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Complementary roles of glial cells in generating region-specific neuroinflammatory responses and phagocytosis in Parkinson’s disease

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neural Regeneration Research 2025年第10期20卷 2917-2918页

作者： Leyre Ayerra Maria s.Aymerich universidad de navarra Facultad de CienciasDepartamento de Bioquímica y GenéticaPamplonaSpain CIMA-universidad de navarra PamplonaSpain IdisnA Instituto de Investigación Sanitaria de NavarraPamplonaSpain

neuroinflammation is associated with Parkinson’s disease:Reactive gliosis and neuroinflammation are hallmarks of Parkinson’s disease(PD),a multisystem neurodegenerative disorder characterized by a progressive loss of dopaminergic *** has long been considered a mere consequence of neuronal loss,but whether it promotes PD or is a key player in disease progression remains to be *** leukocyte antigen.

关键词： inflammation leukocyte generating

Unveiling the brain’s symphony:exploring the necessity and sufficiency of neural networks in behavior control

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neural Regeneration Research 2025年第1期20卷 186-187页

作者： Fernando Jose Bustos instituto de ciencias Biomedicas Facultad de Medicina y Facultad de Ciencias de la VidaUniversidad Andres BelloSantiagoChile Millennium nucleus of neuroepigenetics and Plasticity(Epineuro) SantiagoChile

since the pioneering work by Broca and Wernicke in the 19th century,who examined individuals with brain lesions to associate them with specific behaviors,it was evident that behaviors are complex and cannot be fully attributable to specific brain areas ***,they involve connectivity among brain areas,whether close or *** that time,this approach was considered the optimal way to dissect brain circuitry and *** pioneering efforts opened the field to explore the necessity or sufficiency of brain areas in controlling behavior and hence dissecting brain ***,the connectivity of the brain and the mechanisms through which various brain regions regulate specific behaviors,either individually or collaboratively,remain largely *** animal models,researchers have endeavored to unravel the necessity or sufficiency of specific brain areas in influencing behavior;however,no clear associations have been firmly established.

关键词： behavior connectivity neural

Insecticidal Effect of Green Bimetallic nanoparticles from Crotalaria longirostrata on Cotton Mealybug,Phenacoccus solenopsis

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Journal of Renewable Materials 2022年第10期10卷 2543-2552页

作者： Vianey Mendez-Trujillo Benjamín Valdez-salas Mario Curiel-Alvarez Ernesto Beltran-Partida Arnoldo Alfaro-Corres EsaúRuiz-sanchez Gerardo Bautista-Trujillo Olivia Tzintzun Camacho Onecimo Grimaldo-Juarez Carlos Ceceña-Duran Carlos Ail-Catzin Daniel González-Mendoza Facultad de Medicina de la universidad autónoma de baja california Dr.Humberto Torres Sanginés S/NCentro CívicoMexicaliBaja CaliforniaMéxico instituto de Ingeniería de la universidad autónoma de baja california Calle de la Normal S/N y Boulevard Benito JuárezMexicaliBaja CaliforniaMéxico instituto Tecnológico de Conkal División de Estudios de Posgrado e InvestigaciónAntigua Carretera Mérida-MotulConkalYucatánMéxico Facultad de Medicina Veterinaria y Zootecnia de la universidad autónoma de Chiapas ChiapasMéxico universidad autónoma de baja california Instituto de Ciencias AgrícolasBaja CaliforniaMéxico

The present study was conducted to evaluate the impact of bimetallic nanoparticles(nPs)of copper(Cu)and zinc(Zn)from Crotalaria longirostrata on the insect mortality and cell viability of Phenacoccus *** biosynthesis of bimetallic nanoparticles(Cu/Zn-nPs)from *** was confirmed by the presence of a single peak around 378 *** hydrodynamic diameter of the Cu/Zn nanoparticles varied from 59 to 119 nm and their zeta potential was found to be−30.90 *** EDX analysis showed a strong signal for Cu and Zn(8 and 8.6 keV,respectively).The Cu/Zn-nPs showed an effective insecticide activity against *** with 63%of insect mortality after 96 h ***,further studies about nanotoxicity of Cu/Zn-nPs from *** are needed to reveal the exact mechanism of nanoparticles toxicity in insects.

