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外源性肺泡表面活性剂(Calfactant)对小儿急性肺损伤的疗效:随机对照试验

世界核心医学期刊文摘（儿科学分册） 2005年第6期1卷 1-2页

作者： Willson D. F. Thomas N. J. Markovitz B. P. 李开 univ. virginia children’s med.ctr. PO Box 800-386 Charlottesville VA 22908 United States

Context: Despite evidence that patients with acute lung injury (ALI) have pulmonary surfactant dysfunction, trials of several surfactant preparations to treat adults with ALI have not been successful. Preliminary studies in children with ALI have shown that instillation of a natural lung surfactant (calfactant) containing high levels of surfactant-specific protein B may be beneficial. Objective: To determine if endotracheal instillation of calfactant in infants, children, and adolescents with ALI would shorten the course of respiratory failure. Design, setting, and Patients: A multicenter, randomized, blinded trial of calfactant compared with placebo in 153 infants, children, and adolescents with respiratory failure from ALI conducted from July 2000 to July 2003. Twenty-one tertiary care pediatric intensive care units participated. Entry criteria included age 1 week to 21 years, enrollment within 48 hours of endotracheal intubation, radiological evidence of bilateral lung disease, and an oxygenation index higher than 7. Premature infants and children with preexisting lung, cardiac, or central nervous system disease were excluded. Intervention: Treatment with intratracheal instillation of 2 doses of 80 mL/m2 calfactant or an equal volume of air placebo administered 12 hours apart. Main Outcome Measures: Ventilator-free days and mortality; secondary outcome measures were hospital course, adverse events, and failure of conventional mechanical ventilation. Results: The calfactant group experienced an acute mean (sD) decrease in oxygenation index from 20 (12.9) to 13.9 (9.6) after 12 hours compared with the placebo group’s decrease from 20.5 (14.7) to 15.1 (9.0) (P=.01). Mortality was significantly greater in the placebo group compared with the calfactant group (27/75 vs 15/77; odds ratio, 2.32; 95%confidence interval, 1.15-4.85), although ventilator-free days were not different. More patients in the placebo group did not respond to conventional mechanical ventilation. T

关键词：急性肺损伤 Calfactant 随机对照试验常规机械通气气管内滴注氧合指数呼吸衰竭出生后三级医疗安慰剂

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Differences in willingness to donate cadaveric organ between young donor families and adult donor families： evidence from the Hunan Province, China

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Chinese medical Journal 2013年第15期126卷 2830-2833页

作者： XIE Wen-zhao YE Qi-fa LIU Wei sHAO Ming-jie WAN Qi-quan LI Cui-ying LUO Ai-jing Cent s univ Affiliated Hosp 3 Chinese Minist Hlth Transplantat Med Engn & Techn Res Ctr Changsha 410013 Hunan Peoples R China Cent s univ Coll Publ Hlth Coll Hunan Prov Key Lab Med Informat Res Changsha 410013 Hunan Peoples R China

Background The Red Cross of China and Ministry of Health jointly started a pilot program of organ donation after cardiac death to overcome the shortage of available organs since 2010. The purpose of this qualitative study were to compare the consent rate of organ donation between young donor families and adult donor families; to explore and determine factors associated with differences in willingness to donate organs between them. Research objective was to provide a rationale for further preparation of professionals involved in this sensitive work. Methods Between March 2010 and June 2012, 24 young deceased patients including donors and non-donors and 96 potential adult donors were collected, and consent rates of young donors＇ families and adult donors＇ families were calculated. A X2 test analysis to compare the consent rates of the two groups was conducted. We studied through semi- structured interviews 15 parents of young donors and 15 relatives of old donors who were interviewed for petition of consent. Data collection and analysis of the overall study were performed according to the grounded theory methodology. Factors that influenced the families＇ decisions were identified and classified. We found the differences in willingness to donate organs between the two groups. Results The consent rate of young donor families was 66.67%, while the consent rate of adult donor families was 26.04%. Young donor families easily consented to organ donation than adult donor families （P〈0.005）. The donors＇ families had been affected by various factors throughout the process of deciding to give consent for donation. The findings led to the formulation of an empirically based model of interlinking categories that influence families＇ decision-making process in organ donation. These factors are grouped into five main categories：（1） personal factors, （2） conditions of organ request, （3） interpersonal factors, （4） ethical factors, and （5） traditional views. The funeral tradition infl

关键词： organ donation family decision making China

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德系犹太裔克罗恩病少儿患者与成年患者的NOD2/CARD15基因突变以及基因型-表现型相关性对比研究

