检索结果-南通市图书馆

Impact of STAT-signaling pathway on cancer-associated fibroblasts in colorectal cancer and its role in immunosuppression

维普期刊数据库博看期刊评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastrointestinal Oncology 2024年第5期16卷 1705-1724页

作者： Damián Sánchez-Ramírez Mónica G Mendoza-Rodríguez Omar R Alemán Fernando A Candanedo-González Miriam Rodríguez-Sosa Juan JoséMontesinos-Montesinos Mauricio Salcedo Ismael Brito-Toledo Felipe Vaca-Paniagua Luis I Terrazas Unidad de Investigacion en Biomedicina Facultad de Estudios Superiores IztacalaUniversidad Nacional Autonoma de MexicoTlalnepantla 54090Estado de MexicoMexico department of Biology Facultad de QuimicaUniversidad Nacional Autonoma de MexicoCiudad UniversitariaMexico City 04510Mexico department of Pathology National Medical Center Century XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio de Células Troncales Mesenquimales Unidad de Investigación Médica en Enfermedades OncológicasHospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Unidad de Investigacion en Biomedicina y Oncologia Genomica Instituto Mexciano del Seguro SocialMexico City 07300Mexico Servicio de Colon y Recto Hospital de Oncología Centro Medico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMexico City 06720Mexico Laboratorio Nacional en Salud Facultad de Estudios Superiores IztacalaUniversidad Nacional Autónoma de MéxicoTlalnepantla 54090Estado de MexicoMexico

Colorectal cancer(CRC)remains one of the most commonly diagnosed and deadliest types of cancer worldwide.CRC displays a desmoplastic reaction(DR)that has been inversely associated with poor prognosis;less DR is associated with a better prognosis.This reaction generates excessive connective tissue,in which cancer-associated fibroblasts(CAFs)are critical cells that form a part of the tumor microenvironment.CAFs are directly involved in tumorigenesis through different mechanisms.However,their role in immunosuppression in CRC is not well understood,and the precise role of signal transducers and activators of transcription(STATs)in mediating CAF activity in CRC remains unclear.Among the myriad chemical and biological factors that affect CAFs,different cytokines mediate their function by activating STAT signaling pathways.Thus,the harmful effects of CAFs in favoring tumor growth and invasion may be modulated using STAT inhibitors.Here,we analyze the impact of different STATs on CAF activity and their immunoregulatory role.

关键词： Cancer-associated fibroblasts Signal transducer and activator of transcription signaling Colorectal cancer Immunity Immunosuppression

debaryomyces hansenii supplementation in low fish meal diets promotes growth,modulates microbiota and enhances intestinal condition in juvenile marine fish

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Animal Science and Biotechnology 2024年第1期15卷 253-276页

作者： Ignasi Sanahuja Alberto Ruiz Joana P.Firmino Felipe E.Reyes-López Juan B.Ortiz-delgado Eva Vallejos-Vidal Lluis Tort Dariel Tovar-Ramírez Isabel M.Cerezo Miguel A.Moriñigo Carmen Sarasquete Enric Gisbert Aquaculture Program Institute of Agrifood Research and Technology(IRTA)La Rapita 43540Spain Centro de Biotecnologia Acuicola Universidad de Santiago de ChileSantiagoChile Instituto de Ciencias Marinas de Andalucia(ICMAN-CSIC) Avda.Republica Saharaui no 2Campus Universitario Rio San PedroPuerto RealCadiz 11510Spain Nucleo de Investigaciones Aplicadas en Ciencias Veterinarias y Agronomicas Facultad de Medicina Veterinaria y AgronomiaUniversidad de Las AmericasSantiagoChile department of Cell Biology Physiologyand ImmunologyUniversitat Autonoma de BarcelonaBarcelonaSpain Centro de Investigaciones Biologicas del Noroeste SC CIBNORLa PazMexico department of Microbiology Instituto de Biotecnologia Y Desarrollo Azul(IBYDA)Faculty of SciencesUniversity of Malaga29010 MalagaSpain SCBI Bioinformatic UnitUniversity of Malaga29590 MalagaSpain

