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Artemisia vulgaris Induces Tumor-Selective Ferroptosis and Necroptosis via Lysosomal Ca^(2+) Signaling

Chinese Journal of Integrative Medicine 2024年第6期30卷 525-533页

作者： Lucas dos Santos Zamarioli Michele Rosana Maia Santos Adolfo Garcia Erustes Vanessa Marques Meccatti Thais Cristine Pereira Soraya S Smaili Maria Cristina Marcucci Carlos Rocha Oliveira Gustavo JS Pereira Claudia Bincoletto Department of Pharmacology Paulista School of MedicineFederal University of São PauloSão PauloSP04044-020Brazil Research Group on Phytocomplexes and Cell Signaling School of Health SciencesAnhembi Morumbi UniversitySão PauloSP03164-000Brazil Department of Biosciences and Oral Diagnosis Institute of Science and TechnologySão Paulo State University(ICT-UNESP)São PauloSP12231-280Brazil

Objective To evaluate the chemical composition and effects of Artemisia vulgaris(AV)hydroalcoholic extract(HEAV)on breast cancer cells(MCF-7 and SKBR-3),chronic myeloid leukemia(K562)and NIH/3T3 *** Phytochemical analysis of HEAV was done by high-performance liquid chromatography-mass(HPLC)*** and cell death studies were performed using trypan blue and Annexin/FITC-7AAD,***-1(Fer-1)and necrostatin-1(Nec-1)were used to assess the mode of HEAV-induced cell death and acetoxymethylester(BAPTA-AM)was used to verify the involvement of cytosolic calcium in this *** calcium measurements were made using *** HEAV decreased the viability of MCF-7,SKBR-3 and K562 cells(P<0.05).The viability of HEAV-treated K562 cells was reduced compared to HEAV-exposed fibroblasts(P<0.05).Treatment of K562 cells with HEAV induced cell death primarily by late apoptosis and necrosis in assays using annexin V-FITC/7-AAD(P<0.05).The use of Nec-1 and Fer-1 increased the viability of K562 cells treated with HEAV relative to cells exposed to HEAV alone(P<0.01).HEAV-induced Ca^(2+)release mainly from lysosomes in K562 cells(P<0.01).Furthermore,BAPTA-AM,an intracellular Ca^(2+)chelator,decreased the number of non-viable cells treated with HEAV(P<0.05).Conclusions HEAV is cytotoxic and activates several modalities of cell death,which are partially dependent on lysosomal release of Ca^(2+).These effects may be related to artemisinin and caffeoylquinic acids,the main compounds identified in HEAV.

关键词： Artemisia vulgaris necroptosis ferroptosis late apoptosis Ca^(2+)signaling

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Z-Score in Fetal Echocardiography–Is there Still Room for New Studies?

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Congenital Heart Disease 2024年第3期19卷 305-314页

作者： Marcio Fragoso Vieira Nathalie Jeanne Bravo-Valenzuela Edward Araujo Júnior Department of Obstetrics Paulista School of MedicineFederal University of São Paulo(EPM-UNIFESP)São Paulo-SP04023-062Brazil Department of Obstetrics Federal University of Ceará(UFC)Sobral-CE60020-181Brazil Department of Pediatrics Pediatric CardiologySchool of MedicineFederal University of Rio de Janeiro(UFRJ)Rio de Janeiro-RJ21941-853Brazil

Congenital heart disease(CHD)is the most common type of birth defect,representing a significant cause of peri-natal morbidity and *** diagnosis of such anomalies is crucial for improving *** pro-tocols recommend a qualitative assessment of cardiac structures using two-dimensional ultrasound(2DUS)and color Doppler *** cases of suspected abnormalities,quantitative assessments through cardiac structure measurements and reference curves can aid in accurate *** to centiles widely employed in obste-trics,Z-scores provide more precise quantification of various cardiac structures,particularly at the extremes of the *** the development of reference curves and Z-scores has progressed over the past two decades,a lack of standardization in measurements and statistical methodology for their determination is *** reference curves requires adherence to specific recommendations to improve their *** purpose of this study is to provide a narrative review of the major studies that have generated reference values for cardiac struc-tures using 2DUS and Z-scores,to evaluate their methodology,and to provide a summary of the results.

