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Diffusion tensor imaging in the courtroom:Distinction between scientific specificity and legally admissible evidence

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World Journal of Clinical Cases 2023年第19期11卷 4477-4497页

作者： Jennifer Christine van Velkinburgh Mark D Herbst Stewart M Casper Science Communication Filipodia Publishing LLCSanta FeNM 87505United States Diagnostic radiology Independent Diagnostic Radiology IncSt PetersburgFL 33711United States Personal Injury Law Casper&DeToledo LLCStamfordCT 06905United States

Interest and uptake of science and medicine peer-reviewed literature by readers outside of a paper’s topical subject,field or even discipline is *** the application of knowledge from one field or discipline to others can stimulate innovative solutions to problems facing modern society,it is also fraught with danger for *** the practice of law in the united States,academic papers are submitted to the courts as evidence in personal injury litigation from both the plaintiff(complainant)and *** transcendence of an academic publication over disciplinary boundaries is immediately met with the challenge of application by a group that inherently lacks in-depth knowledge on the scientific method,the practice of evidence-based medicine,or the publication process as a structured and internationally synthesized process involving peer review and guided by ethical standards and norms.A modern-day example of this is the ongoing conflict between the sensitivity of diffusion tensor imaging(DTI)and the legal standards for admissibility of evidence in litigation cases of mild traumatic brain injury(mTBI).In this review,we amalgamate the peer-reviewed research on DTI in mTBI with the court’s rationale underlying decisions to admit or exclude evidence of DTI abnormalities to support claims of brain *** found that the papers which are critical of the use of DTI in the courtroom reflect a primary misunderstanding about how diagnostic biomarkers differ legally from relevant and admissible *** clinical use of DTI to identify white matter abnormalities in the brain at the chronic stage is a valid methodology both clinically as well as forensically,contributes data that may or may not corroborate the existence of white matter damage,and should be admitted into evidence in personal injury trials if supported by a *** also delve into an aspect of science publication and peer review that can be manipulated by scientists and clinicians to

关键词： Diffuse axonal injury Mild brain injury Magnetic resonance imaging Neuroimaging Medicolegal Litigation Medical jurisprudence Ethics Peer review Publishing

Continuous Expression of Interferon Regulatory Factor 4 Sustains CD8^(+)T Cell Immunity against Tumor

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Research 2024年第3期2023卷 433-444页

作者： Anze Yu Jinfei Fu Zheng Yin Hui Yan Xiang Xiao Dawei Zou Xiaolong Zhang Xiongbing Zu Xian C.Li Wenhao Chen Immunobiology and Transplant Science Center Department of SurgeryHouston Methodist Research Institute and Institute for Academic MedicineHouston Methodist HospitalHoustonTXUSA Department of Urology First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdongChina Systems Medicine and Bioengineering Department Houston Methodist Neal Cancer CenterHoustonTXUSA Department of radiology Houston Methodist HospitalWeill Cornell MedicineHoustonTXUSA Department of Urology Xiangya HospitalCentral South UniversityChangshaHunanChina Department of Surgery Weill Cornell MedicineCornell UniversityNew YorkNYUSA.

T-cell-based immunotherapy is gaining momentum in cancer treatment;however,our comprehension of the transcriptional regulation governing T cell antitumor activity remains *** objective of this study was to explore the function of interferon regulatory factor 4(IRF4)in antitumor CD8^(+)T cells using the TRAMP-C1 prostate cancer and B16F10 melanoma *** achieve this,we generated an Irf4^(GFP-DTR) mouse strain and discovered that CD8^(+)tumor-infiltrating lymphocytes(TILs)expressing high levels of *** exhibited a more differentiated PD-1high cell *** administering diphtheria toxin to tumor-bearing Irf4^(GFP-DTR) mice,we partially depleted ***^(+)TILs and observed an accelerated tumor *** specifically explore the function of IRF4 in antitumor CD8^(+)T cells,we conducted 3 adoptive cell therapy(ACT)***,depleting ***^(+)CD8^(+)TILs derived from ACT significantly accelerated tumor growth,emphasizing their crucial role in controlling tumor ***,deleting the Irf4 gene in antitumor CD8^(+)T cells used for ACT led to a reduction in the frequency and effector differentiation of CD8^(+)TILs,completely abolishing the antitumor effects of ***,we performed a temporal deletion of the Irf4 gene in antitumor CD8^(+)T cells during ACT,starting from 20 days after tumor implantation,which significantly compromised tumor ***,sustained expression of IRF4 is essential for maintaining CD8^(+)T cell immunity in the melanoma model,and these findings carry noteworthy implications for the advancement of more potent immunotherapies for solid tumors.

