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重症疟疾患儿视网膜病变的病程及其与疾病预后关系的研究

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 29-30页

作者：汪玲 Beare N.A Southern C Chalira C St.Paul ’s Eye unit Royal Liver-pool University HospitalPrescot S treetLiverpool L78XPUnited King dom.Dr

Objectives:To relate retinal findi ngs in children treated for severe malaria to disease outcom e and to determine the course of changes in the *** ods:A prospective study of children with cerebral mala ria(CM)and severe malarial anemia admitted to the Mala ria Research Project,Blantyre,Malawi,during 2malaria s *** and direct ophthalmoscopy were perform ed on admission and daily,subject to the patients coop ***:Three hundred twenty six patients(91%)with complicated malaria were *** hundred seventy-eight pa-tients had CM and of these 170(61%)had some degree of retinopathy;25(53%)of 47with severe malarial anemia had *** CM,retin opathy was associ-ated with subsequent death(relative risk,3.7;95%confidence interval,1.6-8.5)and papilledema con-ferred the highest risk(relative risk,4.5;95%confi-dence interval,2.7-7.6).Increasing severity of retinal signs was related to increasing risk of a fatal outcome (Ped with p rolonged time to recover consciousness(Ped up longitudinally during a dmission and in 27pa-tients after hospital discharge.A l arge increase in retinal hemorrhages was associated with dea th(P=.02).Reti-nal signs resolved over 1to 4weeks wi thout retinal ***:In childhood C M,severity of retinopathy is related to prolonged coma and *** results support the hypothesis that retinal signs in CM are related to cerebral pathophysiolog y.

关键词：视网膜病变疾病预后检眼镜检查眼底情况眼底病变疾病转归研究计划意识恢复时间病理生理存活者

学龄前儿童弱视治疗时情绪的改变:随机对照试验

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 55-56页

作者：侯慧媛 Hrisos S Clarke M.P Wright C.M Department of Ophthalmolog y University of Newcastle Upon Tyne Newcastle upon Tyne Unit-ed King dom

Purpose To investigate the emotional status of children un-dergoing active treatment for ambly *** Postal survey,in the context of a prospecti ve,multicenter,ran-domized controlled *** ants Parents of 177chil-dren with a unilateral visual impair ment referred from preschool vision *** chi ldren had been re-cruited to a randomized controlled t rial of treatment for u-nilateral visual impairment and ran domly assigned to re-ceive either glasses with or without patches,glasses alone,or treatment deferred for *** A self-completion questionnaire,including a psychom etric behavioral scale,was sent to the parents of all childre n recruited to the trial at age 4years,to 66whose deferred tr eatment began at age5years,and finally to 151remaining in the trial at the end of *** outcome measures Mean scores per treatment group on the Revised Rutte r Parent Scale for Preschool *** of p arent responses to questions assessing the child’s general well-being and dif-ficulties associated with treatmen *** Completed questionnaires were returned for 144of 177(81%)chil-dren at a mean age(standard deviation)of 48months(5.0),for 45of 66(68%)at a mean age of 61months(5.8),and for 78of 151(52%)at a mean age of 67 months(5.0).Most parents reported having diffi culty with patching their child regardless of a ge(77%at age 4years and 73%at age 5years),with fewer reporting difficulties with glasses alone(42%and 53%,respectively).Chil-dren were significantly more upset b y patching than by glasses only(chi-square test,P=0.03for age 4years and P=0.01for age 5years),as were the parents of4-year-olds(chi-square test,P=0.01).Most parents thought their children were happy,c ooperative,and good tempered,and behavioral scores did not differ between treatment *** Treatment for unilateral vi-sual impairment is not easy to implem ent and is commonly associated with some degree of distr *** this,no impact on the ch

关键词：弱视治疗随机对照试验视力减退单眼视力视力筛查精神行为总体健康状况行为评分平均分值一般健康状况

解决Mersilene网引起的慢性眼睑并发症:一种系统的方法

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 39-40页

作者：张晓光 Mehta P Patel P Olver J.M Western Eye Hospital Marylebone Ro adLondon United King dom

*** mesh(polyester fibre)is commonly used in ptosis surgery for frontalis suspension as it is readily available and *** of extrusion can be *** report three case s of extrusion where extremely thick mesh or extremely th in tissue may have contributed to the *** case note study of three adult patients who developed chronic mesh *** and chronic infection occured 5-12months after *** systemic an-tibiotics,all three patients requi red surgical excision of mesh from the eyelid up to the brow,which was *** cases illustrate the need for a systematic approach and the need in some cases to excise the mesh to prevent recurrent infection.

