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Comparison of different surrogate markers of muscle mass for the diagnosis of sarcopenia in patients with colorectal cancer

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Journal of Nutritional Oncology 2024年第1期9卷 25-36页

作者： Jia-Le Li Qi Zhou Qi-WenWang De-Cheng Luo Jiang-Hong Huang Xin-Long Yu Si-Zhi Liang Shuang-Yi Tang Jia-Liang Gan Department of pharmacy the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Department of Colorectal and Anal Surgery the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina Grade 2020 the First Affiliated Hospital of Guangxi Medical UniversityNanning 530021GuangxiChina

Background:This study compared the validity of the creatinine-to-cystatin C ratio(CCR),sarcopenia index(SI),and relative skeletalmuscle index(RSMI)as predictors of sarcopenia in patients with colorectal cancer(CRC)and explored their impact on the patient ***:We retrospectively studied patients with CRC who underwent surgical intervention at the Department of Colorectal and Anal Surgery,situatedwithin the First Affiliated Hospital of GuangxiMedical *** investigation spanned from January 2015 to December 2017,encompassing a cohort of patients subject to surgical management forCRC during this ***’s correlation analysis was employed to evaluate the relationships between the CCR,SI,RSMI,and skeletal muscle index(SMI)and the patient *** operating characteristic(ROC)curves were generated to evaluate the predictive precision of these biomarkers and ascertain the optimal cutoff *** logistic regression analysis was conducted to pinpoint the independent factors linked with *** analyses,contingent on different surrogate markers of muscle mass and sarcopenia,were performed utilizing the Kaplan-Meier method alongside the log-rank ***:Weenrolled 815 patientswithCRC(522 male and 293 female patients)whowere eligible for the *** accordancewith the guidelines set forth by the International Consensus on Sarcopenia,sarcopenia was diagnosed in a collective total of 503 patients.A Pearson’s correlation coefficient(r)analysis demonstrated that the CCR,SI,and RSMI were positively correlated with the *** both male and female patients,the RSMI(male:r=0.400,P<0.001;female:r=0.640,P<0.001)was more strongly correlated with the SMI than with the CCR(male:r=0.203,P<0.001;female:r=0.192,P<0.001)or SI(male:r=0.335,P<0.001;female:r=0.285,P<0.001).In male patients,the areas under the ROC curves(AUC)for the CCR,SI,and RSMI were 0.596[(95%confidence interval(CI)=0.545-0.647)],0.648(95%CI=0.599-0.698),a

关键词： Colorectal cancer Creatinine-to-cystatin C ratio Sarcopenia index Relative skeletal muscle index Sarcopenia

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Study of Behavioral Changes and Photosynthetic Activity of <i>Euglenas gracilis</i>in the Presence of Effluents from the Laboratory of Clinical Analysis

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Journal of Environmental Protection 2020年第12期11卷 1015-1029页

作者： Luciano Henrique Pinto Suellen Zucco Bez Julia Carolina Soares Bruna Bonfim Qushmua Alzahrani Assistant Professor at the Department of pharmacy/Nursing/Medicine in UNIVILLE Joinville SC Brazil Student at the pharmacy course in UNIVILLE Joinville SC Brazil Voluntary Researcher in UNIVILLE Joinville SC Brazil

Healthcare waste has now been increasingly studied in terms of the risks or dangers that can cause the environment and human health. Waste generated in clinical analysis laboratories (CALs) deserves attention, because, due to the advent of the concept of emergent pollution, it is doubtful if the materials or reagents are disposed in the sewage by CALs, which are currently considered non-contaminated or with low risk potential, under current legislation, may actually impact the environment with actions not yet understood. This study was experimental and conducted at the Environmental Laboratory of the University of the Region of Joinville. It was used Euglena gracilis (primary trophic level) algae exposed to effluents from five sectors of a CAL: Biochemistry, Hematology, Viral Load, Tuberculosis and Immunochemistry. Samples were collected from the siphons attached to the wash sinks of the CAL materials. To verify changes in algae that denote environmental danger, behavioral changes were analyzed via NGTOX, and chlorophyll concentration was calculated by chlorophyll extraction according to Mendel’s method. Viral Load (VL) and Hematology (HT) sectors were the ones that most affected algae (Tukey test). In both sectors, there was inhibition of algae mobility and gravitaxy: in VL, due to the presence of chaotropic agents that denature organic structures;and in HT, due to the change in membrane permeability attributed to methylene blue. Also in HT, there was a search for algae adaptation by increasing the rise to the surface in order to overcome the lower luminosity due to the coloration of the environment, which also affects photosynthesis. Regarding the concentration of a-chlorophyll, the VL and HT were the most affected as well, being the first one the one that had more concentration reduction because of the presence of chaotropic agents. Considering new parameters evaluated, the discarded compounds need to be better evaluated for risk, as they affect algal photosynthe

