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Pain Studies and Treatment 2014年第1期2卷 6-10页

作者： Marco Antonio Mibielli Carlos Pereira Nunes Ari Boulanger Scussel Jr. Mendel Suchmacher Neto Lisa Oliveira Mauro Geller Teresópolis medical school-unifeso Rio de Janeiro Brazil

Rationale: In a previously published trial on spinal acute non-traumatic pain, peripheral neuro- regenerative combination of UTP, CMP and hydroxocobalamin presented unexpected analgesicproperties. Objective: To corroborate analgesiceffects of UTP, CMP and hydroxocobalamin combination in a self-paired evolutionary model. Methods: Mean VAS scores from pretreatment, V2 (5th treatment day) and V3 (10th treatment day) were plotted and statistically analyzed (ANOVA) for differences. PFQ scores from pretreatment, V2, and V3 were analyzed using the chisquare test. Results: The difference between V3 and pretreatment mean VAS scores was statistically significant (p < 0.0001). The improvement in PFQ scores throughout the study was found to be statistically significant (p < 0.0001). Conclusion: The combination of UTP, CMP and hydroxocobalamin seems to have analgesic properties in mediumterm use. The complex peripheral neu-roregenerative pharmacodynamics of this combination provides a plausible basis for this finding. Further randomized studies are needed to explore this combination for the indication of neuropathic pain due to spinal structure involvement.

关键词： Uridine Triphosphate Cytidine Monophosphate Hydroxocobalamin Analgesia

Impact of Low Back Pain on Quality of Life: Assessment by Patient Functionality Questionnaire and Treatment Results Using a Combination of Diclofenac plus B Vitamins or Diclofenac Monotherapy

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International Journal of Clinical Medicine 2016年第2期7卷 113-119页

作者： Mauro Geller Marco Antonio Mibielli Carlos Pereira Nunes Adenilson de Souza da Fonseca Stephanie Wrobel Goldberg Lisa Oliveira Teresópolis medical school UNIFESO Rio de Janeiro Brazil Washington University school of Medicine St. Louis MO USA

Objective: To analyze the Patient Functionality Questionnaire (PFQ) scores of the patients treated with either Diclofenac + B vitamins (Group DB) or Diclofenac monotherapy (Group D) in order to better understand the impact of the combination of diclofenac with vitamins B1, B6, and B12 on quality of life. Research Design/Methods: We performed a post-hoc analysis of tabulated data generated during the DOLOR study (Diclofenac plus B vitamins versus diclofenac monotherapy in lumbago: the DOLOR study), using the software GraphPad Prism 5 for Windows, v5.04. The absolute number or percentage of “True”/“False” respondents for each questionnaire item at each study visit, together with the absolute number and percentage of subjects with no change, improvement, or worsening of each PFQ item at each study visit, within and between treatment groups were arranged on contingency tables and analyzed with the Chi-squared or Fisher’s Exact test. Results: At pretreatment there were no statistically significant differences between treatment groups (p > 0.05 for all items). At Visit 2 in both treatment groups, there were statistically significant improvements in individual question responses in each of the 12 items of the questionnaire (p < 0.05 for all items). At Visit 2, comparing the distribution of patients in each treatment group with “improvement”, “no change”, or “worsening”, there was a statistically significant superiority among subjects of group DB in response to items 1, 6, 8, and 10. At Visit 3, both groups had statistically significant (p < 0.001) improvements in each individual item of the PFQ in relation to pretreatment values. The distribution of subjects in each treatment group presenting with “improvement”, “no change”, or “worsening” at Visit 3 varied significantly in favor of group DB in the responses to item 4. At Visit 4, the subjects remaining in treatment in both groups showed statistically significant improvement in PFQ response

关键词： Low Back Pain Quality Of Life Diclofenac Thiamine Pyridoxine Cyanocobalamin

Case Report: Clinical and Diagnostic Aspects of Mayer-Rokitansky-Kuster-Hauser Syndrome

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Health 2019年第10期11卷 1367-1372页

作者： Lucas Ferreira de Paula Filho Guilherme Carolino Neves Laís Figueira Bandoli Lucas Caraline de Almeida Coelho Nathália de Souza Ferreira Feital Renan Vieira Murad Ana Luísa Conceiç o de Jesus Diana Aristótelis de Sá Larissa Bianca Cunha de Sá Jonathan Mwambire Alberto Krayyem Arbex IPEMED medical school/AFYA Educational Postgraduation in Endocrinology Rio de Janeiro Brazil unifeso medical school Teresópolis Brazil Department of Pediatrics Medical School University of So Paulo (USP) So Paulo Brazil medical Clinic in Endocrinology and Diabetology Schleswig-Flensburg Germany.

