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Validation of a HPLC Method for Determination of Glutamine in Food Additives Using Post-Column Derivatization

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American Journal of Analytical Chemistry 2012年第2期3卷 113-117页

作者： Marlus Chorilli Herida Regina Nunes Salgado Fabiana De Santana Santos Lucelia Magalhaes Da Silva Departamento de Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas de AraraquaraUniversidade Estadual Paulista(UNESP)AraraquaraBrazil Faculdade de Americana AmericanaBrazil Programa de Pos-Graduacao em Ciencias Farmaceuticas Faculdade de Ciencias Farmaceuticas de AraraquaraUniversidade Estadual Paulista(UNESP)AraraquaraBrazil

An ion-exchange chromatography (IEC) followed by post-column derivatization method was validated for the determination of glutamine in food additive products. The chromatographic method was carried out on a sodium cation-exchange column and using detection at 570 nm. The mobile phase consisted of sodium eluant, pH 3.15, with 5% sulfolane, sodium eluant, pH 7.40 and sodium column regenerant. The method was linear in the range of 4 - 50 μg/mL (r2 = 0.9999). The accuracy was 99.78%. Moreover, method validation demonstrated acceptable results for precision and robustness. The method was found to be able to use for routine analysis of the glutamine.

关键词： Glutamine Food Additive Product Liquid Chromatography

Protective Effect of Taurine in the Induction of Genotoxicity by Mutagenic Drugs

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Journal of Pharmacy and Pharmacology 2018年第1期6卷 1-9页

作者： Priscila Longhin Bosquesi Caue Benito Scarim Jose Ricardo Soares de Oliveira Ednir de Oliveira Vizioli Jean Leandro dos Santos Chung Man Chin Departamento de Farmacos e Medicamentos Faculdade de Ciencias Farmaceuticas Universidade Estadual Paulista "Julio deMesquita Filho " UNESP Araraquara 14800-903 Brasil

Phase Transformations in PZT Thin Films Prepared by Polymeric Chemical Method

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Advances in Materials Physics and Chemistry 2012年第3期2卷 178-184页

作者： Elton C. Lima Eudes Borges Araújo Faculdade de Engenharia de Ilha Solteira Departamento de Física e Química UNESP—Universidade Estadual Paulista Ilha Solteira Brazil

Lead zirconate titanate Pb(Zr0.50Ti0.50)O3 (PZT) thin films were deposited by a polymeric chemical method on Pt(111)/ Ti/SiO2/Si substrates to understand the mechanisms of phase transformations in these films. PZT films pyrolyzed at temperatures higher than 350℃ present a coexistence of pyrochlore and perovskite phases, while only perovskite phase is present in films pyrolyzed at temperatures lower than 300℃. For films where the pyrochlore and perovskite phase coexists the amount of pyrochlore phase decreases from top surface to the bottom film-electrode interface and the PZT structure near top surface are Ti-rich compositions while near the bottom film-electrode interface the compositions are Zr-rich. For pyrochlore-free PZT thin film, a small (100) orientation tendency near the film-electrode interface was observed.

关键词： PZT Thin Films Phase Transformation

Direct evidence of traps controlling the carriers transport in SnO_(2) nanobelts

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Journal of Semiconductors 2017年第12期38卷 8-12页

作者： Olivia M.Berengue Adenilson J.Chiquito LCCTnano Departamento de Fisica e Quimica-Universidade Estadual Paulista(Unesp)Faculdade de Engenharia de GuaratinguetfiCampus GuaratinguetfiSgo PauloBrasil NanO LaB-Departamento de Fisica Universidade Federal de Sao CarlosCEP 13565-905CP 676Sgo CarlosSgo PauloBrasil

This work reports on direct evidence of localized states in undoped Sn02 nanobelts. Effects of disorder and electron localization were observed in Schottky barrier dependence on the temperature and in thermally stimulated currents. A transition from thermal activation to hopping transport mechanisms was also observed. The energy levels found by thermally stimulated current experiments were in close agreement with transport data confirming the role of localization in determining the properties of devices.

关键词： trap transport SnO2

Relationship between Fusobacterium nucleatum,inflammatory mediators and microRNAs in colorectal carcinogenesis

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World Journal of Gastroenterology 2018年第47期24卷 5351-5365页

作者： Marcela Alcantara Proenca Joice Matos Biselli Maysa Succi Fábio Eduardo Severino Gustavo Noriz Berardinelli Alaor Caetano Rui Manuel Reis David J Hughes Ana Elizabete Silva Department of Biology UNESPUniv. Estadual PaulistaCampus of Sao Jose do Rio PretoSao Jose do Rio PretoSao Paulo 15054-000Brazil Department of Surgery and Orthopedics Faculty of MedicineUNESPUniv. Estadual PaulistaCampus of BotucatuBotucatuSao Paulo 18618-687Brazil Endoscopy Center of Rio Preto Sao Jose do Rio PretoSao Paulo 15015-700Brazil Molecular Oncology Research Center Barretos Cancer HospitalBarretosSao Paulo 14784-400Brazil Life and Health Sciences Research Institute University of MinhoCampus GualtarBraga 4710-057Portugal ICVS/3B’s-PT Government Associate Laboratory Campus GualtarBraga 4710-057Portugal Cancer Biology and Therapeutics Group UCD Conway InstituteUniversity College DublinDublin D04 V1W8Ireland

