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Science China(Life Sciences) 2014年第11期57卷 1072-1079页

作者： HOU Lin MA TianZhou ZHAO HongYu department of Biostatistics Yale School of Public Health VA cooperative studies program coordinating center department of Biostatistics University of Pittsburgh

With recent advances in genotyping and sequencing technologies,many disease susceptibility loci have been ***,much of the genetic heritability remains unexplained and the replication rate between independent studies is still ***,there have been increasing efforts on functional annotations of the entire human genome,such as the Encyclopedia of DNA Elements(ENCODE)project and other similar *** has been shown that incorporating these functional annotations to prioritize genome wide association signals may help identify true association ***,to our knowledge,the extent of the improvement when functional annotation data are considered has not been studied in the *** this article,we propose a statistical framework to estimate the improvement in replication rate with annotation data,and apply it to Crohn’s disease and DNase I hypersensitive *** results show that with cell line specific functional annotations,the expected replication rate is improved,but only at modest level.

关键词： prioritization functional annotation genome wide association studies

从研究设计角度考虑如何避免数据缺失以及由此带来的问题(英文)

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上海精神医学 2012年第3期24卷 181-184页

作者： Julia Y. LIN us department of veterans affairs cooperative studies program coordinating center Palo Alto VA Health Care System

One of the most common challenges in biomedical and psychosocial research is missing data, which occurs when respondents refuse to provide answers to sensitive questions and when study subjects are lost to follow-up during the repeated assessments of longitudinal trials. This paper is the first in a 3-part series focusing on this important topic; it describes different types of missing data and their differential effects on model estimates, focusing on study design strategies that can be used to prevent or minimize missing data and, thus, maintain the scientific integrity of the research. The second paper in the series will discuss implementation strategies

关键词：研究设计 missing longitudinal focusing estimates maintain repeated challenges minimize integrity

精神医学中的生物统计学(10):进行临床试验时对缺失数据的预防和处理(英文)

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上海精神医学 2012年第4期24卷 235-237页

作者： Kousick BISWAS us department of veterans affairs cooperative studies program coordinating center VA Maryland Health Care SystemPerry PointMD USA

1. Introduction This paper is the second in a 3-part series focusing on missing data. In a clinical study missing data can occur for various reasons, with or without any actual loss of study participants because

关键词：临床试验 missing 生物统计学缺失数据精神医学 focusing completion reasons participant items

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建立临床试验的数据监测委员会（英文）

上海精神医学 2014年第1期26卷 54-56页

作者： Julia Y. LIN Ying LU us department of veterans affairs cooperative studies program coordinating center Palo Alto VA Health Care System department of Health Research and Policy Stanford University School of Medicine

数据监测委员会是由研究赞助者指定的一组临床医生和生物统计学家,对临床试验的安全性、科学有效性和完整性进行独立评估。在美国,食品和药物管理局要求在评估所有新的干预时在要成立数据监测委员会。在其他临床研究中,如果存在重大的... 详细信息

数据监测委员会是由研究赞助者指定的一组临床医生和生物统计学家,对临床试验的安全性、科学有效性和完整性进行独立评估。在美国,食品和药物管理局要求在评估所有新的干预时在要成立数据监测委员会。在其他临床研究中,如果存在重大的安全问题、实施双盲治疗分配或者预期对临床实践会产生重大影响,也强烈建议成立数据监测委员会。因为数据监测委员会对经常参加此类研究的弱势群体提供了一层额外的保护,所以他们在精神病学临床研究中是非常重要的。本报告描述了数据监测委员会的作用,组建和运作。

关键词：临床试验数据监测委员会安全问题生物统计学 DMC 临床医生临床实践

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p值之争（英文）

上海精神医学 2015年第6期27卷 381-385页

作者： Lu Y Belitskaya-Levy I VA (veterans affairs) cooperative studies program Palo Alto coordinating center VA Palo Alto Health Care System department of Biomedical Data Science Stanford University

概述:p值是生物医学研究中使用最广泛的统计学概念。最近,学界关于p值的效用以及p值的滥用与已发表的医学研究无法重复性较差之间可能存在的关联性有一些争论。在本文中,我们以通俗易懂的方法介绍p值,并且解释它的随机性和局限性。然而... 详细信息