关键词： Z-scores reference ranges fetal echocardiography

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Unravelling COVID-19 waves in Rio de Janeiro city:Qualitative insights from nonlinear dynamic analysis

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Infectious Disease Modelling 2024年第2期9卷 314-328页

作者： Adriane S.Reis Laurita dos Santos Américo Cunha Jr Thaís C.R.O.Konstantyner Elbert E.N.Macao Institute of Science and Technology Federal University of São PauloSão Josédos CamposSPBrazil Physics Institute University of São PauloSão PauloSPBrazil Scientific and Technological Institute Universidade BrasilSão PauloSPBrazil Department of Applied Mathematics Rio de Janeiro State UniversityRio de JaneiroRJBrazil paulista School of Medicine Federal University of São PauloSão PauloSPBrazil

Since the COVID-19 pandemic was first reported in 2019,it has rapidly spread around the *** countries implemented several measures to try to control the virus *** healthcare system and consequently the general quality of life population in the cities have all been significantly impacted by the Coronavirus *** different waves of contagious were responsible for the increase in the number of cases that,unfortunately,many times lead to *** this paper,we aim to characterize the dynamics of the six waves of cases and deaths caused by COVID-19 in Rio de Janeiro city using techniques such as the Poincaréplot,approximate entropy,second-order difference plot,and central tendency *** results reveal that by examining the structure and patterns of the time series,using a set of non-linear techniques we can gain a better understanding of the role of multiple waves of COVID-19,also,we can identify underlying dynamics of disease spreading and extract meaningful information about the dynamical behavior of epidemiological time *** findings can help to closely approximate the dynamics of virus spread and obtain a correlation between the different stages of the disease,allowing us to identify and categorize the stages due to different virus variants that are reflected in the time series.

关键词： COVID-19 Nonlinear analysis Poincaréplot Central tendency measure

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Hematological reference values and animal welfare parameters of BALB/C-FMABC (Mus musculus) inoculated with Ehrlich tumor kept in the vivarium at ABC Medical School

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Animal Models and Experimental Medicine 2020年第1期3卷 32-39页

作者： Patrick Gabriel dos Santos Pessini Paula Regina Knox de Souza Camila dos Santos Chagas Emily Garcia Sampaio Daniel Santos Neves Giuliana Petri Fernando Luiz Affonso Fonseca Emerson Barbosa da Silva Clinical Analysis Laboratory of the ABC university Health Center Santo AndreBrazil Health Sciences Institute/paulista university–unip Sao PauloBrazil

Background:Biochemical and hematological parameters are important tools for assessing the physiological profile of vital organs,and can be recorded to create reference values used for clinical diagnosis of *** research laboratories lack the means to establish their own set of reference parameters for use in their research,and while there are articles in the literature that discuss laboratory parameters for healthy BALB/c mice,few studies address the evaluation of these parameters in pathological situations,such as in mice inoculated with Ehrlich ***:BALB/c-FMABC mice previously inoculated with Ehrlich tumor were maintained under appropriate *** samples were taken for analysis of hematological parameters using automated and semi-automated equipment to create a set of the animal welfare parameters for ***:Results were obtained for all the hematological parameters for all groups *** showed:statistically significant differences between the initial and final tumor weight;comparable initial tumour volume and weight;an increase in leukocytes in the 7-day group with a characteristic predominance of lymphocytes and neutrophils;statistically significant changes in RDW in the 21-day group and in the welfare parameters in the 28-day ***:The study successfully defined and established reference values for hematological and welfare parameters for all groups analyzed.