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世界核心医学期刊文摘（儿科学分册） 2005年第1期1卷 46-47页

作者： Weiss B. shamir R. Bujanover Y. 张振 Div.Pediat.Gastroenterol.Nutr.safra children's Hospital Chaim Sheba Med.Ctr.Tel-H.HaifaIsrael

目的:NOD2/CARD15基因位点上的等位基因G908R、R702W和1007fs,与克罗恩病(CD)易感性之间存在显著而独立的相关性。笔者选择犹太裔CD患儿(≤16岁)和成年患者作为研究对象,比较分析两组患者NOD2/CARD15基因位点的基因型以及基因型-表现型... 详细信息

目的:NOD2/CARD15基因位点上的等位基因G908R、R702W和1007fs,与克罗恩病(CD)易感性之间存在显著而独立的相关性。笔者选择犹太裔CD患儿(≤16岁)和成年患者作为研究对象,比较分析两组患者NOD2/CARD15基因位点的基因型以及基因型-表现型相关性。方法:分析67例CD患儿和成年患者基因序列,采用等位基因特异性聚合酶链反应和限制性内切酶酶切反应,检测上述3个等位基因的携带率。同时,检测患者的表现型征象。结果:上述3个NOD2/CARD15 相关性等位基因的携带率,儿童组为51.1%,成年组为37.5%,两组间差异具有统计学显著性,P=0.07。G908R是最常见的等位基因,患儿组携带率为18%,成年患者组为11%,两组间差异具有统计学显著性,P= 0.063。德系犹太裔患儿的G908R等位基因携带率最高,远高于德系成年患者,两组的携带率分别为25%和9%,组间差异具有统计学显著性,P:0.003。患儿多有炎症性肠道疾患家族史,多患炎症性疾病,但与其携带的等位基因改变没有相关性。结论:德系犹太裔少儿幼年期发生的CD,与患儿NOD2/CARD15基因位点上出现G908R等位基因突变型存在密切的关联。

关键词：克罗恩病犹太裔 NOD2/CARD15 携带率 CARD 表现型聚合酶链反应基因突变统计学显著性基因位点

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Pedicled greater omentum flap for preventing bile leak in liver transplantation patients with poor biliary tract conditions

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Hepatobiliary & Pancreatic Diseases International 2007年第5期6卷 470-473页

作者： Ye, Qi-Fa Niu, Ying she, Xing-Guo Ming, Ying-Zi Cheng, Ke Ma, Yin Ren, Zu-Hai Cent s univ Xiangya Hosp 3 Res Ctr Natl Hlth Minist Transplantat Med Engn & Technol Changsha 410013 Peoples R China

BACKGROUND: Bile leak remains a main complication in liver transplantation patients with poor biliary tract conditions, mainly caused by an insufficient blood supply or dysplasia of the biliary tract. Although Roux-en-Y modus operandi can be adopted, the risk of other complications of the biliary tract such as infection increases. Using pedicled greater omentum flaps to wrap the anastomotic stoma, which increases the biliary tract blood supply, may reduce the incidence of bile leak. METHODs: Fourteen patients undergoing piggy-back liver transplantation and having poor biliary tract conditions were treated with pedicled greater omentum flaps to wrap the anastomotic stoma of the biliary tract. Their clinical data were analyzed retrospectively. REsULTs: Of the 14 patients, only one (7.1%) had a mild bile leak on the 8th day post-operation and fully recovered after symptomatic treatment. The other patients had no biliary complications. CONCLUsIONs: Using pedicled greater omentum flaps to wrap the anastomotic stoma of the biliary tract is an effective way to prevent bile leak in liver transplantation patients, especially those with poor biliary tract conditions. However, experience with this surgical technique still needs to be further explored.

关键词： liver transplantation bile leak greater omentum flap

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GDNF cDNA-engineered NIH 3T3 cells protect primary dopaminergic neurons

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Chinese science Bulletin 1997年第22期42卷 1921-1925页

作者： Ma, DD Wang, XM Jing, XJ Wang, J Xiong, L song, H Wan, Y Xu, GH sun, QL Cai, D Wang, XH Han, Js Beijing med univ Neurosci Res Ctr Beijing 100083 Peoples R China

IN vitro and in vivo experiments show the protective effects of glial cell line-derived neu-rotrophic factor (GDNF) on dopaminergic (DA) neurons are potent and relatively specif-ic. However, GDNF protein is not small ... 详细信息

关键词： GDNF Parkinson’s disease engineering cells dopaminergic neurons.

