuadalajaraJaliscoMexico Unidad de Biología Molecular Investigacion y DiagnosticoHospital San JavierGuadalajaraJaliscoMexico departamento de Fisiología Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraJaliscoMexico departamento de Biología Molecular y Genomica Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraJaliscoMexico departamento de Clínicas Centro Universitario de los AltosUniversidad de GuadalajaraTepatitlan de MorelosJaliscoMexico departamento de Clínicas Medicas Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraJaliscoMexico Servicio de Hemato-Oncología Pediatrica Hospital Civil de Guadalajara“Dr.Juan I.Menchaca”GuadalajaraJaliscoMexico Hospital Civil de guadalajara“Fray Antonio Alcalde” GuadalajaraJaliscoMexico

Objectives:To determine whether air pollution or changes in SARS-CoV-2 lineages lead to an increase in mortality.Methods:descriptive statistics were used to calculate rates of infection(2020-2021).RT ePCR was used to compare viral loads from October 2020 to February 2021.Nextgeneration sequencing(NGS)(n=92)was used to examine and phylogenetically map SARS-CoV-2 lineages.A correlative“air pollution/temperature”index(I)was developed using regression analysis.PM_(2.5),PM_(10),O_(3),NO_(2),SO_(2),and CO concentrations were analyzed and compared to the mortality.Results:The mortality rate during the last year was~32%.Relative SARS-CoV-2 viral loads increased in december 2020 and January 2021.NGS revealed that approximately 80%of SARS-CoV-2 linages were B.1.243(33.7%),B1.1.222(11.2%),B.1.1(9%),B.1(7%),B.1.1.159(7%),and B.1.2(7%).Two periods were analyzed,the prehigh-and high-mortality periods and no significant lineage differences or new lineages were found.Positive correlations of air pollution/temperature index values with mortality were found for IPM_(2.5) and IPM_(10).INO_(2).ISO_(2),and ICO but not for O_(3).Using ICO,we developed a model to predict mortality with an estimated variation of~±5 deaths per day.

关键词： Air pollution COVID-19 guadalajara Mexico SARS-CoV-2 SARS-CoV-2 lineages

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Random noise stimulation in the treatment of patients with neurological disorders

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Neural Regeneration Research 2022年第12期17卷 2557-2562页

作者： Mateo A.Herrera-Murillo Mario Treviño Elias Manjarrez Facultad de Medicina Plan de Estudios Combinados en Medicina(PECEM)UNAMCircuito InteriorCiudad UniversitariaAv.UniversidadCiudad de MéxicoMéxico Instituto de Neurociencias Universidad de GuadalajaraGuadalajaraJaliscoMéxico Instituto de Fisiología Benemérita Universidad Autónoma de PueblaPueblaMéxico

Random noise stimulation technique involves applying any form of energy(for instance,light,mechanical,electrical,sound)with unpredictable intensities through time to the brain or sensory receptors to enhance sensory,motor,or cognitive functions.Random noise stimulation initially employed mechanical noise in auditory and cutaneous stimuli,but electrical energies applied to the brain or the skin are becoming more frequent,with a series of clinical applications.Indeed,recent evidence shows that transcranial random noise stimulation can increase corticospinal excitability,improve cognitive/motor performance,and produce beneficial aftereffects at the behavioral and psychological levels.Here,we present a narrative review about the potential uses of random noise stimulation to treat neurological disorders,including attention deficit hyperactivity disorder,schizophrenia,amblyopia,myopia,tinnitus,multiple sclerosis,post-stroke,vestibular-postural disorders,and sensitivity loss.Many of the reviewed studies reveal that the optimal way to deliver random noise stimulation-based therapies is with the concomitant use of neurological and neuropsychological assessments to validate the beneficial aftereffects.In addition,we highlight the requirement of more randomized controlled trials and more physiological studies of random noise stimulation to discover another optimal way to perform the random noise stimulation interventions.