关键词： Mersilene 额肌悬吊术上睑下垂纤维网纤维性网丝处理方法

英国北部地区光动力疗法治疗黄斑变性的使用率及效果

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世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 34-35页

作者：姜廷帅 Talks S.J Setty R Clarke L. Department of Ophthalmolog y Royal Victoria InfirmaryQueen Victoria RoadNew castle Upon Tyne NE14LPUnited King dom.Dr.

*** assess the patients who h ave had photody-namic therapy(PDT)in the Northern region of the UK,in relation to the eligibility criteria found to benefit in the TAP study(treatment of age-related macular degeneration with photodynamic therapy study),so as to make an estimate of the number of patients who might benefit from this treat-ment and to present the outcome of the treatment so *** records and fluorescein angiograms (FFAs )of all patients who had had PDT in the Northern region be-tween 2001and 2002were reviewed for compliance with the TAP criteria of >50%classic choroidal neovascular-ization and >34letters on the 2m logM AR Early Treatment Diabetic Retinopathy Study chart.N HS funding has been available in the Northern Region sin ce January 2001for‘second eye’involvement.A review of all the angiograms performed for exudative macular deg eneration in 1year was also *** visual outcome o f those patients 1year from baseline was ***.A total of 82‘second eye’patients were treated between January 2001and December *** gives an incidence of 65per 3million and so about 1300in the whole of the UK(population 60million).In all,238FFAs were performed on exudative macular degeneration,with 21%being found eligible for *** of February 2003,54TAP criteria,macular degeneration patients were1year from initial *** these,12had incomple te follow-up and 13patients had lost more than *** responder rate defined as losing<15letters was 42-13/42=69%.Seven of those who did not make 1-year follow-up had lost more than 15letters when last seen,g iving a responder rate of 54-20/54=63%.*** may not be as many patients eligible for PDT,usin g the TAP criteria,as previously *** outcome of tre atment appears similar to that found in the TAP study.

关键词：黄斑变性光动力疗法北部地区英国北部荧光素血管造影渗出性反应率

Alternative Role of Motif B in Template Dependent Polymerase Inhibition

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Chinese Journal of Chemical Physics 2022年第3期35卷 407-412,I0001页

作者： Xueying Luo Tiantian Xu Xin Gao Lu Zhang State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Computer Science Program ComputerElectrical and Mathematical Sciences and Engineering(CEMSE)DivisionKing Abdullah University of Science and TechnologyThuwal 23955-6900King-dom of Saudi Arabia KAUST Computational Bioscience Research Center(CBRC) King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry Xiamen 361005China

Severe acute respiratory syndrome coronavirus 2(SARS-Co V-2) relies on the central molecular machine RNA-dependent RNA polymerase(Rd Rp) for the viral replication and transcription. Remdesivir at the template strand has been shown to effectively inhibit the RNA synthesis in SARS-Co V-2 Rd Rp by deactivating not only the complementary UTP incorporation but also the next nucleotide addition. However, the underlying molecular mechanism of the second inhibitory point remains unclear. In this work, we have performed molecular dynamics simulations and demonstrated that such inhibition has not directly acted on the nucleotide addition at the active site. Instead, the translocation of Remdesivir from +1 to-1 site is hindered thermodynamically as the posttranslocation state is less stable than the pre-translocation state due to the motif B residue G683. Moreover, another conserved residue S682 on motif B further hinders the dynamic translocation of Remdesivir due to the steric clash with the 1′-cyano substitution. Overall,our study has unveiled an alternative role of motif B in mediating the translocation when Remdesivir is present in the template strand and complemented our understanding about the inhibitory mechanisms exerted by Remdesivir on the RNA synthesis in SARS-Co V-2 Rd Rp.

