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A Solvent-Free Covalent Organic Framework Single-Ion Conductor Based on Ion-Dipole Interaction for All-Solid-State Lithium Organic Batteries

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NANO-MICRO LETTERS 2024年第1期16卷 1-12页

作者： Li, Zhongping Oh, Kyeong-Seok Seo, Jeong-Min Qin, Wenliang Lee, Soohyoung Zhai, Lipeng Li, Changqing Baek, Jong-Beom Lee, Sang-Young Yonsei Univ Dept Chem & Biomol Engn 50 Yonsei Ro Seoul 03722 South Korea ulsan natl inst sci & technol unist Sch Energy & Chem Engn 50 UNIST GilEonyang Eup Ulsan 44919 South Korea Yonsei Univ Dept Battery Engn 50 Yonsei Ro Seoul 03772 South Korea Zhongyuan Univ technol Ctr Adv Mat Res Henan Key Lab Funct Salt Mat Zhengzhou 450007 Peoples R China Yonsei Univ Dept Battery Conflat Engn 50 Yonsei Ro Seoul 03772 South Korea

A class of solvent-free covalent organic framework (COF) single-ion conductors (Li-COF@P) has been designed via ion-dipole interaction as opposed to traditional ion-ion interaction, promoting ion dissociation and Li+ migration through directional ionic *** Li-COF@P enabled long cycle life (88.3% after 2000 cycles) in all-solid-state Li organic batteries (ASSLOBs) under ambient operating conditions, which outperformed those of previously reported *** Li-COF@P strategy holds promise as a viable alternative to the currently prevalent inorganic solid electrolytes. Single-ion conductors based on covalent organic frameworks (COFs) have garnered attention as a potential alternative to currently prevalent inorganic ion conductors owing to their structural uniqueness and chemical versatility. However, the sluggish Li+ conduction has hindered their practical applications. Here, we present a class of solvent-free COF single-ion conductors (Li-COF@P) based on weak ion-dipole interaction as opposed to traditional strong ion-ion interaction. The ion (Li+ from the COF)-dipole (oxygen from poly(ethylene glycol) diacrylate embedded in the COF pores) interaction in the Li-COF@P promotes ion dissociation and Li+ migration via directional ionic channels. Driven by this single-ion transport behavior, the Li-COF@P enables reversible Li plating/stripping on Li-metal electrodes and stable cycling performance (88.3% after 2000 cycles) in organic batteries (Li metal anode||5,5'-dimethyl-2,2'-bis-p-benzoquinone (Me2BBQ) cathode) under ambient operating conditions, highlighting the electrochemical viability of the Li-COF@P for all-solid-state organic batteries.

关键词： Solid organic single-ion conductors Solvent-free covalent organic frameworks All-solid-state Li organic batteries Ion-dipole interaction Pore functionalization COMPOSITE POLYMER ELECTROLYTE CATHODE NANOSHEETS

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Self-supported VO2 on polydopamine-derived pyroprotein-based fibers for ultrastable and flexible aqueous zinc-ion batteries

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CARBON ENERGY 2024年第7期6卷 1-13页

作者： Yeon, Jeong Seok Park, Sul Ki Kim, Shinik Mohite, Santosh V. Kim, Won Il Jang, Gun Jang, Hyun-Seok Bae, Jiyoung Lee, Sang Moon Hong, Won G. Kim, Byung Hoon Kim, Yeonho Park, Ho Seok Sungkyunkwan Univ Coll Engn Sch Chem Engn Seoul Gyeonggi South Korea Sungkyunkwan Univ Coll Engn Sch Chem Engn 2066 Seobu Ro Suwon 440746 Gyeonggi South Korea Univ Cambridge Dept Engn Cambridge England Konkuk Univ Dept Appl Chem Chungju South Korea ulsan natl inst sci & technol unist Coll Nat Sci Dept Chem Ulsan South Korea Konkuk Univ Dept Appl Chem Chungju 27478 South Korea Incheon natl Univ Dept Phys Incheon South Korea Incheon natl Univ Intelligent Sensor Convergence Res Ctr Incheon South Korea Incheon natl Univ Inst Basic Sci Incheon South Korea Incheon natl Univ Dept Phys Incheon 17104 South Korea Korea Basic sci inst Div Mat Anal & Res Daejeon South Korea

