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selective blockade of NF-kappa B by novel mutated I kappa B alpha suppresses CD3/CD28-induced activation of memory CD4(+) T cells in asthma

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南京医科大学学报（自然科学版） 2008年第6期28卷 826-826页

作者： Zhou,L. F. Zhang,M. s. Hu,A. H. Zhu Z. Yin,K. s. Nanjing med univ Affiliated Hosp 1Dept Resp MedNanjing 210029Peoples R China. Johns Hopkins UnivSch MedJohns Hopkins Asthma ＆ Allergy CtrDiv Clin Immunol ＆ AllergyBaltimoreMD USA. Nanjing med univ Dept Microbiol ＆ ImmunolNanjingPeoples R China. univ.Penn Childrens Hosp PhiladelphiaSch MedJoseph Stokes Jr Res InstPhiladelphiaPA 19104 USA Oregon Hlth ＆ sci univ Dept Biochem ＆ Mol BiolPortlandOR 97201 USA

Background:Nuclear factor kappa B(NF-kappa B) overactivation plays a crucial role in T-helper 2 (Th2)-biased allergic airway inflammation by increased activation and decreased apoptosis of CD4(+) T cells. We have shown that targeted NF-kappa B suppression in dendritic cells by adenoviral gene transfer of a novel mutated inhibitor of NF-kappa B(I kappa B alpha) (AdI kappa B alpha M) contributes to T-cell tolerance, but the immunosuppressive action of AdI kappa B alpha M on memory(CD45RO(+)) CD4(+) T cells remains enigmatic. Methods:CD45RO(+) T cells from Dermatophagoides farinaei-sensitized asthmatic patients, untransfected or transfected with AdI kappa B alpha M or AdLacZ(beta-galactosidase) for 24 h, were stimulated with anti-CD3(1.0 mu g/ml) plus anti-CD28(0.5 mu g/ml) monoclonal antibody for an additional 24 h. I kappa B alpha M transgene expression and NF-kappa B activation were detected by polymerase chain reaction(PCR), reverse transcription-PCR(RT-PCR), Western blot analysis, and electrophoretic mobility shift assay. Phenotype and apoptosis were measured by flow cytometry, annexin V binding, and terminal deoxyribonucleotidyl transferase-mediated dUTP nick end labeling analyses. Cytokine production and cell proliferation were determined using enzyme-linked immunosorbent assay andH-3 thymidine incorporation. Results:A unique 801-bp I kappa B alpha M cDNA and a dose-dependent increase in I kappa B alpha M transgene expression were observed in AdI kappa B alpha M-transfected CD45RO(+) T cells. significantly, AdI kappa B alpha M inhibited CD3/CD28-mediated NF-kappa B activation in CD45RO(+) T cells, leading to evident apoptosis, reduction of eotaxin, RANTEs, Th1 interferon (IFN)-gamma and interleukin (IL)-2, and Th2 (IL-4, IL-5, and IL-13 despite a slight decrease in IL-10) cytokines and secondary proliferative response. AdI kappa B alpha M also upregulated cytotoxic T lymphocyte-associated antigen 4(CTLA-4) and downregulated CD69 besides no change in CD28. Conclu

关键词：哮喘治疗方法临床分析 T细胞

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All-trans retinoic acid attenuates ultraviolet radiation-induced down-regulation of aquaporin-3 and water permeability in human keratinocytes

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南京医科大学学报(自然科学版) 2008年第5期 639-639页

作者： Amaral,A Kouttab,N Providence Coll Dept Biol Providence RI 02918 UsA. Brown univ.Dept Mol Microbiol & Immunol Providence RI 02912 UsA. Nanjing med univ.Dept Dermatol Nanjing Peoples R China. Boston univ.Roger Williams med.ctr.Dept Pathol Providence RI UsA. Providence Coll Dept Biol Providence RI 02918 UsA. Brown univ.Dept Mol Microbiol & Immunol Providence RI 02912 UsA. Nanjing med univ.Dept Dermatol Nanjing Peoples R China. Boston univ.Roger Williams med.ctr.Dept Pathol Providence RI UsA.

