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A new small baurioid therocephalian from the Lower Triassic Jiucaiyuan Formation, Xinjiang, China

古脊椎动物学报（中英文） 2024年第3期62卷 201-224页

作者： LIU Jun Fernando ABDALA Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Beijing 100044China College of Earth and Planetary Sciences University of Chinese Academy of Sciences Beijing 100049 Área de Paleontología Unidad Ejecutora LilloCONICETFundación Miguel Lillo Miguel Lillo 251TucumánArgentina Evolutionary Studies Institute University of the Witwatersrand Private Bag 3WITSJohannesburg2050South Africa

Several therocephalian species,mainly represented by cranial material from the late Permian,have been reported from China in recent *** we describe a tiny new baurioid therocephalian,Jiucaiyuangnathus confusus *** ***.,from the Jiucaiyuan Formation,Xinjiang,*** new taxon is represented by a partial snout with occluded partial lower jaw and two postcranial *** juvenile in stage,the new species is diagnosed by the following features:round pit in middle of lateral surface of maxilla;lacrimal contact nasal;fossa for dentary tooth on the posterior end of the premaxilla,lateral to the anterior choana;two small vertical triangular ridges extending dorsally and ventrally on the vomerine anterior portion,and bordering a thin vomerine foramen laterally;anterior projection of the lateral part of the frontal on the nasal;symphyseal region of the dentary projected anteriorly;5 upper premaxillary teeth,upper and lower canines absent,diastema between the last premaxillary upper incisor and first maxillary tooth present,no diastema separating anterior from posterior dentition in the mandible,10 maxillary teeth and 12 dentary teeth,posterior postcanine expands mesiodistally,having a main large cusps and tiny anterior and posterior accessory cusps in line;neural arches of the atlas fused by the neural spine,neural spine of the axis projected posteriorly,procoracoid foramen lies between procoracoid and *** of the dentition resembles those of the small baurioid Ericiolacerta parva from South Africa and Silphedosuchus orenburgensis from *** specimens provide the rare opportunity to know in detail the postcranial skeleton of baurioids.

关键词： Jimsar,Xinjiang Early Triassic Jiucaiyuan Formation Therocephalia,Baurioidea

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Protective effect of some vitamins against the toxic action of ethanol on liver regeneration induced by partial hepatectomy in rats

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World Journal of Gastroenterology 2008年第6期14卷 899-907页

作者： Carlett Ramírez-Farías Eduardo Madrigal-Santillán José Gutiérrez-Salinas nidia Rodríguez-Sánchez Maricela Martínez-Cruz Ilse Valle-Jones Ingrid Gramlich-Martínez Alejandra Hernández-Ceruelos José A Morales-González unidad de Genética de la nutrición Instituto Nacional de Pediatría México Instituto de Ciencias de la Salud Universidad Autónoma del Estado de Hidalgo México Laboratorio de Bioquímica y Medicina Experimental Unidad de Investigación Biomédica División de Investigación Centro Médico Nacional "20 de Noviembre" ISSSTE México Gatorade Sports Science Institute Mexico City México Escuela de Dietética y nutrición ISSSTE México University of Ryerson Toronto

AIM: To investigate the effects of vitamins (A, C and E) on liver injury induced by ethanol administration during liver regeneration in rats. METHODS: Male Wistar rats subjected to 70% partial hepatectomy were divided into five groups (groups 1-5). During the experiment, animals of Group 1 drank only water. The other four groups (2-5) drank 30 mL of ethanol/L of water. Group 3 additionally received vitamin A, those of group 4 vitamin C and those of group 5 received vitamin E. Subsequently serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), albumin and bilirubin were measured colorimetrically. Lipid peroxidation (thiobarbituric-acid reactive substances, TBARS) both in plasma and liver was measured, as well as liver mass gain assessment and total DnA. RESULTS: Compared with sham group, serum AST and ALT increased significantly under ethanol treatment (43% and 93%, respectively, with P n C and vitamin E treatment attenuated the ethanol-induced increases in ALT and AST activity. Ethanol treatment also decreased serum albumin concentration compared to sham group (3.1 ± 0.4 g/dL vs 4.5 ± 0.2 g/dL; P ng liver regeneration vitamins C and E significantly ameliorated liver injury for ethanol administration in hepatic lipid peroxidation (4.92 nmol/mg and 4.25 nmol/mg vs 14.78 nmol/mg, respectively, with P n association with hepatic injury, ethanol administration caused a significant increase in both hepatic and plasma lipid peroxidation. Vitamins (C and E) treatment attenuated hepatic and plasma lipid peroxidation. COnCLUSIOn: Vitamins C and E protect against liver injury and dysfunction, attenuate lipid peroxidation, and thus appear to be significantly more effective than vitamin A against ethanol-mediated toxic effects during liver regeneration.