关键词： SARS-CoV-2 RNA-dependent RNA polymerase Inhibitory mechanism Nu-cleotide analog Molecular dynamics simulation

Non-surgical management of dens invaginatus type IIIB in maxillary lateral incisor with three root canals and 6-year follow-up:A case report and review of literature

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World Journal of Clinical Cases 2022年第33期10卷 12240-12256页

作者： Suraj Arora Gurdeep Singh Gill Shahabe Abullais Saquib Priyanka Saluja Suheel M Baba Shafait Ullah Khateeb Anshad M Abdulla Shashit Shetty Bavabeedu Ahmed Babiker Mohamed Ali Mohamed Fadul A Elagib Department of Restorative Dental Sciences College of DentistryKing Khalid UniversityAbha 61421Saudi Arabia Department of Conservative Dentistry and Endodontics JCD Dental CollegeSirsa 125055India Department of Periodontics and Community Dental Sciences King Khalid UniversityAbha 61421Saudi Arabia Department of Pediatric Dentistry and Orthodontic Sciences King Khalid UniversityAbha 61421Saudi Arabia

BACKGROUND The presence of dens invaginatus(DI)complicates treatment of any tooth,from diagnosis to access cavity and biomechanical preparation and *** of successful non-surgical management of DI type IIIB in maxillary lateral incisor are ***,we report such a case,with three root canals and a long *** SUMMARY A 13-year-old female patient presented with mild pain in the maxillary right lateral incisor(#7)for 10-15 *** examination,the tooth was slightly rotated,with slight tenderness on percussion and grade I mobility but with no caries,pockets or restorations and non-vital pulp(via vitality tests).Radiographic examination revealed unusual configuration of the tooth’s root canals,with an enamel-lined invagination extending to the apex,suggesting the possibility of DI Oehler’s type IIIB and a periapical *** the access cavity lingually revealed one distinct buccal orifice and two distinct palatal orifices;under higher magnification of a dental operating microscope(dom),the mesio palatal and disto-palatal orifices were observed as connected by a C-shaped *** root canals were prepared with hand K-files following a step-back technique,and obturated using a combination technique of lateral condensation and vertical *** the 6-year follow-up,the patient was asymptomatic,and the periapical radiography displayed significant healing around the apical end of the *** Proper knowledge of unusual root canal anatomy is required in treating *** methods of root canal treatment can successfully resolve such complex cases,facilitated by dom and cone-beam computed tomography.

关键词： Dens invaginatus Maxillary lateral incisor Three root canals Root canal Anatomy Treatment Case report

阴道穹隆脱垂的临床检查和动态磁共振成像诊断

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世界核心医学期刊文摘（妇产科学分册） 2005年第2期1卷 59-60页

作者： Cortes E. Reid W.M.N. Singh K. Berger L. 马向东 Royal Free Hospital Acad.Dept.Ob-stet.and Gynecolog yPond StreetHampsteadLondon NW32QGUnited King dom Dr.

OBJECTIVE:To estimate the role of dynamic magnetic resonance imaging(MRI )as a diagnostic tool in the eval-uation of vaginal apex prolapse in wo men with previous ***:Clinical examinations were performed on 51women presenting wit h symptoms of pro-lapse.A preoperative dynamic MRI assessment was *** mid pubic line was the reference level used for prolapse *** parameters of analysis included 1)correlation by compartments of clin ical and MRI grading of prolapse,2)assessment of the accuracy of clinic al exami-nation of the middle compartment,an d 3)identification of any additional information provided by *** films were analyzed and validated by the sa me two ***:Analysis of each compartme nt separately re-vealed poor correlation between cli nical and MRI assess-ment Of the 51cases with clinical vau lt prolapse,27(52.9%)cases were clinically overdiagnose d,3(6%)were underdiagnosed,and there was a greement in 21(41.1%)when compared with MRI ***-tive follow -up of the 18(85%)patients who underwent colposacropexy after intraoperati ve assessment revealed the presence of cystocele in 4(26.6%)occasions and recto-cele in 3(20%),which had been detected on MRI but not confirmed ***:There is poor correlation between clinical and MRI findings when as-sessing vaginal apex *** etic resonance imaging allows the identification of other p rolapsing compartments and may be a complementary diagnostic tool for the diag-nosis of complex vaginal apex prolap se.

