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Energy Management Control StraEnergy Management Control Strategy for Renewable Energy System Based on Spotted Hyena Optimizertegy for Renewable Energy System Based on Spotted Hyena Optimizer

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Computers, Materials & Continua 2021年第5期 2271-2281页

作者： Hegazy Rezk Ahmed Fathy Mokhtar Aly Mohamed N.Ibrahim College of Engineering at Wadi Addawaser Prince Sattam Bin Abdulaziz UniversityWadi Addawaser11991Saudi Arabia Electrical Engineering Department Faculty of EngineeringMinia UniversityMinia61111Egypt Electrical Engineering Department Faculty of EngineeringJouf UniversitySakakaSaudi Arabia Electrical Power and Machine Department Faculty of EngineeringZagazig UniversityZagazigEgypt Department of Electrical Engineering Aswan UniversityAswan81542Egypt Electronics Engineering Department Universidad Tecnica Federico Santa MariaValparaiso2390123Chile Department of Electromechanical Systems and Metal EngineeringGhent UniversityGhent9000Belgium FlandersMake@UGent–corelab EEDt-MP 3001LeuvenBelgium Electrical Engineering Department Kafrelshiekh UniversityKafr el-Sheikh33511Egypt

Hydrocarbons,carbon monoxide and other pollutants from the transportation sector harm human health in many *** cell(FC)has been evolving rapidly over the past two decades due to its efficient mechanism to transform the chemical energy in hydrogen-rich compounds into electrical *** main drawback of the standalone FC is its slow dynamic response and its inability to supply rapid variations in the load ***,adding energy storage systems is ***,to manage and distribute the power-sharing among the hybrid proton exchange membrane(PEM)fuel cell(FC),battery storage(BS),and supercapacitor(SC),an energy management strategy(EMS)is *** this research work,an optimal EMS based on a spotted hyena optimizer(SHO)for hybrid PEM fuel cell/BS/SC is *** main goal of an EMS is to improve the performance of hybrid FC/BS/SC and to reduce the amount of hydrogen *** prove the superiority of the SHO method,the obtained results are compared with the chimp optimizer(CO),the artificial ecosystem-based optimizer(AEO),the seagull optimization algorithm(SOA),the sooty tern optimization algorithm(StOA),and the coyote optimization algorithm(COA).two main metrics are used as a benchmark for the comparison:the minimum consumed hydrogen and the efficiency of the *** main findings confirm that the minimum amount of hydrogen consumption and maximum efficiency are achieved by the proposed SHO based EMS.

关键词： Modelling optimization energy management fuel cell supercapacitor hybrid system

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Chlamydial infections in urological disease: A challenging management

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World Journal of Clinical Urology 2014年第1期3卷 38-43页

作者： tommaso Cai Paolo Verze Sandra Mazzoli Francesca Pisano Daniele tiscione Paolo Gontero Vincenzo Mirone Riccardo Bartoletti Department of Urology Santa Chiara Regional Hospital Department of Urology University of Federico II Sexually transmitted Diseases (StD) Centre Santa Maria Annunziata Hospital Department of Urology University of Turin Department of Urology University of Florence

Chlamydia trachomatis(Ct) infections are the most prevalent sexually transmitted bacterial infections worldwide, causing considerable morbidity and socioeconomic problems. Moreover, Ct infections are asymptomatic in approximately 50% of infected men and 70% of infected women, with the risk for reproductive tract sequelae both in women and men. Recent studies have improved the comprehension of this infection and its natural history, also highlighting its role in decreasing male fertility. Severe complications can be avoided only by a proper early diagnosis and appropriate treatment. We reviewed the literature relating to the new findings in the treatment of Ct infection in sexually active young men. Articles from 1960-2012 were identified through a Medline search using the keywords"Chlamydia trachomatis " combined with "urethritis", "epididymitis", "prostatitis", "treatment" or "management". Currently, several studies have been published about the role of new antibiotic schedules and new associated compounds in order to improve the efficacy in terms of microbiological results and patient quality of life. In particular, several studies stress the fact that Chlamydia is only metabolically active in the host cell and therefore only targeted intracellularly by antibiotics. Even although the standard therapy includes intracellularly-accumulated antibiotics such as tetracyclines or macrolides, recent evidence highlights the role of quinolones. In particular, recent studies highlight the role of prulifloxacin in the treatment of chronic prostatitis for improving the patient's quality of life and decreasing the IL-8 level. However, future studies should focus on delineating the natural history of recurrent infections, paying particular attention to treatment failures.

