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Theoretical Framework for a Polymorphic Network Environment

Engineering 2024年第8期39卷 222-234页

作者： Jiangxing Wu Junfei Li Penghao Sun Yuxiang Hu Ziyong Li PLA Strategic support Force Information Engineering University Zhengzhou 450000China

The question of whether an ideal network exists with global scalability in its full life cycle has always been a first-principles problem in the research of network systems and *** far,it has not been possible to scientifically practice the design criteria of an ideal network in a unimorphic network system,making it difficult to adapt to known services with clear application scenarios while supporting the ever-growing future services with unexpected ***,we theoretically prove that no unimorphic network system can simultaneously meet the scalability requirement in a full cycle in three dimensions—the service-level agreement(S),multiplexity(M),and variousness(V)—which we name as the“impossible SMV triangle”*** is only by transforming the current network development paradigm that the contradiction between global scalability and a unified network infrastructure can be resolved from the perspectives of thinking,methodology,and practice *** this paper,we propose a theoretical framework called the polymorphic network environment(PNE),the first principle of which is to separate or decouple application network systems from the infrastructure environment and,under the given resource conditions,use core technologies such as the elementization of network baselines,the dynamic aggregation of resources,and collaborative software and hardware arrangements to generate the capability of the“network of networks.”This makes it possible to construct an ideal network system that is designed for change and capable of symbiosis and coexistence with the generative network morpha in the spatiotemporal *** environment test for principle verification shows that the generated representative application network modalities can not only coexist without mutual influence but also independently match well-defined multimedia services or custom services under the constraints of technical and economic indicators.

关键词： Polymorphic network environment Impossible triangle Network development paradigm Future network

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Simplified liver imaging reporting and data system for the diagnosis of hepatocellular carcinoma on gadoxetic acid-enhanced magnetic resonance imaging

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2439-2448页

作者： Rong Lyu Wei-Juan Hu Di Wang Jiao Wang Yu-Bing Ye Ke-Feng Jia Department of Radiology Tianjin Third Central HospitalTianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesArtificial Cell Engineering Technology Research CenterTianjin 300170China

BACKGROUND The liver imaging reporting and data system(LI-RADS)diagnostic table has 15 cells and is too *** diagnostic performance of LI-RADS for hepatocellular carcinoma(HCC)is not satisfactory on gadoxetic acid-enhanced magnetic resonance imaging(EOB-MRI).AIM To evaluate the ability of the simplified LI-RADS(sLI-RADS)to diagnose HCC on *** A total of 331 patients with 356 hepatic observations were retrospectively *** diagnostic performance of sLI-RADS A-D using a single threshold was evaluated and compared with LI-RADS v2018 to determine the optimal *** algorithms of sLI-RADS A-D are as follows:The single threshold for sLI-RADS A and B was 10 mm,that is,classified observations≥10mm using an algorithm of 10-19 mm observations(sLI-RADS A)and≥20 mm observations(sLI-RADS B)in the diagnosis table of LI-RADS v2018,respectively,while the classification algorithm remained unchanged for observations0.999).With HBP hypointensity as an MF,the sensitivity of F-sLI-RADS was greater than that of LI-RADS v2018(93.0%vs 87.0%,P<0.001)and sLI-RADS D(93.0%vs 89.8%,P=0.016),without a lower specificity(86.5%vs 90.1%,P=0.062;86.5%vs 89.4%,P=0.125).Compared with that of LI-RADS v2018,the time to classif

关键词： Hepatocellular carcinoma Magnetic resonance imaging Liver Diagnosis Contrast agent

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What is the effect of Tribulus terrestris on testicular morphology and sperm production?An experimental study in the rat model

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Asian Journal of Andrology 2024年第1期26卷 67-70页

作者： Marcello Henrique Araujo Da Silva Gabriela Faria Buys-Goncalves Joao Henrique Duque Reis Estrada Francisco Jose Barcellos Sampaio Diogo Benchimol de Souza Urogenital research unit Rio de Janeiro State UniversityRio de Janeiro 20551-030RJBrazil