关键词： ehrlich tumor carcinoma experimental animal model reference value welfare

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Epidemic threshold influenced by non-pharmaceutical interventions in residential university environments

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Chinese Physics B 2024年第2期33卷 551-556页

作者：卢泽超赵生妹束华中巩龙延 Institute of Signal Processing and Transmission Nanjing University of Posts and TelecommunicationsNanjing 210003China College of Science Nanjing University of Posts and TelecommunicationsNanjing 210003China

The control of highly contagious disease spreading in campuses is a critical *** residential universities,students attend classes according to a curriculum schedule,and mainly pack into classrooms,dining halls and *** move from one place to *** simulate such environments,we propose an agent-based susceptible–infected–recovered model with time-varying heterogeneous contact *** close environments,maintaining physical distancing is the most widely recommended and encouraged non-pharmaceutical *** can be easily realized by using larger classrooms,adopting staggered dining hours,decreasing the number of students per dorm and so *** real-world influence remains *** numerical simulations,we obtain epidemic *** effect of such countermeasures on reducing the number of disease cases is also quantitatively evaluated.

关键词： epidemic threshold susceptible-infected-recovered model non-pharmaceutical interventions time-varying heterogeneous contact networks

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A Novel Disturbance Observer Based Fixed-Time Sliding Mode Control for Robotic Manipulators With Global Fast Convergence

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IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 661-672页

作者： Dan Zhang Jiabin Hu Jun Cheng Zheng-Guang Wu Huaicheng Yan IEEE Zhejiang university of Technology Guangxi Normal university Zhejiang university the East China university of Science and Technology

This paper proposes a new global fixed-time sliding mode control strategy for the trajectory tracking control of uncertain robotic ***,a fixed-time disturbance observer(FTDO) is designed to deal with the adverse effects of model uncertainties and external disturbances in the manipulator *** an adaptive scheme is used and the adaptive FTDO(AFTDO) is developed,so that the priori knowledge of the lumped disturbance is not ***,a new non-singular fast terminal sliding mode(NFTSM) surface is designed by using an arctan function,which helps to overcome the singularity problem and enhance the robustness of the *** on the estimation of the lumped disturbance by the AFTDO,a fixed-time non-singular fast terminal sliding mode controller(FTNFTSMC)is developed to guarantee the trajectory tracking errors converge to zero within a fixed *** settling time is independent of the initial state of the *** addition,the stability of the AFTDO and FTNFTSMC is strictly proved by using Lyapunov ***,the fixed-time NFESM(FTNFTSM) algorithm is validated on a 2-link manipulator and comparisons with other existing sliding mode controllers(SMCs) are *** comparative results confirm that the FTNFTSMC has superior control performance.

关键词： Disturbance observer(DO) fixed-time non-singular sliding mode control robotic manipulator trajectory tracking

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Investigation on occupant presence and appliance operation schedules for university campus in south China sub-tropical area

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Building Simulation 2024年第2期17卷 301-318页

作者： Siwei Lou Zhongyuan Lin Yukai Zou Dawei Xia Yu Huang Zhuohong Li Zhaowen Gu School of Civil Engineering Guangzhou UniversityGuangzhou Higher Edu.Mega CenterGuangzhouChina School of Architecture and Urban Planning Guangzhou UniversityGuangzhou Higher Edu.Mega CenterGuangzhouChina

Building occupant presence during varying periods is crucial to the performance studies of buildings and city ***,the understanding of the building occupancies on the university campus remains *** address this gap,our study employs field measurements,payment records,course arrangements,and building access systems to depict the occupancy patterns of the canteen,dormitory,library,and teaching and lab buildings during weekdays and *** found that the occupancy rates across different buildings are somehow interrelated,given that the total number of occupants on campus is generally ***,dormitory occupancy rates tend to be low during the morning and afternoon course hours,which inversely correlates with the high occupancy rates in the teaching and lab buildings during these ***,canteens experience surges in occupancy during meal times,which coincide with a decrease in library ***,we established appliance operation schedules for dormitories through surveys and on-site *** dispensers and electronic devices were identified as the primary energy consumers for both male and female occupants,with desk-top fans and hairdryers being significant energy users for male and female occupants,*** findings are essential for energy studies within a campus setting,underlining the importance of considering occupant behaviors on a regional scale.