关键词： Chlamydia trachomatis Prostate Male Fertility treatment Review

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Predictive factors of short term outcome after liver transplantation: A review

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World Journal of Gastroenterology 2016年第26期22卷 5936-5949页

作者： Giuliano Bolondi federico Mocchegiani Roberto Montalti Daniele Nicolini Marco Vivarelli Lesley De Pietri Anaesthesiology Intensive Care and Pain Therapy Medical Residency University of Modena and Reggio Emilia Division of Hepatobiliary and transplant Surgery Department of Experimental Medicine Polytechnic University of Marche Division of Anaesthesiology and Intensive Care Unit Department of Cardiology Thoracic and Vascular Surgery Critical Care Medicine Arcispedale Santa Maria Nuova-IRCCS

Liver transplantation represents a fundamental therapeutic solution to end-stage liver disease. the need for liver allografts has extended the set of criteria for organ acceptability, increasing the risk of adverse outcomes. Little is known about the early postoperative parameters that can be used as valid predictive indices for early graft function, retransplantation or surgical reintervention, secondary complications, long intensive care unit stay or death. In this review, we present state-of-the-art knowledge regarding the early post-transplantation tests and scores that can be applied during the first postoperative week to predict liver allograft function and patient outcome, thereby guiding the therapeutic and surgical decisions of the medical staff. Post-transplant clinical and biochemical assessment of patients through laboratory tests (platelet count, transaminase and bilirubin levels, INR, factor V, lactates, and Insulin Growth Factor 1) and scores (model for end-stage liver disease, acute physiology and chronic health evaluation, sequential organ failure assessment and model of early allograft function) have been reported to have good performance, but they only allow late evaluation of patient status and graft function, requiring days to be quantified. the indocyanine green plasma disappearance rate has long been used as a liver function assessment technique and has produced interesting, although not univocal, results when performed between the 1th and the 5th day after transplantation. the liver maximal function capacity test is a promising method of metabolic liver activity assessment, but its use is limited by economic cost and extrahepatic factors. to date, a consensual definition of early allograft dysfunction and the integration and validation of the above-mentioned techniques, through the development of numerically consistent multicentric prospective randomised trials, are necessary. the medical and surgical management of trans

关键词： Liver transplant Liver failure Early allograft dysfunction Primary non-function Initial poor function Outcome predictors Post operative Scoring system Indocyanine green Liver maximal functional capacity

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Urinary polyomavirus infections in neurodevelopmental disorders

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Open Journal of Psychiatry 2013年第2期3卷 18-25页

作者： Ivan Gentile Laura Altieri Carla Lintas Roberto Sacco Paolo Curatolo Arianna Benvenuto Filippo Muratori Elisa Santocchi Carmela Bravaccio Carlo Lenti Raffaella Faggioli Roberto Rigardetto Marina Gandione Giuseppe Portella Emanuela Zappulo Guglielmo Borgia Antonio M. Persico Department of Child Neurology and Psychiatry I.R.C.C.S. “Stella Maris” University of Pisa Pisa Italy Department of Child Neuropsychiatry University “Tor Vergata” Rome Italy Department of Child Neuropsychiatry University of Milan Italy Department of Child Neuropsychiatry University of Turin Turin Italy Department of Clinical Medicine and Surgery University of Naples “Federico II” Naples Italy Department of Experimental Neurosciences I.R.C.C.S. “Fondazione Santa Lucia” Rome Italy Department of translational Medical Science University “Federico II” Naples Italy Fondazione teda per l’Autismo ONLUS Turin Italy Mafalda Luce Center for Pervasive Developmental Disorders Milan Italy Unit of Child and Adolescent Neuropsychiatry Laboratory of Molecular Psychiatry and Neurogenetics University “Campus Bio- Medico” Rome Italy

We have recently reported enhanced frequencies of polyomavirus infection in post-mortem brain tissue of autistic patients compared to controls. to further explore potential contributions to neurodevelopmental disorders by polyomaviruses, we have employed specie-specific taqMan assays to assess the prevalence and titres of BKV, JCV and SV40 inthe urines of 87 patients with autism spectrum disorder, 84 controls matched by sex and age with the autistic sample, 15 subjects with Down syndrome and 13 fragile X individuals. Prevalence rates of urinary BKV infection were significantly greater in Down syndrome and fragile X patients compared to autistic and control individuals (P ty of patients who showed the presence of urinary genomes, viral titres resulted significantly higher among Down syndrome patients (P to controls, autism spectrum disorder and fragile X individuals, who did not significantly differ from each other. Our results are consistent with previous evidence supporting hampered immunological surveillance and/or immune deficits in fragile X and especially in Down syndrome patients.