One of the major characteristics of human skin photoaging induced by ultraviolet(UV) radiation is the dehydration of theskin. Water movement across plasma membrane occurs via diffusion through lipid bilayer and via aquaporins (AQPs). We find thatUV induces aquaporin-3 (AQP3) down-regulation in human skin keratinocytes. MEK/ERK inhibitors PD98059 and U0126 inhibitUV-induced down-regulation of AQP3. Antioxidant N-acetyl-L-cysteine or NAC blocks UV-induced MEK/ERK activation and down-regulation of AQP3. All-trans retinoic acid or atRA, while alone inducing AQP3 expression, attenuates UV-induced down-regulationof AQP3 and water permeability. Using special inhibitors, we find that activation of EGFR and inhibition on ERK activation are in-volved in atRA’s protective effects against UV-induced AQP3 down-regulation. Using specific AQP3’s water transport inhibitors andsiRNA knockdown, we observe that AQP3 is involved in cell migration and in vitro wound healing. UV-induced AQP3 down-regula-tion results in reduced water permeability, decreased cell migration, and delayed wound healing, which are attenuated by atRApretreatment. We conclude that atRA protects against UV-induced down-regulation AQP3 and decrease in water permeability, reduc-tion in cell migration and delayed in vitro wound healing via trans-activation of EGFR and inhibition on ROs-mediated MEK/ERKpathway. This novel finding provides evidence to support possible involvement of AQP3 in UV induced skin dehydration.

关键词： skin in-vivo growth-factor receptor heparin-binding egf photoaged skin topical tretinoin epithelial-cells survival pathway irradiation activation inhibition

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Functional Variant in microRNA-196a2 Contributes to the susceptibility of Congenital Heart Disease in a Chinese Population

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南京医科大学学报（自然科学版） 2009年第11期29卷 1622-1622页

作者： XU , J. Hu, Z.B. Xu, Z.F. Gu, H.Y Yi, L. Cao, H. L. Chen, J. P. Tian, T. Liang, J. Lin, Y. Qiu, W. s. Ma, H.X. shen, H. B Chen, Y. J. Nanjing med univ Affiliated Hosp 1 Dept Thorac &Cardiovasc Surg Nanjing 210029 Peoples R China Nanjing med univ Sch Publ Hlth Dept Epidemiol & Biostat Nanjing 210029 Peoples R China Nanjing med univ Affiliated Nanjing Matern & Child Hlth Hosp Ctr Prenatal Diag Nanjing 210029 Peoples R China Nanjing univ Sch Med Dept Pathol Nanjing 210008 Peoples R China Nanjing med univ Affiliated Hosp 2 Dept Thorac & Cardiovasc Surg Nanjing 210029 Peoples R China

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Nat Genet:科学家发现相同肿瘤中存在不同遗传复杂性的癌细胞

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现代生物医学进展 2017年第3期17卷 I0004-I0004页

作者： Hao, Jia-Jie Lin, De-Chen Dinh, Huy Q. Mayakonda, Anand Jiang, Yan-Yi Chang, Chen Jiang, Ye Lu, Chen-Chen shi, Zhi-Zhou Xu, Xin Zhang, Yu Cai, Yan Wang, Jin-Wu Zhan, Qi-Min Wei, Wen-Qiang Berrnan, Benjamin P. Wang, Ming-Rong Koeffler, H. Phillip Chinese Acad med sci Natl Canc Ctr Canc Hosp State Key Lab Mol Oncol Beijing Peoples R China Peking Union med Coll Beijing Peoples R China univ.Calif Los Angeles Cedars Sinai Med Ctr Sch Med Div Hematol Oncol Los Angeles CA 90048 USA sun Yat sen univ Sun Yat Sen Mem Hosp Med Res Ctr Guangdong Prov Key Lab Malignant Tumor Epigenet & Guangzhou Guangdong Peoples R China Cedars sinai med ctr Biomed Sci Ctr Bioinformat & Funct Genom Los Angeles CA 90048 USA Natl univ.singapore Canc Sci Inst Singapore Singapore Singapore Kunming univ.sci & Technol Fac Med Kunming Peoples R China Linzhou Canc Hosp Dept Pathol Linzhou Henan Peoples R China Chinese Acad med sci Natl Canc Ctr Canc Hosp Dept Canc Epidemiol Beijing Peoples R China Natl univ.singapore Inst Canc Natl Univ Singapore Hosp Singapore Singapore

近日，一项刊登于国际杂志Namre Genetics上的研究报告中。来自美国洛杉矶希达-西奈（Cedars-sinai）医学院的研究人员通过研究在食管肿瘤的组织样本中鉴别出了2000多个基因突变，从而详细阐述了癌症的复杂性。本文研究表明。单一肿瘤... 详细信息

