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Occult hepatitis B virus infection among Mexican human immunodeficiency virus-1-infected patients

World Journal of Gastroenterology 2014年第37期20卷 13530-13537页

作者： Ma Teresa Alvarez-Muoz Angelica Maldonado-Rodriguez Othon Rojas-Montes Rocio Torres-Ibarra Fernanda Gutierrez-Escolano Guillermo Vazquez-Rosales Alejandro Gomez Onofre Muoz Javier Torres Rosalia Lira unidad de investigacion medica en enfermedades infecciosas y parasitarias Hospital de PediatriaCentro Medico Nacional Siglo XXIInstituto Mexicano del Seguro Social Clinica de Hepatitis Hospital de Infectologia Centro Médico Nacional La Raza Hospital General Regional No.72 IMSS unidad de investigacion medica en enfermedades infecciosas y parasitarias Hospital de PediatriaCentro Medico Nacional Siglo XXIInstituto Mexi-cano del Seguro Social Hospital Infantil de Mexico "Federico Gomez"

AIM: To determine the frequency of occult hepatitis B infection(OHBI) in a group of human immunodeficiency virus(HIV)-1+/ hepatitis B surface antigen negative(HBsAg)- patients from Mexico. METHODS: We investigated the presence of OHBI in 49 HIV-1+/HBsAg- patients. Hepatitis B virus(HBV) DNA was analyzed using nested PCR to amplify the Core(C) region and by real-time PCR to amplify a region of the S and X genes. The possible associations between the variables and OHBI were investigated using Pearson's χ2 and/or Fisher's exact ***: We found that the frequency of OHBI was 49% among the group of 49 HIV-1+/HBsAg- patients studied. The presence of OHBI was significantly associated with the HIV-1 RNA viral load [odds ratio(OR) = 8.75; P = 0.001; 95%CI: 2.26-33.79] and with HIVantiretroviral treatment with drugs that interfere with HBV replication(lamivudine, tenofovir or emtricitabine)(OR = 0.25; P = 0.05; 95%CI: 0.08-1.05). CONCLUSION: The OHBI frequency is high among 49 Mexican HIV-1+/HBsAg- patients and it was more frequent in patients with detectable HIV RNA, and less frequent in patients who are undergoing HIV-ARV treatment with drugs active against HBV.

关键词： Hepatitis B virus Occult hepatitis B virus infecti

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Tick-Borne Rickettsial Pathogens in Rodents from Mexico

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Journal of Biomedical Science and engineering 2014年第11期7卷 884-889页

作者： Carolina G. Sosa-Gutiérrez Margarita Vargas Javier Torres Guadalupe Gordillo-Pérez Facultad de Agrobiología Universidad Michoacana de San Nicolas de Hidalgo Uruapan México unidad de Investigación Médica de enfermedades infecciosas y parasitarias Hospital de Pediatría Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Mexico City Mexico

Tick-Borne Rickettsial Diseases (TBRD) are emerging zoonotic diseases, and a problem of human health and veterinary medication. The distribution of these diseases is related to the distribution of vector. The presence of pathogens in the host is a risk indicator of population exposure to these areas. A total of 478 tissues samples from rodents, A. phagocytophilum 18 (3.7%), E. canis 47 (9.8%), Rickettsia rickettsii 18 (3.7%) and E. chaffeensis 19 (3.9%) were detected using species-specific PCR assay. It is the first report in Mexico the presence of rodents infected with A. phagocytophilum and E. chaffeensis. The rodent Peromyscus spp. were the most commonly prevalent host of infection for all the bacteria’s. We have to consider as host of TBRD transmitter and provide a useful contribution to understanding their epidemiology. The health sector should be considered all the fevers of unknown causes in humans and animals in Mexico as infections by these vector-borne rickettsial pathogens.

关键词： Anaplasma phagocytophilum Ehrlichia chaffeensis Rickettsia rickettsii Ehrlichia canis Rodents

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Potential Species Distribution and Richness of Ixodidae Ticks Associated with Wild Vertebrates from Michoacán, Mexico

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Journal of Geographic Information System 2014年第5期6卷 467-477页

作者： Margarita Vargas-Sandoval Angel G. Priego-Santander Alejandra Larrazábal Carolina G. Sosa-Gutiérrez Blanca Lara-Chávez Teresita Avila-Val Facultad de Agrobiología “Presidente Juárez” Universidad Michoacana de San Nicolás de Hidalgo Uruapan México Centro de investigaciones en Geografía Ambiental UNAM Antigua Carretera a Pátzcuaro No. 8701 ExHacienda de San José de la Huerta Morelia México unidad de Investigación Médica de enfermedades infecciosas y parasitarias Hospital de Pediatría Centro Médico Nacional Siglo XXI México DF México

Ticks are regarded as the most relevant vectors of disease-causing pathogens in domestic and wild animals. The diversity of Ixodidae is known for a very small number of ***?are represented by 26 species, and?in?2007 the first reported ticks vectors in Mexico for the causal agent of Lyme disease. Recent rise in tick-borne disease in many parts of the world is a phenomenon in need of an explanation. The main objective of the present work was to map at a regional scale (1:2,000,000)?of?the distribution of ticks of the family Ixodidae that are potentially present on the wild fauna of state of Michoacan, Mexico. We compiled all available literature on ticks at a national level together with complete cartographic and bibliographic georeferenced information of the distribution of hosts in order to build a spatial database in ArcView 3.3. The results indicated that the wild fauna in the state’s territory could potentially include 31 species of ticks of Ixodidae. The map of potential species richness of ixodid ticks on the wild fauna of the state can be categorized into five classes of species richness. The highest potential concentration of ixodid species on wild fauna occurs in the volcanic area of Pico de Tancítaro.

