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Advances in spray products for skin regeneration

Bioactive Materials 2022年第10期7卷 187-203页

作者： Paula Pleguezuelos-Beltran Patricia Galvez-Martín Daniel Nieto-Garcí Juan Antonio Marchal Elena Lopez-Ruiz Biopathology and Regenerative Medicine Institute(IBIMER) Centre for Biomedical Research(CIBM)University of GranadaGranadaSpain Department of Human Anatomy and Embryology Faculty of MedicineUniversity of GranadaGranadaSpain BioFab i3D Lab-Biofabrication and 3D(bio)printing Laboratory GranadaSpain Excellence Research Unit“Modeling Nature”(MNat) University of GranadaGranadaSpain Biosanitary Research Institute of granada(ibs.granada) University Hospitals of Granada-University of GranadaGranadaSpain R&D Human Health Bioib´erica S.A.UBarcelonaSpain Department of Pharmacy and Pharmaceutical Technology Faculty of PharmacyUniversity of GranadaGranadaSpain Complex Tissue Regeneration Department MERLN Institute for Technology Inspired Regenerative MedicineUniversiteitssingel 406229ER Maastrichtthe Netherlands Department of Health Sciences University of Ja´enJa´enSpain

To date,skin wounds are still an issue for healthcare *** numerous approaches have been developed over the years for skin regeneration,recent advances in regenerative medicine offer very promising strategies for the fabrication of artificial skin substitutes,including 3D bioprinting,electrospinning or spraying,among *** particular,skin sprays are an innovative technique still under clinical evaluation that show great potential for the delivery of cells and hydrogels to treat acute and chronic *** sprays present significant advantages compared to conventional treatments for wound healing,such as the facility of application,the possibility to treat large wound areas,or the homogeneous distribution of the sprayed *** this article,we review the latest advances in this technology,giving a detailed description of investigational and currently commercially available acellular and cellular skin spray products,used for a variety of diseases and applying different experimental ***,as skin sprays products are subjected to different classifications,we also explain the regulatory pathways for their commercialization and include the main clinical trials for different skin diseases and their treatment ***,we argue and suggest possible future trends for the biotechnology of skin sprays for a better use in clinical dermatology.

关键词： Skin Spray Tissue engineering Fibrin Hydrogel

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Fundamental Gaps in Numerical Semigroups with Respect to Their Multiplicity

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Acta Mathematica Sinica,English Series 2004年第4期20卷 629-646页

作者： J.C.ROSALES P.A.GARCíA-SANCHEZ J.I.GARCíA-GARCíA J.A.JIMENEZMADRID DepartamentodeAlgebra UniversidaddeGranadaE-18071GranadaSpain InstitutodeAstrofisicadeAndalucia(CSIC) ApartadoPostal300418080GranadaSpain

For a numerical semigroup,we introduce the concept of a fundamental gap with respect to the multiplicity of the *** semigroup is fully determined by its multiplicity and these gaps. We study the case when a set of non-negative integers is the set of fundamental gaps with respect to the multiplicity of a numerical *** semigroups with maximum and minimum number of this kind of gaps are described.

关键词： Numerical semigroup Gap Multiplicity Frobenius number

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Chitosan conduits enriched with fibrin-collagen hydrogel with or without adipose-derived mesenchymal stem cells for the repair of 15-mm-long sciatic nerve defect

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Neural Regeneration Research 2023年第6期18卷 1378-1385页

作者： Marwa El Soury óscar Darío García-García Isabella Tarulli Jesús Chato-Astrain Isabelle Perroteau Stefano Geuna Stefania Raimondo Giovanna Gambarotia Víctor Carriel Department of Clinical and Biological Sciences University of TorinoTorinoItaly Neuroscience Institute Cavalieri Ottolenghi University of TorinoTorinoItaly Department of Histology Tissue Engineering GroupUniversity of GranadaGranadaSpain Instituto de Investigacion Biosanitaria Ibs.GRANADAGranadaSpain