Background The development of a sustainable business model with social acceptance,makes necessary to develop new strategies to guarantee the growth,health,and well-being of farmed animals.debaryomyces hansenii is a yeast species that can be used as a probiotic in aquaculture due to its capacity to i)promote cell proliferation and differen-tiation,ii)have immunostimulatory effects,iii)modulate gut microbiota,and/or iv)enhance the digestive function.To provide inside into the effects of D.hansenii on juveniles of gilthead seabream(Sparus aurata)condition,we inte-grated the evaluation of the main key performance indicators coupled with the integrative analysis of the intestine condition,through histological and microbiota state,and its transcriptomic profiling.Results After 70 days of a nutritional trial in which a diet with low levels of fishmeal(7%)was supplemented with 1.1%of D.hansenii(17.2×10^(5) CFU),an increase of ca.12%in somatic growth was observed together with an improve-ment in feed conversion in fish fed a yeast-supplemented diet.In terms of intestinal condition,this probiotic modu-lated gut microbiota without affecting the intestine cell organization,whereas an increase in the staining intensity of mucins rich in carboxylated and weakly sulphated glycoconjugates coupled with changes in the affinity for certain lectins were noted in goblet cells.Changes in microbiota were characterized by the reduction in abundance of several groups of Proteobacteria,especially those characterized as opportunistic groups.The microarrays-based transcrip-tomic analysis found 232 differential expressed genes in the anterior-mid intestine of S.aurata,that were mostly related to metabolic,antioxidant,immune,and symbiotic processes.Conclusions Dietary administration of D.hansenii enhanced somatic growth and improved feed efficiency param-eters,results that were coupled to an improvement of intestinal condition as histochemical and transcriptomic tools indicated.This probiotic yeast stimulated host-microbiota interactions with

关键词： debaryomyces hansenii Intestine condition Low fish meal diet Microbiota Transcriptomics Yeast probiotic

Provenance and depositional setting of the Late MiocenePleistocene clastic sediments in the eastern Arabian Peninsula and western Iraq using rare earth elements geochemistry

在线全文

学校读者我要写书评

暂无评论

Acta Geochimica 2024年第2期43卷 399-410页

作者： Salih M.Awadh Zinah S.Al-Ankaz Mohanad R.A.Al-Owaidi John S.Armstrong-Altrin department of Geology College of ScienceUniversity of BaghdadBaghdadIraq department of Geology College of ScienceUniversity of WasitWasit 52011Iraq department of Applied Geology College of ScienceUniversity of BabylonBabylon 51001Iraq Unidad de Procesos Oceanicos y Costeros Instituto de Ciencias del Mar y LimnologíaUniversidad Nacional Autonoma de MexicoCiudad Universitaria04510 Mexico CityCDMXMexico department of Marine Sciences Bharathidasan UniversityTiruchirapalliTamil Nadu 620024India

The sandstones of the Late miocene–Pliocene Dibdibba Formation in the Najaf–Karbala Plateau and Basra were examined to determine their source rocks and origin. The rare earth elements(REE) and trace elements(Sc, Co, V, and Th) concentrations in these sandstones revealed that they likely derived from a single source. The steep light rare earth elements(LREE) and flat, heavy rare earth element(HREE) patterns, negative Eu anomaly, and high ΣREE contents in sandstones suggest its derivation from a suggests that a passive continental margin environment and originated from felsic source rocks. The average concentration of ΣREE is 93.5 ppm, which is lower than that of the average crustal compositions like Upper Continental Crust and Post Archean Australian Shale. The higher proportion of LREE compared to HREE implies that these sandstones were recycled and derived from a distal source. The Th/Co, Th/Sc, La/Sc, La/Co, Eu/Eu*and(La/Lu)cn elemental ratios indicated that these Late Miocene–Pliocene sandstones were derived from felsic rocks located in the marginal region of the Arabian Shield.

关键词： REE Dibdibba formation Clastic sediments Passive continental margin

Diet variability of snappers(Teleostei:Lutjanidae)in a bay-to-reef ecosystem of the Mexican Caribbean

在线全文

学校读者我要写书评

暂无评论

Water Biology and Security

Water Biology and Security 2024年第1期3卷 53-59页

作者： Leon Felipe Martínez-Juarez Juan J.Schmitter-Soto Nancy Cabanillas-Teran Norman Mercado-Silva El Colegio de la Frontera Sur 77014ChetumalQuintana RooMexico Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de Morelos62209CuernavacaMorelosMexico

Fishes use environmental resources differently.Snapper ontogenic movements among coastal habitats lead to diverse diets.We investigated the diets of seven snapper species(Lutjanus apodus,L.analis,L.griseus,L.jocu,L.mahogoni,L.synagris,and Ocyurus chrysurus)in three interconnected coastal environments in the western Caribbean:Río Huach channel,Chetumal/Corozal bay,and the adjacent Xcalak reef lagoon.These three encompass all habitats used by the seven species in the study area.Snapper diets were mostly composed of fish and crustaceans,but dominance of either group varied among the studied habitats;for example,fish were the main prey for L.apodus from the reef lagoon zone,but second in the bay.Snappers are piscivorous-invertivorous mesopredators;the species that relied the most on fishes were L.griseus and L.jocu,whereas O.chrysurus preferred crustaceans.Stomach content results revealed a high degree of dietary overlap among species.Our findings suggested a tradeoff in relative weight between fish and crustaceans as the main food source of snappers at these connected areas,supporting the hypothesis of niche segregation.Our results can be used as a baseline to further our understanding of the ecology and differences in resource use by snapper species in an area undergoing important anthropogenic changes.