关键词： auditory noise mechanical noise neurological disorders neuronal noise noise galvanic vestibular stimulation non-invasive brain stimulation transcranial electrical stimulation transcranial random noise stimulation

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激光冲击工艺对6061-T6铝合金侵蚀性能的影响（英文）

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Transactions of Nonferrous Metals Society of China 2016年第6期26卷 1522-1530页

作者： J.IBARRA E.RODRíGUEZ O.JIMéNEZ G.GóMEZ-ROSAS M.FLORES J.VERDUZCO J.CHáVEZ Universidad de Guadalajara Departamento de Ingeniería de Proyectos Universidad de Guadalajara Departamento de Física Centro Universitario de Ciencias Exactas e Ingenierías

采用激光冲击工艺处理6061-T6铝合金,研究了二氧化硅砂对其侵蚀磨损性能的影响。其中冲击角为15°、30°、60°、90°,粒子速率为37和58 m/s,采用两种激光进行辐照。采用3D轮廓测量法表征了侵蚀形貌,并采用SEM研究其侵蚀机理。结果表明... 详细信息

采用激光冲击工艺处理6061-T6铝合金,研究了二氧化硅砂对其侵蚀磨损性能的影响。其中冲击角为15°、30°、60°、90°,粒子速率为37和58 m/s,采用两种激光进行辐照。采用3D轮廓测量法表征了侵蚀形貌,并采用SEM研究其侵蚀机理。结果表明,冲击角较小时,侵蚀磨损最大。侵蚀强度和侵蚀机理不受激光冲击工艺的影响,而与侵蚀的高应变速率有关。侵蚀图之间的差异是由于激光冲击工艺造成的表面粗糙度不同。最大质量损失和最大侵蚀深度分别出现在冲击角度为15°和30°时。最后,发现了明显的侵蚀机理的转移,从低角度的切割机制到90°时的凹坑形成。

关键词： 6061-T6铝合金侵蚀磨损激光冲击工艺

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Evaluating physical changes of iron oxide nanoparticles due to surface modification with oleic acid

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Chinese Physics B 2020年第10期29卷 186-194页

作者： S Rosales N Casillas A Topete O Cervantes G González J A Paz M E Cano Centro Universitario de Ciencias Exactas e Ingenienas Universidad de GuadalajaraBlvd.Marcelino Garcia Burragan 1421C.P.44430GuadalajaraJaliscoMexico Centro Universitario de la Cienegu Universidad de GuadalajaraAv.Universidad 1115C.P.47820OcotlanJaliscoMexico Centro Universitario de Ciencias de In Salud Universidad de Guadalajara.Sierra Mojada 950C.P.44340GuadalajaraJaliscoMexico

The physical characterization of a colloidal system of superficially modified magnetic nanoparticles (MNPs) is presented. The system consists of oleic acid-coated iron oxide nanoparticles (OAMNP) suspended in water. A structural analysis is carried out by using standard physical techniques to determine the diameter and shape of the MNPs and also the width of the coating shell. The colloidal stability and the polydispersity index of this ferrofluid are determined by using Zeta potential measurements. Additionally, the magnetic characterization is conducted by obtaining the DC magnetization loops, and the blocking temperatures are determined according to the ZFC–FC protocol. Finally, the values of power absorption density P of the ferrofluid are estimated by using a magneto-calorimetric procedure in a wide range of magnetic field amplitude H and frequency f. The experimental results exhibit spherical-like shape of OAMNP with (20 ± 4) nm in diameter. Due to the use of coating process, the parameters of the magnetization loops and the blocking temperatures are significantly modified. Hence, while the uncoated MNPs show a blocking state of the magnetization, the OAMNP are superparamagnetic above room temperature (300 K). Furthermore, the reached dependence P versus f and P versus H of the ferrofluid with coated MNPs are clearly fitted to linear and quadratic correlations, respectively, showing their accordance with the linear response theory.

关键词： nanoparticles ferrofluid magnetic hyperthermia functionalization

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Role of dehydroepiandrosterone sulfate as a scavenging antioxidant: the evidence from Caenorhabditis elegans' nervous system under hypoxia

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Neural Regeneration Research 2021年第8期16卷 1537-1538页

作者： Leonardo Hernandez Gabriela Camargo departamento de Fisiología.CUCS-Universidad de Guadalajara GuadalajaraJaliscoMexico departamento de Ciencias de la Salud.CUALTOSUniversidad de Guadalajara TepatitlanJaliscoMexico

In nature,changes in O_(2) levels occur frequently.An inadequate supply of oxygen often happens in living systems,which induces an imbalance between oxygen entering cells and their oxygen demand to produce energy.The condition is known as hypoxia.Although hypoxia takes place in multiple physiological processes,it can be a primary cause of cellular injury and death(Nystul and Roth,2004).Consequently,cells and tissues are habitually at risk,and they have developed many strategies to cope with low oxygen levels leading to pathological conditions(Fawcett et al.,2015).These adaptative responses to hypoxia though not entirely understood,seem to be evolutively conserved.Notwithstanding these responses,hypoxia can still have harmful effects.

