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Platelet count and sustained virological response in hepatitis C treatment

World Journal of Hepatology 2013年第4期5卷 182-188页

作者： Tatsuo Kanda Keizo Kato Akihito Tsubota Nobuo Takada Takayoshi Nishino Shigeru Mikami Tatsuo Miyamura Daisuke Maruoka Shuang Wu Shingo Nakamoto Makoto Arai Keiichi Fujiwara Fumio Imazeki Osamu Yokosuka Department of Gastroenterology and Nephrology Graduate School of MedicineChiba UniversityChiba 260-8677Japan Department of Gastroenterology Narita Red Cross HospitalNarita 286-8523Japan Institute of Clinical Medicine and research Jikei University School of MedicineKashiwa 277-8567Japan Department of Gastroenterology Toho University Sakura Medical CenterSakura 285-8741Japan Department of Gastroenterology Tokyo Women's Medical University Yachiyo Medical CenterYachiyo 276-8524Japan Department of Medicine Kikkoman HospitalNoda 270-0116Japan

AIM:To examine the epidemiological data,hematological safety and treatment responses of peginterferonalpha 2a plus ribavirin therapy for hepatitis ***:Between March 2008 and February 2011,196 hepatitis C virus(HCV)genotype 1 infected Japanese(127 treatment-naive and 69 treatment-experienced patients)patients treated with peginterferonalpha 2a plus ribavirin were *** examined the epidemiological data and treatment responses were retrospectively analyzed in terms of hematological *** RNA was measured by the COBAS TaqMan HCV ***:Overall sustained virological response(SVR)rates of treatment-naive and treatment-experienced patients were 56% and 39%,*** logistic regression analysis showed that SVR was attained independently of early virological response in both treatment-naive and treatment-experienced *** rates did not differ between the pretreatment hemoglobin < 13 g/dL and ≥ 13 g/dL ***,in treatment-naive patients,the SVR rate of the pretreatment platelet count < 130000/μL group was significantly lower than that of the pretreatment platelet count ≥ 130000/μL ***:Attention should be paid to potential thrombocytopenia in the treatment of chronic hepatitis C patients.

关键词： Anemia Antiviral treatment Chronic hepatitis C Platelet count Sustained virological response

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Cell-type specific and non-redundant anti-proliferative effects of shRNA-mediated Galpha12- and Galpha13 knockdown in lung cancer cell lines

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Advances in bioscience and Biotechnology 2014年第1期5卷 73-80页

作者： Thomas R. H. Büch Marius Grzelinski Olaf Pinkenburg Thomas Gudermann Achim Aigner Rudolf-Boehm-Institute for Pharmacology and Toxicology Uni-versity of Leipzig Leipzig Germany Biochemia Pharmacological Institute/bpc Philipps-University Marburg Marburg Germany Rudolf-Boehm-Institute for Pharmacology and Toxicology University of Leipzig Leipzig Germany Biochemia Pharmacological Institute/bpc Philipps-University Marburg Marburg Germany Rudolf-Boehm-Institute for Pharmacology and Toxicology Uni-versity of Leipzig Leipzig Germany Biochemia Pharmacological Institute/bpc Philipps-University Marburg Marburg Germany Present Address: Institute for Immunology Philipps-University Marburg Marburg German Rudolf-Boehm-Institute for Pharmacology and Toxicology Uni-versity of Leipzig Leipzig Germany Biochemia Pharmacological Institute/bpc Philipps-University Marburg Marburg Germany Present Address: Targos Molecular Pathology GmbH Kassel Germany Walther Straub Institute of Pharmacology and Toxicology University of Munich (LMU) Munich Germany Comprehensive Pneumology Center Munich (CPC-M) German Center for Lung Research Munich Germany

In small cell lung cancer cells, various autocrine stimuli lead to the parallel activation of Gq/11 and G12/13 proteins. The contribution of the Gq/11-PLC-β cascade to the mitogenic effects in SCLC cells is well established, but the relevance of G12/13 signaling is less explored. While in prostate and breast cancer, G12/13 activation has been shown previously to promote invasiveness without being involved in cellular proliferation, previous data from our group indicate anti-proliferative effects of G12/13 knockdown in small cell lung cancer (SCLC) cells. To further investigate the role of G12/13-dependent signaling in lung tumor cells, we employed shRNA-mediated targeting of Gα12, Gα13, or both, in SCLC and NSCLC cell lines. Lentiviral expression of shRNAs resulted in specific Gα12 and Gα13 knockdown. Of note, upon single knockdown of one family member, no counter-upregulation of the other one was observed. Interestingly, inhibition of proliferation was cell line dependent. In cell lines where knock-down led to antiproliferation, single knockdown of either Gα12 or Gα13 was sufficient to impair proliferation and double knockdown of Gα12 and Gα13 tended not to further increase anti-proliferative effects. Likewise, when single knockdown was insufficient for an inhibition of proliferation, no effects were observed in double knockdowns. Taken together, these findings indicate that both Gα12 and Gα13 affect cellular proliferation individually and interference with one family member is sufficient for anti-tumor effects.

关键词： KEYWORDS Galpha12 Galpha13 G12/13 Lung Cancer SCLC NSCLC Gene Knockdown

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