关键词： building occupant behavior university campus occupancy schedule appliance operation schedule

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A novel cylindrical sandwich plate inspired by beetle elytra and its compressive properties

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Science China Technological Sciences 2024年第11期67卷 3465-3476页

作者： SONG YiHeng RUAN SiHan HAO Ning OKABE YoJi School of Engineering The University of Tokyo School of Civil Engineering Southeast University School of Engineering RMIT University Institute of Industrial Science The University of Tokyo

The design and experimental analysis of a semi-cylindrical structure known as the cylindrical beetle elytron plate(CBEP) were presented. Radial compression tests and finite element simulation were performed on CBEPs under 30° and 45° inclined sliding support constraints, with a comparison made to cylindrical honeycomb plate(CHP). The study aims to investigate the superior compression performance and enhancement mechanisms of CBEPs. The results demonstrate that CBEPs exhibit a 14%–26% increase in specific load-bearing capacity and a 20% increase in specific energy absorption compared with CHPs with equal core wall thickness. Distinct “Z-shaped” tearing failures were observed, with honeycomb plates showing tearing at the center of the honeycomb walls, while beetle elytron plates exhibited tearing along the midline of the trabeculae. Three different stress patterns,including elastic-plastic development stage of arch, plastic hinge node stage, and rigid node stage, were identified and analyzed to explain the mechanical performance improvements and failure characteristics. Considering that structural damage to trabeculae mostly occurs at its junction with the skin, it is recommended to add chamfers to the junctions of CBEP. Therefore, this paper lays the groundwork for the engineering application of CBEP.

关键词： beetle elytron cylindrical beetle elytron plate compression performance failure characteristics enhancement mechanism

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Synthetic brochosomes:Design,synthesis,and applications

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Nano Research 2024年第2期17卷 734-742页

作者： Lin Wang Jinsol Choi Tak-Sing Wong Department of Mechanical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA Materials Research Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA 16802USA

Brochosomes,which are nanoscopic buckyball-shaped granules produced by leafhoppers,are one of the most intricate structures discovered in *** functions of brochosomes have been proposed but only a few have been experimentally validated due to the challenge of fabricating their synthetic *** in micro-and nanofabrication have recently led to the emergence of synthetic brochosomes,opening up new possibilities for innovative *** review explores the early discovery of natural brochosomes and their geometrical features,followed by the recent progress in fabricating synthetic brochosomes and their *** on future applications and challenges in the scalable manufacturing of synthetic brochosomes are discussed.

关键词： synthetic brochosomes leafhopper antireflection superhydrophobicity surface-enhanced Raman scattering photocatalyst energy harvesting

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Relationship between physical activity and specific working memory indicators of depressive symptoms in university students

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World Journal of Psychiatry 2024年第1期14卷 148-158页

作者： Qun Zhao Xing Wang Shu-Fan Li Peng Wang Xiang Wang Xin Xin Suo-Wang Yin Zhao-Song Yin Li-Juan Mao School of Physical Education Shanghai University of SportShanghai 200438China Department of Physical Education Donghua UniversityShanghai 201620China

BACKGROUND The detection rate of depression among university students has been increasing in recent years,becoming one of the main psychological diseases that endangers their physical and mental *** to statistics,self-harm and suicide,for which there is no effective intervention,are the second leading causes of *** To explore the relationship between different elements and levels of physical activity and college students’depression-symptom-specific working memory *** Of 143 college students were analyzed using the Beck Depression Self-Rating Scale,the Physical Activity Rating Scale,and the Working Memory *** There was a significant difference between college students with depressive symptoms and healthy college students in completing verbal and spatial working memory(SWM)tasks correctly(all P0.05).CONCLUSION An increase in physical exercise among college students,particularly medium-and high-intensity exercise and exercise of 30 min or more,can improve the correct rate of completing working memory tasks.

关键词： Physical activity Depression symptoms university students Working memory

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