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From single to combinatorial therapies in spinal cord injuries for structural and functional restoration

Neural Regeneration Research 2025年第3期20卷 660-670页

作者： Ernesto Doncel-Pérez Gabriel Guízar-Sahagún Israel Grijalva-Otero Hospital Nacional de Parapléjicos de toledo Servicio de Salud de Castilla La Mancha(SESCAM)ToledoSpain Medical Research Unit for Neurological Diseases UMAE Hospital de EspecialidadesCentro Médico Nacional Siglo XXIIMSSCiudad de MéxicoMéxico

Spinal cord injury results in paralysis, sensory disturbances, sphincter dysfunction, and multiple systemic secondary conditions, most arising from autonomic dysregulation. All this produces profound negative psychosocial implications for affected people, their families, and their communities;the financial costs can be challenging for their families and health institutions. Treatments aimed at restoring the spinal cord after spinal cord injury, which have been tested in animal models or clinical trials, generally seek to counteract one or more of the secondary mechanisms of injury to limit the extent of the initial damage. Most published works on structural/functional restoration in acute and chronic spinal cord injury stages use a single type of treatment: a drug or trophic factor, transplant of a cell type, and implantation of a biomaterial. Despite the significant benefits reported in animal models, when translating these successful therapeutic strategies to humans, the result in clinical trials has been considered of little relevance because the improvement, when present, is usually insufficient. Until now, most studies designed to promote neuroprotection or regeneration at different stages after spinal cord injury have used single treatments. Considering the occurrence of various secondary mechanisms of injury in the acute and sub-acute phases of spinal cord injury, it is reasonable to speculate that more than one therapeutic agent could be required to promote structural and functional restoration of the damaged spinal cord. Treatments that combine several therapeutic agents, targeting different mechanisms of injury, which, when used as a single therapy, have shown some benefits, allow us to assume that they will have synergistic beneficial effects. Thus, this narrative review article aims to summarize current trends in the use of strategies that combine therapeutic agents administered simultaneously or sequentially, seeking structural and functional restoratio

关键词： neural regeneration neuroprotection spinal cord injury repair spinal cord injury treatments structural restoration of spinal cord injury

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Design and performance evaluation of a parking management system for automated, multi-story and robotic parking structure

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International Journal of Intelligent Computing and Cybernetics 2019年第4期12卷 444-465页

作者： Gursel Serpen Jayanta Debnath The university of toledo ToledoOhioUSA

Purpose–The purpose of this paper is to present design and performance evaluation through simulation of a parking management system(PMS)for a fully automated,multi-story,puzzle-type and robotic parking structure with the overall objective of minimizing customer wait times while maximizing the space ***/methodology/approach–The presentation entails development and integration of a complete suite of path planning,elevator scheduling and resource allocation *** PMS aims to manage multiple concurrent requests,in real time and in a dynamic context,for storage and retrieval of vehicles loaded onto robotic carts for a fully automated,multi-story and driving-free parking *** algorithm suite employs the incremental informed search algorithm D*Lite with domain-specific heuristics and the uninformed search algorithm Uniform Cost Search for path search and *** optimization methodology based on nested partitions and Genetic algorithm is adapted for scheduling of a group of *** study considered a typical business day scenario in the center of a ***–The simulation study indicates that the proposed design for the PMS is able to serve concurrent storage-retrieval requests representing a wide range of Poisson distributed customer arrival rates in real time while requiring reasonable computing resources under realistic *** customer waiting times for both storage andretrievalrequestsare withinacceptable bounds,whichare set as nomore than 5min,evenin the presence of up to 100 concurrent storage and retrieval *** design is able to accommodate a variety of customer arrival rates and presence of immobilized vehicles which are assumed to be scattered across the floors of the structure to make it possible for deployment in real-time ***/value–The intelligent system design is novel as the fully automated robotic parking structures are just in the process of being matured from a techno

关键词： Robotic parking Automated parking Artificial intelligence Search Dynamic path planning,Scheduling Resource allocation Real-time system

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2-D nonseparable multiscaling function interpolation and approximation with an arbitrary dilation matrix

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Communications in Nonlinear Science and Numerical Simulation 2000年第3期5卷 125-133页

作者： En-Bing LIN and Yi LING(Department of Mathematics, university of toledo, toledo OH 43606, USA e-mail: elin@math. utoledo. edu) Department of Mathematics University of Toledo Toledo OH 43606 USA

We introduce nonseparable multiscaling function interpolation and show that its approximation can provide similar convergence properties as scalar wavelet system. An equivalent condition for approximation accuracy for... 详细信息

关键词： wavelets interpolation approximation accuracy of scaling function nonseparable scaling function

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2-D NONSEPARABLE SCALING FUNCTIONINTERPOLATION AND APPROXIMATION

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Acta Mathematica Scientia 2002年第1期22卷 19-31页

作者： En-Bing, Lin Yi Ling (Department of Mathematics. university of toledo, toledo, OH .43606, USA) Department of Mathematics University of Toledo Toledo OH 43606 USA

The authors introduce nonseparable scaling function interpolation and show that its approximation can provide similar convergence properties as scalar wavelet system. Several equivalent statements of accuracy of nonseparable scaling function are also given. In the numerical experiments, it appears that nonseparable scaling function interpolation has better convergence results than scalar wavelet systems in some cases.