AIM To examine the effect of Fusobacterium nucleatum(F. nucleatum) on the microenvironment of colonic neoplasms and the expression of inflammatory mediators and microRNAs(miRNAs).METHODS Levels of F. nucleatum DNA, cytokine gene mRNA(TLR2, TLR4, NFKB1, TNF, IL1 B, IL6 and IL8), and potentially interacting miRNAs(miR-21-3p, miR-22-3p, mi R-28-5p, miR-34a-5p, miR-135b-5p) were measured by quantitative polymerase chain reaction(qPCR) TaqMan? assays in DNA and/or RNA extracted from the disease and adjacent normal fresh tissues of 27 colorectal adenoma(CRA) and 43 colorectal cancer(CRC) patients. KRAS mutations were detected by direct sequencing and microsatellite instability(MSI) status by multiplex PCR. Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction *** Overabundance of F. nucleatum in neoplastic tissue compared to matched normal tissue was detected in CRA(51.8%) and more markedly in CRC(72.1%). We observed significantly greater expression of TLR4, IL1 B, IL8, and miR-135 b in CRA lesions and TLR2, IL1 B, IL6, IL8, mi R-34 a and miR-135 b in CRC tumours compared to their respective normal tissues. Only two transcripts for miR-22 and miR-28 were exclusively downregulated in CRC tumour samples. The mRNA expression of IL1 B, IL6, IL8 and miR-22 was positively correlated with F. nucleatum quantification in CRC tumours. The mRNA expression of miR-135 b and TNF was inversely correlated. The miRNA:mRNA interaction network suggested that the upregulation of miR-34 a in CRC proceeds via a TLR2/TLR4-dependent response to F. nucleatum. Finally, KRAS mutations were more frequently observed in CRC samples infected with F. nucleatum and were associated with greater expression of miR-21 in CRA, while IL8 was upregulated in MSI-high *** Our findings indicate that F. nucleatum is a risk factor for CRC by increasing the expression of inflammatory mediators through a possible mi RNA-mediated activation of TLR2/TLR4.

关键词： Colorectal cancer Colorectal adenoma Fusobacterium nucleatum Inflammation Cytokines MicroRNAs

Breaking Dormancy of “Tupy” Blackberry in Subtropical Conditions

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American Journal of Plant Sciences 2015年第11期6卷 1760-1767页

作者： Daniela Mota Segantini Sarita Leonel Ana Karolina da Silva Ripardo Marco Antonio Tecchio Manoel Euzebio de Souza Departamento de Horticultura Faculdade de Ciências Agron&ocircmicas Universidade Estadual Paulista (UNESP) Botucatu Brasil Departamento de Agronomia Universidade Estadual de Mato Grosso (UNEMAT) Nova Xavantina Brasil

In subtropical or tropical conditions, the insufficient winter chill accumulation is often a limiting factor to break the dormancy of temperate-climate species such as the blackberry, which requires using products to help break dormancy. This study evaluates the efficacy of compounds in breaking dormancy of blackberry and its consequent influence on phenology and crop yields. The experiment was conducted in S?o Manuel, State of S?o Paulo, Brazil, in the 2011/2012 production cycle. The plants used were two-year-old “Tupy” blackberry (Rubus spp.), with 0.6 × 4.0 m spacing (4.166 plants·ha-1). Pruning was performed in August, followed by the application of these treatments: control (water);hydrogen cyanamide (Dormex?);nitrogen fertilizer (Erger?) and mineral oil (Assist?). The concentrations of each compound used were: 2.0%, 4.0%, 6.0% and 8.0%. The compounds used influenced the budding, flowering and fruit harvest stages, in addition to providing increased yields depending on the concentration used. For hydrogen cyanamide the recommended concentration is of 4.2% and 5.4% for nitrogen fertilizer;doses above these concentrations may cause phytotoxic effects. For mineral oil the dose recommended is of 8.0%.

关键词： Rubus spp. Phenology Yield Growth Regulator

Energy Efficiency Technologies for Hydroelectric Power Plants: A Case Study in Brazil

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Journal of Power and Energy Engineering 2022年第5期10卷 90-115页

作者： Thiago Averaldo Bimestre José Antonio Mantovani Júnior Eliana Vieira Canettieri Celso Eduardo Tuna Pedro Magalhães Sobrinho Chemistry and Energy Department School of Engineering S&#227o Paulo State University UNESP Guaratinguetá Brazil Center for Weather Forecasting and Climate Studies National Institute for Space Research CPTEC/INPE Cachoeira Paulista Brazil

Hydroelectricity has great importance for the global macroeconomy. In Brazil, hydroelectricity has been highlighted as the main source of generation of the electric system both for its economic competitiveness and for the abundance of this energy resource. Based on a diagnosis methodology, this article presents a case study in a Brazilian hydroelectric plant in order to optimize the use of energy and propose improvements regarding the rationalization of its application. The systems associated with energy generation were evaluated and the results proved to be potentially advantageous with an estimated savings of 2910 MWh/year in the electricity consumption of the installation itself, with better use of the equipment and the possibility of increasing the power generated.