关键词： Ticks Ixodidae Michoacán Geographic Distribution Potential Species Richness

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Association between Helicobacter *** and hepatobiliary malignancies:A review

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World Journal of Gastroenterology 2015年第5期21卷 1414-1423页

作者： Fany Karina Segura-López Alfredo Güitrón-Cantú Javier Torres Hospital de Especialidades UMAE No 71 Instituto Mexicano del Seguro SocialTorreónCoahuila 27000México departamento de endoscopia Gastrointestinal Hospital de Especialidades UMAE No 71Instituto Mexicano del Seguro SocialTorreónCoahuila 2700México unidad de Investigación en enfermedades infecciosas y parasitarias Hospital de Pediatría UMAECentro Médico Nacional Siglo XXIInstituto Mexicano del Seguro SocialMéxico CP 06720DFMéxico

Hepatobiliary cancers are highly lethal cancers that comprise a spectrum of invasive carcinomas originating in the liver hepatocellular carcinoma,the bile ducts intrahepatic cholangiocarcinoma and extrahepaticcholangiocarcinoma,the gallbladder and the ampulla of Vater(collectively known as biliary tract cancers).These tumors account for approximately 13% of all annual cancer-related deaths worldwide and for 10%-20% of deaths from hepatobiliary ***(CCA) is a devastating disease that displays a poor survival rate for which few therapeutic options are *** genetics,geographical and environmental factors,cholelithiasis,obesity,parity,and endemic infection with liver flukes have been identified as risk factors that influence the development of biliary tract *** important factors affecting the carcinogenesis of these tumors include chronic inflammation,obstruction of the bile ducts,and impaired bile *** has been suggested that CCA is caused by infection with Helicobacter species,such as Helicobacter bilis and Helicobacter hepaticus,in a manner that is similar to the reported role of Helicobacter pylori in distal gastric *** to the difficulty in culturing these Helicobacter species,molecular methods,such as polymerase chain reaction and sequencing,or immunologic assays have become the methods of choice for ***,clinical studies of benign or malignant biliary tract diseases revealed remarkable variability in the methods and the findings,and the use of uniform and validated techniques is needed.

关键词： Helicobacter bilis Helicobacter hepaticus Helicoba

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Occult hepatitis B virus co-infection in human immunodeficiency virus-positive patients: A review of prevalence, diagnosis and clinical significance

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World Journal of Hepatology 2015年第2期7卷 253-260页

作者： Angelica Maldonado-Rodriguez Ana Maria Cevallos Othon Rojas-Montes Karina enriquez-Navarro Ma Teresa Alvarez-Mu?oz Rosalia Lira unidad de investigacion medica en enfermedades infecciosas y parasitarias Hospital de Pediatria Centro Medico Nacional Siglo XXI Instituto Mexicano del Seguro Social departamento de Biologia Molecular y Biotecnologia Instituto de Investigaciones Biomedicas Universidad Nacional Autonoma de Mexico

The prevalence of human immunodeficiency virus(HIV) and hepatitis B virus(HBV) co-infection is high as they share similar mechanisms of transmission. The development and widespread use of highly sensitive tests for HBV diagnosis has demonstrated that a significant proportion of apparently healthy individuals with evidence of exposure to HBV continue to carry fully functional HBV DNA in their hepatocytes, a situation that predisposes them to the development of progressive liver disease and hepatocellular carcinoma. The presence of co-infections frequently influences the natural evolution of each of the participating infections present by either facilitating their virulence or competing for resources. Furthermore, the drugs used to treat these infections may also contribute to changes in the natural course of these infections, making the analysis of the impact of co-infection more difficult. The majority of studies has examined the impact of HIV on overt chronic hepatitis B, finding that co-infection carries an increased risk of progressive liver disease and the development of hepatocellular carcinoma. Although the effect of HIV on the natural history of occult hepatitis B infection(OBI) has not been fully assessed, all available data suggest a persisting risk of repeated flares of hepatitis and progressive liver disease. We describe studies regarding the diagnosis, prevalence and clinical significance of OBI in HIVpositive patients in this short review. Discrepancies in worldwide prevalence show the urgent need for the standardization of diagnostic criteria, as established by the Taormina statements. Ideally, standardized protocols for testing should be employed to enable the comparison of data from different groups. Additional studies are needed to define the differences in risk for OBI without HIV and in HIV-HBV co-infected patients with or without overt disease.

关键词： Hepatitis B virus Occult hepatitis B Humanimmunodeficiency virus Prevalence Diagnosis Clinicalsignificance

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