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A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren s.Kelly Jennifer A.Munley Erick E.Pons Kolenkode B.Kannan Elizabeth M.Whitley Letitia E.Bible Philip A.Efron Alicia M.Mohr Department of surgery and sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHs),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(BM)erythroid progenitor(CFU-GEMM,BFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CsF)and right lung histologic injury were assessed on day 7,with significance defined as p valuessults:Polytrauma resulted in markedly more profound inhibition of weight gain compared to LCHs(p=0.0002)along with elevated plasma TLR4(pspleen to body weight ratios(p=0.004).Both LCHs and PT demonstrated suppression of CFU-E and BFU-E growth compared to naive(psma G-CsF was elevated in PT compared to both na?ve and LCHs(ps and PT demonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:Multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

Reduction of epinephrine in the lumbar spinal cord following repetitive blast-induced traumatic brain injury in rats

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Neural Regeneration Research 2024年第7期19卷 1548-1552页

作者： shigeharu Tsuda Mustafa Golam Jiamei Hou Kevin K.W.Wang Floyd J.Thompson Prodip Bose Brain Rehabilitation Research Center Malcom Randall VA Medical CenterNorth Florida/South Georgia Veterans Health SystemGainesvilleFLUSA Department of Anesthesiology College of MedicineUniversity of FloridaGainesvilleFLUSA Department of Emergency Medicine University of FloridaGainesvilleFLUSA Department of Neuroscience University of FloridaGainesvilleFLUSA Department of Neurology University of FloridaGainesvilleFLUSA

Traumatic brain inju ry-induced unfavorable outcomes in human patients have independently been associated with dysregulated levels of monoamines,especially epinephrine,although few preclinical studies have examined the epinephrine level in the central nervous system after traumatic brain *** has been shown to regulate the activities of spinal motoneurons as well as increase the heart rate,blood pressure,and blood flow to the hindlimb ***,the purpose of the present study was to determine the impact of repeated blast-induced traumatic brain injury on the epinephrine levels in seve ral function-s pecific central nervous system regions in *** three repeated blast injuries at 3-day intervals,the hippocampus,motor cortex,locus coeruleus,vestibular nuclei,and lumbar spinal cord were harvested at post-injury day eight and processed for epinephrine assays using a high-sensitive electrochemical detector cou pled with high-performance liquid *** results showed that the epinephrine levels were significantly decreased in the lumbar spinal cord tissues of blast-induced traumatic brain injury animals compared to the levels detected in age-and sex-matched sham *** other function-specific central nervous system regions,although the epinephrine levels were slightly altered following blast-induced tra u matic brain injury,they were not statistically *** results suggest that blast injury-induced significant downregulation of epinephrine in the lumbar spinal cord could negatively impact the motor and cardiovascular *** is the first repo rt to show altered epinephrine levels in the spinal cord following repetitive mild blast-induced traumatic brain injury.

关键词： balance blood flow cardiovascular system central nervous system epinephrine ischemic damage lumbar spinal cord muscle tone repeated blast spasticity traumatic brain injury

Calcium/calcimimetic via calcium-sensing receptor ameliorates cholera toxin-induced secretory diarrhea in mice

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World Journal of Gastroenterology 2024年第3期30卷 268-279页

作者： Lie-Qi Tang Johnathan Fraebel shi Jin steven P Winesett Jane Harrell Wen-Han Chang sam Xianjun Cheng Department of Pediatrics University of FloridaGainesvilleFL 32610United States College of Medicine University of FloridaGainesvilleFL 32610United States Applied Physiology and Kinesiology University of FloridaGainesvilleFL 32610United States Brain Rehabilitation Research Center Malcom Randall VA Medical CenterGainesvilleFL 32610United States Department of Medicine Endocrine Research UnitVeterans Affairs Medical CenterUniversity of CaliforniaSan FranciscoSan FranciscoCA 94121United States Department of Pediatric Gastroenterology Hepatologyand NutritionUniversity of Florida Shands Children’s HospitalGainesvilleFL 32608United States

