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Evaluation of periodontal healing in class II furcation defects following guided tissue regeneration with two different types of poly lactic acid membranes

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Chinese Medical Journal 2004年第2期17卷 270-274页

作者： Deniz Cetiner Berrinnsal Ates Parlar ElifGültekin BülentKurtis Department of periodontology Faculty of Dentistry Gazi University Ankara TurkeyDepartment of Periodontology Faculty of Dentistry Gazi University Ankara TurkeyDepartment of Periodontology Faculty of Dentistry Gazi University Ankara TurkeyDepartment of Pathology Faculty of Dentistry Gazi University Ankara TurkeyDepartment of Periodontology Faculty of Dentistry Gazi University Ankara Turkey

Background Guided tissue regeneration procedures provide predictable reconstruction of periodontal tissues in the treatment of furcation involvements in animals and huamns. This study was to compare long-term effectiveness of two different types of polylactic acid (PLA) membranes on periodontal regeneration in surgically created class II furcation defects in dogs.Methods Full thickness mucoperiosteal flap was raised on the buccal aspects of the experimental teeth and class II furcation defects having 5 mm vertical dimensions were created on mandibular premolar III and IV on each quadrant. The exposed root surfaces were thoroughly planed and PLA membranes were placed over the experimental defects on both sites. One site received liquid polymer membrane (LPM), and resorbable periodontal mesh (RPM) membranes were applied to the other site. The animals were sacrificed at 7 months after surgery and the specimens were processed for histological evaluation.Results The average length of new attachment formed on the treated roots in both groups ranged from 3. 02 mm to 4. 5 mm. Complete bone filling was observed at the furcation sites. No statistically significant differences were found between two membranes in any of the parameters (P>0. 05).Conclusion This study demonstrates favorable regenerative outcomes by the use of two different types of PLA membranes that could be used as alternatives for guided tissue regeneration (GTR).

关键词： guided tissue regeneration polyfactic acid membranes furcation/surgery experimental studies

Gingival unit transfer using in the Miller Ⅲ recession defect treatment

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World Journal of Clinical Cases 2015年第2期3卷 199-203页

作者： Selin Y?ld?r?m Bahar Kuru Department of periodontology Dental FacultyMarmara University

The most significant factor for the success in soft tissue grafts is the synergistic relation between vascular configuration and involved tissues. In the soft tissue graft procedures, site specific donor tissue is assumed to have improved potential for function and aesthetic survive at recipient sites. On a clinical level, using site specific gingival unit graft that placed on traditionally prepared recipient site, results in predictable root coverage. In this case report the clinical effectiveness of gingival unit transfer(GUT) technique performed on Miller Ⅲ recession was presented and a similar recession case treated with free gingival graft(FGG) technique for comparison. Probing depth, recession depth, keratinized tissue width and clinical attachment level clinical parameters were measured at baseline and postoperative 8 mo. Percentage of defect coverage was evaluated at postoperative 8 mo. Creeping attachment was assessed at postoperative 1, 3, 6 and 8 mo. The GUT revealed better defect coverage and creeping attachment results than the FGG in the treatment of Miller Ⅲ defects.

关键词： Autografting Gingiva Gingival recession Tooth root Transplants

Immunomodulatory properties of dental tissue-derived mesenchymal stem cells: Implication in disease and tissue regeneration

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World Journal of Stem Cells 2019年第9期11卷 604-617页

作者： Oleh Andrukhov Christian Behm Alice Blufstein Xiaohui Rausch-Fan Division of Conservative Dentistry and periodontology University Clinic of Dentistry Medical University of Vienna

Mesenchymal stem cells(MSCs)are considered as an attractive tool for tissue regeneration and possess a strong immunomodulatory *** tissuederived MSCs can be isolated from different sources,such as the dental pulp,periodontal ligament,deciduous teeth,apical papilla,dental follicles and *** to numerous in vitro studies,the effect of dental MSCs on immune cells might depend on several factors,such as the experimental setting,MSC tissue source and type of immune cell *** studies have shown that the immunomodulatory activity of dental MSCs is strongly upregulated by activated immune *** exert mostly immunosuppressive effects,leading to the dampening of immune cell ***,the reciprocal interaction between dental MSCs and immune cells represents an elegant mechanism that potentially contributes to tissue homeostasis and inflammatory disease *** the immunomodulatory potential of dental MSCs has been extensively investigated in vitro,its role in vivo remains obscure.A few studies have reported that the MSCs isolated from inflamed dental tissues have a compromised immunomodulatory ***,the expression of some immunomodulatory proteins is enhanced in periodontal disease and even shows some correlation with disease ***-based immunomodulation may play an essential role in the regeneration of different dental ***,immunomodulation-based strategies may be a very promising tool in regenerative dentistry.

