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Percutaneous Ethanol Intratumoral Injection for Treatment of Small Primary Liver Cancer：Summary of 240 Cases

The Chinese-German Journal of Clinical Oncology 2002年第2期1卷 75-77页

作者： GUOJia CHENHan 等 ultrasounddepartment EastrnHepatobiliarySugeryHospitolSecondMilitaryMedicalUniversityShanghai200438 ultrasounddepartment EastrnHepatobiliarySugeryHospitolSecondMilitaryMedicalUniversityShanghai200

Objective To evaluate the therapeutic effects of percutaneous ethanol intratumoral injection (PEIT) for treatment of small primary liver cancer (SPLC).Methods 240 patients with surgically or pathologically proved SPLC ( < 3 cm in diameter) were treated by PEIT ( under the guidance of B-ultrasound) . Of the" 240 patients, 163 had recurrent liver cancer, 55 had inoperable liver cancer because of cardiac, pulmonary, hepatic and renal dysfunctions or due to the close proximity of tumor to the major vessels, and 22 refused to receive surgical resection. In 40 patients who received surgical resection after PEIT treatment, the resected tumors were pathologically evaluated for necrotic status and the patients were followed up *** Postoperative 1-, 2- and 3-year survival rate of the 240 patients was 94.9% , 84.2% and 66.3% respectively. Conclusion PEIT can be used as a non-invasive treatment for SPLC, and preoperative PEIT appears to be helpful in reducing recurrence of postoperative liver cancer.

关键词： primary liver cancer percutaneous ethanol intratumoral injection

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Experimental and clinical assessment of percutaneous hepatic quantified ethanol injection in treatment of hepatic carcinoma

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World Journal of Gastroenterology 2004年第21期10卷 3112-3117页

作者： Li-WuLin Xue-YingLin Yi-MiHe Shang-DaGao En-ShengXue Xiao-DongLin Li-YunYu FujianProvincialUltrasonicMedicineInstitute UltrasoundDepartmentUnionHospitalofFujianMedicalUniversityFuzhou350001FujianProvinceChina

AIM: To detect the relationship between absolute ethanol injection quantity, the interval and formation of fibreboard, the curative effect in treatment of hepatocarcinoma and to evaluate the clinical application of percutaneous hepatic quantified ethanol injection (PHQEI) in treatment of hepatic carcinoma (HCC).METHODS: (1) Experimental study: Twenty-four human hepatic carcinoma SMMC-7721 xenografted nude mice were randomly divided into three groups: group A injected with quantified ethanol at short intervals (QESI), group B with quantified ethanol at long intervals (QELI) and group C with a small quantity of ethanol at long intervals (SQLI). The tumor tissues were sent for patho-histology and electron microscopic examinations. The diameters of tumors were measured with high frequency ultrasound before and after therapies and tumor growth index (TGI) was calculated. (2) Clinical study: Tumors of 122 cases of pathologically proved HCC were injected with quantified ethanol guided by ultrasound every 3-5 d 4-10 times per period of treatment. The quantity of ethanol was calculated according to the regressive equations where Y = 2.885X when the mass was ≤5 cm in diameter and Y = 1.805X when the mass was >5 cm in diameter (X is the maximal diameter of the mass with the unit cm, Y is the ethanol quantity with the unit mL). The survival rates of 1, 2, 3 and 4 years and recurrent rates in situas well as dystopia in the liver were ***: (1) Experimental study: TGI of QESI group (0.072:1:0.018) and QELI group (0.094:1:0.028) was apparently lower than that of SQLI group (1.982:1:0.482) (P0.05) between two groups. Severe degeneration and necrosis could be seen in QESI group by patho-histology examination. Coagulative necrosis could be seen in most tumors of QESI group and there were no residual cancer cells under electronic microscope, while the residual cance

关键词：临床实验经皮注射法酒精量化肝脏疾病肝癌肿瘤消化系统

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