检索结果-南通市图书馆

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong Liu Xiaolin Li Xiaowei Zhou Wei Chen Aidong Wen Minna Liu Yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

Combination for Conflicting Interval-Valued Belief Structures with CSUI-DST Method

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Electronics 2022年第5期31卷 980-990页

作者： LI Shuangming GUAN Xin YI Xiao SUN Guidong Naval Aviation University unit 92941 of pla unit 32801 of pla

Since the basic probability of an intervalvalued belief structure(IBS) is assigned as interval number, its combination becomes difficult. Especially, when dealing with highly conflicting IBSs, most of the existing combination methods may cause counter-intuitive results,which can bring extra heavy computational burden due to nonlinear optimization model, and lose the good property of associativity and commutativity in Dempster-Shafer theory(DST). To address these problems, a novel conflicting IBSs combination method named CSUI(conflict,similarity, uncertainty, intuitionistic fuzzy sets)-DST method is proposed by introducing a similarity measurement to measure the degree of conflict among IBSs, and an uncertainty measurement to measure the degree of discord, non-specificity and fuzziness of IBSs. Considering these two measures at the same time, the weight of each IBS is determined according to the modified reliability degree. From the perspective of intuitionistic fuzzy sets, we propose the weighted average IBSs combination rule by the addition and number multiplication operators. The effectiveness and rationality of this combination method are validated with two numerical examples and its application in target recognition.

关键词： interval-valued belief structure inference mechanisms interval number reliability degree fuzzy set theory uncertainty measurement DST CSUI uncertainty handling Dempster-Shafer theory similarity measurement weighted average IBSs combination rule reliability conflict similarity uncertainty intuitionistic fuzzy sets

Role of nutrition in diabetes mellitus and infections

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2025年第3期13卷 1-8页

作者： Xue-Lu Yu Li-Yun Zhou Xiao Huang Xin-Yue Li Ming-Ke Wang Ji-Shun Yang Naval Medical Center of pla Naval Medical UniversityShanghai 200052China

In this editorial,we have commented on the article that has been published in the recent issue of World Journal of Clinical *** authors have described a case of unilateral thyroid cyst and have opined that the acute onset of infection may be linked to diabetes mellitus(DM).We have focused on the role of nutrition in the association between DM and *** with DM are at a high risk of infection,which could also be attributed to nutrition-related *** interventions for patients with diabetes are mainly based on a low-calorie diet,which can be achieved by adhering to a low-carbohydrate ***,dietary fiber supplementation is recommended to maintain the diversity of the gut ***,high-quality protein can prevent the increased risk of infection due to *** of vitamins C,vitamins A,vitamins D,and folic acid improves blood sugar control and facilitates immune *** deficiencies augment the risk of infection,but the relationship with diabetes is mostly U-shaped and a good intake should be maintained.

关键词： Diabetes mellitus Infection Macronutrients Vitamins Minerals

Automatic web services classification based on rough set theory

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Central South University 2013年第10期20卷 2708-2714页

作者：陈立张英宋自林苗壮 Institute of Command Automation PLA University of Science and Technology unit 61539 of pla unit 61672 of pla

With development of web services technology, the number of existing services in the internet is growing day by day. In order to achieve automatic and accurate services classification which can be beneficial for service related tasks, a rough set theory based method for services classification was proposed. First, the services descriptions were preprocessed and represented as vectors. Elicited by the discernibility matrices based attribute reduction in rough set theory and taking into account the characteristic of decision table of services classification, a method based on continuous discernibility matrices was proposed for dimensionality reduction. And finally, services classification was processed automatically. Through the experiment, the proposed method for services classification achieves approving classification result in all five testing categories. The experiment result shows that the proposed method is accurate and could be used in practical web services classification.

关键词： web services services classification rough set theory discernibility matrices

Tribological properties of cobalt-based alloy coating with different cobalt contents by electro-spark deposition

在线全文

学校读者我要写书评

暂无评论

Rare Metals 2013年第1期32卷 40-46页

作者： Qi-Feng Jing Ye-Fa Tan Engineering Institute of Engineering Corps PLA University of Science & Technology unit 78649 of pla

The cobalt-based alloy coating with different Co contents was deposited on 45 steel by electro-spark deposition with the self-made electrode. The coating has a compact and uniform microstructure with low porosity and no visible microcracks. When Co content increases grad- ually, oxygen content of coating samples 1-5 decreases first and then increases in the range of 2.52 wt%-3.05 wt%; sample 3 has the lowest oxygen content of 2.52 %. Mi- crohardness of the coating is improved remarkably com- pared with the substrate （HV 230.18）. With Co content increasing, microhardness of the coating samples 1-5 first rises slightly and then declines rapidly in the range of HV 580.61-1052.33. Sample 3 gets the maximum of HV 1052.33, which is about 4.6 times that of the substrate. The coating presents excellent wear resistance, which first increases and then decreases when Co content increases. Sample 3 shows the best wear resistance of about 6.4 times that of the substrate. Main wear mechanism of the coating is abrasive wear and fatigue wear, along with oxidation wear under high speed or heavy load conditions.