关键词： Mesenchymal stem cells Dental tissue Immunomodulation Peripheral blood mononuclear cells Oral diseases Tissue regeneration

The role of HBD-2,HBD-3,and calprotectin in the relationship between chronic periodontitis and atherosclerosis

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BIOCELL 2020年第3期44卷 337-344页

作者： MEHMET TASPINAR ALIHAN BOZOGLAN ABDULLAH SECKIN ERTUGRUL LEVENT ELMAS Faculty of Medicine Aksaray UniversityAksarayTurkey Faculty of Medicine Yuzuncu Yil UniversityVanTurkey Department of periodontology Faculty of DentistryFırat UniversityElazığTurkey Department of periodontology Faculty of DentistryYuzuncu Yil UniversityVanTurkey Department of periodontology Faculty of Dentistryİzmir KatipÇelebi UniversityİzmirTurkey Faculty of Medicine Pamukkale UniversityDenizliTurkey

This study was carried out to compare individuals diagnosed with atherosclerosis and periodontal periodontitis based on the degree of change in the human beta-defensins(HBD)HBD-2,HBD-3,and *** is the most frequently observed cardiovascular *** and periodontal infections are known to provide a considerable basis for atheroma plaque *** study group consists of a total number of 40 subjects,with 20 patients diagnosed with atherosclerosis and chronic periodontitis and 20 systemically healthy patients diagnosed with chronic *** periodontal and blood parameters and HBD-2,HBD-3,and calprotectin biomarkers in the gingival crevicular fluid were *** both groups,following clinical periodontal treatment,a statistically significant decrease in white blood cells(WBC),low-density lipoproteins(LDL),fibrinogen,creatinine,and platelets(PLT),a statistically significant increase in high-density lipoproteins(HDL)in blood samples,statistically meaningful decrease in HBD-2,HBD-3,and calprotectin in the gingival crevicular fluid were *** values and HBD-2,HBD-3,calprotectin amounts in the gingival crevicular fluid were increased significantly in the test group compared to the control group.A positive correlation was observed between decreases in HBD-2,HBD-3,calprotectin,and clinical periodontal *** in systemic inflammation was observed after clinical periodontal *** is concluded that nonsurgical periodontal treatment of chronic periodontitis positively affects atherosclerosis prognosis.

关键词： Atherosclerosis Periodontal Diseases HBD-2 HBD-3 Calprotectin

Mouth the mirror of lungs： where does the connection lie？

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Frontiers of Medicine 2016年第4期10卷 405-409页

作者： Jananni Muthu Sivaramakrishnan Muthanandam Jaideep Mahendra Department of periodontology lndira Gandhi Institute of Dental Sciences Pondicherry 605005 India Department of Oral Pathology and Microbiology lndira Gandhi Institute of Dental Sciences Pondicherry 605005 lndia Department of periodontology Meenakshi Ammal Dental College & Hospital Chennai 600095 lndia

Periodontitis is the chronic destructive disease of the periodontium （Gums） caused by host bacterial interactions. The effect of such host bacterial interactions in oral cavity also evokes a systemic response. Numerous studies have found common mechanisms of destruction for periodontal diseases and other chronic diseases like diabetes mellitus, atherosclerosis, respiratory diseases, and adverse pregnancy outcomes. Oral colonization by respiratory pathogens appears to be a risk factor for development of respiratory diseases and oral interventions aimed at reducing oral bacterial count have resulted in reduced incidence of these reparatory illness. This reflects the importance of oral hygiene among patients with respiratory illness. This review highlights the association between periodontal diseases and respiratory diseases.