Mayer-Rokitansky-Kuster-Hauser Syndrome (MRKH) is a rare disease characterized by total or partial vagina agenesis, karyotype 46, XX with normal secondary sexual characters. Still, it is the second leading cause of primary amenorrhea. The absence of obvious signs and symptoms often causes the syndrome to be diagnosed only after puberty. The case presented here highlights exactly this difficulty of early diagnosis, which meets the objective of the study, and is precisely to provide reliable material that facilitates the diagnosis and management of patients with MRKH syndrome.

关键词： Mayer-Rokitansky-Kuster-Hauser Syndrome Primary Amenorrhea Gonadal Dysgenesis

Assessment of Acute Episodes in Chronic Stable Angina: A Clinical-Laboratory Approach to the Use of the Coronary Vasodilator Propatyl Nitrate

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World Journal of Cardiovascular Diseases 2016年第7期6卷 246-252页

作者： Gerson Goldwasser Renato Kaufman Carlos Pereira Nunes Alexandre Hid Stephanie Wrobel Goldberg Alessandra Santos Lisa Oliveira Adenilson de Souza da Fonseca Mauro Geller Souza Marques medical school Rio de Janeiro Brazil Universidade Estadual do Rio de Janeiro Rio de Janeiro Brazil unifeso medical school Teresópolis Brazil Washington University school of Medicine St. Louis MO USA

Background/Objectives: Propatyl nitrate is a coronary vasodilator with immediate and prolonged action, indicated in the treatment and prevention of acute angina pectoris episodes. Methods: This was an open, self-paired comparative study performed at unifeso medical school evaluating the clinical and laboratory results of treatment with propatyl nitrate in patients with chronic stable angina pectoris. Subjects received 10 mg of propatyl nitrate, at the dose of three sublingual tablets per day, to be taken at 8:00 A.M., 2:00 P.M., and 8:00 P.M. Subjects returned to the study center after 15 days of treatment for Visit 2 assessments, and at the end of the 30-day treatment period (Visit 3). Results: A total of 200 subjects were included in the study. There was a statistically significant reduction in blood pressure (p < 0.0001) and heart rate (p = 0.0001), but no change in respiratory rate (p = 0.23). Laboratory results did not vary throughout the treatment period. There was no significant change from pretreatment in the SAQ Physical Limitation scale (p = 0.7415). The Angina Stability, Angina Frequency, and Treatment Satisfaction, and Quality of Life scales showed a significant improvement from pretreatment (p < 0.0001). Adverse events were observed among 41 subjects at Visit 2 and 35 subjects at Visit 3. Conclusions: Propatyl nitrate was safe and effective in treating chronic stable angina pectoris over the course of the 30-day treatment period. Treatment with propatyl nitrate increased angina stability and reduced angina frequency while increasing treatment satisfaction and quality of life in the patient population evaluated.

关键词： Propatyl Nitrate Stable Chronic Angina Pectoris Seattle Angina Questionnaire

Pain Exposure Physical Therapy(PEPT)in Complex Regional Pain Syndrome Type 1:A Systematic Review

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Journal of Pharmacy and Pharmacology 2019年第3期7卷 124-131页

作者： Nicoli Greco Müller Glória Maria Moraes Vianna da Rosa Graduated by Centro Universitário IBMR FVS’s Gymnasium Sports PhysiotherapyEFI PhysiotherapyRio de JaneiroRJBrazil school of Physiotherapy Serra dos Orgaos University Center(UNIFESO)TeresolisRJBrazil

Complex regional pain syndrome type 1(CRPS-1)is a debilitating and progressive pathology in which chronic symptoms affect the functional capacity,and there are discussions about its best form of *** aim of this study was to investigate the effectiveness of pain exposure physical therapy(PEPT)on functional recovery of these patients and to compare with conventional *** bibliographic searches were performed with qualitative and quantitative exploratory objective of scientific articles of the last 10 years in the databases PubMed,EBSCO and *** studies were selected to analyze:Ek et al.(2009)conducted evaluations at baseline and 3 months after the last session,with 106 *** evaluations by Meent et al.‘s paper(2011)realized pre-treatment and 12 months after last session,with 20 *** Barnhoorn et al.‘s article(2015)the only one to perform controlled and randomized study with 56 patients divided into PEPT and conventional,and evaluations were pre-treatment,3,6,and 9 months after the last session;performed 5 treatment sessions of 40 minutes,as well as in the other *** were positive and significant outcomes on the intervention of PEPT in CRPS-1,showing that this treatment is effective in functional recovery of these patients.