概述:p值是生物医学研究中使用最广泛的统计学概念。最近,学界关于p值的效用以及p值的滥用与已发表的医学研究无法重复性较差之间可能存在的关联性有一些争论。在本文中,我们以通俗易懂的方法介绍p值,并且解释它的随机性和局限性。然而,目前提出其它能替代p值的概念也有同样的局限。我们得出了如下的结论:对于检验临床试验的中的零假设(null hypothesis)和替代假设(alternative hypothesis)来说,使用p值是一种有效的方法。然而,仅仅利用从某单一统计检验所得出的p值来判断研究项目的科学价值则是一种对p值的滥用;为得到可信的临床研究结果,我们需要将利用P值得到的推断检验的结果与次要结果以及其它数据进行整合。对于在研究中阐释统计结果而言,了解p值的多样性和局限性是至关重要的。

关键词： p值统计推断假设检验统计显著性科学可重复性

veterans health administration hepatitis B testing and treatment with anti-CD20 antibody administration

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World Journal of Gastroenterology 2016年第19期22卷 4732-4740页

作者： Christine M Hunt Lauren A Beste Elliott Lowy Ayako Suzuki Cynthia A Moylan Hans L Tillmann George N Ioannou Joseph K Lim Michael J Kelley Dawn Provenzale department of Medicine Duke University School of Medicine Durham NC 27710 United States department of Medicine Durham VA Medical Center Durham NC 27705 United States department of Medicine Veterans Affairs Puget Sound Health Care System Seattle WA 98108 United States Health Services Research and Development Veterans Affairs Puget Sound Health Care System Seattle WA 98108 United States department of Medicine University of Washington Seattle WA 98195 United States University of Washington School of Public Health Seattle WA 98195 United States department of Medicine University of Arkansas for Medical Sciences Little Rock AR 72205 United States Division of Hepatology Central Arkansas Veterans Heathcare System Little Rock AR 72205 United States department of Medicine Eastern Carolina University Greenville NC 27858 United States Yale Liver center Section of Digestive Diseases Yale University School of Medicine New Haven CT 06520 United States Office of Patient Care Services Department of Veterans Affairs Washington DC 20420 United States Hematology-Oncology Service Durham Veterans Affairs Medical Center Durham NC 27705 United States cooperative studies program Epidemiology center-Durham Durham Veterans Affairs Medical Center Durham NC 27705 United States center for Health Services Research in Primary Care Durham Veterans Affairs Medical Center Durham NC 27710 United States

AIM: To evaluate pretreatment hepatitis B virus (HBV) testing, vaccination, and antiviral treatment rates in veterans affairs patients receiving anti-CD20 Ab for quality ***: We performed a retrospective cohort study using a national repository of veterans Health Administration (VHA) electronic health record data. We identified all patients receiving anti-CD20 Ab treatment (2002-2014). We ascertained patient demographics, laboratory results, HBV vaccination status (from vaccination records), pharmacy data, and vital status. The high risk period for HBV reactivation is during anti-CD20 Ab treatment and 12 mo follow up. Therefore, we analyzed those who were followed to death or for at least 12 mo after completing anti-CD20 Ab. Pretreatment serologic tests were used to categorize chronic HBV (hepatitis B surface antigen positive or HBsAg+), past HBV (HBsAg-, hepatitis B core antibody positive or HBcAb+), resolved HBV (HBsAg-, HBcAb+, hepatitis B surface antibody positive or HBsAb+), likely prior vaccination (isolated HBsAb+), HBV negative (HBsAg-, HBcAb-), or unknown. Acute hepatitis B was defined by the appearance of HBsAg+ in the high risk period in patients who were pretreatment HBV negative. We assessed HBV antiviral treatment and the incidence of hepatitis, liver failure, and death during the high risk period. Cumulative hepatitis, liver failure, and death after anti-CD20 Ab initiation were compared by HBV disease categories and differences compared using the χ2 test. Mean time to hepatitis peak alanine aminotransferase, liver failure, and death relative to anti-CD20 Ab administration and follow-up were also compared by HBV disease ***: Among 19304 VHA patients who received anti-CD20 Ab, 10224 (53%) had pretreatment HBsAg testing during the study period, with 49% and 43% tested for HBsAg and HBcAb, respectively within 6 mo pretreatment in 2014. Of those tested, 2% (167/10224) had chronic HBV, 4% (326/7903) past HBV, 5%

关键词： Hepatitis B Hepatitis B reactivation Anti-CD20 antibody Rituximab Lymphoma Chemotherapy Hepatitis B antivirals Vaccination Veteran

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用于分类与预测的决策树分析（英文）

上海精神医学 2015年第2期27卷 130-135页

作者： Yan-yan SONG Ying LU department of Pharmacology and Biostatistics Institute of Medical Sciences Shanghai Jiao Tong University School of Medicine Division of Biostatistics Department of Health Research and Policy Stanford University veterans affairs cooperative studies program Palo Alto coordinating center the VA Palo Alto Health Care System