关键词： Autism BKV Down Syndrome Fragile X Syndrome JCV SV40

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Intermediate-advanced hepatocellular carcinoma in Argentina:treatment and survival analysis

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World Journal of Gastroenterology 2019年第27期25卷 3607-3618页

作者： federico Pinero Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Gustavo Romero Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva Hospital Universitario Austral Facultad de Ciencias BiomédicasUniversidad AustralBuenos Aires B1629HJArgentina Latin American Liver Research Educational and Awareness Network(LALREAN) Buenos Aires B1629HJArgentina Hospital Italiano de Buenos Cuidad Autónoma de Buenos AiresBuenos Aires C1424BYEArgentina Hospital Británico Cuidad Autonoma de Buenos AiresBuenos Aires C1280AEBArgentina Hospital G Rawson San Juan 5400Argentina Hospital Aleman Cuidad Autonoma de Buenos AiresBuenos Aires C1280AEBArgentina Sanatorio Allende from Córdoba Córdoba 5016Argentina Centro de Educación Médica e Investigaciones Clínicas“Norberto Quirno”(CEMIC) Ciudad de Buenos Aires 1431Argentina Hospital Udaondo Cuidad Autonoma de Buenos Aires C1264AAAArgentina Hospital Ramos Mejía Ciudad de Buenos Aires C1221ADCArgentina Centro Especialidades Medicas Ambulatorias(CEMA) Mar del PlataBuenos Aires 7600Argentina Clínica de Nefrología Santa Fe 3000Argentina Hospital del Centenario RosarioSanta Fe S2002KDTArgentina

BACKGROUND Hepatocellular carcinoma(HCC) represents the sixteenth most frequent cancer in Argentina. the rise of new therapeutic modalities in intermediate-advanced HCC opens up a new paradigm for the treatment of *** to describe real-life treatments performed in patients with intermediateadvanced HCC before the approval of new systemic *** this longitudinal observational cohort study was conducted between 2009 and2016 in 14 different regional hospitals from Argentina. Included subjects had intermediate-advanced Barcelona Clinic Liver Cancer(BCLC) HCC stages(BCLC B to D). Primary end point analyzed was survival, which was assessed for each BCLC stage from the date of treatment until last patient follow-up or *** Meier survival curves and Cox regression analysis were performed, with hazard ratios(HR) calculations and 95% confidence intervals(95%CI).RESULtS From 327 HCC patients, 41% were BCLC stage B, 20% stage C and 39% stage *** median survival were 15 mo(IQR 5-26 mo), 5 mo(IQR 2-13 mo)and 3 mo(IQR 1-13 mo)(P tively. Among BCLC-B patients(n =135), 57% received tACE with a median number of 2 sessions(IQR 1-3 sessions).Survival was significantly better in BCLC-B patients treated with tACE HR =0.29(CI: 0.21-0.40) than those without tACE. After tumor reassessment by RECISt 1.1 criteria following the first tACE, patients with complete response achieved longer survival (HR = 0.15(CI: 0.04-0.56, P = 0.005))Eighty-two patients were treated with sorafenib, mostly BCLC-B and C(87.8%). However,12.2% were BCLC-D. Median survival with sorafenib was 4.5 mo(IQR 2.3-11.7 mo);which was lower among BCLC-D patients 3.2 mo(IQR 2.0-14.1 mo). A total of 36 BCLC-B patients presented tumor progression after tACE. In these patients,treatment with sorafenib presented better survival when compared to those patients who received sorafenib without prior tACE [HR = 0.26(CI: 0.09-0.71);P= 0.013].CONCLUSION In this real setting, our results we

关键词： Hepatocellular carcinoma therapeutics Survival Real-life

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transoesophageal echocardiography during liver transplantation

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World Journal of Hepatology 2015年第23期7卷 2432-2448页

