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Imaging mass spectrometry:a molecular microscope for studying the role of lipids in Parkinson's disease

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Neural Regeneration Research 2024年第6期19卷 1179-1180页

作者： Vinata Vedam-Mai Jacob M.samuel Boone M.Prentice Department of Neurology University of FloridaGainesvilleFLUSA Department of Chemistry University of FloridaGainesvilleFLUSA

Parkinson's disease–A lipidopathy?The histopathological hallmark of Parkinson's disease(PD)and dementia with Lewy bodies are inclusions enriched inα-synuclein(α-syn),known as Lewy bodies,which are not only composed of proteins,but also a core of lipid *** has been thus far principally thought of as a“proteinopathy”caused by the misfolding of α-syn.

关键词： lipids species folding

A rat model of multicompartmental traumatic injury and hemorrhagic shock induces bone marrow dysfunction and profound anemia

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Animal Models and Experimental Medicine 2024年第3期7卷 367-376页

作者： Lauren s.Kelly Jennifer A.Munley Erick E.Pons Kolenkode B.Kannan Elizabeth M.Whitley Letitia E.Bible Philip A.Efron Alicia M.Mohr Department of surgery and sepsis and Critical Illness Research Center University of Florida College of MedicineGainesvilleFloridaUSA Pathogenesis LLCGainesvilleFloridaUSA

Background:severe trauma is associated with systemic inflammation and organ *** rodent trauma models are the mainstay of postinjury research but have been criticized for not fully replicating severe human *** aim of this study was to create a rat model of multicompartmental injury which recreates profound traumatic ***:Male sprague-Dawley rats were subjected to unilateral lung contusion and hemorrhagic shock(LCHs),multicompartmental polytrauma(PT)(unilateral lung contusion,hemorrhagic shock,cecectomy,bifemoral pseudofracture),or na?ve ***,plasma toll-l ike receptor 4(TLR4),hemoglobin,spleen to body weight ratio,bone marrow(BM)erythroid progenitor(CFU-GEMM,BFU-E,and CFU-E)growth,plasma granulocyte colony-stimulating factor(G-CsF)and right lung histologic injury were assessed on day 7,with significance defined as p valuessults:Polytrauma resulted in markedly more profound inhibition of weight gain compared to LCHs(p=0.0002)along with elevated plasma TLR4(pspleen to body weight ratios(p=0.004).Both LCHs and PT demonstrated suppression of CFU-E and BFU-E growth compared to naive(psma G-CsF was elevated in PT compared to both na?ve and LCHs(ps and PT demonstrated significant histologic right lung injury with poor alveolar wall integrity and interstitial ***:Multicompartmental injury as described here establishes a reproducible model of multicompartmental injury with worsened anemia,splenic tissue enlargement,weight loss,and increased inflammatory activity compared to a less severe *** may serve as a more effective model to recreate profound traumatic injury to replicate the human inflammatory response postinjury.

关键词： anemia i nflammation polytrauma pseudofracture shock

Reduction of epinephrine in the lumbar spinal cord following repetitive blast-induced traumatic brain injury in rats

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Neural Regeneration Research 2024年第7期19卷 1548-1552页

作者： shigeharu Tsuda Mustafa Golam Jiamei Hou Kevin K.W.Wang Floyd J.Thompson Prodip Bose Brain Rehabilitation Research Center Malcom Randall VA Medical CenterNorth Florida/South Georgia Veterans Health SystemGainesvilleFLUSA Department of Anesthesiology College of MedicineUniversity of FloridaGainesvilleFLUSA Department of Emergency Medicine University of FloridaGainesvilleFLUSA Department of Neuroscience University of FloridaGainesvilleFLUSA Department of Neurology University of FloridaGainesvilleFLUSA

Traumatic brain inju ry-induced unfavorable outcomes in human patients have independently been associated with dysregulated levels of monoamines,especially epinephrine,although few preclinical studies have examined the epinephrine level in the central nervous system after traumatic brain *** has been shown to regulate the activities of spinal motoneurons as well as increase the heart rate,blood pressure,and blood flow to the hindlimb ***,the purpose of the present study was to determine the impact of repeated blast-induced traumatic brain injury on the epinephrine levels in seve ral function-s pecific central nervous system regions in *** three repeated blast injuries at 3-day intervals,the hippocampus,motor cortex,locus coeruleus,vestibular nuclei,and lumbar spinal cord were harvested at post-injury day eight and processed for epinephrine assays using a high-sensitive electrochemical detector cou pled with high-performance liquid *** results showed that the epinephrine levels were significantly decreased in the lumbar spinal cord tissues of blast-induced traumatic brain injury animals compared to the levels detected in age-and sex-matched sham *** other function-specific central nervous system regions,although the epinephrine levels were slightly altered following blast-induced tra u matic brain injury,they were not statistically *** results suggest that blast injury-induced significant downregulation of epinephrine in the lumbar spinal cord could negatively impact the motor and cardiovascular *** is the first repo rt to show altered epinephrine levels in the spinal cord following repetitive mild blast-induced traumatic brain injury.