关键词： Lipid peroxidation Antioxidant vitamins Alcohol-induced liver injury Liver regeneration

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Superoxide dismutase prevents development of adenocarcinoma in a rat model of Barrett's esophagus

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World Journal of Gastroenterology 2005年第47期11卷 7436-7443页

作者： Elena Piazuelo Carmelo Cebrián Alfredo Escartín Pilar Jiménez Fernando Soteras Javier Ortego Angel Lanas Instituto Aragonés de Ciencias de la Salud Unidad Mixta de InvestigaciónC/Domingo Miral s/n 50009 ZaragozaSpain Service of Pathology Hospital Clínico Universitario "Lozano Blesa"Avenida San Juan Bosco15 50009 ZaragozaSpain unidad Mixta de Investigatión University of ZaragozaDomingo Miral s/n 50009 ZaragozaSpain unidad Mixta de investigación University of ZaragozaDomingo Miral s/n 50009 ZaragozaSpain Service of Gastroenterology Hospital Clínico Universitario "Lozano Blesa"Avenida San Juan Bosco15 50009 ZaragozaSpain

AIM： To test whether antioxidant treatment could prevent the progression of Barrett＇s esophagus to adenocarcinoma. METHODS： In a rat model of gastroduodenoesophageal reflux by esophagojejunal anastomosis with gastric preservation, groups of 6-10 rats were randomized to receive treatment with superoxide dismutase （SOD） or vehicle and followed up for 4 too. Rat＇s esophagus was assessed by histological analysis, superoxide anion and peroxinitrite generation, SOD levels and DnA oxidative damage. RESULTS： All rats undergoing esophagojejunostomy developed extensive esophageal mucosal ulceration and inflammation by mo 4. The process was associated with a progressive presence of intestinal metaplasia beyond the anastomotic area （9% 1st mo and 50% 4th too）（94% at the anastomotic level） and adenocarcinoma （11% 1^ST mo and 60% 4th too）. These changes were associated with superoxide anion and peroxinitrite mucosal generation, an early and significant increase of DnA oxidative damage and a significant decrease in SOD levels （P〈0.05）. Exogenous administration of SOD decreased mucosal superoxide levels, increased mucosal SOD levels and reduced the risk of developing intestinal metaplasia beyond the anastomotic area （odds ratio = 0.326; 95%CI： 0.108-0.981; P = 0.046）, and esophageal adenocarcinoma （odds ratio = 0.243; 95%CI： 0.073-0.804; P = 0.021）. COnCLUSIOn： Superoxide dismutase prevents the progression of esophagitis to Barrett＇s esophagus and adenocarcinoma in this rat model of gastrointestinal reflux, supporting a role of antioxidants in the chemoprevention of esophageal adenocarcinoma.

关键词： Barrett's esophagus Esophageal adenocarcinoma Free radicals Oxidative damage Superoxide dismutase

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Impact of device resistances in the performance of graphene‑based terahertz photodetectors

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Frontiers of Optoelectronics 2024年第2期17卷 87-97页

作者： O.Castelló Sofía M.López Baptista K.Watanabe T.Taniguchi E.Diez J.E.Velázquez-Pérez Y.M.Meziani J.M.Caridad J.A.delgado-notario department of Applied Physics University of Salamanca37008 SalamancaSpain unidad de Excelencia en Luz y Materia Estructurada(LUMES) University of Salamanca37008 SalamancaSpain Research Center for Electronic and Optical Materials National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan Research Center for Materials nanoarchitectonics National Institute for Materials Science1-1 NamikiTsukuba 305-0044Japan nanotechnology Group USAL-NanolabUniversity of Salamanca37008 SalamancaSpain

In recent years,graphene field-effect-transistors(GFETs)have demonstrated an outstanding potential for terahertz(THz)photodetection due to their fast response and *** features are essential to enable emerging THz applications,including 6G wireless communications,quantum information,bioimaging and ***,the overall performance of these photodetectors may be utterly compromised by the impact of internal resistances presented in the device,so-called access or parasitic *** this work,we provide a detailed study of the influence of internal device resistances in the photoresponse of high-mobility dual-gate GFET *** dual-gate architectures allow us to fine tune(decrease)the internal resistance of the device by an order of magnitude and consequently demonstrate an improved responsivity and noise-equivalent-power values of the photodetector,*** results can be well understood by a series resistance model,as shown by the excellent agreement found between the experimental data and theoretical *** findings are therefore relevant to understand and improve the overall performance of existing high-mobility graphene photodetectors.