关键词： sustained immunity implantation

Optimal b value of diffusion-weighted imaging on a 3.0T magnetic resonance scanner in Crohn's disease

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World Journal of Gastroenterology 2014年第35期20卷 12621-12627页

作者： Qi Feng Yun-Qi Yan Jiong Zhu Jin-Lu Tong Jian-Rong Xu Department of radiology Renji HospitalSchool of MedicineShanghai Jiao Tong University Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong University

AIM: To determine the optimal b value of diffusion-weighted imaging for detecting active inflammation in Crohn’s disease.

关键词： Crohn’ s disease Diffusion-weighted imaging b value Magnetic resonance image 3.0 Tesla

Adaptive Binary Coding for Scene Classification Based on Convolutional Networks

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Computers, Materials & Continua 2020年第12期65卷 2065-2077页

作者： Shuai Wang Xianyi Chen Department of radiology and Biomedical Research Imaging Center University of North Carolina at Chapel HillChapel HillUSA Mathematics and Computer Science University of North Carolina at PembrokePembrokeUSA

With the rapid development of computer technology,millions of images are produced everyday by different *** to efficiently process these images and accurately discern the scene in them becomes an important but tough *** this paper,we propose a novel supervised learning framework based on proposed adaptive binary coding for scene ***,we first extract some high-level features of images under consideration based on available models trained on public ***,we further design a binary encoding method called one-hot encoding to make the feature representation more *** from the proposed adaptive binary coding,our method is free of time to train or fine-tune the deep network and can effectively handle different *** results on three public datasets,i.e.,UIUC sports event dataset,MIT Indoor dataset,and UC Merced dataset in terms of three different classifiers,demonstrate that our method is superior to the state-of-the-art methods with large margins.

关键词： Scene classification convolutional neural network one-hot encoding supervised feature training

CT结肠成像的辐射剂量在日常应用与筛检方案的趋势及差异

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国际医学放射学杂志 2008年第A6期31卷 523-524页

作者： M.H.Liedenbaum H.W.Venema J.Stoker 邓贺然 Department of radiology Academic Medical Center University of Amsterdam Postbus 22660 1100 DD Amsterdam The Netherlands.

本研究的目的在于评价当前CT结肠成像的有效剂量和发展趋势。在PubMed上对关于CT结肠成像的文献和会议摘要进行检索。

关键词： CT结肠成像放射剂量结直肠肿瘤 CT

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根据手术标本病理结果评价常规、动态增强及扩散加权MRI对克罗恩病的定量评估价值

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国际医学放射学杂志 2014年第3期 294-295页

作者： J.A.W.Tielbeek M.L.W.Ziech Z.Li C.Lavini S.Bipat W.A.Bemelman 王鹤 academic Medical Center Department of RadiologyUniversity of AmsterdamMeibergdreef 91105AZ AmsterdamThe Netherlands

摘要目的前瞻性对照克罗恩病的常规MR序列、动态增强(DEC)MRI和扩散加权成像(DWI)与手术标本的组织病理学表现。方法对安排4周内手术的连续克罗恩病病人

关键词： MRI 组织病理学 DWI 病理组织学组织学手术标本动态增强肠炎克罗恩病局限性回肠炎常规

Clinical manifestations of imaging demonstrations of AIDS-related nervous system infections

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Chinese Medical Journal 2013年第22期126卷 4371-4379页

