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Retinal image quality with multifocal,EDoF,and accommodative intraocular lenses as studied by pyramidal aberrometry

Eye and Vision 2021年第6期8卷 374-384页

作者： Jorge L.Alio Francesco D’Oria Francesca Toto Joan Balgos Antonio Palazon Francesco Versaci Jorge L.Alio del Barrio Vissum Innovation AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezVissum Miranzac/Cabañal103016 AlicanteSpain Section of Ophthalmology Department of Basic Medical ScienceNeuroscience and Sense OrgansUniversity of BariBariItaly department of Clinical Medicine Miguel Hernández UniversitySan Juan de AlicanteSpain R&D department Costruzione Strumenti Oftalmici(CSO)FlorenceItaly

Background:To study and compare the clinical optical image quality following implantation with different premium IOLs by analysing the point spread function(PSF)Strehl ratio using a pyramidal wavefront sensor(PWS)-based ***:This study included 194 eyes implanted with:(a)19 AcrySof SA60AT(control group);(b)19 Miniwell;(c)24 LENTIS Mplus LS-313 MF30;(d)33 LENTIS Mplus LS-313 MF15;(e)17 AkkoLens Lumina;(f)31 AT LISA Tri 839MP;(g)20 Precizon Presbyopic;(h)20 AcrySof IQ PanOptix;(i)11 Tecnis *** outcome measures were PSF Strehl ratio,PSF Strehl ratio excluding second-order aberrations(PSFw2),total root mean square(RMS),low-order aberration(LOA)and high-order aberration(HOA)RMS measured by PWS ***:AT LISA Tri had the highest PSFw2 Strehl ratio at both 3.0-and 4.0-mm pupil size(0.52±0.14 and 0.31±0.10;Pde a significantly better retinal image quality than PanOptix at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.004).Mplus MF15 was found to be significantly better than Mplus MF30 at both 3.0 mm(P<0.0001)and 4.0 mm(P=0.002).Total RMS,LOA RMS,HOA RMS,PSF Strehl ratio and PSFw2 varied significantly between the studied groups(P<0.001).Conclusions:Far distance clinical image quality parameters measured by PWS aberrometer differed significantly according to the technology of the implanted *** LISA Tri,SA60AT and PanOptix showed the highest values of far distance retinal image quality,while the lowest PSFw2 Strehl ratios were displayed by Miniwell,Mplus MF30 and Precizon Presbyopic.

关键词： Cataract surgery Pyramidal aberrometry Multifocal IOL Extended depth of focus Accommodative IOL

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Potential of video games for the promotion of neuroadaptation to multifocal intraocular lenses: a narrative review

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International Journal of Ophthalmology(English edition) 2019年第11期12卷 1782-1787页

作者： Maria Begona Coco-Martin Pedro LValenzuela Miguel JMaldonado-López Alejandro Santos-Lozano Ainhoa Molina-Martin David P Pinero Research Unit Hospital Clínico Universitario de Valladolid.ICSCYLValladolid 47003Spain Grupo de Cirugía Refractivay Rehabilitación Visual.Instituto Universitario de Oftalmobiología Aplicada(IOBA) Universidad de ValladolidValladolid 47011Spain Physiology Unit Systems Biology DepartmentUniversity of AlcaláMadrid 28801Spain Grupo de Investigación i+Health Departamento de Ciencias de la SaludUniversidad Europea Miguel de CervantesValladolid 47012Spain department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicante 03690Spain department of Ophthalmology(IMQO-Oftalmar) Vithas Medimar International HospitalAlicante 03016Spain

Multifocal intraocular lenses(IOLs) are currently usually implanted for the treatment of cataracts because they have been proved to be superior to monofocal IOLs with respect to spectacle independence. In turn, they are associated with a higher prevalence of dysphotopsia symptoms that is one of the most common causes of patient dissatisfaction. Neuroadaptation seems to play a major role in the optimal adaptation to multifocal IOLs. In this context, the development of strategies that facilitate the neuroadaptation process to multifocality might be an effective strategy to reduce patients' dissatisfaction. Video games have been proved to be effective for the improvement of visual acuity and for the promotion of neuroplasticity in elderly subjects and other populations with cortical-related visual impairment. This narrative review highlights the physiological potential of video games as a perceptual strategy to improve visual acuity and promote neuroplasticity in patients using multifocalIOLs, although research is still needed to confirm these benefits in this specific population, with only one comparative study to this date providing evidence of them.