关键词： Resource partitioning Chetumal/Corozal bay Quintana Roo Trophic ecology

Global prevalence and gender inequalities in at least 60 min of self-reported moderate-to-vigorous physical activity 1 or more days per week:An analysis with 707,616 adolescents

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第5期13卷 709-716页

作者： Raphael H.O.Araujo AndrúO.Werneck Clarice L.Martins Luciana L.Barboza Rafael M.Tassitano Nicolas Aguilar-Farias Gilmar M.Jesus Robinson Ramírez-Véelez Riki Tesler Adewale L.Oyeyemi Ellen C.M.Silva Robert G.Weaver Mark S.Tremblay Javier Brazo-Sayavera Grégore I.Mielke Danilo R.P.Silva Graduation Program in Health Sciences Londrina State University(UEL)Londrina 86057-970Brazil Center for Epidemiological Research in Nutrition and Health Department of NutritionSchool of Public HealthUniversidade de Sao Paulo(USP)Sao Paulo 01246-904Brazil department of Physical Education Federal University of ParaıbaParaıba 58051-900Brazil Research Centre of Physical Activity Health and LeisureFaculty of SportsLaboratory for Integrative and Translational Research in Population Health(ITR)University of PortoPorto 4500Portugal Postgraduate Program in Physical Education University of BrasıliaBrasılia 70910-900Brazil department of Kinesiology and Community Health University of Illinois at Urbana-ChampaignChampaignIL 61801-3841USA department of Physical Education Sports and RecreationUniversidad de La FronteraTemuco 4680000Chile department of Health State University of Feira de SantanaFeira de Santana 44036-900Brazil Navarrabiomed Hospital Universitario de Navarra(HUN)Navarra Institute for Health Research(IdiSNA)Universidad Publica de Navarra(UPNA)Pamplona 31006Spain Facultad de Ciencias de la Educacion Unidad Central del Valle del Cauca(UCEVA)TuluaValle del Cauca 763022Colombia Health Management department Faculty of Heath sciencesAriel UniversityAriel 40700Israel College of Health Solutions Arizona State UniversityPhoenixAZ 85004USA Arnold School of Public Health University of South CarolinaColumbiaSC 29208USA Healthy Active Living and Obesity Research Group Children’s Hospital of Eastern Ontario Research InstituteOttawaON K1H 8L1Canada department of Pediatrics University of OttawaOttawaON K1H 8L1Canada department of Health Sciences Carleton UniversityOttawaON K1S 5B6Canada department of Sports and Computer Science Universidad Pablo de Olavide(UPO)Seville 41013Spain Centro Universitario Regional Noreste Universidad de la RepublicaRivera 40000Uruguay School of Public Health The University of QueenslandBrisbaneQLD 4006Australia department of Physical Education

Background:Guidelines recommend that adolescents should accumulate an average of 60 min per day of moderate-to-vigorous physical activity(MVPA).However,using only this cut-off could hide important information.For instance,from a population-level point of view,increasing physical activity for those with no or low physical activity could provide more health benefits than increasing physical activity for those with intermediate levels.Also,including a more sensitive cut-point of≥1 days per week could be an additional strategy for identifying those with low access/opportunities for physical activity practice.Thus,the current study aims to estimate the prevalence of≥60 min of MVPA≥1 days per week among adolescents globally,and to describe any relevant gender inequalities.Methods:We used representative datasets from 146 countries/territories collected between 2003 and 2019.MVPA was self-reported.Participants were grouped into younger(≤14 years old)and older(>14 years old)adolescents.Crude Poisson regression models were used to identify the relative differences in≥60 min of MVPA≥1 days per week between boys and girls,and random-effects meta-analysis models were used to identify the pooled estimates.Analyses were stratified by country and region.Results:Approximately 80%of both younger and older adolescents reported≥60 min of MVPA≥1 days per week.This prevalence was≥94%in Europe and Central Asia and North America,while the estimates for the other regions weredest adolescents(Prevalence ratio_(≤14y)=1.04(95%confidence interval(95%CI)):1.03-1.04)vs.Prevalence ratio_(>14y)=1.09(95%CI:1.08-1.10)).Conclusion:Approximately 8 out of 10 adolescents reported accumulating≥60 min of MVPA≥1 days per week,with notable differences between regions.Gender differences were observed in several countries,especially among the oldest adolescents.Priorities for physical activity promotion among adolescents