The objective of this study was to investigate whether treatment with Tribulus terrestris(Tt)has any impact on the testicular morphology and function in a rodent *** male rats were divided into a control group and a group receiving 100 mg kg^(-1) body weight of Tt *** 4o days of experiment,the animals were submitted to euthanasia;epididymal tail spermatozoa were collected;and spermatozoa concentration,motility,and viability were *** addition,testicles were collected and processed for histomorphometrical *** were compared using the Student's t-test and considered significant when P<*** concentration,motility,and viability showed no difference between the ***,testicular weight and volume,seminiferous tubule diameter,tunica propria surface density,seminiferous epithelium surface density,and intertubular compartment surface density were statistically similar between the ***,seminiferous epithelium height and tubular lumen surface density were augmented in animals treated with *** with Tt does not cause a major impact on testicular morphology,promoting only subtle *** difference on spermatozoa parameters was observed.

关键词： morphometry testicle Tribulus terrestris

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Cellular precision modulation of JAK1:tailoring therapies for allergic lung inflammation

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Signal Transduction and Targeted Therapy 2024年第7期9卷 2843-2844页

作者： Xiaocheng Yan Siegfried Ussar research unit Adipocytes&Metabolism(ADM) Helmholtz Diabetes CenterHelmholtz Zentrum MünchenGerman Research Center for Environmental Health GmbH85764 NeuherbergGermany German Center for Diabetes research(DZD) 85764 NeuherbergGermany

In a recent publication published in Cell,Tamari et *** a previously unrecognized role of JAK1 signaling in vagal sensory neurons regulating the immune response to allergic lung inflammation.1 The authors show that sensory neuromodulation could be an important therapeutic avenue for the treatment of lung *** is now well established that the number of patients suffering from allergic disorders,like those suffering from obesity and the metabolic syndrome,is rapidly increasing world-wide,accelerating the burden on individual health and healthcare ***,basic and clinical researchers urgently need to develop novel therapeutics and approaches to limit or prevent disease development or progression.

关键词： JAK1 allergic lung

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Need for operational simplicity and timely disbursal of benefits—a qualitative exploration of the implementation of a direct benefit transfer scheme for persons with tuberculosis in India

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贫困所致传染病(英文) 2024年第3期13卷 1-15页

作者： Mohan Malu Thangaraj Jeromie W. V. Pandey Sumit Priya G. Sri Lakshmi Arunachalam Sivavallinathan Sharma Rahul Shewade Hemant Deepak Aishwarya B. Afeeq K. Khatoon Afsana Gokulvijay B. Sireesha Gude Chandra Kavita Nandhakumar S. Samuel Prince Viswanathan C. Nanditha Shanmugasundaram Devika Rao Raghuram Murhekar Manoj V. Jeyashree Kathiresan Indian Council of Medical research-National Institute of Epidemiology R-127 TNHB Ayapakkam Chennai Tamil Nadu India TB support Network WHO Country Office for India New Delhi India Central Tuberculosis Division Government of India New Delhi India

Background Ni-kshay Poshan Yojana (NPY) is a direct benefit transfer scheme of the Government of India introduced in 2018 to support the additional nutritional requirements of persons with TB (PwTB). Our recent nationwide evaluation of implementation and utilization of NPY using programmatic data of PwTB from nine randomly selected Indian states, reported a 70% coverage and high median delay in benefit credit. We undertook a qualitative study between January and July 2023, to understand the detailed implementation process of NPY and explore the enablers and barriers to effective implementation and utilization of the NPY *** We followed a grounded theory approach to inductively develop theoretical explanations for social phenomena through data generated from multiple sources. We conducted 36 in-depth interviews of national, district and field-level staff of the National Tuberculosis Elimination Programme (NTEP) and NPY beneficiaries from 30 districts across nine states of India, selected using theoretical sampling. An analytical framework developed through inductive coding of a set of six interviews, guided the coding of the subsequent interviews. Categories and themes emerged through constant comparison and the data collection continued until theoretical *** Stakeholders perceived NPY as a beneficial initiative. Strong political commitment from the state administration, mainstreaming of NTEP work with the district public healthcare delivery system, availability of good geographic and internet connectivity and state-specific grievance redressal mechanisms and innovations were identified as enablers of implementation. However, the complex, multi-level benefit approval process, difficulties in accessing banking services, perceived inadequacy of benefits and overworked human resources in the NTEP were identified as barriers to implementation and *** The optimal utilization of NPY is enabled by strong political commitment and