关键词： multifocal intraocular lens dysphotopsia photic phenomena halos video games neuroadaptation neuroplasticity

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Does Muller Cell Differentiation Occur Prior to the Emergence of Synapses in Embryonic Turtle Retina？

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Journal of Life Sciences 2012年第11期6卷 1200-1205页

作者： Yolanda Segovia Rosa Maria Perez Norberto Mauricio Grzywacz Joaquin de Juan departamento de Biotecnologia Universidad de Alicante Alicante 03080 Spain departamento de Enfermeria Universidad de Alicante Alicante 03080 Spain department of Biomedical Engineering University of Southern California Los Angeles CA 90089-111 USA

Müller cells are the main glial cells in the retina, and are related to plexiform layer activity. Recent studies have demonstrated that Müller cells are involved in the synaptic conservation, plasticity, development and metabolism of glutamate. During turtle retinal development, layers, cells and synapses appear at different times. The aim of this research is to study the emergence of Müller cells during embryonic development and their relationship with the synaptogenesis. The authors used retinas from embryos at stages S14, 18, 20, 23, and 26. Some retinas were processed with immunocytochemistry in order to detect the presence of glutamine synthetase in Müller cells, which was used as a marker of these cells. Other retinas from the same stages were processed for ultrastructural studies. Samples were observed in confocal and transmission electron microscopes, respectively. The present results show that glutamine synthetase expression in Müller cells occurs at S18, before the emergence of the retinal layers and the early synapses.

关键词：神经胶质细胞黄缘闭壳龟神经突触胚胎发育视网膜谷氨酰胺合成酶电子显微镜观察分化

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Refractive lens exchange in modern practice: when and when not to do it?

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Eye and Vision 2014年第1期1卷 59-71页

作者： Jorge L Alió Andrzej Grzybowski Dorota Romaniuk Vissum Corporation AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain department of Ophthalmology Poznan City HospitalPoznańPoland Chair of Ophthalmology University of Warmia and MazuryOlsztynPoland Clinical department of Ophthalmology Silesian University of MedicineKatowicePoland Avda de denia s/n Edificio Vissum03016 AlicanteSpain

Cataract surgery due to advances in small incision surgery evolved from a procedure concerned with the primary focus on the safe removal of cataractous lens to a procedure focused on the best possible postoperative refractive *** the outcomes of cataract surgery became better,the use of lens surgery as a refractive modality in patients without cataracts has increased in interest and in *** of the crystalline lens for refractive purposes or refractive lens exchange(RLE)presents several advantages over corneal refractive *** with high degrees of myopia,hyperopia and astigmatism are still not good candidates for laser ***,presbyopia can currently only be corrected with monovision or reading *** supplemented with multifocal or accommodating intraocular lenses(IOLs)in combination with corneal astigmatic procedures might address all refractive errors including presbyopia,and eliminate the future need for cataract surgery.

关键词： Refractive lens exchange Clear lens exchange Refractive surgery Lens surgery Ophthalmology Eye surgery

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Community‑based screening of Chagas disease among Latin American migrants in a non‑endemic country: an observational study

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Infectious Diseases of Poverty 2021年第5期10卷 14-27页