Hollow conduits of natural or synthetic origins have shown acceptable regeneration results in short nerve gap repair;however,results are still not comparable with the current gold standard technique“autografts”.Hollow conduits do not provide a successful regeneration outcome when it comes to critical nerve gap *** the lumen of conduits with different extracellular materials and cells could provide a better biomimicry of the natural nerve regenerating environment and is expected to ameliorate the conduit *** this study,we evaluated nerve regeneration in vivo using hollow chitosan conduits or conduits enriched with fibrin-collagen hydrogels alone or with the further addition of adipose-derived mesenchymal stem cells in a 15 mm rat sciatic nerve transection *** changes in the hydrogel consistency and structural stability in vivo led to a failure of nerve regeneration after 15 ***,the molecular assessment in the early regeneration phase(7,14,and 28 days)has shown an upregulation of useful regenerative genes in hydrogel enriched conduits compared with the hollow *** composed of fibrin-collagen were able to upregulate the expression of soluble NRG1,a growth factor that plays an important role in Schwann cell *** further enrichment with adipose-derived mesenchymal stem cells has led to the upregulation of other important genes such as ErbB2,VEGF-A,BDNF,c-Jun,and ATF3.

关键词： adipose-derived stem cells chitosan conduit fibrin and collagen hydrogel nerve regeneration nerve repair neuregulin 1 peripheral nerve sciatic nerve

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Importance of BRCA mutation for the current treatment of pancreatic cancer beyond maintenance

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World Journal of Gastroenterology 2021年第39期27卷 6515-6521页

作者： Joaquina Martínez-Galán Isabel Rodriguez Octavio Caba Department of Medical Oncology Virgen de las Nieves University HospitalGranada 18014Spain Institute of Biopathology and Regenerative Medicine(IBIMER) University of GranadaGranada 18016Spain

In this editorial,we comment on pancreatic cancer(PC),one of the most aggressive and lethal *** minimal improvements in survival rates have been achieved over recent *** chemotherapeutic regimens have little impact,and surgical resection remains the only reliable curative *** address current treatment options for these patients,focusing on the usefulness of breast cancer(BRCA)gene mutation as a prognostic biomarker and predictor of response to *** survival outcomes have been reported in patients with PC and mutant BRCA gene treated with first-line platinum-based ***,it appears appropriate to include BRCA gene status among clinical criteria used to select the chemotherapy *** addition,maintenance treatment with poly(ADP-ribose)polymerase inhibitors has been found to improve progression-free survival in patients with PC and mutated BRCA whose disease does not progress after first-line platinum-based *** combination has therefore been proposed as the optimal treatment regimen for these patients.

关键词： Pancreatic cancer Treatment BRCA Mutation Poly(ADP-ribose)polymerase inhibitor Maintenance

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Factors affecting populations of the endemic Iberian hare(Lepus granatensis)after the first myxomatosis outbreaks in Central Spain

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Integrative Zoology 2023年第6期18卷 981-993页

作者： Carlos LÁZARO JoséLuis GUZMÁN Fabián CASAS Carlos SÁNCHEZ-GARCÍA Department of Research Fundación ArtemisanCiudad RealSpain Department of Zoology Faculty of SciencesUniversity of GranadaGranadaSpain

The Iberian hare(Lepus granatensis)is an endemic species distributed in Spain and *** outbreaks affecting this species were detected in 2018 in Central and Southern Spain,spreading *** to evaluate factors affecting the status of hare population after the arrival of myxomatosis,we conducted 108 nocturnal hare counts in Central Spain during two study periods(winter/spring and summer/autumn)in 54 different hunting grounds,covering 1071 km and observing 884 *** mean density in winter/spring was 7.66 hares/100 ha,(range 6.14-9.54/100 ha),while in summer/autumn,it was 3.4 hares/100 ha(range 2.6-4.4/100 ha).Densities of hares were not affected by the dominant habitat and the presence/absence of myxomatosis *** were more abundant at hunting grounds at a higher altitude and in those conducting targeted management,while detection of myxomatosis was related to lower altitude and higher levels of game management.A MaxEnt model used to generate a risk map for myxomatosis occurrence showed that the temperature annual range was the most important predictor,which suggests that environmental factors affecting myxomatosis vectors(mosquitoes,fleas,and ticks)could play a key role in disease *** myxomatosis in hares is becoming endemic,hare densities may be improved by game management and the monitoring and surveillance of this emerging *** surveillance programs could be the basis of effective collaborations between hunters,researchers,and environmental managers.