关键词：磁共振成像诊断阴道穹隆阴道固定术检查和动态磁共振成像临床病变参考水平鉴别诊断临床评定膀胱膨出

利用间-四羟基苯二氢卟酚光动力疗法治疗Barrett食管柱状层中的重度异常增生和早期癌症

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世界核心医学期刊文摘（胃肠病学分册） 2006年第2期2卷 45-46页

作者： Lovat L.B. Jamieson N.F. Novelli M.R. 陈瑜 National Medical Laser Centre UCL 67- 73 Riding House St. London W1W 7EJ United King-dom Dr.

Background: Many patients with high-grade dysplasia and localized adenocarcinoma in Barrett’s esophagus have localized disease but are either unfit for major surgery or decline esophagectomy. Photodynamic therapy with the powerful photosensitizer m-tetrahydroxyphenyl chlorinmay be a nonsurgical therapeutic option. Methods: This is a pilot study to evaluate the efficacy and complications of m-tetrahydroxyphenyl chlorin photodynamic therapy. The design is a case series of 19 consecutive patients at a tertiary referral unit with a special interest in photodynamic therapy. The study included 7 patients with high-grade dysplasia and 12 with early esophageal cancer, who had refused or were unfit for esophagectomy. Three days after photosensitization with 0.15 mg/kg m-tetrahydroxyphenyl chlorin, red or green light was delivered endoscopically when using either a bare fiber or a diffuser device. Results were assessed by endoscopic surveillance. Results: By using red light via the diffuser, 4/6 patients with cancer and 3/4 with high-grade dysplasia were successfully treated with photodynamic therapy alone. When using the bare-tipped fiber, there was one procedure- related death and only 1/5 patients with cancers were successfully treated. Two others were downgraded to high-grade dysplasia. With green light delivered via a diffuser, 0/3 patients with high-grade dysplasia are in long-term remission. Two serious complications arose (including one death) from taking multiple biopsy specimens too soon after therapy. Two esophageal strictures occurred. Conclusions: Photodynamic therapy with m-tetrahydroxyphenyl chlorin is, potentially, a valuable therapeutic option for localized esophageal neoplasia. Red light via a diffuser device appears to be the most effective light-delivery technique. Biopsy specimens should not be taken for at least 2 months after treatment.

关键词： Barrett食管光动力疗法异常增生早期癌症羟基苯柱状层早期食管癌光敏剂内镜监测光

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英国白内障术后眼内炎的监控

世界核心医学期刊文摘（眼科学分册） 2005年第1期1卷 33-34页

作者：姜廷帅 Kamalarajah S Silvestri G Sharma N Altanag elvin Hospita l Glensha-neRoad Londonderry BT476SBUnite d King -dom

*** estimate the incidence of ac ute-onset presumed infectious endophthalmitis(PIE)following cataract surgery in the UK and provide epidemiologica l data on the pre-sentation,management,microbiolo gy,and outcome of cases of *** were identified prospectively by active surveillan ce through the British Ophthalmological Surveillance Uni t reporting card system,for the 12-month period October 1999to September *** data were obtained from ophthal-mologists throughout the UK at baseline and 6months after ***-reporting was estimated by independently contacting units with infection *** were available on 213patients at baseline and 201patients at *** minimum estimated incidence of PIE was0.086per 100cataract extractions a nd the corrected inci-dence was 0.14per 100cataract extra *** the management of PIE,96%of patients re ceived intravitreal,30%subconjunctival,65%oral,and 17%intravenous *** all,17%of patients received intravitreal *** the intraocular sampl es taken for microbio-logical analysis,56%were culture p *** follow-up,48%of patients achieved visual acui ty of 6/12or better and 66%achieved better than 6/60.13%of patients were unable to perceive light or had evisc eration of the *** incidence of PIE after cataract surgery in the UK is comparable to that of other s ***-mately 50%of patients achieved a vis ual acuity close to the driving standard.

关键词：白内障术眼科医生类固醇治疗感染性眼内炎流行病学数据疑似病例无光感眼球摘除术微生物学检查疾病转归