作者： Violeta Ramos‑Sesma Miriam Navarro Jara Llenas‑García Concepción Gil‑Anguita Diego Torrus‑Tendero Philip Wikman‑Jorgensen María García‑López Concepción Amador‑Prous María‑Paz Ventero‑Martín Pedro Guevara‑Hernández Ana Garijo‑Saiz Ares Sanchez‑Sanchez Cristina Bernal‑Alcaraz Ana‑Isabel Pujades‑Tarraga Roser Muñoz‑Perez María Flores‑Chávez José‑Manuel Ramos‑Rincón Internal Medicine Service HLA Inmaculada HospitalGranadaSpain Public Health Science History and Gynecology DepartmentUniversidad Miguel Hernández de ElcheAlicanteSpain Epidemiology Unit Public Health Center of Elche AlicanteSpain Internal Medicine department Hospital Vega Baja de Orihuela(AlicanteSpain)-Foundation for the Promotion of Health and Biomedical Research of the Valencia Region(FISABIO)AlicanteSpain Clinical Medicine department University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal Medicine department Hospital Marina BaixaLa Vila Joiosa(AlicanteSpain)-FISABIOAlicanteSpain Internal Medicine department General University Hospital of Alicante–Biomedical and Health Research Institute of Alicante(ISABIAL)AlicanteSpain Parasitology Area University Miguel Hernández of ElcheSant Joan d’AlacantSpain Internal Medicine department University Hospital of Sant Joan(Sant Joan d’AlacantSpain)–FISABIOAlicanteSpain Microbiology Service General University Hospital of Alicante–ISABIALAlicanteSpain Pediatric department General University Hospital of Alicante–ISABIALAlicanteSpain Digestive Service General University Hospital of Alicante–ISABIALAlicanteSpain Reference and Research Laboratory in Parasitology National Center of Microbiology/Mundo Sano FoundationMadridSpain

Background:Chagas disease is a parasitic disease endemic to Latin America,but it has become a disease of global concern due to migration *** carriers may host the parasite for years,without knowing they are *** aim of this study is to assess prevalence of Chagas disease and evaluate the participants’level of knowl‑edge between Latin American migrants attending a community-based screening ***:Three community-based campaigns were performed in alicante(Spain)in 2016,2017 and 2018,including educational chats and blood tests for Trypanosoma cruzi *** completed a questionnaire assessing knowledge about the mechanisms of transmission,disease presentation,diagnosis,and *** seroposi‑tive for *** underwent diagnostic confrmation by two diferent *** were analyzed by multivariable logistic regression and expressed as adjusted odds ratios(aORs),adjusting for age,sex,and time in ***:A total of 596 participants were included in the study;17%were aged under 18 *** in adults was 11%[54/496;95%confdence interval(CI):8.3–14.5%]versus 0%among *** but one case were in *** was independently associated with having been born in Bolivia(aOR:102,95%CI:13–781)and a primary school-level education(aOR:2.40,95%CI:1.14–5.06).Of 54 people diagnosed with Chagas disease(most of whom were asymptomatic),42(77.7%)returned to the clinic at least once,and 24(44.4%)received *** analysis showed that coming from Argentina(aOR:13,95%CI:1.61–1188)or Bolivia(aOR:1.90,95%CI:1.19–3.39)and having received information about Chagas disease in Spain(aOR:4.63,95%CI:2.54–8.97)were associ‑ated with a good level of knowledge on the *** primary level studies(aOR:0.59,95%CI:0.34–0.98)and coming from Ecuador(aOR:4.63,95%CI:2.52–847)were independently associated with a lower level of ***:Community-based interventions are a good strategy for diagnosi

关键词： Chagas disease Trypanosoma cruzi Knowledge Community-based intervention Migrant Early diagnosis Screening

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打破干旱区土地退化与贫困的联结

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Science Bulletin 2022年第24期67卷 2508-2512页

作者：吕楠傅伯杰 Mark Stafford-Smith Fernando T.Maestre 程临海 State Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China University of Chinese Academy of Sciences Beijing 100049China CSIRO Land&Water Canberra ACT 2601Australia department of Ecology University of AlicanteCarretera de San Vicente del RaspeigAlicante 03690Spain Multidisciplinary Institute for Environment Studies“Ramon Margalef” University of AlicanteCarretera de San Vicente del RaspeigAlicante 03690Spain

Drylands cover approximately 41%of the global land surface and provide homes to more than two billion people. Collectively,drylands constitute the largest terrestrial biome on the planet,and despite their low productivity per land area compared to other ecosystems, they have a major impact on the ecological functioning and climate of our planet through carbon storage, albedo, dust production, and water cycling [1].