A conventional electrode composite for rechargeable zinc-ion batteries (ZIBs) includes a binder for strong adhesion between the electrode material and the current collector. However, the introduction of a binder leads to electrochemical inactivity and low electrical conductivity, resulting in the decay of the capacity and a low rate capability. We present a binder- and conducting agent-free VO2 composite electrode using in situ polymerization of dopamine on a flexible current collector of pyroprotein-based fibers. The as-fabricated composite electrode was used as a substrate for the direct growth of VO2 as a self-supported form on polydopamine-derived pyroprotein-based fibers (pp-fibers@VO2(B)). It has a high conductivity and flexible nature as a current collector and moderate binding without conventional binders and conducting agents for the VO2(B) cathode. In addition, their electrochemical mechanism was elucidated. Their energy storage is induced by Zn2+/H+ coinsertion during discharging, which can be confirmed by the lattice expansion, the formation of by-products including Znx(OTf)y(OH)(2x-y)center dot nH(2)O, and the reduction of V4+ to V3+. Furthermore, the assembled Zn//pp-fibers@VO2(B) pouch cells have excellent flexibility and stable electrochemical performance under various bending states, showing application possibilities for portable and wearable power sources.

关键词： aqueous battery binder free conducting agent-free flexible electrode zinc-ion battery CATHODE MATERIALS LOW-COST ELECTROLYTE MECHANISM STORAGE ENERGY OXIDE V2O5

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Manipulating photogenerated electron flow in nickel single-atom catalysts for photocatalytic CO2 reduction into tunable syngas

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CARBON ENERGY 2024年第8期6卷 205-213页

作者： Zhang, Yida Wang, Qingyu Wu, Lihui Pan, Haibin Liu, Chengyuan Lin, Yue Wang, Gongming Zheng, Xusheng Univ sci & technol China Natl Synchrotron Radiat Lab Hefei 230029 Anhui Peoples R China Univ sci & technol China Coll Chem & Mat Sci Hefei Anhui Peoples R China Univ sci & technol China Hefei Natl Res Ctr Phys Sci Microscale Dept Chem Hefei Anhui Peoples R China

The key to designing photocatalysts is to orient the migration of photogenerated electrons to the target active sites rather than dissipate at inert sites. Herein, we demonstrate that the doping of phosphorus (P) significantly enriches photogenerated electrons at Ni active sites and enhances the performance for CO2 reduction into syngas. During photocatalytic CO2 reduction, Ni single-atom-anchored P-modulated carbon nitride showed an impressive syngas yield rate of 85 mu mol g(cat)(-1) h(-1) and continuously adjustable CO/H-2 ratios ranging from 5:1 to 1:2, which exceeded those of most of the reported carbon nitride-based single-atom catalysts. Mechanistic studies reveal that P doping improves the conductivity of catalysts, which promotes photogenerated electron transfer to the Ni active sites rather than dissipate randomly at low-activity nonmetallic sites, facilitating the CO2-to-syngas photoreduction process.

关键词： carbon nitride CO2 photoreduction electron flow Ni single atoms syngas GRAPHITIC CARBON NITRIDE CHARGE-TRANSFER ENVIRONMENTAL REMEDIATION WATER

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Highly efficient vanadium redox flow batteries enabled by a trilayer polybenzimidazole membrane assembly

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CARBON ENERGY 2024年第7期6卷 191-204页

作者： Bui, Trung Tuyen Shin, Mingyu Rahimi, Mohammad Bentien, Anders Kwon, Yongchai Henkensmeier, Dirk Korea inst sci & technol KIST Hydrogen Fuel Cell Res Ctr Seoul South Korea Univ sci & technol KIST Sch Div Energy & Environm Technol Seoul South Korea Korea Univ Grad Sch Energy & Environm Seoul South Korea Korea inst sci & technol KIST Hydrogen Fuel Cell Res Ctr Seoul 02792 South Korea Seoul natl Univ sci & technol Dept Chem & Biomol Engn Seoul South Korea Seoul natl Univ sci & technol Dept Chem & Biomol Engn 232 Gongneung ro Seoul 01811 South Korea Aarhus Univ Dept Biol & Chem Engn Aarhus Denmark