关键词： balance blood flow cardiovascular system central nervous system epinephrine ischemic damage lumbar spinal cord muscle tone repeated blast spasticity traumatic brain injury

synthesis and characterization of ultra-soft alginate hydrogel mimicking lung tissue

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International Journal of smart and Nano Materials 2024年第3期15卷 593-609页

作者： Xiangpeng Li Jihua Gou Chiranjit Maiti Olusegun J.Ilegbusi Department of Mechanical and Aerospace Engineering University of Central FloridaOrlandoFLUSA

Alginate hydrogels possess properties analogous to those of the extracellular matrix(ECM).Thus,their mechanical behavior approx-imates soft tissue,which makes them desirable for the production of tissue-equivalent soft deformable *** study aims to determine the synthesis-structure-property relationship for alginate hydrogel with the Young’s modulus in the range of 10°~101 kPa,mimicking to that of human lung ***,a 3D polymer network embedded in a water-rich *** alginate hydrogels are synthesized by a direct mixture of sodium alginate and CaCO3,followed by the addition of D-glucono-δ-lactone(GDL)to initiate in-situ Ca^(2+)release and *** influence of alginate concentration and molar ratio of the constitu-ent calcium ion to carboxyl group from alginate monomer are evaluated while the Young’s modulus of the hydrogel is carefully controlled within the desired *** and sEM are used to characterize the influence of synthesis parameters at the molecular and microstructure *** and compression testing are performed to determine the Young’s modulus of the *** relations are established between synthesis parameters and the mechanical *** result of the study will be subse-quently used to guide the additive manufacturing of soft deform-able structures based on alginate hydrogels.

关键词： Alginate hydrogels Ultra-low modulus lung tissue-mimicking materials

Analysis and Optimization of Boost Converter Parameters in Internal Model Control for Voltage source Converter-based AC Microgrids

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CsEE Journal of Power and Energy systems 2024年第5期10卷 2038-2054页

作者： Chiebuka Eyisi Qifeng Li Department of Electrical and Computer Engineering University of Central FloridaOrlandoFL 32816 USA.

This paper investigates integration of distributed energy resources(DERs)in microgrids(MGs)through two-stage power conversion structures consisting of DC-DC boost converter and DC-AC voltage source converter(VsC)*** contrast to existing investigations that treated DC-link voltage as an ideal constant voltage,this paper considers the non-ideal dynamic coupling between both subsystems for completeness and higher accuracy,which introduces additional DC-side dynamics to the *** analysis shows parameters of the boost converter’s power model that impact stability through the *** selecting these parameters can mitigate this effect on stability and improve dynamic performance across the ***,an optimization framework is developed to facilitate in selecting adequate boost converter parameters in designing a stable voltage source converter-based microgrid(VsC-MG).The developed optimization framework,based on particle swarm optimization,considers dynamic coupling between both subsystems and is also effective in avoiding inadequate boost converter parameters capable of propagating instability through the DC-link to the *** are performed with MATLAB/simulink to validate theoretical analyses.

关键词： AC microgrid boost converter dead-time droop control internal model control particle swarm optimization small-signal analysis time delay virtual impedance voltage source converter

Photoacoustic/ultrasound dual-modal imaging of human nails: A pilot study

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Journal of Innovative Optical Health sciences 2024年第6期17卷 15-28页

作者： Yanting Wen Yijie Huang Lin Huang Dan Wu Renbin Zhong shixie Jiang Yudi Zhang Ting Liu Xiaotian Liu Huabei Jiang Department of Ultrasound Chengdu Fifth People's Hospital Chengdu 611137P.R.China school of Computer science and Technology Chongqing university of Posts and Telecommunications Chongqing 400065 P.R.China school of Electronic science and Engineering university of Electronic science and Technology Chengdu 611731 P.R.China Department of Psychiatry university of florida College of Medicine GainesvilleFL 32610USA Department of Medical Engineering university of south florida Tampa 33620USA