关键词： game management habitat Iberian hare MaxEnt monitoring myxomatosis

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Remarks on “A new non-specificity measure in evidence theory based on belief intervals”

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Chinese Journal of Aeronautics 2018年第3期31卷 529-533页

作者： Joaquín ABELLAN Department of Computer Science and Artificial Intelligence University of Granada

Two types of uncertainty co-exist in the theory of evidence： discord and *** 90s, many mathematical expressions have arisen to quantify these two parts in an *** important aspect of each measure presented is the verification of a coherent set of *** non-specificity, so far only one measure verifies an important set of those properties. Very recently, a new measure of non-specificity based on belief intervals has been presented as an alternative measure that quantifies a similar set of properties（Yang et al., 2016）. It is shown that the new measure really does not verify two of those important properties. Some errors have been found in their corresponding proofs in the original publication.

关键词： Additivity Imprecise probabilities Non-specificity Subadditivity Theory of evidence Uncertainty measures

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Associations of physical activity, sedentary time, and physical fitness with mental health during pregnancy: The GESTAFIT project

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Journal of Sport and Health Science 2021年第3期10卷 379-386页

作者： Maria Rodriguez-Ayllon Pedro Acosta-Manzano Irene Coll-Risco Lidia Romero-Gallardo Milkana Borges-Cosic Fernando Estevez-Lopez Virginia A.Aparicio PROFITH“PROmoting FITness and Health through physical activity”Research Group Sport and Health University Research Institute(iMUDS)Department of Physical Education and SportsFaculty of Sport SciencesUniversity of GranadaGranada 18071Spain Department of Physical Education and Sport Faculty of Sport SciencesUniversity of GranadaGranada 18071Spain Sport and Health univ.rsity Research Institute(iMUDS) University of GranadaGranada 18007Spain Department of Psychology Faculty of Social and Behavioral SciencesUtrecht UniversityCS Utrecht 3584the Netherlands Department of Physiology Faculty of Pharmacy and Institute of Nutrition and Food TechnologyUniversity of GranadaGranada 18011Spain

Purpose:This study was aimed to analyze the associations of objectively measured physical activity(PA),sedentary time,and physical fitness with mental health in the early second trimester(16§2 gestational weeks)of ***:From 229 women initially contacted,124 pregnant women participated in the present cross-sectional *** were collected between November 2015 and March *** participants wore Actigraph GT3X+Triaxial accelerometers for 9 consecutive days to objectively measure their PA levels and sedentary time.A performance-based test battery was used to measure physical ***-report questionnaires assessed psychological ill-being(i.e.,negative affect,anxiety,and depression),and psychological well-being(i.e.,emotional intelligence,resilience,and positive affect).Linear regression analyses were adjusted for age,educational level,accelerometer wear time,miscarriages,and low back ***:Moderate-to-vigorous PA was negatively associated with depression(b=0.222,adjusted R2=0.050,p=0.041).Higher levels of sedentary time were negatively associated with positive affect(b=0.260,adjusted R2=0.085,p=0.017).Greater upper-body flexibility was positively associated with better emotional regulation(b=0.195,adjusted R2=0.030,p=0.047).The remaining associations were not significant(all p>0.05).Conclusion:An active lifestyle characterized by higher levels of moderate-to-vigorous PA and lower levels of sedentary time during pregnancy might modestly improve the mental health of pregnant *** previous research has focused on the benefits of cardiorespiratory exercise,the present study shows that only upper-body flexibility is related to emotional regulation in early pregnant *** the present findings are corroborated in further experimental research,physical exercise programs should focus on enhancing flexibility to promote improvements in emotional regulation during early second-trimester of pregnancy.