决策树是一种常用的数据挖掘方法,用于多变量分析时建立分类系统或制定预测结果变量的算法。此方法将一个数据群分割成分枝状节段,构造出包括根节点、内部节点和叶节点的倒置形树状模型。该算法运用非参数方法,不需要套用任何复杂的参... 详细信息

决策树是一种常用的数据挖掘方法,用于多变量分析时建立分类系统或制定预测结果变量的算法。此方法将一个数据群分割成分枝状节段,构造出包括根节点、内部节点和叶节点的倒置形树状模型。该算法运用非参数方法,不需要套用任何复杂的参数模型就能有效地处理大型复杂的数据库。当样本足够大时,可将研究数据分为训练数据集和验证数据集。使用训练数据集构建决策树模型,使用验证数据集来决定树的适合大小,以获得最优模型。本文介绍了构建决策树的常用算法(包括CART,C4.5,CHAID和QUEST),并描述了SPSS和SAS软件中将树结构可视化的程序。

关键词：决策树方法预测算法分类系统决策树模型应用 QUEST SAS程序数据集

Estimating treatment effects in observational studies

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上海精神医学 2011年第6期23卷 380-382页

作者： Julia Y. LIN Ying LU us department of veterans affairs cooperative studies program coordinating center Palo Alto VA Health Care System Palo Alto CA USA department of Health Research and Policy Stanford University Palo Alto CA USA

In randomized treatment studies the randomization of subjects to the different treatment conditions ensures that the treatment groups are comparable in their baseline characteristics-measured or unmeasured-so we can c... 详细信息

关键词：精神医学精神病学临床诊断

精神医学中的生物统计学(16) 把握度分析在横断面研究和纵向研究设计中的应用(英文)

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上海精神医学 2013年第4期25卷 259-262页

作者： Naiji LU Yu HAN Tian CHEN Douglas David GUNZLER Yinglin XIA Julia LIN Xin Ming TU department of Biostatistics University of Rochester Medical CenterRochesterNYUSA veterans Integrated Service Network 2 center of Excellence for Suicide Prevention Canandaigua VA Medical CenterCanandaiguaNYUSA department of Biostatistics University of Rochester Medical CenterRochester NYUSA School of Medicine Case Western Reserve UniversityCenter for Health Care Research&Policy MetroHealth Medical Center ClevelandOHUSA us department of veterans affairs cooperative studies program coordinating center Palo Alto VA Health Care SystemPalo AltoCAUSA department of Biostatistics University of Rochester Medical Center RochesterNYUSA department of Psychiatry University of Rochester Medical CenterRochesterNYUSA

*** Power and sample size estimation constitutes an important component of designing and planning modern scientific *** provides information for assessing the feasibility of a study to detect treatment effects and for estimating the resources needed to conduct the *** tutorial discusses the basic concepts of power analysis and the major differences between hypothesis testing and power *** also

关键词：功率分析横断面设计组成部分现代科学治疗效果假设检验功耗分析

血管紧张素受体阻断剂预防男性人群痴呆发生风险研究：前瞻性队列分析（摘要）

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英国医学杂志中文版 2010年第2期13卷 108-109页

作者： Nien-Chen Li Austin Lee Rachel A Whitmer Miia Kivipelto Elizabeth Lawler Lewis E Kazis Benjamin Wolozin 夏曙(译) 于世英(校) center for the Assessment of Pharmaceutical Practices and Pharmaceutical Assessment Management and Policy Program Department of Health Policy and Management Boston University School of Public Health Boston MA USA center for Health Quality Outcomes and Economic Research Veteran Affairs Medical Center Bedford MA department of Surgery Massachusetts General Hospital Boston MA Division of Research Epidemiology Etiology and Prevention Kaiser Permanente Oakland CA USA Aging Research center Karolinska Institute Stockholm Sweden MAVERIC VA Cooperative Studies Program Boston MA department of Pharmacology and department of Neurology Boston University School of Medicine Boston MA 02118-2526 USA 华中科技大学同济医院肿瘤科

目的探讨血管紧张素受体拮抗剂能否预防阿尔茨海默病和老年痴呆症，或同时减少两种疾病的进展。设计前瞻性队列分析。资料来源2002—2006年美国退伍军人数据库。

关键词：血管紧张素受体阻断剂老年痴呆症队列分析发生风险男性人群预防血管紧张素受体拮抗剂摘要