近日，一项刊登于国际杂志Namre Genetics上的研究报告中。来自美国洛杉矶希达-西奈（Cedars-sinai）医学院的研究人员通过研究在食管肿瘤的组织样本中鉴别出了2000多个基因突变，从而详细阐述了癌症的复杂性。本文研究表明。单一肿瘤的不同区域或许具有多种遗传模式。

关键词：食管肿瘤遗传模式复杂性 Nat 癌细胞科学家基因突变研究人员

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巨大先天性黑色素痣与肝脏黑色素沉积

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世界核心医学期刊文摘（儿科学分册） 2006年第2期2卷 4-4页

作者： Prais D. Nussinovitch M. Kornreich L. Amir J. 张振 Department of Paediatrics C Schneider Children' s Med. Ctr. I. Petah Tikva 49202 Israel

This report describes a neonate with a giant congenital pigmented naevus over most of the trunk surface area, along with multiple satellite lesions, especially over the legs. Magnetic resonance imaging of the abdomen showed large deposits of melanin in the glutei bilaterally, the rectus abdominis muscles and the liver. Treatment consisted of repeated dermabrasion of the naevus over the lower back with CO2 laser (silk Touch), followed by autologous skin grafting. No evidence of malignant transformation was observed. Conclusion: Giant congenital melanocytic naevus may be associated with involvement of internal organs other than the central nervous system.

关键词：黑色素沉积黑色素痣先天性肝脏内巨大磁共振成像检查二氧化碳激光器自体皮片移植术中枢神经系统新生儿患者

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Editorial for Biomedical Applications of AIE special section

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CCs Chemistry 2022年第2期4卷 392-396页

作者： Xi Zhang Dan Ding Zhong Tang Donna J.Minton Natl univ.singapore Singapore Singapore Nankai univ Frontiers Sci Ctr Cell Responses State Key Lab Med Chem Biol Key Lab Bioact MatMinist Educ Tianjin Peoples R China Nankai univ Coll Life Sci Tianjin Peoples R China Hong Kong univ.sci & Technol Hong Kong Peoples R China CCs Beijing Peoples R China Chinese univ.Hong Kong Hong Kong Peoples R China

The Chinese New Year is just under way,and we would like to wish all of our readers“新年快乐”or Happy Chinese New Year!There is much to look forward to in the Year of the Tiger,not the least of which is the 90th Anniversary of *** every editorial throughout 2022,we are taking a look back at the development of chemistry in China,as well as the formation of CCs as a scientific *** month,we covered the founding of the society in a meeting in August 1932 in *** dedication and commitment by the society’s original members resulted in the society becoming fully established within a few years.

关键词：新年快乐 founding becoming

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直肌移位术联合后固定缝线术治疗双上提肌麻痹

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世界核心医学期刊文摘(眼科学分册) 2005年第10期 61-61页

作者： snir M. Friling R. Kalish-stiebel H. 王永强 Ophthalmology Unit Schneider Children's Med. Ctr. I. Petah Tiqva 49202 Israel Dr.

Purpose: To evaluate the surgical and functional results of full horizontal te ndon rectus muscle transposition to the superior rectus (sR) insertion, augmente d by posterior fixation sutures, in patients with double-elevator palsy (DEP). Design: Retrospective nonconcurrent interventional comparative case series. Part icipants: Fourteen consecutive patients with DEP. Intervention: six patients tre ated for DEP by vertical transposition of the horizontal muscles to the sR inser tion (Knapp procedure)-were compared with 8 patients treated by the Knapp proce dure combined with fixation of the transposed muscles to the sclera, adjacent to the sR, with nonabsorbable sutures. Main Outcome Measures: Postoperative ocular alignment, ductions, binocular functions, and rate of reoperation. Results: Ocu lar deviation: Mean distance and near deviations decreased by 84%and 83%, resp ectively (P=0.012), in the augmented-surgery group versus 48%and 47%, respect ively (P = 0.03), in the standard-surgery group. Duction: Mean elevation defici ency in abduction and adduction improved by 64%and 65%, respectively (P=0.01), in the augmented surgery group versus 42%and 55%(P = 0.02) in the standard gr oup. Binocular functions: 3 patients (37%), all in the study group, gained bino cular function. Reoperation was required in 5 patients (83.3%) in the control g roup. The difference in postoperative improvement between the groups was statist ically significant for all 4 parameters. No postoperative complications or ducti on anomalies were observed during the follow-up period of 15.4 months (standard deviation, 5.5). Conclusions: The augmented Knapp procedure with superior poste rior fixation suture is the preferred surgical treatment for patients with DEP. Its use in this series avoided the need for multiple surgeries on other extraocu lar muscles.