关键词： Graphene THz Photodetector Field-effect transistor Plasmonic

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Physiopathology of ischemic stroke and its modulation using memantine:evidence from preclinical stroke

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neural Regeneration Research 2021年第3期16卷 433-439页

作者： Hilda Martínez-Coria Isabel Arrieta-Cruz María-Esther Cruz Héctor E.López-Valdés División de investigación Facultad de MedicinaUniversidad Nacional Autónoma de México(UNAM)Ciudad de MéxicoMéxico Laboratorio Experimental de Enfermedades neurodegenerativas Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico departamento de investigación Básica Instituto Nacional de GeriatríaCiudad de MéxicoMéxico unidad de investigación en Biología de la Reproducción Laboratorio de NeuroendocrinologíaFacultad de Estudios Superiores ZaragozaUNAMCiudad de MéxicoMéxico unidad Periférica de neurociencia Facultad de MedicinaUNAM/Instituto Nacional de Neurología y NeurocirugíaCiudad de MéxicoMéxico

Ischemic stroke is the most common type of cerebrovascular disease and is caused by an interruption of blood flow in the *** this disease,two different damage areas are identifying:the lesion core,in which cells quickly die;and the penumbra(surrounding the lesion core),in which cells are functionally weakened but may recover and restore their *** currently approved treatments for ischemic stroke are the recombinant tissue plasminogen activator and endovascular thrombectomy,but they have a short therapeutic window(4.5 and 6 hours after stroke onset,respectively)and a low percentage of stroke patients actually receive these *** is an approved drug for the treatment of Alzheimer's *** is a noncompetitive,low affinity and use-dependent antagonist of n-methyl-D-aspartate glutamate *** has several advantages over developing a new drug to treat focal ischemic stroke,but the most important is that it has sufficient safe probes in preclinical models and humans,and if the preclinical studies provide more evidence about pharmacological actions in tissue protection and repair,this could help to increase the number of clinical *** present review summarizes the physiopathology of isquemic stroke and the pharmacological actions in neuroprotection and neuroplasticity of memantine in the post stroke stage of preclinical stroke models,to illustrate their potential to improve functional recovery in human patients.

关键词： focal ischemic stroke memantine neuroplasticity neuroprotection stroke therapy

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Refractory hepatic encephalopathy in a patient with hypothyroidism: Another element in ammonia metabolism

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World Journal of Gastroenterology 2017年第28期23卷 5246-5252页

作者： Fernando Díaz-Fontenla Marta Castillo-Pradillo Arantxa Díaz-Gómez Luis Ibanez-Samaniego Pilar Gancedo Juan Adan Guzmán-de-Villoria Pilar Fernández-García Rafael Banares-Canizares Rita García-Martínez unidad de Hepatología Servicio de Aparato DigestivoHospital General Universitario Gregorio Maranón Instituto de investigación Sanitaria Hospital Gregorio Maranón Servicio de Aparato Digestivo Hospital Santa Bárbara Servicio de Radiodiagnóstico Hospital General Universitario Gregorio Maranón Centro de investigación Biomédica en Red de Salud Mental Centro de investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas Facultad de Medicina Universidad San Pablo CEU

Hepatic encephalopathy(HE) remains a diagnosis of exclusion due to the lack of specific signs and symptoms. Refractory HE is an uncommon but serious condition that requires the search of hidden precipitating events(i.e.,portosystemic shunt) and alternative diagnosis. Hypothyroidism shares clinical manifestations with HE and is usually considered within the differential diagnosis of HE. Here,we describe a patient with refractory HE who presented a large portosystemic shunt and post-ablative hypothyroidism. Her cognitive impairment,hyperammonaemia,electroencephalograph alterations,impaired neuropsychological performance,and magnetic resonance imaging and spectroscopy disturbances were highly suggestive of HE,paralleled the course of hypothyroidism and normalized after thyroid hormone replacement. There was no need for intervention over the portosystemic shunt. The case findings support that hypothyroidism may precipitate HE in cirrhotic patients by inducing hyperammonaemia and/or enhancing ammonia brain toxicity. This case led us to consider hypothyroidism not only in the differential diagnosis but also as a precipitating factor of HE.