Traditional diagnostic techniques including visual examination,ultrasound(Us),and magnetic resonance imaging(MRI)have limitations of in-depth information for the detection of nail disorders,resolution,and *** pilot study,for thefirst time,evaluates a dualmodality imaging system that combines photoacoustic tomography(PAT)with the Us for the multiparametric quantitative assessment of human *** study involved a small cohort offive healthy volunteers who underwent PAT/Us imaging for acquiring the nail unit *** PAT/Us dual-modality imaging successfully revealed thefine anatomical structures and microvascular distribution within the nail and nail ***,this system utilized multispectral PAT to analyze functional tissue parameters,including oxygenated hemoglobin,deoxyhemoglobin,oxygen saturation,and collagen under tourniquet and cold stimulus tests to evaluate changes in the microcirculation of the nail *** quantitative analysis of multispectral PAT reconstructed images demonstrated heightened sensitivity in detecting alterations in blood oxygenation levels and collagen content within the nail bed,under simulated different physiological *** pilot study highlights the potential of PAT/Us dual-modality imaging as a real-time,noninvasive diagnostic modality for evaluating human nail health and for early detection of nail bed pathologies.

关键词： Nail photoacoustic tomography ultrasound multi-modality quantitative parameter

Going straight for the gut:gut-brain axis pathology and treatment of Parkinson's disease

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Neural Regeneration Research 2024年第10期19卷 2111-2112页

作者： Dominique Ebedes Cesar V.Borlongan university of south florida Morsani College of Medicine TampaFLUSA Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of MedicineTampaFLUSA

This perspective focuses on the recent literature regarding the role of the gut-brain axis(GBA) in fecal microbiota transplantation(FMT) and stem cell therapy(sCT) in Parkinson's disease(PD).PD is the second most common neurodegenerative disease in the United states,yet therapies remain *** research suggests that the GBA may play a role in the pathogenesis of *** FMT as well as sCT offer promising new avenues for PD *** bing the interactions between FMT and sCT with the GBA may reveal novel therapeutics for PD.

关键词： straight pathology pathogenesis

Mucopolysaccharidosis typeⅢB:a current review and exploration of the AAV therapy landscape

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Neural Regeneration Research 2024年第2期19卷 355-359页

作者： Courtney J.Rouse Victoria N.Jensen Coy D.Heldermon Lacerta Therapeutics AlachuaFLUSA university of florida College of Medicine GainesvilleFLUSA

Mucopolysaccharidoses typeⅢB is a rare genetic disorder caused by mutations in the gene that encodes for *** results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological *** treatment options are expensive,limited,and presently there are no approved cures for mucopolysaccharidoses typeⅢ***-associated virus gene therapy has significantly advanced the field forward,allowing researchers to successfully design,enhance,and improve potential *** group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores N-acetyl-alpha-glucosaminidase levels,auditory function,and lifespan in the murine model for mucopolysaccharidoses typeⅢB to that seen in healthy ***,we review the current state of the field in relation to the capsid landscape,adeno-associated virus gene therapy and its successes and challenges in the clinic,and how novel adenoassociated virus capsid designs have evolved research in the mucopolysaccharidoses typeⅢB field.

关键词： adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIB N-acetyl-alpha-glucosaminidase newborn screening

Airway management of a patient with linear immunoglobulin A bullous dermatosis:A case report

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World Journal of Clinical Cases 2024年第13期12卷 2263-2268页

作者： Olga C Nin Robert Hutnik Neil N Chheda David Hutchinson Department of Anesthesiology University of Florida College of MedicineGainesvilleFL 32610United States Department of Otolaryngology University of Florida College of MedicineGainesvilleFL 32610United States

BACKGROUND There is limited literature on managing the airway of patients with linear immunoglobulin A(IgA)bullous dermatosis,a rare mucocutaneous disorder that leads to the development of friable *** clinical decision making is necessary when there is a risk of bleeding into the airway,and a multidisciplinary team approach may lead to decreased patient morbidity during these high-risk scenarios,especially when confronted with an unusual cause for *** sUMMARY A 45-year-old African American female presented to our ambulatory surgical center for right corneal transplantation due to corneal perforation after blunt trauma in the setting of cicatricial conjunctivitis and diffuse corneal neovascularization from linear IgA bullous *** diagnosis of IgA dermatosis was recent,and the patient had been lost to *** severity of the disease and extent of airway involvement was unknown at the time of the *** airway bleeding was noticed upon intubation and the otorhinolaryngology team had to be called to the operating *** patient required transfer to the intensive care unit where a multidisciplinary team was involved in her *** patient was extubated on postoperative day *** A multidisciplinary approach to treating this disease is the best course of action before a surgical *** our case,key communication between the surgery,anesthesia,and dermatology teams led to the quick and safe treatment of our patient’s *** surgery should not be considered for these cases unless they are in full remission and there is no mucous membrane involvement.

关键词： Airway management Bleeding risk Linear immunoglobulin A bullous dermatosis Multidisciplinary approach Outpatient procedure Case report