关键词： hypoxia entirely system

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Social Skills and Behavioral Problems in Adolescents with Child Sexual Abuse, and Their Relation to Basal Cortisol

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Journal of Behavioral and Brain Science 2022年第5期12卷 252-270页

作者： Araceli Sanz-Martin Sofía Preciado-Mercado Olga Inozemtseva Instituto de Neurociencias CUCBA Universidad de Guadalajara Guadalajara México

Child sexual abuse (CSA) is a stressful associated with alterations in the hypothalamic-hypophyseal-adrenal (HPA) axis and behavioral problems. Children and adolescents with history of CSA could have higher cortisol levels, as these have been associated with deleterious changes in brain regions involved in controlling social behavior and self-control. The aim of the present study was to determine the relationship among basal cortisol levels, social skills and behavioral problems in adolescents with CSA by evaluating two groups: one consisting of 12 - 15-year-old girls with CSA (n = 23), the other healthy comparison adolescents with no history of child abuse (n = 23). Social skills and behavioral problems were assessed using the Social Skills Improvement System. Three saliva samples were collected from each participant. The girls with CSA had lower social skills and more behavioral problems, as well as, higher cortisol concentrations. Besides, these participants showed significant negative correlations among cortisol levels and social skills, as well as, positive correlations with behavioral problems scales. It is feasible to suggest that the social deficiencies observed in these participants with CSA are related to alterations of the HPA.

关键词： Adolescents Behavioral Problems Child Sexual Abuse Cortisol Social Skills

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Melatonin modifies SOX2^+ cell proliferation in dentate gyrus and modulates SIRT1 and MECP2 in long-term sleep deprivation

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Neural Regeneration Research 2019年第10期14卷 1787-1795页

作者： Alan Hinojosa-Godínez Luis F. Jave-Suarez Mario Flores-Soto Alma Y. Gálvez-Contreras Sonia Luquín Edith Oregon-Romero Oscar González-Pérez Rocio E. González-Castaneda Laboratorio de Microscopía de Alta Resolución Departamento de NeurocienciasCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Laboratorio de Neurociencias Facultad de PsicologíaUniversidad de ColimaColimaMéxico División de Inmunología Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico División de Neurociencias Centro de Investigación Biomédica de OccidenteInstituto Mexicano del Seguro SocialGuadalajaraMéxico Instituto de Investigación en Ciencias Biomédicas (IICB) Departamento de Biología Molecular y GenómicaCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico Unidad de Atención en Neurociencias Departamento de Neurociencias. Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajaraMéxico

Melatonin is a pleiotropic molecule that,after a short-term sleep deprivation,promotes the proliferation of neural stem cells in the adult hippocampus.However,this effect has not been observed in long-term sleep deprivation.The precise mechanism exerted by melatonin on the modulation of neural stem cells is not entirely elucidated,but evidence indicates that epigenetic regulators may be involved in this process.In this study,we investigated the effect of melatonin treatment during a 96-hour sleep deprivation and analyzed the expression of epigenetic modulators predicted by computational text mining and keyword clusterization.Our results showed that the administration of melatonin under sleep-deprived conditions increased the MECP2 expression and reduced the SIRT1 expression in the dentate gyrus.We observed that let-7 b,mir-132,and mir-124 were highly expressed in the dentate gyrus after melatonin administration,but they were not modified by sleep deprivation.In addition,we found more Sox2^+/5-bromo-2’-deoxyuridine(BrdU)^+cells in the subgranular zone of the sleep-deprived group treated with melatonin than in the untreated group.These findings may support the notion that melatonin modifies the expression of epigenetic mediators that,in turn,regulate the proliferation of neural progenitor cells in the adult dentate gyrus under long-term sleep-deprived conditions.All procedures performed in this study were approved by the Animal Ethics Committee of the University of guadalajara,Mexico(approval No.CI-16610)on January 2,2016.