作者： Lesley De Pietri federico Mocchegiani Chiara Leuzzi Roberto Montalti Marco Vivarelli Vanni Agnoletti Division of Anaesthesiology and Intensive Care Unit Azienda Ospedaliero-Universitaria di Modena-Policlinico transplantation Unit Polytechnic University of Marche Unit of Interventional Cardiology Arcispedale Santa Maria Nuova IRCCS Division of Anaesthesiology and Intensive Care Unit Arcispedale Santa Maria Nuova IRCCS

Liver transplantation(Lt) has become the standard of care for patients with end stage liver disease. the allocation of organs, which prioritizes the sickest patients, has made the management of liver trans-plant candidates more complex both as regards their comorbidities and their higher risk of perioperative complications. Patients undergoing Lt frequently display considerable physiological changes during the pro-cedures as a result of both the disease process and the surgery. transoesophageal echocardiography(tEE), which visualizes dynamic cardiac function and overall contractility, has become essential for perioperative Lt management and can optimize the anaesthetic management of these highly complex patients. More-over, tEE can provide useful information on volume status and the adequacy of therapeutic interventions and can diagnose early intraoperative complications, such as the embolization of large vessels or development of pulmonary hypertension. In this review, directed at clinicians who manage tEE during Lt, we show why the procedure merits a place in challenging anaesthetic environment and how it can provide essential information in the perioperative management of compromised patients undergoing this very complex surgical procedure.

关键词： Liver transplantation transoesophageal echocardiog

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Feasibility and physics potential of detecting ^(8)B solar neutrinos at JUNO

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Chinese Physics C 2021年第2期45卷 93-110页

作者： Angel Abusleme thomas Adam Shakeel Ahmad Sebastiano Aiello Muhammad Akram Nawab Ali Fengpeng An Guangpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Andrej Babic Wander Baldini Andrea Barresi Eric Baussan Marco Bellato Antonio Bergnoli Enrico Bernieri David Biare thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Max Buesken Mario Buscemi Jose Busto Ilya Butorov Anatael Cabrera Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Jinfan Chang Yun Chang Pingping Chen Po-An Chen Shaomin Chen Shenjian Chen Xurong Chen Yi-Wen Chen Yixue Chen Yu Chen Zhang Chen Jie Cheng Yaping Cheng Alexander Chepurnov Davide Chiesa Pietro Chimenti Artem Chukanov Anna Chuvashova Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Salvatore Costa Flavio Dal Corso Christophe De La taille Jiawei Deng Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky tadeas Dohnal Georgy Donchenko Jianmeng Dong Damien Dornic Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Shuxian Du Stefano Dusini Martin Dvorak timo Enqvist Heike Enzmann Andrea Fabbri Lukas Fajt Donghua Fan Lei Fan Can Fang Jian Fang Marco Fargetta Anna Fatkina Dmitry Fedoseev Vladko Fekete Li-Cheng Feng Qichun Feng Richard Ford Andrey Formozov Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Alexandre Göttel Christoph Genster Marco Giammarchi Agnese Giaz Nunzio Giudice Franco Giuliani Maxim Gonchar Guanghua Gong Hui Gong Oleg Gorchakov Yuri Gornushkin Marco Grassi Christian Grewing Maxim Gromov Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Nunzio Guardone Maria Gul Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yan Yerevan Physics Institute YerevanArmenia UniversitéLibre de Bruxelles BrusselsBelgium universidade Estadual de Londrina LondrinaBrazil Pontificia universidade Catolica do Rio de Janeiro RioBrazil Pontificia universidad Católica de Chile SantiagoChile universidad tecnica federico santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of technology HarbinChina University of Science and technology of China HefeiChina the Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi’an Jiaotong University Xi’anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhouChina Institute of Physics National Chiao-tung University Hsinchu National United University Miao-Li Department of Physics National T