BACKGROUND Enterotoxins produce diarrhea through direct epithelial action and indirectly by activating the enteric nervous ***-sensing receptor(CasR)inhibits both *** latter has been well documented in vitro but not in *** hypothesis to be tested was that activating CasR inhibits diarrhea in *** To determine whether CasR agonists ameliorate secretory diarrhea evoked by cholera toxin(CTX)in *** CTX was given orally to C57BL/6 mice to induce *** and calci-mimetic R568 were used to activate *** maximize their local intestinal actions,calcium was administered luminally via oral rehydration solution(ORs),whereas R568 was applied serosally using an intraperitoneal *** verify that their actions resulted from the intestine,effects were also examined on Cre-lox intestine-specific CasR *** outcome was measured biochemically by monitoring changes in fecal Cl-or clinically by assessing stool consistency and weight *** CTX induced secretory diarrhea,as evidenced by increases in fecal Cl-,stool consistency,and weight loss following CTX exposure,but did not alter CasR,neither in content nor in ***,calcium and R568 were each able to ameliorate diarrhea when applied to diseased *** CasR involvement is suggested by gene knockout experiments where the anti-diarrheal actions of R568 were lost in intestinal epithelial CasR knockouts(villinCre/Casrflox/flox)and neuronal CasR knockouts(nestinCre/Casrflox/flox).CONCLUsION Treatment of acute secretory diarrheas remains a global *** advances in diarrhea research,few have been made in the realm of diarrhea *** therapy has remained the standard of care,although it does not halt the losses of intestinal fluid and ions caused by *** is no cost-effective therapeutic for *** and other studies suggest that adding calcium to ORs or using calcimimetics to activate intestinal CasR might

关键词： Cholera Enteric nervous system secretory diarrhea Oral rehydration solution Calcium-sensing receptor Gene knockout

Going straight for the gut:gut-brain axis pathology and treatment of Parkinson's disease

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Neural Regeneration Research 2024年第10期19卷 2111-2112页

作者： Dominique Ebedes Cesar V.Borlongan university of south florida Morsani College of Medicine TampaFLUSA Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of MedicineTampaFLUSA

This perspective focuses on the recent literature regarding the role of the gut-brain axis(GBA) in fecal microbiota transplantation(FMT) and stem cell therapy(sCT) in Parkinson's disease(PD).PD is the second most common neurodegenerative disease in the United states,yet therapies remain *** research suggests that the GBA may play a role in the pathogenesis of *** FMT as well as sCT offer promising new avenues for PD *** bing the interactions between FMT and sCT with the GBA may reveal novel therapeutics for PD.

关键词： straight pathology pathogenesis

Mucopolysaccharidosis typeⅢB:a current review and exploration of the AAV therapy landscape

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Neural Regeneration Research 2024年第2期19卷 355-359页

作者： Courtney J.Rouse Victoria N.Jensen Coy D.Heldermon Lacerta Therapeutics AlachuaFLUSA university of florida College of Medicine GainesvilleFLUSA

Mucopolysaccharidoses typeⅢB is a rare genetic disorder caused by mutations in the gene that encodes for *** results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological *** treatment options are expensive,limited,and presently there are no approved cures for mucopolysaccharidoses typeⅢ***-associated virus gene therapy has significantly advanced the field forward,allowing researchers to successfully design,enhance,and improve potential *** group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores N-acetyl-alpha-glucosaminidase levels,auditory function,and lifespan in the murine model for mucopolysaccharidoses typeⅢB to that seen in healthy ***,we review the current state of the field in relation to the capsid landscape,adeno-associated virus gene therapy and its successes and challenges in the clinic,and how novel adenoassociated virus capsid designs have evolved research in the mucopolysaccharidoses typeⅢB field.

关键词： adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIB N-acetyl-alpha-glucosaminidase newborn screening

Airway management of a patient with linear immunoglobulin A bullous dermatosis:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2263-2268页

作者： Olga C Nin Robert Hutnik Neil N Chheda David Hutchinson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BACKGROUND There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare mucocutaneous disorder that leads to the development of friable *** clinical decision making is necessary when there is a risk of bleeding into the airway,and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios,especially when confronted with an unusual cause for *** sUMMARY A 45-year-old African American female presented to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous *** diagnosis of IgA dermatosis was recent,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required transfer to the intensive care unit where a multidisciplinary team was involved in her *** patient was extubated on postoperative day *** A multidisciplinary approach to treating this disease is the best course of action before a surgical *** our case,key communication between the surgery,anesthesia,and dermatology teams led to the quick and safe treatment of our patient’s *** surgery should not be considered for these cases unless they are in full remission and there is no mucous membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisciplinary approach Outpatient procedure Case report