关键词： Wavelets nonseparable scaling function interpolation accuracy of scaling function. 2-D MRA

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Microtubule dynamics in axon guidance

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Neuroscience Bulletin 2014年第4期30卷 569-583页

作者： Guofa Liu Trisha Dwyer Department of Biological Sciences University of Toledo ToledoOH 43606USA

Precise modulation of the cytoskeleton is involved in a variety of cellular processes including cell division, migration, polarity, and adhesion. In developing post-mitotic neurons, extracellular guidance cues not only trigger signaling cascades that act at a distance to indirectly regulate microtubule distribution, and assembly and disassembly in the growth cone, but also directly modulate microtubule stability and dynamics through coupling of guidance receptors with microtubules to control growth-cone turning. Microtubule-associated proteins including classical microtubule-associated proteins and microtubule plus-end tracking proteins are required for modulating microtubule dynamics to influence growth-cone steering. Multiple key signaling components, such as calcium, small GTPases, glycogen synthase kinase-313, and c-Jun N-terminal kinase, link upstream signal cascades to microtubule stability and dynamics in the growth cone to control axon outgrowth and projection. Understanding the functions and regulation of microtubule dynamics in the growth cone provides new insights into the molecular mechanisms of axon guidance.

关键词： axon guidance growth cone microtubule dynamics signal transduction

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Morphology of single inhalable particle inside public transit biodiesel fueled bus

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Journal of Environmental Sciences 2010年第2期22卷 263-270页

作者： Kaushik K.Shandilya Ashok Kumar Department of Civil Engineering The University of Toledo

In an urban-transit bus, fueled by biodiesel in toledo, Ohio, single inhalable particle samples in October 2008 were collected and detected by scanning electron microscopy and energy dispersive X-ray spectrometry （SEM/EDS）. Particle size analysis found bimodal distribution at 0.2 and 0.5 μm. The particle morphology was characterized by 14 different shape clusters： square, pentagon, hexagon, heptagon, octagon, nonagon, decagon, agglomerate, sphere, triangle, oblong, strip, line or stick, and unknown, by quantitative order. The square particles were common in the samples. Round and triangle particles are more, and pentagon, hexagon, heptagon, octagon, nonagon, decagon, strip, line or sticks are less. Agglomerate particles were found in abundance. The surface of most particles was coarse with a fractal edge that can provide a suitable chemical reaction bed in the polluted atmospheric environment. The three sorts of surface patterns of squares were smooth, semi-smooth, and coarse. The three sorts of square surface patterns represented the morphological characteristics of single inhalable particles in the air inside the bus in toledo. The size and shape distribution results were compared to those obtained for a bus using ultra low sulfur diesel.

关键词： individual particle environmental scanning electron microscope urban-public transit bus ultra low sulfur diesel

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Revealing the microstructures of metal halide perovskite thin films via advancedtransmission electron microscopy

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Chinese Physics B 2024年第9期33卷 30-41页

作者： Yeming Xian Xiaoming Wang Yanfa Yan Department of Physics and Astronomy and Wright Center for Photovoltaics Innovation and Commercialization The University of ToledoToledoOhio 43606United States

Metal halide perovskites (MHPs) are excellent semiconductors that have led to breakthroughs in applications in thinfilmsolar cells, detectors, and light-emitting diodes due to their remarkable optoelectronic properties and defect ***, the performance and stability of MHP-based devices are significantly influenced by their microstructures includingthe formation of defects, composition fluctuations, structural inhomogeneity, etc. Transmission electron microscopy(TEM) is a powerful tool for direct observation of microstructure at the atomic-scale resolution and has been used to correlatethe microstructure and performance of MHP-based devices. In this review, we highlight the application of TEMtechniques in revealing the microstructures of MHP thin films at the atomic scale. The results provide critical understandingof the performance of MHP devices and guide the design of strategies for improving the performance and stability ofMHP devices.