关键词： planet 土地退化 cycling

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Clinical outcomes with a newvdesign in multifocal intraocular lens:a pilot study

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Eye and Vision 2022年第5期8卷 13-21页

作者： Jorge L.Alio Pilar Yébana Mario Canto Ana B.Plaza Alfredo Vega Jorge L.Alio del Barrio Francisco Lugo Vissum Corporation Avda de Denia s/nEdificio Vissum03016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernandezAlicanteSpain

Purpose:To evaluate the clinical and visual outcomes,quality of near vision and the influence of photic phenomena in patients bilaterally implanted with a new Precizon Presbyopic multifocal intraocular lens(IOL).Methods:In this prospective consecutive case series,20 eyes of 10 patients were included(mean age 63.80±12.55 years).Uncorrected and corrected visual acuity(far,intermediate and near),subjective refraction,binocular defocus curve,contrast sensitivity(CSV-1000)and quality of vision and satisfaction questionnaires were *** follow-up was 12 months after ***:At 12 months after surgery,uncorrected distance visual acuity(UDVA)improved with surgery(P=0.001)with a value of 0.08±0.08 *** near visual acuity(UNVA)was 0.22±0.12 logMAR and distance corrected near visual acuity(DCNVA)was 0.16±0.13 *** distance visual acuity(UIVA)was 0.22±0.10 *** sensitivity outcomes were similar to normal population in photopic conditions and slightly reduced in mesopic conditions of *** curve showed that this multifocal iOL was able to provide a visual acuity(VA)equal to or better than 0.16 logMAR between defocus levels of+1.00 to-2.50 *** patient satisfaction was obtained in quality of vision and satisfaction questionnaires ***:The Precizon Presbyopic NVA IOL(OPHTEC BV)provides good visual *** multifocal IOL provides a high percentage of spectacle independence due to good VA at far,intermediate and near distances and satisfactory contrast *** patient satisfaction was observed in quality of vision and satisfaction questionnaires with a low percentage of patients manifesting photic phenomena.

关键词： Multifocal intraocular lens Near vision Photic phenomena Continuous transitional focus

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Approximating Ordinary Differential Equations by Means of the Chess Game Moves

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Journal of Applied Mathematics and Physics 2022年第10期10卷 3240-3263页

作者： Maria Teresa Signes-Pont Joan Boters-Pitarch José Juan Cortés-Plana Higinio Mora-Mora department of Computer Science and Technology University of Alicante Alicante Spain

The chess game provides a very rich experience in neighborhood types. The chess pieces have vertical, horizontal, diagonal, up/down or combined movements on one or many squares of the chess. These movements can associate with neighborhoods. Our work aims to set a behavioral approximation between calculations carried out by means of traditional computation tools such as ordinary differential equations (Odes) and the evolution of the value of the cells caused by the chess game moves. Our proposal is based on a grid. The cells’ value changes as time pass depending on both their neighborhood and an update rule. This framework succeeds in applying real data matching in the cases of the Odes used in compartmental models of disease expansion, such as the well-known Susceptible-Infected Recovered (SIR) model and its derivatives, as well as in the case of population dynamics in competition for resources, depicted by the Lotke-Volterra model.