关键词： sleep-deprivation melatonin microRNA neurogenesis Sirtuin 1 SIRT1 methyl-CpG-binding protein 2 MECP2 epigenetic text-mining mir-9 let-7b

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Insular effect on sexual size dimorphism in the clouded anole Anolis nebulosus\when Rensch meets Van Valen

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Current Zoology 2020年第5期66卷 589-591页

作者： Zarem A.Anaya-Meraz Armando H.Escobedo-Galvan Centro Universitario de la Costa Universidad de GuadalajaraAv.Universidad 20348280 Puerto VallartaJaliscoMexico

Insular biodiversity has aroused the curiosity of biologists in assessing ecological and evolutionary hypotheses concerning their mainland counterparts.Comparisons of particular life history traits between island and mainland populations have provided a broader view of phenotypic and behavioral plasticity at both intraspecific and interspecific levels(Meiri 2007).

关键词： mainland island cloud

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Gingival enlargement induced by cyclosporine in Medullary aplasia:A case report

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World Journal of Clinical Cases 2022年第34期10卷 12750-12760页

作者： Giovanna Victory Rodríguez Alondra del Carmen Ruiz Gutiérrez Juan Ramón Gómez Sandoval Sarah Monserrat LomelíMartínez Periodontics Program Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico Research Institute of dentistry Department of Integrated Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340JaliscoMexico department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810JaliscoMexico

BACKGROUND Cyclosporine is an immunosuppressive agent used effectively for treatment of a rare haematological disorder known as medullary aplasia.This drug prevents several side effects,including gingival enlargement(GE)which compromises aesthetics,phonetics and chewing,and also predisposes patients to periodontitis.CASE SUMMARY This clinical case reports a 41-year-old woman who presented with cyclosporineinduced GE with underlying periodontitis and medullary aplasia.The management of the disease was approached through multidisciplinary strategy which allowed for accurate diagnosis and a strategic treatment based on the systemic condition and severity of oral pathology.The diagnosis was confirmed through histopathological analysis.The treatment was carried out in phases:Initial(oral hygiene motivation,mechanical supragingival plaque control,and non-surgical therapy);systemic treatment,corrective treatment,and maintenance.CONCLUSION Multidisciplinary management of cyclosporine-induced GE and medullary aplasia allows for correct diagnosis and effective treatment of this pathological expression through a phased therapeutic approach.

关键词： Cyclosporine Gingival enlargement Medullary aplasia Periodontal surgery Case report

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Microsurgical management of radicular cyst using guided tissue regeneration technique:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1346-1355页

作者： Juan Carlos Gómez Mireles Eugenia Karina Martínez Carrillo Katia Alcalá Barbosa Evangelina Gutiérrez Cortés Javier González Ramos Luis Antonio González Gómez Rubén Alberto Bayardo González Sarah Monserrat Lomelí Martínez Periodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Specialty in Oral Pathology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent Researcher Guadalajara 44340Mexico department of Integral dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

BACKGROUND Radicular cyst is a lesion of odontogenic origin that arises from epithelial remains due to periapical periodontitis caused by inflammatory reactions generated at the apex of affected teeth with infected or necrotic pulps.The therapeutic mana gement of radicular cysts is controversial.There is only one case report of enucleation of a radicular cyst managed with microsurgery and apicoectomy,but without the use of the guided tissue regeneration(GTR)technique in the same surgical procedure.The present clinical case describes the management of a radicular cyst with microsurgical approach,performance of an apicoectomy of the tooth associated with the entity,application of GTR technique,use of a resorbable membrane of type I bovine collagen,and bovine xenograft.CASE SUMMARY A 68-year-old patient presented with a radicular cyst from an upper lateral incisor.The microsurgical management used was aimed at enucleating the chemical membrane,performing apicoectomy of the tooth along with careful and precise retrograde filling,and implementing GTR technique using a resorbable collagen membrane and bovine xenograft.The diagnosis of radicular cyst was confirmed using histopathological analysis.The patient underwent follow-up evaluations at 10 and 30 d postoperatively.At 4 months postoperative evaluation,she remained asymptomatic,and radiographs showed significant periapical healing with adequate bone formation.CONCLUSION These results suggest that microsurgical management using the GTR technique with collagen membrane and xenograft,contributes to bone regeneration.

关键词： Odontogenic cysts Apical periodontal cyst dental root end cyst Case report

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