关键词： perovskite defect inhomogeneity transmission electron microscopy

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Extracorporeal shock wave for plantar flexor spasticity in spinal cord injury:A case report and review of literature

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World Journal of Clinical Cases 2023年第1期11卷 127-134页

作者： Natalia Comino-Suárez Julio Gómez-Soriano Silvia Ceruelo-Abajo Eduardo Vargas-Baquero Ana Esclarín Juan Avendaño-Coy toledo Physiotherapy Research Group Faculty of Physiotherapy and NurseryCastilla La Mancha UniversityToledo 45071ToledoSpain Department of Physical and Rehabilitation Medicine Hospital Nacional de ParapléjicosSescamToledo 45071ToledoSpain

BACKGROUND Approximately 65%-78%of patients with a spinal cord injury(SCI)develop any symptom of *** aim of this study was to investigate the tolerability and short-term effects of radial extracorporeal shock wave therapy(r ESWT)on plantar flexor spasticity in a patient with incomplete *** SUMMARY An 18-year-old man with an incomplete SCI completed five sessions of r *** primary outcomes were the changes in ankle-passive range of motion(APROM)and passive resistive force to ankle *** outcomes were assessed at baseline(T0),immediately after treatment(T1)and 1 wk after the end of treatment(T2).The A-PROM increased by 15 degrees at T1 and 25 degrees at T2 compared with *** passive resistive force to ankle dorsiflexion at low velocity decreased by 33%at T1 and 55%at T2 in the gastrocnemius muscle and by 41%at T1 and 39%at T2 in the soleus muscle compared with *** high velocity,it also decreased by 44%at T1 and 30%at T2 in the gastrocnemius muscle compared with ***,in the soleus muscle,the change was minor,with a decrease of 12%at T1 and increased by 39%at T2 compared with *** In this patient,the findings showed that r ESWT combined with conventional therapy was well-tolerated and could be effective in improving A-PROM and passive resistive force to ankle dorsiflexion in the *** randomized controlled clinical trials with longer period of follow-up are necessary to confirm the results obtained in patients with SCI.

关键词： Spasticity Spinal cord injury Radial extracorporeal shock wave therapy Rehabilitation Case report

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Interactive Effects of Elevated CO_2 and Ozone on Leaf Thermotolerance in Field-grown Glycine max

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Journal of Integrative Plant Biology 2008年第11期50卷 1396-1405页

作者： Sasmita Mishra Scott A. Heckathorn Deepak Barua Dan Wang Puneet Joshi E. William Hamilton III Jonathan Frantz Department of Environmental Sciences University of Toledo Toledo Ohio USA Department of Biology Washington and Lee University Lexington Virginia USA United States Department of Agricuffure-Agricultural Research Service University of Toledo Toledo Ohio 43606 USA

Humans are increasing atmospheric CO2, ground-level ozone （O3）, and mean and acute high temperatures. Laboratory studies show that elevated CO2 can increase thermotolerance of photosynthesis in C3 plants. O3-related oxidative stress may offset benefits of elevated CO2 during heat-waves. We determined effects of elevated CO2 and O3 on leaf thermotolerance of field-grown Glycine max （soybean, C3）. Photosynthetic electron transport （Фet） was measured in attached leaves heated in situ and detached leaves heated under ambient CO2 and O3. Heating decreased Фet, which O3 exacerbated. Elevated CO2 prevented O3-related decreases during heating, but only increased Фet under ambient O3 in the field. Heating decreased chlorophyll and carotenoids, especially under elevated CO2. Neither CO2 nor O3 affected heat-shock proteins. Heating increased catalase （except in high O3） and Cu/Zn-superoxide dismutase （SOD）, but not Mn- SOD; CO2 and O3 decreased catalase but neither SOD. Soluble carbohydrates were unaffected by heating, but increased in elevated CO2. Thus, protection of photosynthesis during heat stress by elevated CO2 occurs in field-grown soybean under ambient O3, as in the lab, and high CO2 limits heat damage under elevated O3, but this protection is likely from decreased photorespiration and stomatal conductance rather than production of heat-stress adaptations.

关键词： anti-oxidants global change heat-shock proteins photosynthesis.

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The influence of gut microbiota alteration on age-related neuroinflammation and cognitive decline

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Neural Regeneration Research 2022年第11期17卷 2407-2412页

作者： Amsha S.Alsegiani Zahoor A.Shah Department of Medicinal and Biological Chemistry College of Pharmacy and Pharmaceutical SciencesUniversity of ToledoToledoOHUSA

Recent emerging research on intestinal microbiota and its contribution to the central nervous system during health and disease has attra cted significant ***-related intestinal microbiota changes initiate brain aging and age-related neurodegenerative *** is one of the critical predisposing risk factors for the development of neurodegenerative *** a healthy gut microbiota is essential for a healthy body and aging,but dys biosis could initiate many chro nic *** the underlying mechanisms of gut microbiota alterations/dys biosis will help identify biomarkers for aging-related chro nic *** review summarizes recent advances in micro biota-neurodegenerative disease research and will enhance our unde rstanding of gut microbiota dys biosis and its effects on brain aging.

关键词： brain aging cognitive decline dysbiosis fecal microbiota transplantation gut-microbiota neuroinflammation prebiotics probiotics

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