A novel polybenzimidazole (PBI)-based trilayer membrane assembly is developed for application in vanadium redox flow battery (VRFB). The membrane comprises a 1 mu m thin cross-linked poly[2,2'-(p-oxydiphenylene)-5,5'-bibenzimidazole] (OPBI) sandwiched between two 20 mu m thick porous OPBI membranes (p-OPBI) without further lamination steps. The trilayer membrane demonstrates exceptional properties, such as high conductivity and low area-specific resistance (ASR) of 51 mS cm(-1) and 81 m Omega cm(2), respectively. Contact with vanadium electrolyte increases the ASR of trilayer membrane only to 158 m Omega cm(2), while that of Nafion is 193 m Omega cm(2). VO2+ permeability is 2.73 x 10(-9) cm(2) min(-1), about 150 times lower than that of Nafion NR212. In addition, the membrane has high mechanical strength and high chemical stability against VO2+. In VRFB, the combination of low resistance and low vanadium permeability results in excellent performance, revealing high Coulombic efficiency (>99%), high energy efficiency (EE; 90.8% at current density of 80 mA cm(-2)), and long-term durability. The EE is one of the best reported to date.

关键词： polybenzimidazole porous membrane proton conductivity trilayer VRFBs PROTON-EXCHANGE MEMBRANES CONDUCTIVITY PERFORMANCE DEGRADATION STABILITY MECHANISM SOLVENT STORAGE ENERGY

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Light-Material Interactions Using Laser and Flash Sources for Energy Conversion and Storage Applications

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NANO-MICRO LETTERS 2024年第1期16卷 1-47页

作者： Park, Jung Hwan Pattipaka, Srinivas Hwang, Geon-Tae Park, Minok Woo, Yu Mi Kim, Young Bin Lee, Han Eol Jeong, Chang Kyu Zhang, Tiandong Min, Yuho Park, Kwi-Il Lee, Keon Jae Ryu, Jungho Kumoh natl inst technol Dept Mech Engn Dept Aeronaut Mech & Elect Convergence Engn 61 Daehak Ro Gumi 39177 Gyeongbuk South Korea Pukyong natl Univ Dept Mat Sci & Engn 45 Yongso Ro Busan 48513 South Korea Lawrence Berkeley natl Lab Energy Technol Area Berkeley CA 94720 USA Korea Adv inst sci & technol KAIST Dept Mat Sci & Engn 291 Daehak Ro Daejeon 34141 South Korea Jeonbuk natl Univ Div Adv Mat Engn Jeonju 54896 Jeonbuk South Korea Harbin Univ sci & technol Sch Elect & Elect Engn Harbin 150080 Peoples R China Harbin Univ sci & technol Key Lab Engn Dielect & Its Applicat Minist Educ Harbin 150080 Peoples R China Kyungpook natl Univ Dept Mat Sci & Met Engn 80 Daehak ro Daegu 41566 South Korea Yeungnam Univ Sch Mat Sci & Engn Gyongsan Si 38541 Gyeongsangbuk D South Korea

This review paper provides a comprehensive analysis of light-material interaction (LMI) parameters, offering insights into their significance in material *** examines a wide array of photothermal and photochemical processes, showcasing their versatility in creating advanced materials for energy conversion and storage *** review presents a multidisciplinary approach to advancing LMI technologies and highlights their potential contribution to the commercialization of future energy conversion and storage systems. This review provides a comprehensive overview of the progress in light-material interactions (LMIs), focusing on lasers and flash lights for energy conversion and storage applications. We discuss intricate LMI parameters such as light sources, interaction time, and fluence to elucidate their importance in material processing. In addition, this study covers various light-induced photothermal and photochemical processes ranging from melting, crystallization, and ablation to doping and synthesis, which are essential for developing energy materials and devices. Finally, we present extensive energy conversion and storage applications demonstrated by LMI technologies, including energy harvesters, sensors, capacitors, and batteries. Despite the several challenges associated with LMIs, such as complex mechanisms, and high-degrees of freedom, we believe that substantial contributions and potential for the commercialization of future energy systems can be achieved by advancing optical technologies through comprehensive academic research and multidisciplinary collaborations.

