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Molecular signaling of 5-HT<sub>1A</sub>and presence of serotonergic cells in the fetal cerebral cortex

World Journal of neuroscience 2013年第2期3卷 76-82页

作者： Alfonso B. M. de Oca Gabriel M. Gutiérrez Jorge H. Rodríguez Laboratorio de neurontogenia Departamento de Fisiología Biofísica y Neurociencias Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Ciudad de México México unidad de investigación biomolecular Hospital de Cardiología Centro Médico Nacional Siglo XXI Instituto Mexicano del Seguro Social Ciudad de México México

Early appearance of the serotonergic system in the fetal brain and the various effects of serotonin (5-HT) on brain morphogenesis, have given support to a neurotrophic role of serotonin. This function of serotonin is accomplished through a system of serotonin nerve terminals in the target regions that involves various 5-HT receptors. In visual, auditory and somatosensory cortex an early and intense serotonergic innervation is particularly important. The neuronal somata of these terminals are normally located in the mesencephalon and they have not been observed in the maturing cerebral cortex, neither in the adult brain. By using immunolabeling techniques, fluorescence and confocal microscopy, we observe the presence of both, 5-HT terminals and 5-HT cells in mesencephalon (Me, E17) and in the neopallium (np, E13-E16) cocultures. Cells immunopositive to 5-HT and to tryptophan-5-hydroxilase are also observed in the np on day 12 of culture. These results concerning the unexpected presence of serotonergic cells in the fetal cerebral cortex are interesting and may be of importance in corticogenesis. As it happens with other elements of the serotonergic system, the presence of these phenotypically serotonergic cells in the early cerebral cortex may be transitory and probably supporting cortex maturation processes. The molecular signaling path of the 5-HT1A receptor has also been identified.

关键词： Serotonergic System Serotonin Receptor 5-HT1A Molecular Signaling Paths

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Increased serotonin concentration and tryptophan hydroxylase activity in reproductive organs of copulator males:a case of adaptive plasticity

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Advances in Bioscience and Biotechnology 2011年第2期2卷 75-84页

作者： Ana Ingrid Pichardo Jose L.Tlachi-Lopez Francisco Jimenez-Trejo Alma L.Fuentes-Farias Armida Baez-Saldana Maria L.Molina-Ceron Gabriel Manjarrez-Gutierrez Gabriel Gutierrez-Ospina Rosa Angelica Lucio departamento de Biologia Celular y Fisiologia Instituto de Investigaciones BiomedicasUniversidad Nacional Autonoma de MexicoCiudad Universitaria 04510MexicoD.F.Mexico Centro Tlaxcala de Biologia de la Conducta Universidad Autonoma de TlaxcalaCarretera Tlaxcala-Puebla km 1.5 s/nLoma Xicotencatl90062TlaxcalaMexico departamento de Farmacologia Facultad de MedicinaUniversidad Nacional Autonoma de MexicoCiudad Universitaria 04510MexicoD.F.Mexico Laboratorio de Invertebrados y Ecofisiologia Facultad de BiologiaUniversidad Michoacana de San Nicolas de HidalgoCiudad Universitaria 58030MichoacanMexico unidad de investigacion biomolecular Hospital de CardiologiaCentro Medico Nacional Siglo XXIInstituto Mexicano del Seguro Social 06720MexicoD.F.Mexico

Individual male rats may systematically display or not copulatory behavior when paired with receptive females. Although these phenotypes are associated with differences in brain organization and function, they might also do so at the level of the reproductive organs. We then used high performance liquid chromatography to quantify serotonin concentration and the activity of tryptophan hydroxylase in the reproductive organs of copulator and non-copulator males. Sexual behavior display was compared between groups and parameters of fertility and reproductive fitness were determined for copulator males. Copulator males had higher concentrations of serotonin in the epididymis, testicle and ventral prostate than their non-copulator counterparts, as it was found for epididymal and testicular tryptophan hydroxylase activity. However, preliminary data shows that serotonin elevation occurs in copulator males only until they have accumulated several sexual encounters, so it might be a response to genital gratification or sexual rewarding. Interestingly, only epididymal serotonin concentration correlated with reproductive fitness, offspring number, mating success and seminal plug volume in copulator males. Our results support that copulator and non-copulator male rats feature a phenotype-specific serotoninergic tone in the epididymis, testicle and ventral prostate gland. The observation documenting that epididymal serotonin concentration correlated with parameters that monitor male fertility and reproductive fitness in copulator males predicts that epididymal factors increase their chances of parenting offspring.

关键词： Sexual Accessory Glands Copulation Indolamines Seminal Fluid Seminal Plug Successful Mating Reproductive Fitness

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