关键词： Chess Game Neighborhood Update Rule Ode SIR Model Lotke-Volterra Model

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Corneal transplantation outcomes after the extrusion of an intrastromal keratoprosthesis:a pilot study

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Eye and Vision 2020年第2期7卷 250-254页

作者： Chiara Fariselli Ibrahim Toprak Olena Al-Shymali Jorge L.Alio del Barrio Jorge L.Alio Research and development department Calle Cabañal1 Edificio Vissum03016 AlicanteSpain department of Ophthalmology Pamukkale UniversityDenizliTurkey Cornea and Refractive Surgery department Calle Cabañal1 Edificio Vissum03016 AlicanteSpain Division of Ophthalmology Universidad Miguel HernándezAlicanteSpain

This short report includes 5 eyes of 5 patients(mean age 63.2±12 years)who underwent a tectonic keratoplasty[deep anterior lamellar keratoplasty(DALK)or penetrating keratoplasty(PK)]in order to rehabilitate the eye after the extrusion of the non-perforating keratoprosthesis(Kpro)KeraKlear(KeraMed,USA).The non-perforating Kpro was extruded after a mean period of 21.4±21.8 months due to *** two cases,the keratoplasty was performed the same day of the non-perforating Kpro removal due to a severe melting,while in the other three cases it was performed one to 3 months *** eyes received a DALK,but in 3 eyes a macroscopic descemet membrane perforation forced the conversion into a *** mean follow-up period after the keratoplasty was 16.8±6.6 *** cases of rejection were *** the 5 eyes achieved“anatomical success”(transparent graft,with no signs of infection or inflammation).Two eyes showed limited“functional success”because the achievement of the best visual potential was prevented by the development of glaucomatous optic atrophy during the follow-up *** conclusion,this short report presents an unexpected success of a keratoplasty performed with a tectonic purpose after the extrusion of the non-perforating Kpro because the corneal graft remained transparent,without neovascularization or scarring during the follow-up *** initial evidence shows some encouraging results regarding graft survival rate and the achievement of a useful visual rehabilitation with keratoplasty after a nonperforating Kpro failure instead of repeating the Kpro implantation.

关键词： Keratoprosthesis Extrusion Keratoplasty Corneal transplantation

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Topography versus non-topography-guided photorefractive keratectomy with corneal cross-linking variations in keratoconus

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International Journal of Ophthalmology(English edition) 2022年第5期15卷 721-727页

作者： Sana Niazi Jorge Alio del Barrio Azad Sanginabadi Farideh Doroodgar Cyrus Alinia Alireza Baradaran-Rafii Feaizollah Niazi Hossein Mohammad-Rabei Mohammad Mehdi Sadoughi Jorge L.Alio department of Ophthalmology Shahid Beheshti University of Medical SciencesTehran 3113Iran Vissum Alicante 03016Spain Division of Ophthalmology Universidad Miguel HernándezAlicante 03016Spain department of Optometry Iran University of Medical SciencesTehran 4599Iran Negah Specialty Ophthalmic Research Center Shahid Beheshti University of Medical ScienceTehran 4599Iran department of Public Health School of Public HealthUrmia University of Medical SciencesUrmiaWest Azerbaijan 3734Iran department of ophthalmology University of South FloridaTampaFlorida 33617USA

AIM:To compare the visual results of non-topographyguided and topography-guided photorefractive keratectomy(PRK)applying sequential and simultaneous corneal crosslinking(CXL)treatment for ***:Interventional and comparative prospective ***-nine eyes(36 patients)suffering from keratoconus(stages 1 Amsler-Krumeich classification)were divided into four groups:sequential topography-guided photorefractive keratectomy with CXL,simultaneous topography-guided photorefractive keratectomy with CXL,simultaneous nontopography guided photorefractive keratectomy with CXL,and sequential non-topography guided photorefractive keratectomy with *** main outcome measures were pre-and postoperative uncorrected distance visual acuity(UDVA),best corrected distance visual acuity(CDVA),manifest refraction,contrast sensitivity,and ***:All analyzed visual,contrast sensitivity,and refractive parameters showed a significant improvement in the four groups(all Pded groups in comparison to non-topography-guided groups(Pdegree of stability to the end of the ***:The treatment priorities in all four groups are safety,efficacy,and predictability in the correction of the sphero-cylindrical errors in mild and moderate *** significant differences among groups in the recorded objective outcomes were found.

关键词： photorefractive keratectomy corneal collagen cross-linking keratoconus

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