the Jiangmen Underground Neutrino Observatory(JUNO)features a 20 kt multi-purpose underground liquid scintillator sphere as its main *** of JUNO's features make it an excellent location for^8B solar neutrino measurements,such as its low-energy threshold,high energy resolution compared with water Cherenkov detectors,and much larger target mass compared with previous liquid scintillator *** this paper,we present a comprehensive assessment of JUNO's potential for detecting^8B solar neutrinos via the neutrino-electron elastic scattering process.A reduced 2 MeV threshold for the recoil electron energy is found to be achievable,assuming that the intrinsic radioactive background^(238)U and^(232)th in the liquid scintillator can be controlled to 10^(-17)g/*** ten years of data acquisition,approximately 60,000 signal and 30,000 background events are *** large sample will enable an examination of the distortion of the recoil electron spectrum that is dominated by the neutrino flavor transformation in the dense solar matter,which will shed new light on the inconsistency between the measured electron spectra and the predictions of the standard three-flavor neutrino oscillation *** m^(2)_(21)=4.8times10^(-5);(7.5times10^(-5))eV^(2),JUNO can provide evidence of neutrino oscillation in the Earth at approximately the 3sigma(2sigma)level by measuring the non-zero signal rate variation with respect to the solar zenith ***,JUNO can simultaneously measureDelta m^2_(21)using^8B solar neutrinos to a precision of 20% or better,depending on the central value,and to sub-percent precision using reactor antineutrinos.A comparison of these two measurements from the same detector will help understand the current mild inconsistency between the value of Delta m^2_(21)reported by solar neutrino experiments and the KamLAND experiment.

关键词： neutrino oscillation solar neutrino JUNO

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Changing trends in corneal graft surgery： a ten-year review

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 48-52页

作者： Ugo de Sanctis camilla alovisi Luigi Bauchiero Guido Caramello Gianfranco Girotto Claudio Panico Luisa Vinai federico Genzano Antonio Amoroso federico grignolo Department of Surgical Sciences Eye Clinic University of Turin Turin 10121 Italy Ophthalmic Unit Hospital of Ivrea Ivrea 10015 Italy Ophthalmic Unit Hospital Santa Croce e Carle Cuneo 12100 Italy Unit for Ocular trauma Turin Eye Hospital Turin 10121Italy Eye Bank of Piedmont Citta della Salute Turin 10126 Italy Department of Medical Sciences University of Turin Turin 10126 Italy

AIM：to review indications and corneal tissue use for penetrating and lamellar surgery between 2002 and 2011.·MEtHODS：the surgical reports of corneal grafts performed during 2002-2011,using tissues supplied by the Eye Bank of Piedmont（Italy）,were reviewed *** demographic data,date of intervention,indication for surgery,and surgical technique used were *** techniques included penetrating keratoplasty（PK）,deep anterior lamellar keratoplasty（DALK）and endothelial keratoplasty（EK）.the2test was used to compare the distribution of indications and types of surgical technique used,for corneal grafts done during 2002-2006 versus those done during 2007-2011.·RESULtS：the number of corneal grafts increased by30.7%from 2002-2006 to 2007-2011（from 1567 to 2048）.Comparing the two periods,both main indications and surgical techniques changed *** 2007-2011,the proportion of interventions for aphakic/pseudophakic bollous keratopathy（from 16.8%to 21.3%）,graft failure（from 16.4%to 19.1%）and Fuchs endothelial dystrophy（from 12.8%to 16.7%）all increased significantly（〈0.05）,while those for keratoconus decreased significantly（from35.6%to 27.3%;〈0.001）.In 2007-2011,the proportion of PK decreased significantly（from 92.4%to 57.2%;〈0.001）while that of EK and DALK went from 0.4%to48 30.2%（〈0.001）and from 7.2%to 12.6%（〈0.001）respectively.·CONCLUSION：During 2002-2011 the number of interventions increased significantly for corneal endothelial diseases and graft *** growing demand for interventions for these diseases corresponded to the widespread adoption of EK *** use of DALK also increased,but more moderately than EK procedures.

关键词： indications for corneal graft lamellarkeratoplasty penetrating keratoplasty

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Sub-percent precision measurement of neutrino oscillation parameters with JUNO

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Chinese Physics C 2022年第12期46卷 28-49页