关键词： Light Light-material interaction Nanomaterials Energy conversion and storage devices SENSITIZED SOLAR-CELLS THIN-FILM TRANSISTORS HIGH-PERFORMANCE INDUCED CRYSTALLIZATION ELECTRICAL-PROPERTIES AMORPHOUS-SILICON LI+ CONDUCTIVITY GRAPHITE OXIDE GRAPHENE OXIDE HIGH-CAPACITY

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microRNA-2184 orchestrates Mauthner-cell axon regeneration in zebrafish via syt3 modulation

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JOURNAL OF GENETICS AND GENOMICS 2024年第9期51卷 911-921页

作者： Chen, Xinghan Shen, Yueru Song, Zheng Wang, Xinliang Yao, Huaitong Cai, Yuan Zhao, Zi-Ang Hu, Bing Univ sci & technol China Hefei Natl Res Ctr Phys Sci Microscale Hefei 230026 Anhui Peoples R China Univ sci & technol China Ctr Adv Interdisciplinary Sci & Biomed IHM Div Life Sci & Med Hefei 230026 Anhui Peoples R China Univ sci & technol China Affiliated Hosp USTC 1 Div Life Sci & Med Hefei 230026 Anhui Peoples R China

MicroRNAs (miRNAs) play a significant role in axon regeneration following spinal cord injury. However, the functions of numerous miRNAs in axon regeneration within the central nervous system (CNS) remain largely unexplored. Here, we elucidate the positive role of microRNA-2184 (miR-2184) in axon regeneration within zebrafish Mauthner cells (M-cells). The upregulation of miR-2184 in a single M-cell can facilitate axon regeneration, while the specific sponge-induced silencing of miR-2184 leads to impeded regeneration. We show that syt3, , a downstream target of miR-2184, negatively regulates axon regeneration, and the regeneration suppression modulated by syt3 depends on its binding to Ca2 & thorn;. 2 & thorn; . Furthermore, pharmacological stimulation of the cAMP/PKA pathway suggests that changes in the readily releasable pool may affect axon regeneration. Our data indicate that miR-2184 promotes axon regeneration of M-cells within the CNS by modulating the downstream target syt3, , providing valuable insights into potential therapeutic strategies. Copyright (c) 2024, institute of Genetics and Developmental Biology, Chinese Academy of sciences, and Genetics Society of China. Published by Elsevier Limited and science Press. All rights reserved.

关键词： Axon regeneration Axon ablation miR-2184 syt3 Readily releasable pool READILY RELEASABLE POOL CA2+ SENSORS SMALL RNAS PHOSPHORYLATION SYNAPSES SPONGES FORM SIZE

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Enhanced performance of solution-processed carbon nanotube transparent electrodes in foldable perovskite solar cells through vertical separation of binders by using eco-friendly parylene substrate

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CARBON ENERGY 2024年第7期6卷 83-93页

作者： Kim, Unsoo Nam, Jeong-Seok Yoon, Jungjin Han, Jiye Choi, Mansoo Jeon, Il Seoul natl Univ Dept Mech Engn Seoul South Korea Seoul natl Univ Global Frontier Ctr Multiscale Energy Syst Seoul South Korea Frontier Energy Solut Seoul South Korea Seoul natl Univ Dept Mech Engn Seoul 08826 South Korea Penn State Univ Dept Mat Sci & Engn University Pk PA USA Sungkyunkwan Univ SKKU SKKU Adv Inst Nanotechnol SAINT Dept Nano Engn Dept Nano Sci & Technol Suwon South Korea Sungkyunkwan Univ SKKU SKKU Adv Inst Nanotechnol SAINT Dept Nano Engn Dept Nano Sci & Technol Suwon 16419 South Korea

The successful utilization of an eco-friendly and biocompatible parylene-C substrate for high-performance solution-processed double-walled carbon nanotube (CNT) electrode-based perovskite solar cells (PSCs) was demonstrated. Through the use of a novel inversion transfer technique, vertical separation of the binders from the CNTs was induced, rendering a stronger p-doping effect and thereby a higher conductivity of the CNTs. The resulting foldable devices exhibited a power conversion efficiency of 18.11%, which is the highest reported among CNT transparent electrode-based PSCs to date, and withstood more than 10,000 folding cycles at a radius of 0.5 mm, demonstrating unprecedented mechanical stability. Furthermore, solar modules were fabricated using entirely laser scribing processes to assess the potential of the solution-processable nanocarbon electrode. Notably, this is the only one to be processed entirely by the laser scribing process and to be biocompatible as well as eco-friendly among the previously reported nonindium tin oxide-based perovskite solar modules. Eco-friendly and biocompatible parylene substrate induced the vertical separation of binders from carbon nanotubes (CNTs) via an inversion technique for solution-processed double-walled CNT electrodes. By applying them to perovskite solar cells, a record power conversion efficiency of 18.11% with a mechanical stability of over 10,000 folding cycles was achieved. The first entirely laser-scribed solar modules were fabricated using the same electrode, showcasing the potential for e-skin applications. image