关键词： Global School-based Student Health Survey Health Behaviour Among School-aged Children survey Inequality Surveillance Youth

Sensitivity,specificity and predictive values of anterior chamber tap in cases of bacterial endophthalmitis

在线全文

学校读者我要写书评

暂无评论

Eye and Vision 2017年第1期4卷 100-105页

作者： Carl Sjoholm-Gomez de Liano Vidal F.Soberon-Ventura Guillermo Salcedo-Villanueva Abril Santos-Palacios Jose Luis Guerrero-Naranjo Jans Fromow-Guerra Gerardo García-Aguirre Virgilio Morales-Canton Raul Velez-Montoya Retina department Asociación para Evitar la Ceguera en MexicoHospital“Dr.Luis Sanchez Bulnes”IAPMexico CityMexico universidad popular autonoma del estado de puebla PueblaMexico Ophthalmology department Macula Retina ConsultantsMexico CityMexico

Background:To assess the sensitivity,specificity,positive predictive value and negative predictive value of anterior chamber tap for the diagnosis of bacterial endophthalmitis on a population with high prevalence.Methods:Retrospective,single centre,case series study.We reviewed all medical records with clinical diagnosis of bacterial endophthalmitis in our hospital from January 1st,2000 to december 31st 2014.From each record,we documented general demographic data,best corrected visual acuity and vitreous and aqueous tap microbiological results.All cases were further divided according to the endophthalmitis aetiology to perform individual calculations of sensitivity,specificity,positive predictive value,negative predictive value,accuracy and prevalence.We used the results of the vitreous tap as the gold standard for diagnosis of bacterial endophthalmitis.We excluded those records in which the aqueous and vitreous samples were not taken simultaneously or had an incomplete microbiological report.Significance were assessed with chi squared statistics,with an alpha value of 0.05 for statistical significance.Results:A total of 190 cases fulfilled the inclusion/exclusion criteria.Positive culture rate from vitreous samples was 64.74%.Positive culture rate from aqueous sample was 32.11%.Bacteria isolated from aqueous samples matched those isolated from vitreous samples 78.68%of the time.The overall sensitivity was 38.21%,specificity:75.51%,positive predictive value:79.66%,negative predictive value:32.74%(p=0.08).Subgroup analysis showed that anterior chamber taps in cases of post-surgical endophthalmitis had a moderate to low sensitivity(37.73%),high specificity(93%)and high positive predictive value(95%)(pdecisions in patients with suspected bacterial endophthalmitis.In cases of post-surgical endophthalmitis,the result of an anterior chamber tap could be used for therapeutic guidance,but only

关键词： Aqueous humour Endophthalmitis Anterior chamber tap Diagnostic test Vitreous tap Aqueous sampling Sensibility Sensitivity

Employment Creation and Investment Attraction by Means of the Internet Portal of puebla （Mexico） Government

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Computer Technology and Application 2011年第9期2卷 698-704页

作者： Juan Carlos Botello Osorio Business School Universidad Popular Autonoma del Estado de Puebla

Some transactional governmental services are now offered to citizens world-wide by means of the internet. Principally, these transactions consist of applications for birth certificates, tax payments, payments of fines, however, very rarely, or never can someone incorporate a business by means of e-government services. Rare also, are cases in which the consequences of business incorporation can be evaluated through the internet—-for example employment creation or the attraction of investments. With respect to business incorporation the internet portal of the government of the state of puebla is of no help, since it must be done in person in every case.

关键词：政府服务门户网站就业机会互联网招商引资墨西哥商业公司服务业务

Effect of Aspergillus niger prolyl endopeptidase in patients with celiac disease on a long-term gluten-free diet

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第11期30卷 1545-1555页

作者： Juan Pablo Stefanolo Verónica Segura Martina Grizzuti Abel Heredia Isabel Comino Ana Florencia Costa Roberto puebla María Paz Temprano Sonia Isabel Niveloni Gabriel de Diego María E Oregui Edgardo Gustavo Smecuol Mauricio C de Marzi Elena F Verdú Carolina Sousa Julio César Bai Small Bowel Section Department of MedicineGastroenterology Hospital of Buenos Aires“Dr.C.Bonorino Udaondo”Buenos Aires 1264Argentina department of Microbiology and Parasitology Faculty of PharmacyUniversity of SevilleSeville 41080Spain department of Medicine Dr.C.Bonorino Udaondo Gastroenterology HospitalBuenos Aires 1264Argentina Basic and Applied Research Group in Immunology and Bioactives(GIBAIB) Institute of Ecology and Sustainable Development(INEDES)National University of LujanLuján 6700Buenos AiresArgentina department of Medicine Farncombe Family Digestive Health Research InstituteMcMaster UniversityHamilton L8S 4L8OntarioCanada Facultad de Medicina Universidad del SalvadorBuenos Aires C1051ABBArgentina