作者： Angel Abusleme thomas Adam Shakeel Ahmad Rizwan Ahmed Sebastiano Aiello Muhammad Akram Abid Aleem Fengpeng An Qi An Giuseppe Andronico Nikolay Anfimov Vito Antonelli tatiana Antoshkina Burin Asavapibhop João Pedro Athayde Marcondes de André Didier Auguste Weidong Bai Nikita Balashov Wander Baldini Andrea Barresi Davide Basilico Eric Baussan Marco Bellato Antonio Bergnoli thilo Birkenfeld Sylvie Blin David Blum Simon Blyth Anastasia Bolshakova Mathieu Bongrand Clément Bordereau Dominique Breton Augusto Brigatti Riccardo Brugnera Riccardo Bruno Antonio Budano Jose Busto Ilya Butorov Anatael Cabrera Barbara Caccianiga Hao Cai Xiao Cai Yanke Cai Zhiyan Cai Riccardo Callegari Antonio Cammi Agustin Campeny Chuanya Cao Guofu Cao Jun Cao Rossella Caruso Cédric Cerna Chi Chan Jinfan Chang Yun Chang Guoming Chen Pingping Chen Po-An Chen Shaomin Chen Xurong Chen Yixue Chen Yu Chen Zhiyuan Chen Zikang Chen Jie Cheng Yaping Cheng Yu Chin Cheng Alexey Chetverikov Davide Chiesa Pietro Chimenti Artem Chukanov Gérard Claverie Catia Clementi Barbara Clerbaux Selma Conforti Di Lorenzo Daniele Corti Flavio Dal Corso Olivia Dalager Christophe De La taille Zhi Deng Ziyan Deng Wilfried Depnering Marco Diaz Xuefeng Ding Yayun Ding Bayu Dirgantara Sergey Dmitrievsky tadeas Dohnal Dmitry Dolzhikov Georgy Donchenko Jianmeng Dong Evgeny Doroshkevich Marcos Dracos Frédéric Druillole Ran Du Shuxian Du Stefano Dusini Martin Dvorak timo Enqvist Heike Enzmann Andrea Fabbri Donghua Fan Lei Fan Jian Fang Wenxing Fang Marco Fargetta Dmitry Fedoseev Zhengyong Fei Li-Cheng Feng Qichun Feng Richard Ford Amélie Fournier Haonan Gan Feng Gao Alberto Garfagnini Arsenii Gavrikov Marco Giammarchi Nunzio Giudice Maxim Gonchar Guanghua Gong Hui Gong Yuri Gornushkin Alexandre Göttel Marco Grassi Vasily Gromov Minghao Gu Xiaofei Gu Yu Gu Mengyun Guan Yuduo Guan Nunzio Guardone Cong Guo Jingyuan Guo Wanlei Guo Xinheng Guo Yuhang Guo Paul Hackspacher Caren Hagner Ran Han Yang Han Miao He Wei He tobias Heinz Patrick Hellmuth Yuekun Heng Rafael Herrera YuenKeung Ho Yerevan Physics Institute YerevanArmenia UniversiéLibre de Bruxelles BrusselsBelgium universidade Estadual de Londrina LondrinaBrazil Pontificia universidade Catolica do Rio de Janeiro Rio de JaneiroBrazil Pontificia universidad Católica de Chile SantiagoChile universidad tecnica federico santa Maria ValparaisoChile Beijing Institute of Spacecraft Environment Engineering BeijingChina Beijing Normal University BeijingChina China Institute of Atomic Energy BeijingChina Institute of High Energy Physics BeijingChina North China Electric Power University BeijingChina School of Physics Peking UniversityBeijingChina tsinghua University BeijingChina University of Chinese Academy of Sciences BeijingChina Jilin University ChangchunChina College of Electronic Science and Engineering National University of Defense TechnologyChangshaChina Chongqing University ChongqingChina Dongguan University of technology DongguanChina Jinan University GuangzhouChina Sun Yat-Sen University GuangzhouChina Harbin Institute of technology HarbinChina University of Science and technology of China HefeiChina the Radiochemistry and Nuclear Chemistry Group in University of South China HengyangChina Wuyi University JiangmenChina Shandong University JinanChinaand Key Laboratory of Particle Physics and Particle Irradiation of Ministry of EducationShandong UniversityQingdaoChina Institute of Modern Physics Chinese Academy of SciencesLanzhouChina Nanjing University NanjingChina Guangxi University NanningChina East China University of Science and technology ShanghaiChina School of Physics and Astronomy Shanghai Jiao Tong UniversityShanghaiChina tsung-Dao Lee Institute Shanghai Jiao Tong UniversityShanghaiChina Institute of Hydrogeology and Environmental Geology Chinese Academy of Geological SciencesShijiazhuangChina Nankai University TianjinChina Wuhan University WuhanChina Xi'an Jiaotong University Xi'anChina Xiamen University XiamenChina School of Physics and Microelectronics Zhengzhou UniversityZhengzhou

JUNO is a multi-purpose neutrino observatory under construction in the south of *** publication presents new sensitivity estimates for the measurement of the △m_(31)^(2),△m_(21)^(2),sin^(2)θ_(12),and sin^(2)θ_(13) oscillation parameters using reactor antineutrinos,which is one of the primary physics goals of the *** sensitivities are obtained using the best knowledge available to date on the location and overburden of the experimental site,the nuclear reactors in the surrounding area and beyond,the detector response uncertainties,and the reactor antineutrino spectral shape constraints expected from the tAO satellite *** is found that the △m_(21)^(2) and sin^(2)θ_(12) oscillation parameters will be determined to 0.5%precision or better in six years of data *** the same period,the △m_(31)^(2) parameter will be determined to about 0.2%precision for each mass ordering *** new precision represents approximately an order of magnitude improvement over existing constraints for these three parameters.