关键词： Phytonanoparticles chipilin biocontrol agronanotechnology

Green synthesis of Bimetallic nanoparticles From Prosopis juliflora(sw)DC.,and Its Effect Against Cotton Mealybug,Phenacoccus solenopsis(Hemiptera:Pseudococcidae)

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Phyton-International Journal of Experimental Botany 2019年第3期88卷 269-275页

作者： V.Mendez-Trujillo B.Valdez-salas M.Carrillo-Beltran M.A.Curiel-Alvarez O.Tzintzun-Camacho C.Ceceña-Duran D.Gonzalez-Mendoza Facultad de Medicina de la universidad autónoma de baja california Dr.Humberto Torres Sanginés S/NCentro Cívico21000MexicaliBaja CaliforniaMéxico instituto de Ingeniería de la universidad autónoma de baja california Calle de la Normal S/N y Boulevard Benito Juárez21100MexicaliBaja CaliforniaMéxico instituto de ciencias agrícolas de la universidad autónoma de baja california(ICA-UABC).carretera a delta s/n C.P.21705 Ejido Nuevo LeónBaja CaliforniaMéxico

Phenacoccus solenopsis has been recognized as an aggressively invasive species on cotton plants in different *** study was conducted to investigate the effect of green synthesized Cu/Zn-nanoparticles using aqueous leaf extract of Prosopis juliflora(mezquite)against *** scanning electron microscope(sEM)showed bimetallic nanoparticles of Cu/Zn-nPs with spherical shape with varying size of 74.33 nm to 59.46 *** than 30%mortality of *** was observed with Cu/Zn-nanoparticles(100 ppm)at 96 hours after *** mortality of *** was recorded with Cu/Zn solution(100 ppm)and aqueous *** *** results of the viability test for Cu/Zn-nanoparticles of *** showed a significant reduction of the cell viability by 50%in insect exposed to Cu/*** studies about nanotoxicity of Cu/Zn-nPs of *** are needed to reveal the mechanism of toxicity this phytonanoparticles in ***.

关键词： Photosynthesis biocontrol cotton mealybug nanoinsecticide

Amyloid-beta pathology-induced nanoscale synaptic disruption:the case of the GABA_B-GIRK assembly

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neural Regeneration Research 2025年第5期20卷 1409-1410页

作者： Rafael Lujan Alejandro Martín-Belmonte sergi Ferré Francisco Ciruela synaptic structure Laboratory Instituto de Biomedicina de la UCLM(IB-UCLM)Departamento de Ciencias MédicasInstituto de Investigación en Salud de Castilla-La Mancha(IDISCAM)Facultad de MedicinaUniversidad Castilla-La ManchaCampus BiosanitarioC/AlmansaAlbaceteSpain Integrative neurobiology section National Institute on Drug AbuseIntramural Research ProgramNational Institutes of HealthBaltimoreMDUSA Pharmacology Unit Department of Pathology and Experimental TherapeuticsSchool of Medicine and Health SciencesInstitute of NeurosciencesUniversity of BarcelonaNeuropharmacology&Pain GroupNeuroscience ProgramBellvitge Institute for Biomedical ResearchL’Hospitalet de LlobregatSpain

Alzheimer's disease (AD) is characterized by an imbalance between excitatory and inhibitory brain networks,leading to aberrant homeostatic synaptic *** has progressively been recognized as syna ptopathy and syna ptic dysfunction has been identified as a key component of its pathogenesis (schirinzi et al.,2020).syna ptic dysfunction is believed to precede synapse loss,a primary biological correlate of cognitive decline in AD,inevita bly associated with neuronal death.