关键词： Hepatic encephalopathy Hypothyroidism Cognitive impairment Cirrhosis Portosystemic shunt Magnetic resonance spectroscopy

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Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

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neural Regeneration Research 2022年第1期17卷 31-37页

作者： Mercedes A.Hernández-Sapiéns Edwin E.Reza-Zaldívar Ana L.Márquez-Aguirre Ulises Gómez-Pinedo Jorge Matias-Guiu Ricardo R.Cevallos Juan C.Mateos-Díaz Víctor J.Sánchez-González Alejandro A.Canales-Aguirre unidad de Evaluación Preclínica Unidad de Biotecnología Médica y FarmacéuticaCentro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Instituto de neurociencias IdISSCHospital Clínico San CarlosMadridEspaña Biochemistry and Molecular Genetics department University of AlabamaBirminghamAlabama unidad de Biotecnología Industrial Centro de Investigación y Asistencia en Tecnología y Diseño del Estado de JaliscoGuadalajaraMéxico Centro Universitario de los Altos Universidad de GuadalajaraGuadalajaraMéxico

The presenilin genes(PSEn1 and PSEn2)are mainly responsible for causing early-onset familial Alzheimer’s disease,harboring~300 causative mutations,and representing~90%of all mutations associated with a very aggressive disease *** 1 is the catalytic core of theγ-secretase complex that conducts the intramembranous proteolytic excision of multiple transmembrane proteins like the amyloid precursor protein,notch-1,n-and E-cadherin,LRP,Syndecan,delta,Jagged,CD44,ErbB4,and *** 1 plays an essential role in neural progenitor maintenance,neurogenesis,neurite outgrowth,synaptic function,neuronal function,myelination,and ***,an imbalance caused by mutations in presenilin 1/γ-secretase might cause aberrant signaling,synaptic dysfunction,memory impairment,and increased Aβ42/Aβ40 ratio,contributing to neurodegeneration during the initial stages of Alzheimer’s disease *** review focuses on the neuronal differentiation dysregulation mediated by PSEn1 mutations in Alzheimer’s ***,we emphasize the importance of Alzheimer’s disease-induced pluripotent stem cells models in analyzing PSEn1 mutations implication over the early stages of the Alzheimer’s disease pathogenesis throughout neuronal differentiation impairment.

关键词： familial Alzheimer’s disease familial Alzheimer’s disease-induced pluripotent stem cells models induced pluripotent stem cells neurogenesis neuronal differentiation notch presenilin 1 PSEn1 mutations γ-secretase complex

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Seasonal variation and chemical composition of particulate matter： A study by XPS, ICP-AES and sequential microanalysis using Raman with SEM/EDS

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Journal of Environmental Sciences 2018年第12期30卷 32-49页

作者： Lucy T.González Francisco E.Longoria-Rodríguez Margarita Sánchez-Domínguez Cesar Leyva-Porras Karim Acuna-Askar Boris I.Kharissov Alejandro Arizpe-Zapata Juan M.Alfaro-Barbosa Universidad Autónoma de nuevo León Facultad de Ciencias Químicas Laboratorio de Química Analítica AmbientalCódigo Postal 64570MaonterreyN.L.Mexico Centro de investigación en Materiales Avanzados SC Unidad MonterreyAlianza Notre 202 Código Postal 66628 Apodaca Nueuo León Mexico Centro de investigación en Materiales Avanzados SC Miguel de Cervantes # 120 Código Postal 31109 Chihuahua Chih. Mexico Universidad Autónoma de nuevo León Facultad de Medicina Laboratorio de Biorremediación AmbientalCódigo Postal 64460 MonterreyN.L. Mexico

During the winter period（January–March 2016）, the total suspended particles（TSP） and particulate matter smaller than 2.5 μm（PM2.5） were characterized by the application of various analytical techniques in four zones of the Metropolitan Area of Monterrey in Mexico. To evaluate the seasonal variation of some elements in the particulate matter, the results of this study were compared with those obtained during the summer season（July–September 2015）. The speciation of the C_（1s） signal by X-ray photoelectron spectroscopy revealed the contribution of aromatic and aliphatic hydrocarbons as the main components in both seasons. Conversely, carboxylic groups associated with biogenic emissions were detected only in winter. The percentages of SO_4^（2-） ions were lower in winter, possibly caused by the decrease in the solar radiation, and relative humidity recorded. The results of the ICP analysis revealed that Fe, Zn and Cu were the most abundant metals in both TSP and PM2.5 in the two seasons. There were significant seasonal variations for concentrations of As, ni and Zn in the urban area and for Fe, As, Cd, ni and Zn in the industrial zone. This was attributed to the greater burning of fuels as well as to an increase in vehicular traffic, the effect of thermal inversion and changes in some meteorological parameters. The results of the sequential microanalysis by Raman spectroscopy and SEM/EDS allowed observation of deposits of carbonaceous material on the particles and to perform the speciation of particles rich in Fe and Pb, which helped infer their possible emission sources.