关键词： neutrino oscillation reactor antineutrino precision measurement JUNO

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Fatty liver disease,an emerging etiology of hepatocellular carcinoma in Argentina

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World Journal of Hepatology 2018年第1期10卷 41-50页

作者： federico Pinero Josefina Pages Sebastián Marciano Nora Fernández Jorge Silva Margarita Anders Alina Zerega Ezequiel Ridruejo Beatriz Ameigeiras Claudia D’Amico Luis Gaite Carla Bermúdez Manuel Cobos Carlos Rosales Gustavo Romero Lucas McCormack Virginia Reggiardo Luis Colombato Adrián Gadano Marcelo Silva Hepatology and Liver transplantation Unit Hospital Universitario AustralBuenos Aires 1629Argentina Hepatology Section Liver Transplant ProgramDepartment of Academic ResearchHospital Italiano from Buenos AiresBuenos Aires 1424Argentina Sanatorio trinidad San Isidro Buenos Aires 1642Argentina Clínica Privada San Fernando Buenos Aires 2013Argentina Hepatology and Gastroenterology Hospital BritánicoBuenos Aires 1280Argentina Hepatobiliary Surgery Hospital G RawsonSan Juan 5400Argentina Department of Hepatology and Liver transplant Program Hospital AlemanBuenos Aires 1118Argentina Department of Hepatology and Liver transplantation Sanatorio AllendeCórdoba 5016Argentina Hepatology Section Department of MedicineCentro de Educación Médica e Investigaciones Clínicas Norberto Department of Hepatology Hospital Ramos MejíaBuenos Aires 1221Argentina Department of Hepatology Centro Especialidades Medicas Ambulatorias(CEMA)Mar del Plata 7600Argentina Department of Hepatology and Liver transplantation Clínica de Nefrología de Santa FeSanta Fe 3000Argentina Department of Hepatology and Gastroenterology Hospital C Bonorino UdaondoBuenos Aires 1264Argentina Department of Hepatology and Gastroenterology Hospital CentenarioSanta Fe 2002Argentina

AIM to investigate any changing trends in the etiologies of hepatocellular carcinoma(HCC) in Argentina during the last years. MEtHODS A longitudinal cohort study was conducted by 14 regional hospitals starting in 2009 through 2016. All adult patients with newly diagnosed HCC either with pathology or imaging criteria were included. Patients were classified as presenting non-alcoholic fatty liver disease(NAFLD) either by histology or clinically, provided that all other etiologies of liver disease were ruled out, fatty liver was present on abdominal ultrasound and alcohol consumption was excluded. Complete follow-up was assessed in all included subjects since the date of HCC diagnosis until death or last medical *** A total of 708 consecutive adults with HCC were included. Six out of 14 hospitals were liver transplant centers(n = 484). the prevalence of diabetes mellitus was 27.7%. Overall, HCV was the main cause of liver disease related with HCC(37%) including cirrhotic and non-cirrhotic patients, followed by alcoholic liver disease 20.8%, NAFLD 11.4%, cryptogenic 9.6%, HBV 5.4% infection, cholestatic disease and autoimmune hepatitis 2.2%, and other causes 9.9%. A 6-fold increase in the percentage corresponding to NAFLDHCC was detected when the starting year, i.e., 2009 was compared to the last one, i.e., 2015(4.3% vs 25.6%; P tes mellitus was present in NAFLD-HCC group 61.7% when compared to other than NAFLD-HCC 23.3%(P t HCC diagnosis were observed between NAFLD-HCC and non-NAFLD groups(6.6 ng/m L vs 26 ng/m L; P = 0.02). Neither NAFLD nor other HCC etiologies were associated with higher *** the growing incidence of NAFLD-HCC documented in the United States and Europe is also observed in Argentina, a confirmation with important Public Health implications.

关键词： Hepatocellular carcinoma Etiology Fatty liver South America

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