关键词： Alzheimer pathology

Azospirillum brasilense and saccharomyces cerevisiae as Alternative for decrease the Effect of salinity stress in Tomato(Lycopersicon esculentum)Growth

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Phyton-International Journal of Experimental Botany 2022年第1期91卷 21-32页

作者： Ali Abdelmoteleb Daniel Gonzalez-Mendoza Ahmed Mohamed Elbaalawy Botany department Faculty of AgricultureMenoufia UniversityShebin El-KomPo 32511Egypt instituto de ciencias agrícolas Universidad Autónoma de Baja CaliforniaCarretera a Delta s/n Ejido Nuevo LeónBaja CaliforniaCP 21705México department of soil science Faculty of AgricultureMenoufia UniversityShebin El-KomPo 32511Egypt

The salinity stress is one of the most relevant abiotic stresses that affects the agricultural *** present study was performed to study the improvement of the salt tolerance of tomato plants which is known for their susceptibility to salt *** present study aimed to assess to what extent strain Azospirillum brasilense(n040)and saccharomyces cerevisiae improve the salt tolerance to tomato plants treated with different salt *** inoculant strain ***(n040)was previously adapted to survive up to 7%naCl in the basal media.A greenhouse experiment was conducted to evaluate the effect of this inoculation on growth parameter such as:plant height,root length,fresh and dry weight,fruits fresh weight,chlorophyll content,proline and total soluble sugar in tomato plants under salt stress *** results revealed that co-inoculation of Azospirillum brasilense(n040)and saccharomyces cerevisiae significantly increased the level of proline(8.63 mg/g FW)and total soluble sugar(120 mg/g FW)of leaves under salinity condition comparing to non-inoculated plants(2.3 mg/g FW and 70 mg/g FW,respectively).Plants co-inoculated with adapted strain of *** and *** showed the highest significant(pncrease in fruit yield(1166.6 g/plant),plant high(115 cm)and roots length(52.6)compared whit un-inoculated control plants(42 g/pant,43.3 cm and 29.6 cm,respectively).In contrast,na^(+)ion content was significantly decreased in the leaves of salt stressed plants treated with the ***(n040)and ***,the results showed that dual benefits provided by both ***(n040)and *** can provide a major way to improve tomato yields in saline soils.

关键词： salinity stress tomato proline exopolysaccharides microorganism

synthesis of activated carbons from black sapote seeds,characterization and application in the elimination of heavy metals and textile dyes

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Chinese Journal of Chemical Engineering 2020年第2期28卷 613-623页

作者： Alejandra Alicia Peláez-Cid Vincent Romero-Hernández Ana María Herrera-González Alejandro Bautista-Hernández Oscar Coreno-Alonso Facultad de Ingeniería Benemérita Universidad Autónoma de PueblaMexico instituto de ciencias Básicas e Ingeniería Universidad Autónoma del Estado de HidalgoMexico División de Ingenierías Universidad de GuanajuatoMexico

Many different techniques may be used to remove industrial pollutants from wastewater. Adsorption using activated carbon has been reported to be an effective method. This work proposes the use of a vegetable residue(black sapote seeds) as a raw material for its synthesis. These carbons were chemically activated using phosphoric acid and carbonized at 673 and 873 K. Adsorption isotherms were constructed for the textile dyes on the carbons, and this data was treated using Langmuir’s equation to quantitatively describe the adsorption process. The synthesized carbons were characterized using FTIR, EA, sEM, nitrogen adsorption(specific surface areas of 879 and 652 m2·g-1), and their points of zero charge(2.1 and 2.3). It was possible to adsorb both heavy metals and textile dyes present in aqueous solutions and wastewaters using these activated carbons. Heavy metals were adsorbed almost completely by both carbons. Cationic dyes where adsorbed(58–59.8 mg·g-1) in greater amounts compared to anionic dyes(10–58.8 mg·g-1). The amount of anionic dyes adsorbed increased almost 30% by changing the pH of the solutions. One of the carbons was thermally regenerated on three occasions without losing its adsorption capacity and it was proved in a flow system.