关键词： double-walled carbon nanotubes parylene substrates perovskite modules perovskite solar cells solution-processable electrodes surfactant removal GRAPHENE EFFICIENCY CATHODE LAYERS FILMS OXIDE

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Photocatalytic degradation of antibiotic sulfamethizole by visible light activated perovskite LaZnO3

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JOURNAL OF ENVIRONMENTAL sciENCES 2024年第10期144卷 212-224页

作者： Huy, Bui The Nguyen, X. Cuong Bui, Vu Khac Hoang Tri, Nguyen Ngoc Rabani, Igra Tran, Nhu Hoa Thi Ly, Quang Viet Truong, Hai Bang Pukyong natl Univ Coll Informat Technol & Convergence Div Smart Healthcare Biomed Engn Busan 48513 South Korea Duy Tan Univ Inst Res & Dev Ctr Adv Chem Da Nang 550000 Vietnam Duy Tan Univ Fac Environm & Chem Engn Da Nang 550000 Vietnam Sejong Univ Dept Environm & Energy Seoul 05006 South Korea Quy Nhon Univ Fac Nat Sci Dept Chem Lab Computat Chem & Modelling Qui Nhon Vietnam Sejong Univ Dept Nanotechnol & Adv Mat Engn Seoul 05006 South Korea Univ sci Fac Mat Sci & Technol Ho Chi Minh City 700000 Vietnam Vietnam natl Univ Ho Chi Minh City 700000 Vietnam Seoul natl Univ sci & technol Dept Environm Engn Seoul 01811 South Korea Van Lang Univ Sci & Technol Adv Inst Opt Mat Res Grp Ho Chi Minh City Vietnam Van Lang Univ Fac Appl Technol Sch Technol Ho Chi Minh City Vietnam

In this work, the perovskite LaZnO3 was synthesized via sol-gel method and applied for photocatalytic treatment of sulfamethizole (SMZ) antibiotics under visible light activation. SMZ was almost completely degraded (99.2% + 0.3%) within 4 hr by photocatalyst LaZnO3 at the optimal dosage of 1.1 g/L, with a mineralization proportion of 58.7% + 0.4%. The efficient performance of LaZnO3 can be attributed to its wide-range light absorption and the appropriate energy band edge levels, which facilitate the formation of active agents such as center dot O2 -, h+ , and center dot OH. The integration of RP-HPLC/Q-TOF-MS and DFT-based computational techniques revealed three degradation pathways of SMZ, which were initiated by the deamination reaction at the anilin ring, the breakdown of the sulfonamide moieties, and a process known as Smile-type rearrangement and SO2 intrusion. Corresponding toxicity of SMZ and the intermediates were analyzed by quantitative structure activity relationship (QSAR), indicating the effectiveness of LaZnO3-based photocatalysis in preventing secondary pollution of the intermediates to the ecosystem during the degradation process. The visible -light -activated photocatalyst LaZnO3 exhibited efficient performance in the occurrence of inorganic anions and maintained high durability across multiple recycling tests, making it a promising candidate for practical antibiotic treatment. (c) 2024 The Research Center for Eco-Environmental sciences, Chinese Academy of sciences. Published by Elsevier B.V.

关键词： Perovskite Antibiotics Photocatalysis Density functional theory Toxicity INORGANIC-IONS SULFAMETHOXAZOLE SUPEROXIDE

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Fluorine-Modulated MXene-Derived Catalysts for Multiphase Sulfur Conversion in Lithium-Sulfur Battery

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NANO-MICRO LETTERS 2024年第1期16卷 1-16页

作者： Gu, Qinhua Cao, Yiqi Chen, Junnan Qi, Yujie Zhai, Zhaofeng Lu, Ming Huang, Nan Zhang, Bingsen Chinese Acad sci Inst Met Res Shenyang Natl Lab Mat Sci Shenyang 110016 Peoples R China Univ sci & technol China Sch Mat Sci & Engn Shenyang 110016 Peoples R China Jilin Normal Univ Joint Lab MXene Mat Key Lab Funct Mat Phys & Chem Key Lab Preparat Applicat Environm Friendly MatMi Changchun 130103 Peoples R China