关键词：肌麻痹缝线术直肌上提

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垂直肌完全移位术联合内直肌后部固定缝线术治疗内收功能不足

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世界核心医学期刊文摘（眼科学分册） 2005年第10期1卷 61-61页

作者： snir M. Friling R. Kalish-stiebel H. 王永强 Pediatric Ophthalmology Unit Schneider Children's Med. Ctr. I. Petah Tiqva 49202 Israel Dr.

Purpose: To compare the surgical and functional results of full tendon rectus muscle transposition to the medial rectus muscle augmented with posterior medial fixation sutures in patients with adduction deficiency (ADD) and Duane's syndr ome type 2. Design: Retrospective nonconcurrent interventional comparative case series. Participants: Twelve consecutive patients with ADD and Duane's syn drome type 2. Interventions: six patients treated by the full tendon rectus mu scle transposition procedure alone were compared with 6 patients treated by the full tendon rectus muscle transposition combined with posterior medial fixation sutures. Main Outcome Measures: Postoperative ocular alignment, duction improvem ent, binocular functions, and reoperation. Results: In the augmented surgery gro up, mean distance and near deviation decreased by 74.5%and 74%, respectively, versus 56%and 59%, respectively, in the control group (P=0.007 and 0.02, betwe en-group comparison for distance and near deviation, respectively). Mean ductio n improved in 73%of the study group compared with 52%of controls (P=0.025). No postoperative complications or duction anomalies were observed during follow-u p in the entire cohort; reoperation was needed in 1 patient in the study group a nd in all 6 patients in the control group. Conclusions: The augmented full verti cal rectus muscle procedure is a beneficial surgical approach for patients with ADD and Duane's retraction syndrome type 2, reducing the need for multiple extr aocular muscle surgery.

关键词：后固定缝线术双上肌麻痹直肌移位术眼位偏斜视功能眼球转动眼外肌干预性

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Human mesenchymal stem cells overexpressing pigment epitheliumderived factor inhibit hepatocellular carcinoma in nude mice（摘要）

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南京医科大学学报（自然科学版） 2010年第8期30卷 1064-1064页

作者： Gao, Y Yao, A Zhang, W Lu, s Yu, Y Deng, L Yin, A Xia, Y sun, B Wang, X 不详 Nanjing med univ Liver Transplantat Ctr Affiliated Hosp 1 Nanjing 210029 Jiangsu Peoples R China Nanjing med univ Ctr Canc Nanjing 210029 Jiangsu Peoples R China

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FAs promoter polymorphisms and cancer risk： a meta-analysis based on 34 casecontrol studies

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南京医科大学学报（自然科学版） 2009年第4期29卷 444-444页

作者： Zhang, Z. Z. Xue, H. C. Gong, W. D. Wang, M. L. Yuan, L. Han, s. P. Zhang, Z. D. Nanjing med univ Sch Publ Hlth Dept Mol &Genet Toxicol Ctr Canc Nanjing 210029 Peoples R China. Nanjing med univ Key Lab Reprod Med Nanjing 210029 Peoples R China. Yangzhong Peoples Hosp Dept Thorac Surg Inst Canc Res Yangzhong 212200 Peoples R China. Yixing Peoples Hosp Dept Surg Yixing 214200 Peoples R Chino. Nanjing med univ Affiliated Hosp 1 Dept Obstet & Gynecol Nanjing 210029 Peoples R China.

FAs is a cell surface receptor involved in apoptotic signal transmission and plays important roles in the etiology of cancer. The-1377G > A and-670A > G polymorphisms of the FAs gene influence the FAs transcription and have been implicated in cancer risk. However, the results from the published studies on the association between these two FAs polymorphisms and cancer risk are conflicting. To derive a more precise estimation of association between the FAs polymorphisms and risk of cancer, we performed a meta-analysis of 11 461 cancer cases and 12 708 controls from 34 published case-control studies for these two polymorphisms. We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of the association.

关键词：病因学医学肿瘤治疗临床

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