作者： LI Hong-jun LI Yun-fang LI Ning MI Hai-feng CHENG Jing-liang Department of Diagnostic radiology the First Affiliated HospitalZhengzhou University Zhengzhou Henan 450052 China Department of radiology Affiliated Beijing You'an Hospital CapitalMedical University Beijing 100069 China

HIV is a neurotropic virus and can be engulfed macrophagocytes. It invades the brain tissue via the blood-brain barrier and multiplies in the cerebrospinal fluid （CSF）. HIV has been isolated from the brain, spinal marrow, peripheral nerve, and the CSF. Electronic microscopy, immunohistochemistry, and in situ hybridization have demonstrated monocytes and multinucleated cells containing HIV virus.

关键词： AIDS diagnostic imaging pathology nervous system infections

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The association between radiological spreading pattern and clinical outcomes in necrotizing external otitis

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Journal of Otology 2022年第3期17卷 156-163页

作者： W.Leentje van der Meer Ahmed B.Bayoumy Josje J.Otten Jerome J.Waterval Henricus P.M.Kunst Alida A.Postma Department of radiology&Nuclear Medicine Maastricht University Medical Centerthe Netherlands Department of Otorhinolaryngology and Head and Neck Surgery Maastricht University Medical Centerthe Netherlands Department of Otorhinolaryngology and Head and Neck Surgery Radboud Institute for Health SciencesRadboud University Medical Centerthe Netherlands School for Mental Health&Neuroscience Maastricht UniversityMaastrichtthe Netherlands Dutch academic Alliance Skull Base Pathology Maastricht University Medical Center+Radboud University Medical CenterMaastricht/Nijmegenthe Netherlands

Objectives: Necrotizing external otitis(NEO) is a rare infectious disease of the skull base. The purpose of this study was to determine whether clinical outcomes of NEO can be correlated to different infectious spread ***: Retrospective chart review from 2010 to 2019 with NEO patients, who were divided into two cohorts: single spreading patterns(group A) or complex spreading patterns(group B) as diagnosed by *** symptoms, diagnostic and treatment delay, course of disease, complications, and duration of antibiotic exposure were retrospectively collected from patient ***: 41 NEO patients were included, of which 27 patients belonged to group A(66%). The diseaserelated mortality rate was 12.2% among the entire cohort, no differences were found between group A and B. Higher rates of ***(42.9% vs 14.8% P = 0.047) and N. IX palsies were found in group B compared to group A(28.6% vs 3.7%, P = 0.039). The median duration of antibiotic use was significantly different for a complex spreading pattern, clinical recovery and hospitalizations. Complications were associated with higher diagnostic delay and with a complex spread pattern. The median duration of follow-up was 12.0(IQR 6.0-19.5) ***: NEO is a severe disease, with significant mortality and morbidity(cranial nerve palsies). The radiological spread pattern may assist in predicting clinical outcome. Furthermore, complex spread patterns are associated with higher rates of clinical nerve palsies(N. VII and ***), complications, surgery rates and longer duration of antibiotic use. Diagnostic delay was associated with mortality, complications and facial palsies.

关键词： Necrotizing external otitis Malignant external otitis Skull base osteomyelitis Clinical manifestation Spreading routes Antibiotic exposure Facial nerve palsy

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应用扩散加权成像评估青少年特发性关节炎的滑膜炎症:有望替代钆对比剂的影像学生物标志

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国际医学放射学杂志 2018年第1期 117-117页

作者： A.M.Barendregt E.C.van Gulik C.Lavini C.M.Nusman J.M.van den Berg D.Schonenberg-Meinema 窦克冬 Department of radiology Academic Medical Center/University of Amsterdam

摘要目的比较动态对比增强(DCE)MRI和扩散加权成像(DWI)定量评价青少年特发性关节炎(JIA)滑膜炎症的优劣。方法于T1DCE MRI和T2DWI影像上,在JIA病人滑

关键词：加权成像 DCE 滑膜炎症 DWI 关节炎活动性特发性