关键词： ActiGraph GT3X Emotional dysregulation Psychological health Sedentary behavior Stretching

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Parabolic Trough Collector and Central Receiver Coupled with Fresnel Lens:Experimental Tests

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International Journal of Automation and computing 2020年第4期17卷 572-587页

作者： Angelica Palacios Dario Amaya Olga Ramos univ.rsidad Militar Nueva granada Bogota 110121Colombia

Renewable energies have a high impact on power energy production and reduction of environmental pollution worldwide,so high efforts have been made to improve renewable technologies and research about *** paper presents the thermal performance results obtained by simulation and experimental tests of a parabolic trough collector with central receiver coupled to Fresnel lens,under different configurations on the *** simulation method was computational fluid dynamics(CFD)analysis in SolidWorks(R)soft-ware tool,which works with Naiver-Stokes equations to converge on a *** tests were formed with all configurations proposed and three observations for each one,a total of 12 observations were performed in all *** a result,the best thermal performance in simulation was achieved with the Fresnel lens and black pipe collector,with a maximum temperature of 116℃under 1000 W/m^2 radiation,the same system achieved in experimental tests a maximum temperature of 96℃with a radiation of 983 W/m^2.

关键词： Solar collector parabolic trough collector Fresnel lens thermal conductivity solar power

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Lessons from glaucoma: rethinking the fluid-brain barriers in common neurodegenerative disorders

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Neural Regeneration Research 2019年第6期14卷 962-966页

作者： Francisco Javier Carreras Department of Surgery Faculty of MedicineUniversity of Granada

Glaucoma has been recently characterized as a member of the group of anoikis-related diseases. Anoikis, a form of apoptosis, can be triggered by the unfastening of adherent junctions present in astrocytes. In those areas of the central nervous system in which the soma of the neurons or their axons and dendrites are metabolically dependent on the activity of astrocytes, a derangement of the lactate shuttle caused by a separation between the plasma membranes of neurons and astrocytes would result in metabolic impairment of the neurons themselves. In glaucoma, the triggering event has been attributed to the posterior deviation of aqueous humor towards the astrocyte-rich prelaminar tissue of the optic nerve head. The mean calcium content in the aqueous is able to interfere with calcium-dependent adherent junctions and induce anoikis of the astrocytes. As the cerebrospinal fluid has a similar base calcium concentration, a shunt of cerebrospinal fluid through the cerebral parenchyma would be able to interfere in the astrocytic architecture with dire consequences to the metabolically dependent neurons. Here the similitude between glaucoma,amyotrophic lateral sclerosis and Alzheimer's disease are discussed and the concept of the break in the fluid-brain barrier, as an event separated from the blood-brain barrier, is stressed.

关键词： fluid-brain barriers blood-brain barrier cerebrospinal fluid aqueous humor calcium ion glaucoma amyotrophic lateral sclerosis Alzheimer’s disease

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Successful treatment of psychosis induced by interferon alpha and ribavirin with paliperidone:first case reported

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General Psychiatry 2019年第4期32卷 214-217页

作者： Carmen Maura Carrillo de Albornoz Calahorro Maria Isabel Navarrete Paez Margarita Guerrero Jimenez Luis Gutierrez Rojas Psychiatry Hospital Universitario Virgen de las NievesGranadaSpain Hospital univ.rsitario San Cecilio University of GranadaGranadaSpain

Several clinical studies have shown a large number of mental symptoms by immunomodulatory treatment with interferon (IFN). The most frequently described symptoms are depression, suicidal behaviour, manic symptoms, anxiety, psychosis and delirium, associated with other non-specific symptoms such as fatigue, irritability, psychomotor retardation, decreased libido, insomnia, difficulty in concentration and attention. Having a history of mental disorder contraindicates the use of IFN-alpha. These adverse effects that affect the mental state appear usually at the beginning of the treatment (most after 3 weeks of treatment). The incidence of psychotic episodes is low and the episodes usually remit when treatment is interrupted;only some cases require antipsychotic treatment. We present the case of a patient affected with hepatitis C who began to present self-referential delirious symptoms after receiving the treatment with IFN and who was successfully treated with paliperidone. This patient could be classified within the group of high-risk psychiatric patients given the family history of schizophrenia and his personal history of illegal drug consumption. The pharmacological actions of paliperidone are similar to other high potency atypical antipsychotics.丁he receptorbinding profile of paliperidone most closely resembles that of risperidone and ziprasidone. Paliperidone differs from risperidone and most other antipsychotics by its relatively low extent of enzymatic hepatic metabolism. To the best of our knowledge, this is the first case described that was successfully treated with paliperidone.

关键词： psychosis interferon alpha ribavirin

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