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Prehospital road traffic injuries among the elderly in Beijing, China： data from the Beijing Emergency medical Center, 2004-2010

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Chinese medical Journal 2013年第15期126卷 2859-2865页

作者： AN shuai ZHANG Jin-jun ZHANG Pei-xun YIN Xiao-feng KOU Yu-hui WANG Yan-hua WANG Zhen-wei JIANG Bao-guo WANG Tian-bing Peking univ Peoples Hosp Dept Orthopaed & Traumatol Beijing 100044 Peoples R China Peking univ Traff Med Ctr Beijing 100191 Peoples R China Beijing Emergency med ctr Beijing 100031 Peoples R China

Background Road traffic injuries （RTIs） are a worldwide issue associated with increasing development and motorization. However, statistical studies do not include any analyses of Beijing＇s geriatric population. Using data from the Beijing Emergency medical Center, we present the main characteristics of traffic injuries involving the elderly in Beijing. We also provide objective information for those concerned with the safety of traffic systems and the prevention of traffic injuries. Methods In a longitudinal, retrospective study, data were collected on 1706 victims aged 65 years and older who sustained traffic injuries in Beijing between 2004 and 2010. Personal information, time of injury event, emergency care response time, road user type, striking vehicle type, injury site, and severity of injury were analyzed using ;~2 tests and Logistic regression analysis. Results The annual rate of traffic injuries was 21.80 per 100 000 elderly people in Beijing, and the morbidity rate decreased from 2004 to 2010 （P 〈0.001）. The mean age was （72.92＋5.67） years, and 911 （53.40%） of the victims were male. The majority of victims sustained head and lower limb injuries and were classified as being of medium severity. Traffic collisions occurred most frequently in the daytime excluding rush hours; these collisions included being hit by a car （85.64%） and pedestrian victim injuries （79.19%）. Our statistical analysis found three factors for injury severity： abdominal injuries （P 〈0.001）, number of injury sites （P=0.027）, and head injuries （P=0.034）. The decline in traffic injuries is due to a decrease in victims aged 65-74 years and pedestrians; the sevedty of RTIs also decreased. Conclusions This study highlights the declining trend in traffic injuries among older adults in Beijing. However, traffic injuries remain a serious public health problem for the elderly and effective measures are required to reduce their incidence.

关键词： road traffic injury older adults emergency medical services

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Liver transplant recipients with portal vein thrombosis:a single center retrospective study

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Hepatobiliary & Pancreatic Diseases International 2009年第1期8卷 34-39页

作者： Tao, Yi-Feng Teng, Fei Wang, Zheng-Xin Guo, Wen-Yuan shi, Xiao-Min Wang, Gui-Hua Ding, Guo-shan Fu, Zhi-Ren second Mil med univ Changzheng Hosp Organ Transplantat Ctr Shanghai 200003 Peoples R China

BACKGROUND: Portal vein thrombosis (PVT) used to be a contraindication for liver transplantation (LT). This obstacle has been delt with following the improvement of LT-related techniques and therapeutic approaches to thrombosis. But the effect of PVT on LT outcomes is still controversial. We reviewed retrospectively the outcome of LT patients with PVT as well as risk factors and surgical management according to PVT grades. METHODs: A total of 465 adult LTs were performed from December 2002 through December 2006. Operative findings and the result of preoperative ultrasonography and imaging were reviewed for PVT grading (Yerdel grading). Comparison of risk factors, variables associated with perioperative period and prognosis between recipients with and without PVT is based on the grades. REsULTs: In the 465 LTs, 42 were operatively confirmed to have PVT (9.0%) (19 recipients with grade I, 14 with grade 2, 7 with grade 3, and 2 with grade 4). Increased age and treatment of portal hypertension were associated with PVT. Grade 1 or 2 PVT was treated by direct anastomosis or single thrombectomy. In grade 3 PVT patients, the donor PV was directly anastomosed to the dilated branch of the recipient portal venous system or to the distal open superior mesenteric vein through an interposition vein graft if needed. Grade 4 PVT was managed by our modified cavoportal hemitransposition technique. The comparison between PVT patients and controls showed no significant difference in operative duration and blood transfusion (P > 0.05). The flow rate of the PV was lower in the PVT patients (48.881 +/- 12.788 cm/s) than in the controls (57.172 +/- 21.715 cm/s, P s had such postoperative complications as renal failure and PV rethrombosis (P survival rates in PVT and non-PVT patients were 78.6% and 76.4% respectively (P > 0.05); the 3-year survival rates were 58.8% and 56.4% respectively (P > 0.05). CONCLUsIONs: PVT is not contraindicated for LT i