关键词： Ecotoxicity Emerging Pollutants Chaotropic Agent Methylene Blue Effluent from Clinical Analysis Laboratory Residues

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“Block and attack”strategy for tumor therapy through ZnO_(2)/siRNA/NIR-mediating Zn^(2+)-overload and amplified oxidative stress

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聚集体(英文) 2023年第4期4卷 152-165页

作者： Yuping Jiang Kai Shao Fenglan Zhang Tianyi Wang Lei Han Xiaoying Kong Jinsheng Shi College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural UniversityQingdaoChina School of Medicine and pharmacy Ocean University of ChinaQingdaoChina Department of Central Laboratory Qilu Hospital(Qingdao)Cheeloo College of MedicineShandong UniversityQingdaoChina Department of Public course Teaching University of Health and Rehabilitation SciencesQingdaoChina

Intracellular zinc ion(Zn^(2+))accumulation disrupts the Zn^(2+)homeostasis,providing an ion-overloading anticancer strategy with great *** self-adaptation of tumor cells to ion concentration,however,puts forward higher requirements for the design of ion-overloading ***,“block and attack”antitumor strategy was applied through a composite nanomaterials(UHSsPZH NPs).The strategy demonstrated powerful ion interference ability through both“blocking”the efflux of excess Zn^(2+)via gene silencing and“attacking”tumor cells via target delivery of ZnO_(2).After cellular internalization,ZnO_(2) was degraded to Zn^(2+)and hydrogen peroxide(H_(2)O_(2)),and the gene expression of zinc transporter 1(ZnT1)was silenced by targeting of released siRNA,which together caused intracellular Zn2+-*** of Zn^(2+)further interfered with intracellular Ca^(2+)homeostasis,inhibited the electron transport chain and promoted the production of endogenous reactive oxygen species(ROS),which assisted the“attack”to tumor cells together with the exogenous ROS generated by UHSsPZH NPs under 980 nm laser *** summary,this work supplies a“block and attack”strategy for the application of ion homeostasis interference in tumor therapy.

关键词： photodynamic therapy siRNA tumor therapy Zn^(2+)-overload ZnO_(2)

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Flavonoid Contents and Antioxidant Activity in Fruit,Vegetables and Other Types of Food

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Agricultural Sciences 2015年第4期6卷 426-435页

作者： Juliana Cristina Pereira Calado Paula Adriana Albertao Erica Aparecida de Oliveira Mario Henrique Sisto Letra Alexandra Christine Helena Frankland Sawaya Maria Cristina Marcucci Post-Graduated School in pharmacy Anhanguera University of Sao Paulo(UNIAN-SP)Sao PauloBrazil Department of Plant Biology and pharmacy course Institute of BiologyUniversidade Estadual de CampinasUNICAMPCampinasBrazil

Flavonoids are a class of natural polyphenolic compounds which cannot be synthesized by humans. These substances possess a series of biological properties, acting on biological systems as antioxidants. The purpose of this study was to analyze the properties of certain foods, determining the total flavonoids as well as their antioxidant activity and fat concentration. We evaluated several foods purchased at the local market, with respect to its antioxidant activity, using two experimental models, the discoloration of DPPH˙ radical and ABTS-. Some foods such as pitanga showed antioxidant activity. The lipid content of fatty foods like aaí, cacao and cupuaú was determined. Other foods, including pitanga, aaí, cacao and cupuaú, were evaluated for flavonoid content and antioxidant activity using multivariate statistical analysis (PCA) as a statistical tool to evaluate the correlation between these two parameters. As samples with ED50 up to 500 μg/mL show promising antioxidant activity, several Brazilian fruit and vegetables could be consumed to this end, with a good correlation between flavonoid content and antioxidant activity in most samples. The daily dose of different types of food for antioxidant activity has been calculated based on these results.