关键词： National Tuberculosis Elimination Programme Nutritional status Direct benefit transfer Ni-kshay Poshan Yojana Implementation Cash transfer scheme Grounded theory India

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Structural energy storage composites based on modified carbon fiber electrode with metal-organic frame enhancing layered double hydroxide

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Nano research 2024年第3期17卷 1552-1563页

作者： Jinrui Ye Zhongbao Wang Qin Lei Lei Sun Jinfeng Gu School of Aerospace Engineering Beijing Institute of TechnologyBeijing 100081China Tangshan research Institute Beijing Institute of TechnologyTangshan 063000China School of Materials Science and Engineering Shenyang Jianzhu UniversityShenyang 110168China Department of Stomatology PLA Strategic Support Force Characteristic Medical CenterBeijing 100101China Beijing Electromechanical Engineering research Institute Beijing 100074China

Structural energy storage composites present advantages in simultaneously achieving structural strength and electrochemical *** of carbon fiber electrodes and resin structural electrolytes in energy storage composite poses challenges in maintaining good mechanical and electrochemical properties at reasonable cost and ***,we report a simple method to fabricate structural supercapacitor using carbon fiber electrodes(modified by Ni-layered double hydroxide(Ni-LDH)and in-situ growth of Co-metal-organic framework(Co-MOF)in a two-step process denoted as Co-MOF/Ni-LDH@CF)and bicontinuous-phase epoxy resin-based structural ***-MOF/Ni-LDH@CF as electrode material exhibits improved specific capacity(42.45 F·g^(-1))and cycle performance(93.3%capacity retention after 1000 cycles)in a three-electrode *** bicontinuous-phase epoxy resin-based structural electrolyte exhibits an ionic conductivity of 3.27×10^(-4) S·cm^(-1).The fabricated Co-MOF/Ni-LDH@CF/SPE-50 structural supercapacitor has an energy density of 3.21 Wh·kg^(-1) at a power density of 42.25 W·kg^(-1),whilst maintaining tensile strength and modulus of 334.6 MPa and 25.2 *** results show practical potential of employing modified commercial carbon fiber electrodes and epoxy resin-based structural electrolytes in structural energy storage applications.

关键词： carbon fiber electrode structural electrolyte structural energy storage composites supercapacitor

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The evolution of cancer genomic medicine in Japan and the role of the National Cancer Center Japan

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Cancer Biology & Medicine 2024年第1期21卷 29-44页

作者： Teruhiko Yoshida Yasushi Yatabe Ken Kato Genichiro Ishii Akinobu Hamada Hiroyuki Mano Kuniko Sunami Noboru Yamamoto Takashi Kohno Department of Genetic Medicine and Services National Cancer Center HospitalTokyo 104-0045Japan Department of Diagnostic Pathology National Cancer Center HospitalTokyo 104-0045Japan Clinical research support Offce Clinical Research Coordinating SectionBiobank Translational Research Support SectionNational Cancer Center HospitalTokyo 104-0045Japan Department of Pathology and Clinical Laboratories National Cancer Center Hospital EastChiba 277-8577Japan Division of Molecular Pharmacology National Cancer Center Research InstituteTokyo 104-0045Japan National Cancer Center research Institute Tokyo 104-0045Japan Department of Laboratory Medicine National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan Division of Genome Biology National Cancer Center Research InstituteTokyo 104-0045Japan

The journey to implement cancer genomic medicine(CGM)in oncology practice began in the 1980s,which is considered the dawn of genetic and genomic cancer *** the time,a variety of activating oncogenic alterations and their functional significance were unveiled in cancer cells,which led to the development of molecular targeted therapies in the 2000s and *** CGM is still a relatively new discipline and it is difficult to predict to what extent CGM will benefit the diverse pool of cancer patients,the National Cancer Center(NCC)of Japan has already contributed considerably to CGM advancement for the conquest of *** back at these past achievements of the NCC,we predict that the future of CGM will involve the following:1)A biobank of paired cancerous and non-cancerous tissues and cells from various cancer types and stages will be *** quantity and quality of these samples will be compatible with omics *** biobank samples will be linked to longitudinal clinical information.2)New technologies,such as whole-genome sequencing and artificial intelligence,will be introduced and new bioresources for functional and pharmacologic analyses(e.g.,a patient-derived xenograft library)will be systematically deployed.3)Fast and bidirectional translational research(bench-to-bedside and bedside-to-bench)performed by basic researchers and clinical investigators,preferably working alongside each other at the same institution,will be implemented;4)Close collaborations between academia,industry,regulatory bodies,and funding agencies will be established.5)There will be an investment in the other branch of CGM,personalized preventive medicine,based on the individual's genetic predisposition to cancer.