关键词： portal vein thrombosis liver transplantation prognosis

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Long-term efficacy of perioperative chemoradiotherapy on esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2010年第13期16卷 1649-1654页

作者： Lv, Jin Cao, Xiu-Feng Zhu, Bin Ji, Lv Tao, Lei Wang, Dong-Dong Nanjing med univ Affiliated Nanjing Hosp 1 Dept Surg Ctr Oncol Nanjing 210006 Jiangsu Peoples R China

AIM: To investigate the role of perioperative chemoradiotherapy (CRT) in the treatment of locally advanced thoracic esophageal squamous cell carcinoma (EsCC). METHODs: Using preoperative computed tomography (CT)-based staging criteria, 238 patients with EsCC (stage ⅡⅢ ) were enrolled in this prospective study between January 1997 and June 2004. With informed consent, patients were randomized into 3 groups: preoperative CRT (80 cases), postoperative CRT (78 cases) and surgery alone (s) (80 cases). The 1-, 3-, 5and 10-year survival were followed up. Progressionfree survival (PFs) was chosen as the primary endpoint by treatment arm measured from study entry until documented progression of disease or death from any cause. The secondary endpoint was overall survival (Os) determined as the time (in months) between the date of therapy and the date of death. Other objectives were surgical and adjuvant therapy ***: With median follow-up of 45 mo for all the enrolled patients, significant differences in the 1-, 3-, 5-, 10-year Os (91.3%, 63.5%, 43.5%, 24.5% vs 91%, 62.8%, 42.3%, 24.4% vs 87.5%, 51.3%, 33.8%, 12.5%, P = 0.0176) and PFs (89.3%, 61.3%, 37.5%, 18.1% vs 89.1%, 61.1%, 37.2%, 17.8% vs 84.5%, 49.3%, 25.9%, 6.2%, P = 0.0151) were detected among the 3 arms. There were no significant differences in Os and PFs between the preoperative CRT and postoperative CRT arm (P > 0.05). For the patients who had radical resection, significant differences in median PFs (48 mo vs 61 mo vs 39.5 mo, P = 0.0331) and median Os (56.5 mo vs 72 mo vs 41.5 mo, P = 0.0153) were detected among the 3 arms, but there were no significant differences in Os and PFs between the preoperative CRT and postoperative CRT arm (P > 0.05). The local recurrence rates in the preoperative CRT, postoperative CRT group and s group were 11.3%, 14.1% and 35%, respectively (P significant differences were detected among the 3 groups when comparing complications but tended to be in favor

关键词： Esophageal cancer surgery Esophagectomy Chemotherapy Radiation therapy

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Pancreaticoduodenal transplantation with portal venous and enteric drainage in rats

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World Journal of Gastroenterology 2000年第6期6卷 914-916页

作者： Gu YP Gu JY Li Js Nanjing univ Nanjing Gen Hosp Sch Med Transplantat Ctr Nanjing 210002 Jiangsu Provinc Peoples R China

INTRODUCTIONThe use of combined pancreatic and renaltransplantation in patients with diabetes and end-stage renal failure has gained widespreadrecognition as an acceptable treatment *** method used for transplantation... 详细信息

关键词： pancreaticoduodenal transplantation kidney transplantation portal venous drainage enteric drainage postoperative complications rats

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Change of glutamic acid decarboxylase antibody and protein tyrosine phosphatase antibody in Chinese patients with acute-onset type 1 diabetes mellitus

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Chinese medical Journal 2013年第21期126卷 4006-4012页

作者： Chao Chen Huang Gan Li Xia Yang Lin Lin Jian Jin Ping Luo shuo-ming Zhang Yi-yu Pan Ling-ling Zhou Zhi-guang Cent s univ Xiangya Hosp 2 Diabet CtrInst Metab & EndocrinolMinist Educ Hunan Key Lab Med EpigenomKey Lab Diabet Immunol Changsha 410011 Hunan Peoples R China

Background Glutamic acid decarboxylase antibody （GADA） and protein tyrosine phosphatase antibody （IA-2A） are two major autoantibodies, which exert important roles in the process of type 1 diabetes mellitus （T1D）. Our study aimed to investigate the changes in positivity and titers of GADA and IA-2A during the course of Chinese acute-onset T1D patients and their relationships with clinical features.

关键词： C-peptide diabetes mellitus, type 1 glutamic acid decarboxylase antibody," protein tyrosine phosphatase antibody

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