关键词： Amount of Lipids Antioxidant Activity Chemometric Analysis Fat Content Flavonoids Food Fruit Vegetables

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Regulatory factors of Nrf2 in age-related macular degeneration pathogenesis

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International Journal of Ophthalmology(English edition) 2024年第7期17卷 1344-1362页

作者： Zi-Ling Hu Yu-Xuan Wang Zi-Yue Lin Wen-Shuo Ren Bo Liu Hui Zhao Qiong Qin Five Year Program of Ophthalmology and Optometry 2019 Beijing Tong Ren HospitalCapital Medical UniversityBeijing 100054China Four Year Program of Traditional Chinese pharmacy 2020 School of Traditional Chinese MedicineCapital Medical UniversityBeijing 100069China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China Beijing Key Laboratory of TCM Collateral Disease Theory Research Beijing 100069China Five Year Program of Ophthalmology and Optometry 2021 School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China Biochemistry&Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Age-related macular degeneration(AMD)is a complicated disease that causes irreversible visual *** evidences pointed retinal pigment epithelia(RPE)cells as the decisive cell involved in the progress of AMD,and the function of anti-oxidant capacity of PRE plays a fundamental physiological *** factor erythroid 2 related factor 2(Nrf2)is a significant transcription factor in the cellular anti-oxidant system as it regulates the expression of multiple anti-oxidative *** functions of protecting RPE cells against oxidative stress(OS)and ensuing physiological changes,including inflammation,mitochondrial damage and autophagy dysregulation,have already been *** the roles of upstream regulators of Nrf2 could provide further insight to the OS-mediated AMD *** the first time,this review summarized the reported upstream regulators of Nrf2 in AMD pathogenesis,including proteins and miRNAs,and their underlying molecular mechanisms,which may help to find potential targets via regulating the Nrf2 pathway in the future research and further discuss the existing Nrf2 regulators proved to be beneficial in preventing AMD.

关键词： Nrf2 upstream regulators retinal pigment epithelia age-related macular degeneration oxidative stress

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Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics

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Chinese Journal of Natural Medicines 2023年第4期21卷 308-320页

作者： ZHANG Ruizhen DUAN Rong WANG Weiqing YU Zhiguo LI Yun ZHAO Yunli Department of Pharmaceutical Analysis School of PharmacyShenyang Pharmaceutical UniversityShenyang 110016China Department of pharmacy the Second Hospital of Dalian Medical UniversityDalian 116023China

Viscum coloratum(Kom.)Nakai is a well-known medicinal ***,the optimal harvest time for *** is *** studies were performed to analyze compound variation during storage and to improve post-harvest quality *** study aimed to comprehensively evaluate the quality of *** in different growth stages,and determine the dynamic variation of ***-performance liquid chromatography tandem mass spectrometry was used to quantify 29 compounds in *** harvested in six growth periods,and the associated biosynthetic pathways were *** accumulation of different types of compounds were analyzed based on their synthesis *** relational analysis was used to evaluate the quality of *** across different *** compound variation during storage was analyzed by a high-temperature high-humidity accelerated *** results showed that the quality of *** was the hightest in March,followed by November,and became the lowest in *** storage,compounds in downstream steps of the biosynthesis pathway were first degraded to produce the upstream compounds and some low-molecular-weight organic acids,leading to an increase followed by a decrease in the content of some compounds,and resulted in a large gap during the degradation time course among different *** to the rapid rate and large degree of degradation,five compounds were tentatively designated as“early warning components”for quality *** report provides reference for better understanding the biosynthesis and degradation of metabolites in *** and lays a theoretical foundation for rational application of *** and better quality control of *** during storage.

关键词： Viscum coloratum Harvesting period Storage Plant metabolomics Quality control

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Development of a C3c-based ELISA method for the determination of anti-complementary potency of Bupleurum polysaccharides

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Acta Pharmaceutica Sinica B 2015年第4期5卷 316-322页

作者： Mulu Wu Hong Li Yunyi Zhang Daofeng Chen Department of Pharmacology School of Pharmacy Fudan University Department of Microbiology Yong Loo Lin School of Medicine National University of Singapore Department of Pharmacognosy School of Pharmacy Fudan University

Traditionally, determination of inhibitory potency of complement inhibitors is performed by the hemolytic assay. However, this assay is not applicable to the lectin pathway, thus impeding the understanding of complement inhibitors against the overall function of the complement system. The main objective of our study was to develop a specific enzyme-linked immunosoihent assay (ELISA) as an alternative method to assess the anti-complement activity, particularly against the lectin pathway. By using respective coating substrates against different activation pathways, followed by capturing the stable C3c fragments, our ELBA method can be used to screen complement inhibitors against the classical pathway and the lectin pathway. The inhibitory effect of sununin on the classical pathway, as measured by our hemolytic assay is consistent with previous reports. Further assessment of suramin and Bupleurum polysaccharides against the lectin pathway showed a good reproducibility of the method. Comparison of the lectin pathway IC5is between *** var, purviPliam polysaccharides (1.055 ingtmE) and Buplcurann chinense polysaccharides (0.98 ing/mL) showed that similar to the classical and alterative pathway, these two Bupleurum polysaccharides had comparable anti complementary properties against the lectin pathway. The results demonstrate that the described EIASA assay can compensate for he shortcomings of the hemolytic assay in lectin pathway. (C) 2015 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://***/licenses/by-nc-nd/4.0/).