关键词： Cancer genomic medicine biobank patient-derived xenograft multi-gene panel test whole genome sequencing

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Genomic medicine in clinical practice:national genomic medicine program in Japan

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Cancer Biology & Medicine 2024年第1期21卷 4-9页

Cancer statistics in Japan Cancer is the most common cause of death in Japan based on Statistics 2021~*** statistics were first gathered,infectious diseases,such as tuberculosis,and cerebrovascular disease have been the main causes of death in *** surpassed cerebrovascular disease as the main cause of death in 1981,and the number of cancer deaths has *** 38,000 people died of cancer in *** National Cancer Center(NCC)reported that the 5-year survival rate for patients with cancer was improving(62%for males and 66.9%for females)in a population-based cancer registry.

关键词： Cancer cancer death

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Impact of uterine artery embolization on ovarian function and pregnancy outcome after uterine-fibroids treatment:A prospective study

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World Journal of Clinical Cases 2024年第15期12卷 2551-2559页

作者： Jing-Lei Liu Zhi-Hui Liang Bao Cui Jian-Yu Liu Li Sun Department of Interventional Treatment 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina Department of Obstetrics and Gynecology 980(Bethune International Peace)Hospital of PLA Joint Logistics Support ForcesShijiazhuang 050082Hebei ProvinceChina

Uterine fibroids are benign tumors that originate from smooth muscle cells of the *** is the most common gynecological disorder,affecting up to 80%of women of reproductive *** fibroids can cause various symptoms such as abnormal uterine bleeding,pelvic pain,infertility,and pregnancy *** treatment options for uterine fibroids include medical therapy,surgical intervention,and minimally invasive *** To compare ovarian function of women with uterine fibroids who did or did not undergo uterine artery embolization(UAE).METHODS This prospective cohort study enrolled 87 women with symptomatic uterine fibroids who underwent UAE,and 87 women with the same symptoms who did not undergo UAE but received conservative management or other *** two groups were matched for age,body mass index,parity,and baseline characteristics of uterine *** primary outcome was ovarian function that was evaluated by serum levels of follicle-stimulating hormone(FSH),luteinizing hormone(LH),estradiol(E2),and anti-Müllerian hormone(AMH),as well as ovarian reserve tests,such as antral follicle count(AFC)and ovarian volume(OV).The secondary outcome was fertility that was evaluated based on the menstrual cycle,ovulation,conception,pregnancy,and *** participants were followed-up for 36 months and assessed at 1,3,6,12,24,and 36 months after *** The study found that the most common minor complication of UAE was postembolization syndrome in 73.6% of women,resolving within a *** significant differences were observed between the UAE group and the control group in serum levels of reproductive hormones(FSH,LH,E2,AMH)and ovarian reserve indicators(AFC,OV)at any point up to 36 months ***,there were no significant differences in conception,pregnancy,or delivery rates,with the average time to conception and gestational age at delivery being similar between the two *** weights were also ***

关键词： Uterine fibroids Uterine artery embolization Ovarian function Fertility Pregnancy outcome Embolic agent

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Mission of the National Cancer Center Hospital in Japan to promote clinical trials for precision medicine

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Cancer Biology & Medicine 2024年第1期21卷 1-3页

作者： Kazuaki Shimada Kenichi Nakamura Noboru Yamamoto Department of Hepatobiliary and Pancreatic Surgery National Cancer Center HospitalTokyo 104-0045Japan Clinical research support Offce National Cancer Center HospitalTokyo 104-0045Japan Department of Experimental Therapeutics National Cancer Center HospitalTokyo 104-0045Japan

Precision medicine is a growing field *** its potential benefit to many patients,several major obstacles must be overcome before precision medicine can be more widely used in clinical *** main obstacles are associated... 详细信息

关键词： clinical Cancer overcome

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