关键词： Activated carbons Black sapote seeds Heavy metal adsorption Textile dye adsorption Wastewater treatment

Effects of Hedera helix *** on the understory early regeneration in an oak temperate forest in Mexico City

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Ecological Processes 2023年第1期12卷 438-449页

作者： Héctor Adrián Jiménez-Hernández Leticia Bonilla-Valencia Yuriana Martínez-Orea Mara Jessica Zamora-Almazan Francisco Javier Espinosa-García silvia Castillo-Argüero Facultad de ciencias Universidad Nacional Autónoma de MéxicoMexico CityMexico instituto de Investigaciones en Ecosistemas y sustentabilidad Universidad Nacional Autónoma de MéxicoMichoacánMexico

Background Hedera helix *** an invasive weed species introduced in several regions of the world,so it is relevant to study its effects on the plant community and the changes occurring after its *** established invaded(with/without removal of ***)and non-invaded(with/without removal of the understory)plots to compare some community attributes in an oak forest in Mexico City and monitored them every 2 months for 1 year,taking soil samples to compare some edaphic variables between the *** invasive species negatively affect natural regenera-tion,seedlings of native species would be less abundant in plots invaded by *** than in the non-invaded *** invasive species modify the soil microbiota through exudates and often allelochemicals,soil chemical variables would differ between invaded and non-invaded *** The abundance of native species was lower in the invaded plots,but the richness and diversity of species were not statistically *** composition of the two invaded plots was similar to each other and more alike to that of the non-invaded *** species composition of the invaded plots was associated with soil potassium and phosphorus concentrations,whereas that of the non-invaded plots was more associated with soil nitrogen *** Following the removal of ***,several native species were registered,leading to a similar species composition as in the non-invaded plots,suggesting that some vegetation recovery can be expected following *** removal in 1 year.

关键词： Ivy Invasive plant Mechanical control Diversity species composition

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Gold nanoshells： Contrast agents for cell imaging by cardiovascular optical coherence tomography

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nano Research 2018年第2期11卷 676-685页

作者： Jie Hu Francisco sanz-Rodríguez Fernando Rivero Emma Martín Rodríguez Río Aguilar Torres Dirk H. Ortgies José García solé Fernando Alfonso Daniel Jaque Fluorescence Imaging Group Departamento de Física de Materiales Instituto Nicolás Cabrera Facultad de Ciencias Universidad Autónoma de Madrid Madrid Spain instituto Ramón y Cajal de Investigación sanitaria Hospital Ramón y Cajal Madrid spain departamento de Biología universidad autónoma de Madrid Madrid spain Cardiology department Hospital Universitario de la Princesa IIS-IP Universidad Autónoma de Madrid Madrid Spain

Optical coherence tomography （OCT） has gained considerable attention in interventional cardiovascular medicine and is currently used in clinical settings to assess atherosclerotic lesions and to optimize stent placement. Artery imaging at the cellular level constitutes the first step towards cardiovascular molecular imaging, which represents a major advance in the development of personalized noninvasive therapies. In this work we demonstrate that cardiovascular OCT can be used to detect individual cells suspended in biocompatible fluids. Importantly, the combination of this catheter-based clinical technique with gold nanoshells （Gnss） as intracellular contrast agents led to a substantial enhancement in the backscattered signal produced by individual cells. This cellular contrast enhancement was attributed to the large backscattering cross-section of Gnss at the OCT laser wavelength （1,300 nm）. A simple intensity analysis of OCT cross-sectional images of suspended cells makes it possible to identify the sub-population of living cells that successfully incorporated Gnss. The generalizability of this method was demonstrated using two different cell lines （HeLa and Jurkat cells）. This work provides novel insights into cardiovascular molecular imaging using specifically modified Gnss.

关键词： optical coherencetomography (OCT)intravascular imaging gold nanoparticles three-dimensional (3D)imaging