关键词： Reflex sympathetic dystrophy PEPT quality of life

A case of 25-year-old giant neurofibromatosis

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Plastic and Aesthetic Research 2016年第1期3卷 279-281页

作者： Marcos Sforza Renato Zaccheddu Bruno Lopes Cancado Deborah Sforza Plastic Surgery Dolan Park HospitalStoney Lane B601LYUK school of Medicine SESAMinas Gerais 35430-302Brazil school of Medicine UNIFESORio de Janeiro 25964-000Brazil Private Practice Rio de Janeiro 22410-003Brazil

In this paper,the authors presented a case report of a 39-year-old man taken to the Emergency Unit with a 25-year-old giant ***,the treatment applied for this case and the physiopathology of the neurofibromatosis dise... 详细信息

关键词： Giant neurofibromatosis physiopathology neurofibromas

Clinical Assessment of Treatment Outcomes Following Borago officinalis Extract Therapy in Patients Presenting with Cyclical Mastalgia

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International Journal of Clinical Medicine 2015年第6期6卷 363-371页

作者： Carlos Romualdo Barboza Gama Ricardo Lasmar Gustavo Falcao Gama Lisa Oliveira Erika Cesar de Oliveira Naliato Marcia Goncalves Ribeiro Flavia de Paoli Adenilson de Souza da Fonseca Camila Sirieiro Abreu Mauro Geller Alessandra Santos Teresopolis medical school—unifeso Rio de JaneiroBrazil Universidade Federal Fluminense—UFF Rio de JaneiroBrazil Universidade Federal de Juiz de Fora—UFJF Juiz de ForaBrazil Universidade Federal do Rio de Janeiro—UFRJ Rio de JaneiroBrazil Instituto de Pós-Graduacao Medica Carlos Chagas Rio de JaneiroBrazil

In order to evaluate the safety and efficacy of Borago officinalis (900 mg borage oil capsules) in the treatment of patients presenting with cyclic mastalgia, 91 subjects were included in the study. Efficacy assessments were performed based on data obtained prior to the start of treatment (Pretreatment), and after each menstrual cycle (Assessment 2—following 45 days of treatment;and Assessment 3—at the end of the 90-day treatment period). Primary efficacy measures considered the results of the Mastalgia Questionnaire, including a 100 mm visual analog pain scale assessing mean, most intense mastalgia severity, and impact on work, sleep, and sexual activity. Safety and tolerability measures included any changes in vital signs and physical exam in relation to pretreatment, any changes in clinical laboratory exams in relation to pretreatment, and the occurrence of adverse events after the first dose of study medication. The VAS scores of the mean mastalgia and most severe mastalgia both showed statistically significant

关键词： Cyclic Mastalgia Borago officinalis Borage Oil

Meningococcal disease, a clinical and epidemiological review

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Asian Pacific Journal of Tropical Medicine 2017年第11期10卷 1019-1029页

作者： Rodrigo Siqueira Batista Andreia Patricia Gomes Jorge Luiz Dutra Gazineo Paulo Sergio Balbino Miguel Luiz Alberto Santana Lisa Oliveira Mauro Geller Laboratorio de Agentes Patogenicos Departamento de Medicina e Enfermagem Universidade Federal de VicosaVicosaMGBrazil Curso de Medicina Faculdade Dinamica do Vale do PirangaPonte NovaMGBrazil Hospital Universitario Clementino Fraga Filho Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Curso de Medicina Centro Universitario Serra dos Orgaos (UNIFESO)TeresopolisRJBrazil school of Medicine New York University–NYUNew YorkUSA Departamento de Genetica Medica Universidade Federal do Rio de Janeiro (UFRJ)Rio de JaneiroRJBrazil

Meningococcal disease is the acute infection caused by Neisseria meningitidis, which has humans as the only natural host. The disease is widespread around the globe and is known for its epidemical potential and high rates of lethality and morbidity. The highest number of cases of the disease is registered in the semi-arid regions of sub-Saharan Africa. In Brazil, it is endemic with occasional outbreaks, epidemics and sporadic cases occurring throughout the year, especially in the winter. The major epidemics of the disease occurred in Brazil in the 70's caused by serogroups A and C. Serogroups B, C and Y represent the majority of cases in Europe, the Americas and Australia. However, there has been a growing increase in serogroup W in some areas. The pathogen transmission happens for respiratory route(droplets) and clinically can lead to meningitis and sepsis(meningococcemia). The treatment is made with antimicrobial and supportive care. For successful prevention, we have some measures like vaccination, chemoprophylaxis and droplets' precautions. In this review, we have described and clarify clinical features of the disease caused by N. meningitidis regarding its relevance for healthcare professionals.