关键词： ELISA Complement C3c Suramin Bupleurum smithti var. parvifolium Bupleurum chinense Polysaccharides

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Direct interaction of DNMT inhibitors to PrP^C suppresses pathogenic process of prion

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Acta Pharmaceutica Sinica B 2019年第5期9卷 952-959页

作者： Dae-Hwan Kim Chunyan Ren Chongsuk Ryou Jiaojie Li Institute of Pharmaceutical Science and Technology Hanyang UniversityAnsan15588Republic of Korea School of undergraduate Studies College of Transdisciplinary StudiesDaegu Gyeongbuk Institute of Science and TechnologyDaegu42988Republic of Korea Boston Children’s Hospital Harvard Medical SchoolBostonMA02115USA Department of pharmacy Hanyang UniversityAnsan15588Republic of Korea Department of Chemistry Gwangju Institute of Science and TechnologyGwangju61005Republic of Korea

The conversion of the normal cellular prion protein(PrP^C) to the misfolded pathogenic scrapie prion protein(Pr PSc) is the biochemical hallmark of prion replication. So far, various chemical compounds that inhibit this conformational conversion have been identified. Here, we report the novel anti-prion activity of SGI-1027 and its meta/meta analogue(M/M), previously known only as potent inhibitors of DNA methyltransferases(DNMTs). These compounds effectively decreased the level of Pr PSc in cultured cells with permanent prion infection, without affecting PrP^Cat the transcriptional or translational levels. Furthermore, SGI-1027 prevented effective prion infection of the cells. In a Pr P aggregation assay, both SGI-1027 and M/M blocked the formation of misfolded Pr P aggregates, implying that binding of these compounds hinders the Pr P conversion process. A series of binding and docking analyses demonstrated that both SGI-1027 and M/M directly interacted with the C-terminal globular domain of PrP^C, but only SGI-1027 bound to a specific region of PrP^C with high affinity, which correlates with its potent antiprion efficacy. Therefore, we report SGI-1027 and related compounds as a novel class of potential antiprion agents that preferentially function through direct interaction with PrP^C.

关键词： Prion DNMT Therapeutic compounds PrP^C Epigenetic regulation

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Macrocyclic peptides as regulators of protein-protein interactions

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Chinese Chemical Letters 2018年第7期29卷 1067-1073页

作者： Yang Jiang Hongyi Long Yujie Zhu Yi Zeng College of pharmacy and Bioengineering Chengdu University School of Science Xihua University

Protein-protein interactions(PPIs) are recognized as attractive therapeutic targets. However targeting PPIs especially intracellular ones has been proven extremely difficult for conventional drug-like small molecules, and biological drugs such as monoclonal antibodies have difficulty in reaching intracellular targets. Macrocyclic peptides are promising candidates of PPI regulators for their potential in combining high potency and biological stability together. Cell permeability of macrocyclic peptides may also be achieved by structural modifications or conjugation to a cell-penetrating sequence. Significant progress has been made in this research area in recent years. Important technology progress and recent examples of macrocyclic peptide PPI modulators are reviewed.

关键词： Macrocycle Macrocyclic peptide Protein-protein interaction Inhibitor Cell-penetrating peptide

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The Clinical Pharmacology of Propofol:A Brief Review

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Open Journal of Anesthesiology 2013年第8期3卷 367-373页

作者： Mohamed Abo El Hamd Department of Pharmaceutical Analytical Chemistry Faculty of Pharmacy Al-Azhar University Assiut Egypt Department of Clinical pharmacy Division of Analytical Research for Pharmacoinformatics Doctoral Course of Pharmaceutical Sciences Graduate School of Biomedical Sciences Nagasaki University Nagasaki Japan

The following article has been retracted due to the investigation of complaints received against it. The Editorial Board found that substantial portions of the text came from other published papers. The scientific community takes a very strong view on this matter, and the OJAnes treats all unethical behavior such as plagiarism seriously. This paper published in Vol.3 No. 8, 367-373(pages), 2013, has been removed from this site.

关键词： Propofol Pharmacokinetics Pharmacodynamics

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