关键词： Electro-spark deposition Cobalt Content Microstructure Wear resistance Wear mechanism

IFCEM based recognition method for target with interval-overlapped hybrid attributes

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2023年第2期34卷 408-421页

作者： GUAN Xin LI Shuangming SUN Guidong WANG Haibin Naval Aviation University Yantai 264001China unit 92941 of pla Huludao 125001China unit 32801 of pla Beijing 100082China

When the attributes of unknown targets are not just numerical attributes,but hybrid attributes containing linguistic attributes,the existing recognition methods are not *** addition,it is more difficult to identify the unknown targets densely distributed in the feature space,especially when there is interval overlap between attribute measurements of different target *** address these problems,a novel method based on intuitionistic fuzzy comprehensive evaluation model(IFCEM)is *** numerical attributes,targets in the database are divided into individual classes and overlapping classes,and for linguistic attributes,continuous interval-valued linguistic term set(CIVLTS)is used to describe target characteristic.A cloud modelbased method and an area-based method are proposed to obtain intuitionistic fuzzy decision information of query target on numerical attributes and linguistic attributes *** improved inverse weighted kernel fuzzy c-means(IWK-FCM)algorithm is proposed for solution of attribute weight *** possibility matrix is applied to determine the identity and category of query ***,a case study composed of parameter sensitivity analysis,recognition accuracy *** comparison with other methods,is taken to verify the superiority of the proposed method.

关键词： intuitionistic fuzzy comprehensive evaluation model(IFCEM) interval overlapping cloud model area-based method inverse weighted kernel fuzzy c-means(IWK-FCM)

LPI radar signal detection based on the combination of FFT and segmented autocorrelation plus PAHT

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2017年第5期28卷 890-899页

作者： Chengzhi Yang Zhiwei Xiong Yang Guo Bolin Zhang Department of Information Countermeasures Aviation University of Air Force College of Communication Engineering Jilin University unit 94691 of pla unit 94810 of pla

This paper proposes a desirable method to detect different kinds of low probability of intercept (LPI) radar signals, targeted at the main intra-pulse modulation method of LPI radar signals including the signals of linear frequency modulation, phase code, and frequency code. Firstly, it improves the coherent integration of LPI radar signals by adding the periodicity of the ambiguity function. Then, it develops a frequency domain detection method based on fast Fourier transform (FFT) and segmented autocorrelation function to detect signals without features of linear frequency modulation by virtue of the distribution characteristics of noise signals in the frequency domain. Finally, this paper gives a verification of the performance of the method for different signal-to-noise ratios by conducting simulation experiments, and compares the method with existing ones. Additionally, this method is characterized by the straightforward calculation and high real-time performance, which is conducive to better detecting all kinds of LPI radar signals.

关键词： low probability of intercept (LPI) signal detection period ambiguity function segmented autocorrelation channelization

Research on fixed-time time-varying formation of heterogeneous multi-agent systems based on tracking error observer under DoS attacks OA

在线全文

学校读者我要写书评

暂无评论

Defence Technology（防务技术） 2024年第12期42卷 211-225页

作者： Jiqing Luo Husheng Fang Yue Zhong Jing Zhang Shengli Song Army Engineering University of pla Nanjing 210000China unit 63966 of pla Beijing 100000China

In this paper,the fixed-time time-varying formation of heterogeneous multi-agent systems(MASs) based on tracking error observer under denial-of-service(DoS) attacks is ***,the dynamic pinning strategy is used to reconstruct the communication channel for the system that suffers from DoS attacks to prevent the discontinuous transmission information of the communication network from affecting MASs ***,considering that the leader state is not available to each follower under DoS attacks,a fixed-time distributed observer without velocity information is constructed to estimate the tracking error between followers and the ***,adaptive radial basis function neural network(RBFNN) is used to approximate the unknown ensemble disturbances in the system,and the fixed-time time-varying formation scheme is designed with the constructed *** effectiveness of the proposed control algorithm is demonstrated by the numerical simulation.

关键词： Denial-of-service attacks Dynamic pinning Fixed-time tracking error observer Adaptive RBFNN Fixed-time time-varying formation

A Fast Bayesian Evaluation Algorithm Based on the Second Category of Maximum Likelihood

在线全文

学校读者我要写书评

暂无评论

Journal of Donghua University(English Edition) 2015年第2期32卷 305-309页

作者：孟晶郑榕刘君 Key Laboratory of National Defense Science and Technology for Underwater Acoustic Warfare Unit 91388 of the PLA unit 92961 of the pla unit 91872 of the pla

Directing at evaluation for qualifying rate in weaponry test,this article discusses firstly how field test information is flooded with lots of prior *** a fast Bayesian evaluation algorithm is presented based on the elaborate analysis of prior information reliability and the second category of maximum *** example demonstrates that the algorithm presented in this article is better and more robust compared with classical evaluation algorithm for safe-or-failure test and normal Bayesian method,which can make the best of prior information.

关键词： Bayesian prior Likelihood likelihood elaborate conjugate applying calculating confidence consistency