BACKGROUND The gluten-free diet(GFD)has limitations,and there is intense research in the development of adjuvant therapies.AIM To examine the effects of orally administered Aspergillus niger prolyl endopeptidase protease(AN-PEP)on inadvertent gluten exposure and symptom prevention in adult celiac disease(CeD)patients following their usual GFD.METHODS This was an exploratory,double-blind,randomized,placebo-controlled trial that enrolled CeD patients on a long-term GFD.After a 4-wk run-in period,patients were randomized to 4 wk of two AN-PEP capsules(GliadinX;AVI Research,LLC,United States)at each of three meals per day or placebo.Outcome endpoints were:(1)Average weekly stool gluten immunogenic peptides(GIP)between the run-in and end of treatments and between AN-PEP and placebo;(2)celiac symptom index(CSI);(3)CeD-specific serology;and(4)quality of life.Stool samples were collected for GIP testing by ELISA every Tuesday and Friday during run-ins and treatments.RESULTS Forty patients were randomized for the intention-to-treat analysis,and three were excluded from the per-protocol assessment.Overall,628/640(98.1%)stool samples were collected.GIP was undetectable(detected.Only 0.5%of samples had GIP concentrations sufficiently high(>0.32μg/g)to potentially cause mucosal damage.Median GIP concentration in the AN-PEP arm was 44.7%lower than in the run-in period.One-third of patients exhibiting GIP>0.08μg/g during run-in had lower or undetectable GIP after AN-PEP treatment.Compared with the run-in period,the proportion of symptomatic patients(CSI>38)in the AN-PEP arm was significantly lower(P<0.03).AN-PEP did not result in changes in specific serologies.CONCLUSION This exploratory study conducted in a real-life setting revealed high adherence to the GFD.The AN-PEP treatment did not significantly reduce the overall GIP stool concentration.However,given the observation of a significantly lower prevalence of patients with severe symptoms in the AN-P

关键词： Celiac disease Aspergillus niger prolyl endoprotease Gluten immunogenic peptides Trial Symptoms Real-life trial

Chromomagnetic and chromoelectric dipole moments of quarks in the reduced 331 model

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics C 2021年第11期45卷 11-24页

作者： A.I.Hemandez-Juarez G.Tavares-Velasco A.Moyotl Facultad de Ciencias Fisico Matematicas Benemerita Universidad Autonoma de PueblaApartado Postal 1152PueblaPueblaMexico Ingenieria en Mecatronica Universidad Politecnica de PueblaTercer Carril del Ejido Serrano s/nSan Mateo CuanalaJuan C.BonillaPueblaPueblaMexico

The one-loop contributions to the chromomagnetic dipole momentˆμt(q2)and electric dipole momentˆd t(q2)of the top quark are calculated within the reduced 331 model(RM331)for non-zero q2.It is argued that the results are gauge independent and thus represent valid observable quantities.In the RM331,ˆμt(q2)receives new contributions from two heavy gauge bosons,namely Z′and V±,and one neutral scalar boson h2,along with a new contribution from the standard model's Higgs boson via flavor changing neutral currents.The latter,which is also mediated by the Z′gauge boson and the scalar boson h2,can provide a non-vanishingˆd t(q2)if there is a CP-violating phase.The analytical results are presented in terms of both Feynman parameter integrals and Passarino-Veltman scalar functions,which are useful to cross-check the numerical results.Bothˆμt(q2)andˆd t(q2)are numerically evaluated for parameter values still allowed by the constraints from experimental data.It is found that the new one-loop contributions of the RM331 to the real(imaginary)part ofˆμt(q2)are of the order of 10−5(10−6),which means at least three orders of magnitude smaller than the standard model prediction but larger than the predictions of other models of new physics.In the RM331,the dominant contribution arises from the V±gauge boson for‖q‖in the 30-1000 GeV interval and a mass mV of the order of a few hundreds of GeV.As forˆd t(q2),it receives its largest contribution from h2 exchange and can reach values of the order of 10−19,i.e.,smaller than the contributions predicted by other standard model extensions.

关键词： chromomagnetic chromoelectric 331 models