关键词： periodontitis respiratory diseases acute pneumonia COPD

Recombinant amelogenin regulates the bioactivity of mouse cementoblasts in vitro

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International Journal of Oral Science 2018年第2期10卷 117-126页

作者： Sema S.Hakki S.Buket Bozkurt Emre Türkay Michel Dard Nuhan Purali Werner Gotz Department of periodontology Faculty of DentistrySelcuk University Research Center of Dental Faculty Selcuk University Department of Orthodontics Oral Biology LaboratoryFaculty of DentistryUniversity of Bonn Department of periodontology and Implant Dentistry College of DentistryNew York University Department of Biophysics Faculty of MedicineHacettepe University

Amelogenin（AMG） is a cell adhesion molecule that has an important role in the mineralization of enamel and regulates events during dental development and root formation. The purpose of the present study was to investigate the effects of recombinant human AMG（rhAMG） on mineralized tissue-associated genes in cementoblasts. Immortalized mouse cementoblasts（OCCM-30）were treated with different concentrations（0.1, 1, 10, 100, 1 000, 10 000, 100 000 ng · mL^-1） of recombinant human AMG（rhAMG）and analyzed for proliferation, mineralization and mRNA expression of bone sialoprotein（BSP）, osteocalcin（OCN）, collagen type I（COL I）, osteopontin（OPN）, runt-related transcription factor 2（Runx2）, cementum attachment protein（CAP）, and alkaline phosphatase（ALP） genes using quantitative RT-PCR. The dose response of rhAMG was evaluated using a real-time cell *** RNA was isolated on day 3, and cell mineralization was assessed using von Kossa staining on day 8. COL I, OPN and lysosomalassociated membrane protein-1（LAMP-1）, which is a cell surface binding site for amelogenin, were evaluated using immunocytochemistry. F-actin bundles were imaged using confocal microscopy. rhAMG at a concentration of 100 000 ng · mL^-1 increased cell proliferation after 72 h compared to the other concentrations and the untreated control group. rhAMG（100 000 ng · mL^-1） upregulated BSP and OCN mRNA expression levels eightfold and fivefold, respectively. rhAMG at a concentration of 100 000 ng · mL^-1 remarkably enhanced LAMP-1 staining in cementoblasts. Increased numbers of mineralized nodules were observed at concentrations of 10 000 and 100 000 ng · mL^-1 rhAMG. The present data suggest that rhAMG is a potent regulator of gene expression in cementoblasts and support the potential application of rhAMG in therapies aimed at fast regeneration of damaged periodontal tissue.

关键词： AMG Recombinant amelogenin regulates the bioactivity of mouse cementoblasts in vitro OCN

Impact of osteoporosis in dental implants:A systematic review

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World Journal of Orthopedics 2015年第2期6卷 311-315页

作者： Gabriela Giro Leandro Chambrone Abrao Goldstein Jose Augusto Rodrigues Elton Zenóbio Magda Feres Luciene Cristina Figueiredo Alessandra Cassoni Jamil Awad Shibli Department of periodontology and Oral Implantology Dental Research DivisionUniversity of Guarulhos

AIM: To assess the failure and bone-to-implant contact rate of dental implants placed on osteoporotic subjects. METHODS: Extensive examination strategies were created to classify studies for this systematic review. MEDLINE(via Pub Med) and EMBASE database were examined for studies in English up to and including May 2014. The examination presented a combination of the MeS H words described as follow: "osteoporosis" or "osteopenia" or "estrogen deficiency" AND "implant" or "dental implant" or "osseointegration". Assessment of clinical and/or histological peri-implant conditions in osteoporosis subjects treated with titanium dental implants. The examination included a combination of the MeS H terms described as follow: "osteoporosis" or "osteopenia" or "estrogen deficiency" AND "implant" or "dental implant" or "osseointegration".RESULTS: Of 943 potentially eligible articles, 12 were included in the study. A total of 133 subjects with osteoporosis, 73 subjects diagnosed with osteopenia and 708 healthy subjects were assessed in this systematic review. In these subjects were installed 367, 205, 2981 dental implants in osteoporotic, osteopenic and healthy subjects, respectively. The failure rate of dental implant was 10.9% in osteoporotic subjects, 8.29% in osteopenic and 11.43% in healthy ones. Bone-to-implant contact obtained from retrieved implants ranged between 49.96% to 47.84%, for osteoporosis and non-osteoporotic subjects. CONCLUSION: Osteoporotic subjects presented higher rates of implant loss, however, there is a lower evidence to strengthen or refute the hypothesis that osteoporosis may have detrimental effects on bone healing. Consequently, final conclusions regarding the effect of osteoporosis in dental implant therapy cannot be made at this time. There are no randomized clinical trial accessible for evaluation and the retrospectivenature of the evaluated studies shall be taken in account when interpreting this study.