Exploring Variability in sea Level at a Tide Gauge station through Control Charts

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Journal of Environmental & Earth sciences 2024年第1期6卷 11-18页

作者： H.Bâkiİz Independent scholar Boca Raton Florida33496USA

Monitoring temporal changes in sea level is important in assessing coastal *** level anomalies at a tide gauge station,if kinematically conceived,include systematic variations such as trend,acceleration,periodic oscillations,and random *** them,the non-stationary nature of the random sea level variations of known or unknown origin at coastal regions has been long recognized by the sea level *** study proposes the analyses of subgroups of random residual statistics of a rigorously formulated kinematic model solution of tide gauge variations using X-bar and s control *** approach is demonstrated using Key West,florida tide gauge *** mean and standard errors of 5-year-long subgroups of the residuals revealed that sea level changes at this location have been progressively intensifying from 1913 to the *** oscillations in sea level at this locality may be attributed partly to the thermal expansion of seawater with increasing temperatures causing larger buoyancy-related sea level fluctuations as well as the intensification of atmospheric events including wind patterns and the impact of changes in inverted barometer effects that will alter coastal risk assessments for the future.

关键词： Climate change sea level variance X-bar s control charts

Research evolution of metal organic frameworks: A scientometric approach with human-in-the-loop

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Journal of Data and Information science 2024年第3期9卷 44-64页

作者： Xintong Zhao Kyle Langlois Jacob Furst Yuan An Xiaohua Hu Diego Gomez Gualdron Fernando Uribe-Romo Jane Greenberg Drexel university 3141 Chestnut StPhiladelphiaPAUSA university of Central florida 4000 Central Florida BlvdOrlandoFLUSA Colorado school of Mines 1500 Illinois StGoldenCOUSA

Purpose:This paper reports on a scientometric analysis bolstered by human-in-the-loop,domain experts,to examine the field of metal-organic frameworks(MOFs)*** analyses reveal the intellectual landscape of a *** study engaged MOF scientists in the design and review of our research *** materials are an essential component in next-generation renewable energy storage and biomedical *** research approach demonstrates how engaging experts,via human-in-the-loop processes,can help develop a comprehensive view of a field’s research trends,influential works,and specialized ***/methodology/approach:Ascientometric analysis was conducted,integrating natural language processing(NLP),topic modeling,and network analysis *** analytical approach was enhanced through a human-in-the-loop iterative process involving MOF research scientists at selected *** researcher feedback was incorporated into our *** data sample included 65,209 MOF research ***3 and software tool VOsviewer were used to perform the ***:The findings demonstrate the value of including domain experts in research workflows,refinement,and interpretation of *** each stage of the analysis,the MOF researchers contributed to interpreting the results and method refinements targeting our focus Research evolution of metal organic frameworks:A scientometric approach with human-in-the-loop on MOF *** study identified influential works and their *** findings also underscore four main MOF research directions and *** limitations:This study is limited by the sample(articles identified and referenced by the Cambridge structural Database)that informed our *** implications:Our findings contribute to addressing the current gap in fully mapping out the comprehensive landscape of MOF ***,the results will help domain scientists target future research directions.

关键词： scientometric Metal-Organic Frameworks(MOFs) Network analysis Topic modeling Human-in-the-loop

smart electrochemical sensing of amyloid-beta to manage total Alzheimer's diseases

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Neural Regeneration Research 2024年第6期19卷 1185-1186页

作者： Ajeet Kaushik school of Engineering University of Petroleum and Energy Studies (UPES) NanoBioTech Laboratory Department of Environmental Engineering Florida Polytechnic University

Need for Alzheimer ’s disease progression monitoring: Alzheimer ’s disease(AD) is an irreversible progressive brain disorder that causes severe and incurable neuro-impairment. The World Health Organization estimates that 55 million people are affected by AD dementia by 2020 which may exceed 78 million by 2030 and 139 in 2050. The estimated cost to manage AD is above Us$ 1.3 trillion, which will further increase to Us$ 2.8 trillion by 2030.

关键词： IMMUNOsENsOR