By introducing fluorine modulation into MXene, a new MXene-derived material TiOF/Ti3C2 was successfully synthesized with a distinctive three-dimensional structure and a tailored F *** situ characterizations and electrochemical analyses demonstrate that TiOF/Ti3C2 catalysts effectively coupled the multiphase sulfur species conversion *** investigations reveal that the theoretical basis of the fluorine catalysis in Li-S batteries originated from Lewis acid-base mechanisms and charge compensation mechanisms. Fluorine owing to its inherently high electronegativity exhibits charge delocalization and ion dissociation capabilities; as a result, there has been an influx of research studies focused on the utilization of fluorides to optimize solid electrolyte interfaces and provide dynamic protection of electrodes to regulate the reaction and function performance of batteries. Nonetheless, the shuttle effect and the sluggish redox reaction kinetics emphasize the potential bottlenecks of lithium-sulfur batteries. Whether fluorine modulation regulate the reaction process of Li-S chemistry? Here, the TiOF/Ti3C2 MXene nanoribbons with a tailored F distribution were constructed via an NH4F fluorinated method. Relying on in situ characterizations and electrochemical analysis, the F activates the catalysis function of Ti metal atoms in the consecutive redox reaction. The positive charge of Ti metal sites is increased due to the formation of O-Ti-F bonds based on the Lewis acid-base mechanism, which contributes to the adsorption of polysulfides, provides more nucleation sites and promotes the cleavage of S-S bonds. This facilitates the deposition of Li2S at lower overpotentials. Additionally, fluorine has the capacity to capture electrons originating from Li2S dissolution due to charge compensation mechanisms. The fluorine modulation strategy holds the promise of guiding the construction of fluorine-based catalysts and facilitating the seamless integration of m

关键词： Catalysis Fluorination MXene Lithium-sulfur battery Shuttle effect PERFORMANCE LI ARCHITECTURES CATHODE

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A deep learning-driven discovery of berberine derivatives as novel antibacterial against multidrug-resistant Helicobacter pylori

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SIGNAL TRANSDUCTION AND TARGETED THERAPY 2024年第1期9卷 1-18页

作者： Guo, Xixi Zhao, Xiaosa Lu, Xi Zhao, Liping Zeng, Qingxuan Chen, Fenbei Zhang, Zhimeng Xu, Mengyi Feng, Shijiao Fan, Tianyun Wei, Wei Zhang, Xin Pang, Jing You, Xuefu Song, Danqing Wang, Yanxiang Jiang, Jiandong Chinese Acad Med sci & Peking Union Med Coll Inst Med Biotechnol Beijing 100050 Peoples R China Hefei Comprehens natl sci Ctr Inst Hlth & Med Hefei 230601 Anhui Peoples R China Northeast Normal Univ Sch Informat Sci & Technol Changchun 130117 Peoples R China Jining Med Univ Affiliated Hosp Dept Pharm Jining 272029 Shandong Peoples R China

Helicobacter pylori (H. pylori) is currently recognized as the primary carcinogenic pathogen associated with gastric tumorigenesis, and its high prevalence and resistance make it difficult to tackle. A graph neural network-based deep learning model, employing different training sets of 13,638 molecules for pre-training and fine-tuning, was aided in predicting and exploring novel molecules against H. pylori. A positively predicted novel berberine derivative 8 with 3,13-disubstituted alkene exhibited a potency against all tested drug-susceptible and resistant H. pylori strains with minimum inhibitory concentrations (MICs) of 0.25-0.5 mu g/mL. Pharmacokinetic studies demonstrated an ideal gastric retention of 8, with the stomach concentration significantly higher than its MIC at 24 h post dose. Oral administration of 8 and omeprazole (OPZ) showed a comparable gastric bacterial reduction (2.2-log reduction) to the triple-therapy, namely OPZ + amoxicillin (AMX) + clarithromycin (CLA) without obvious disturbance on the intestinal flora. A combination of OPZ, AMX, CLA, and 8 could further decrease the bacteria load (2.8-log reduction). More importantly, the mono-therapy of 8 exhibited comparable eradication to both triple-therapy (OPZ + AMX + CLA) and quadruple-therapy (OPZ + AMX + CLA + bismuth citrate) groups. SecA and BamD, playing a major role in outer membrane protein (OMP) transport and assembling, were identified and verified as the direct targets of 8 by employing the chemoproteomics technique. In summary, by targeting the relatively conserved OMPs transport and assembling system, 8 has the potential to be developed as a novel anti-H. pylori candidate, especially for the eradication of drug-resistant strains.

关键词： INFECTION SECA

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