关键词： Dental implants Osteoporosis Failures Osteopenia Osseointegration

Periodontal and inflammatory bowel diseases: Is there evidence of complex pathogenic interactions?

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World Journal of Gastroenterology 2016年第35期22卷 7963-7972页

作者： Ronaldo Lira-Junior Carlos Marcelo Figueredo Department of periodontology Faculty of Odontology Rio de Janeiro State University Rio de Janeiro RJ 20551-030 Brazil

Periodontal disease and inflammatory bowel disease(IBD) are both chronic inflammatory diseases. Their pathogenesis is mediated by a complex interplay between a dysbiotic microbiota and the host immuneinflammatory response, and both are influenced by genetic and environmental factors. This review aimed to provide an overview of the evidence dealing with a possible pathogenic interaction between periodontal disease and IBD. There seems to be an increased prevalence of periodontal disease in patients with IBD when compared to healthy controls, probably due to changes in the oral microbiota and a higher inflammatory response. Moreover, the induction of periodontitis seems to result in gut dysbiosis and altered gut epithelial cell barrier function, which might contribute to the pathogenesis of IBD. Considering the complexity of both periodontal disease and IBD, it is very challenging to understand the possible pathways involved in their coexistence. In conclusion, this review points to a complex pathogenic interaction between periodontal disease and IBD, in which one disease might alter the composition of the microbiota and increase the inflammatory response related to the other. However, we still need more data derived from human studies to confirm results from murine models. Thus, mechanistic studies are definitely warranted to clarify this possible bidirectional association.

关键词： Periodontal disease Inflammatory bowel disease Crohn’s disease Ulcerative colitis Inflammation

Differential molecular profiles and associated functionalities characterize connective tissue grafts obtained at different locations and depths in the human palate

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International Journal of Oral Science 2023年第4期15卷 701-717页

作者： Maria B.Asparuhova Xiaoqing Song Dominic Riedwyl Geert van Geest Dieter D.Bosshardt Anton Sculean Laboratory of Oral Cell Biology School of Dental MedicineUniversity of BernBernSwitzerland Department of periodontology School of Dental MedicineUniversity of BernBernSwitzerland Interfaculty Bioinformatics unit University of BernBernSwitzerland Robert K.Schenk Laboratory of Oral Histology School of Dental MedicineUniversity of BernBernSwitzerland

The present study aimed to assess the molecular profiles of subepithelial connective tissue grafts(CTGs)obtained at different locations and depths in the human ***-four CTGs belonging to anterior deep(AD),anterior superficial(AS),posterior deep(PD),and posterior superficial(PS)groups were subjected to RNA-Sequencing and their transcriptomes were analyzed *** correlations characterizing the CTG groups were validated by cell biological experiments using primary human palatal fibroblasts(HPFs)extracted from the CTGs.A clearly more pronounced location-dependent than depth-dependent difference between the grafts,with a minimal number of genes(4)showing no dependence on the location,was ***,endothelial,and monocytic cell migration was strongly(P<0.001)potentiated by AD-and ***,significantly increased expression of genes encoding C-C and C-X-C motif chemokine ligands as well as significantly(P<0.01)activated p38 signaling suggested immunomodulatory phenotype for AD-and *** growth factor gene expression and significantly activated(P<0.001)Erk and Akt signaling in HPFs originating from A-CTGs implied their involvement in cell survival,proliferation,and *** collagen-rich expression profile contributing to high mechanical stability,increased osteogenesis-related gene expression,and strongly activated(P<0.001)Smad1/5/8 signaling characterized HPFs originating from *** present data indicate that in humans,differences between palatal CTGs harvested from different locations and depths appear to be location-rather than *** findings provide the basis for future personalization of the therapeutic strategy by selecting an optimal graft type depending on the clinical indications.

关键词： selecting characterizing showing