关键词： Hydropower Plant Renewable Energy Technology Energy Efficiency Energetic Diagnosis Sustainable

Spatial-temporal pattern of cutaneous leishmaniasis in Brazil

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Infectious Diseases of Poverty 2021年第3期10卷 47-57页

作者： Tatiana P.Portella Roberto A.Kraenkel Departsmento de Ecologia Instituto de BiocienciasUniversidade de Sao PauloSao PauloBrazil lnstituto de Fisica Teorica Universidade Estadual PaulistaSao PauloBrazil.

Background:Cutaneous leishmaniasis(CL)is a vector-borne disease classified by the World Health Organization as one ofthe most neglected tropical *** has the highest incidence of CL in America and is one of the ten countries in the world with the highest number of *** the spatiotemporal dynamics of CL is essential to provide guidelines for public health policies in *** the present study we used a spatial and temporal statistical approach to evaluate the dynamics ofCL in ***:We used data of cutaneous leishmaniasis cases provided by the Ministry of Health of Brazil from 2001 to *** calculated incidence rates and used the Mann-Kendall trend test to evaluate the temporal trend of CL in each *** addition,we used Kuldorff scan method to identify spatiotemporal clusters and emerging hotspots test to evaluate hotspot areas and their temporal ***:We found a general decrease in the number of CL cases in Brazil(from 15.3 to 8.4 cases per 100000 habitants),although 3.2%of municipalities still have an increasing tendency of CL incidence and 72.5%showed no tendency at *** scan analysis identified a primary cluster in northern and central regions and 21 secondary clusters located mainly in south and southeast *** emerging hotspots analysis detected a high spatial and temporal variability of hotspots inside the main cluster area,diminishing hotspots in eastern Amazon and permanent,emerging,and new hotspots in the states of Amapa and parts of Para,Roraima,Acre and Mato *** central coast the state of Bahia is one of the most critical areas due to the detection of a cluster of the highest rank in a secondary cluster,and because it is the only area identified as an intensifying ***:Using a combination of statistical methods we were able to detect areas of higher incidence of CL and understand how it changed over *** suggest that these areas,especially those identified as perman

关键词： Cutaneous leishmaniasis Spatiotemporal cluster Emerging hotspot Temporal trend Brazil

Foliar Nutrient Balance Standards for Maize (<i>Zea mays</i>L.) at High-Yield Level

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American Journal of Plant Sciences 2014年第4期5卷 497-507页

作者： Viviane Cristina Modesto Serge-étienne Parent William Natale Léon Etienne Parent Departamento de Solos e Adubos Unesp Universidade Estadual Paulista Jabotocabal Brazil ERSAM Department of Soils and Agrifood Engi-neering Université Laval Québec Canada

Maize is one of the most nutrient demanding staple crops. Tissue nutrient diagnosis of maize is currently conducted using critical nutrient concentration or dual ratio ranges, but such diagnoses are pathological as biased by data redundancy, sub-compositional incoherence and non-normal distribution. The use of orthogonal balances, a compositional data analysis technique, avoids such biases. Our objective was to develop foliar nutrient balance standards for maize. We collected 758 grain yields (15.5% moisture content) and foliar samples at silk stage in maize fields of southern Quebec, Canada, and analyzed ten nutrients in tissues (N, P, K, Ca, Mg, B, Cu, Zn, Mn, Fe). Nutrients were arranged into ad hoc balances and computed as isometric log ratios (ilr). An optimized binary classification performed by a customized receiver operating characteristic procedure showed that a critical Mahalanobis distance of 4.21 separated balanced from imbalanced specimens about yield cut-off of 11.83 Mg grain·ha-1 with test performance of 86%. Quebec maize balance standards differed from published standards computed from DRIS norms collected in other agroecosystems. The Redfield N/P ratio in maize leaves was found to be the least variable balance across regions of the world. The DRIS dual ratios and raw concentration values were found to be geometrically inadequate for conducting diagnosis. The unbiased nutrient balance diagnosis combined the critical Mahalanobis distance and a mobile representation of nutrient balances with ilr means of true negative (TN) specimens centered at fulcrums and back-transformed ilr values of TN specimens into raw concentrations loading the buckets below. Nutrients can be appreciated as relative shortage, adequacy or excess in the concentration domain following statistical analysis and diagnosis in the unbiased balance domain.

关键词： Compositional Data Analysis Critical Range Diagnosis and Recommendation Integrated System DRIS Ionomics Nutrient Balance Nutrient Interactions