关键词： Neisseria meningitidis Bacterial infection Meningococcal disease

Clinical Assessment of the Use of Propinox Hydrochloride and Scopolamine Hydrochloride in the Treatment of Abdominal Colic: A Retrospective, Comparative Study

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International Journal of Clinical Medicine 2016年第7期7卷 474-480页

作者： Helio Rzetelna Carlos Frederico Porto Alegre Rosa Mario Kirzner Lucas Pereira Jorge de Medeiros Camila Melo Marcia Gonçalves Ribeiro Lisa Oliveira José Galvão Alves Mauro Geller Gastroenterology Department Universidade Federal do Rio de Janeiro (UFRJ) Rio de Janeiro Brazil Clinical Medicine Department Centro Universitário Volta Redonda (UNIFOA) Volta Redonda Brazil Clinical Medicine and Gastroenterology Department Universidade Estácio de Sá (UNESA) Rio de Janeiro Brazil Clinical Medicine Department Escola de Medicina Souza Marques Rio de Janeiro Brazil 5Inflammatory Bowel Diseases Outpatient Unit-18 ª enfermaria da Santa Casa da Misericórdia do Rio de Janeiro Rio de Janeiro Brazil Federação Brasileira de Gastroenterologia S&atildeo Paulo Brazil Grupo de Estudos de Doenças Inflamatórias Intestinais Rio de Janeiro Brazil UNESA Rio de Janeiro Brazil Gastroenterology Post-Graduation Program-PUC-Rio Rio de Janeiro Brazil Neurology Post-Graduation Program Universidade Federal do Estado do Rio de Janeiro (UERJ) Rio de Janeiro Brazil Pharmacology Department—UFRJ Rio de Janeiro Brazil medical Genetics Service IPPMG-Universidade Federal Rio de Janeiro Rio de Janeiro Brazil Immunology Department Teresópolis Medical School (UNIFESO) Teresópolis Brazil Clinical Immunology Instituto de Pós-Gradua&ccedil&atildeo Médica Carlos Chagas (IPGMCC) Rio de Janeiro Brazil

Objectives: The purpose of this study was to evaluate and compare the use of propinox hydrochloride and scopolamine hydrochloride in patients presenting abdominal colic (abdominal pain), in terms of treatment efficacy and tolerability. Material & Methods: This was an analytical, retrospective, comparative study based on hospital records of outpatients treated at Serviço de Clínica Médica do Hospital das Clínicas Costantino Otaviano (HCTCO) and at Santa Casa de Misericórdia do Rio de Janeiro, from 1988-1998. Subjects were divided into two groups: patients from Group 1 were treated with propinox hydrochloride, while patients from Group 2 were treated with scopolamine hydrochloride. Statistical analysis was performed using GraphPad Prism version 5.0. For comparison of categorical variables, we used the chi-squared or Fisher’s test, while continuous variables were analyzed using ANOVA or the Student’s T test. Results: A total of 1042 subjects were included, of which 525 were allocated to Group 1 and 517 to Group 2. Mean treatment duration was 9.166 days (±4.208) in Group 1 and 8.795 days (±5.052) in Group 2, with no statistically significant difference in treatment duration between the two groups (p = 0.198). All subjects in Group 1 were treated with propinox 10 mg (2 coated tablets, three times per day) while all subjects in Group 2 were treated with scopolamine hydrochloride 10 mg (2 coated tablets, three times per day). There were no statistically significant between-group differences in weight, BMI, heart rate, and respiratory rate at pre- and post-treatment;with the exception of higher post-treatment systolic blood pressure in Group 1, blood pressure measures also remained homogenous. Adverse events were reported among both treatment groups with no significant between-group difference in incidence (p = 0566). At pretreatment, pain intensity was more severe in Group 1 (p = 0.0257), while at post-treatment, there was no statistically significant difference betw

关键词： Abdominal Colic Propinox Hydrochloride Scopolamine Hydrochloride