关键词： Seasonal variation Total suspended particles PM2.5 X-ray photoelectron spectroscopy Micro-Raman spectroscopy

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Mesenchymal stem cells from different sources and their derived exosomes: A pre-clinical perspective

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World Journal of Stem Cells 2020年第2期12卷 100-109页

作者： María álvarez-Viejo unidad de Terapia Celulary Medicina Regenerativa Servicio de Hematologíay Hemoterapia Hospital Universitario Central de Asturias Plataforma de Terapias Avanzadas Instituto de Investigación Sanitaria del Principado de Asturias

Since the introduction of cell therapy as a strategy for the treatment of many diseases,mesenchymal stem cells have emerged as ideal candidates,yet the underlying mechanisms of their beneficial effects are only partially *** the start of the 21st century,a paracrine effect was proposed as a mechanism of tissue repair by these *** addition,a role was suggested for a heterogeneous population of extracellular vesicles in cell-to-cell *** of these vesicles including exosomes have been isolated from most fluids and cells,as well as from supernatants of in vitro cell *** research in the field of regenerative medicine suggests that exosomes derived from mesenchymal stem cells could be a powerful new therapeutic *** review examines the therapeutic potential of these exosomes obtained from the sources most used in cell therapy:bone marrow,adipose tissue,and umbilical cord.

关键词： Mesenchymal stem cells Exosomes Cellular therapy

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neuroprotective effect of immunomodulatory peptides in rats with traumatic spinal cord injury

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neural Regeneration Research 2021年第7期16卷 1273-1280页

作者： Dulce Parra-Villamar Liliana Blancas-Espinoza Elisa Garcia-Vences Juan Herrera-García Adrian Flores-Romero Alberto Toscano-Zapien Jonathan Vilchis Villa Rodríguez Barrera-Roxana Soria Zavala Karla Antonio Ibarra Raúl Silva-García unidad de investigación Médica en Inmunología Hospital de PediatríaCentro Médico Nacional Siglo XXI/Instituto Mexicano del Seguro Social/Ciudad de MéxicoMéxico Centro de investigación en Ciencias de la Salud(CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac MéxicoCampus NorteHuixquilucanEdo de MéxicoMéxico Centro de investigación del Proyecto Camina A.C Ciudad de MéxicoMéxico

Several therapies have shown obvious effects on structural conservation contributing to motor functional recovery after spinal cord injury(SCI).nevertheless, neither strategy has achieved a convincing *** purposed a combined therapy of immunomodulatory peptides that individually have shown significant effects on motor functional recovery in rats with *** objective of this study was to investigate the effects of the combined therapy of monocyte locomotion inhibitor factor(MLIF), A91 peptide, and glutathione monoethyl ester(GSH-MEE) on chronic-stage spinal cord *** Sprague-Dawley rats underwent a laminectomy of the T9 vertebra and a moderate *** groups were included: sham, PBS, MLIF + A91, MLIF + GSH-MEE, A91 + GSH-MEE, and MLIF + A91 + *** months after injury, motor functional recovery was evaluated using the open field *** and white matter preservation was evaluated using hematoxylin & eosin staining and Luxol Fast Blue staining, *** number of motoneurons in the ventral horn and the number of axonal fibers were determined using hematoxylin & eosin staining and immunohistochemistry, *** deposition was evaluated using Masson's trichrome *** combined therapy of MLIF, A91, and GSH-MEE greatly contributed to motor functional recovery and preservation of the medullary parenchyma, white matter, motoneurons, and axonal fibres, and reduced the deposition of collagen in the lesioned *** combined therapy of MLIF, A91, and GSH-MEE preserved spinal cord tissue integrity and promoted motor functional recovery of rats after *** study was approved by the national Commission for Scientific Research on Bioethics and Biosafety of the Instituto Mexicano del Seguro Social under registration number R-2015-785-116(approval date november 30, 2015) and R-2017-3603-33(approval date June 5, 2017).

关键词： glutathione monoethyl ester monocyte locomotion inhibitor factor motor functional recovery neuroprotection neurorestoration peptides protective autoimmunity spinal cord injury

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